ATE277041T1 - Verfahren und zwischenprodukte für die herstellung von 5-(4-(benzisothiazol-3-yl)- piperazin-1-yl)ethyl)-6 chlor-1,3-dihydro-indol-2-one - Google Patents
Verfahren und zwischenprodukte für die herstellung von 5-(4-(benzisothiazol-3-yl)- piperazin-1-yl)ethyl)-6 chlor-1,3-dihydro-indol-2-oneInfo
- Publication number
- ATE277041T1 ATE277041T1 AT94910016T AT94910016T ATE277041T1 AT E277041 T1 ATE277041 T1 AT E277041T1 AT 94910016 T AT94910016 T AT 94910016T AT 94910016 T AT94910016 T AT 94910016T AT E277041 T1 ATE277041 T1 AT E277041T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- alkyl
- compound
- benzisothiazole
- indol
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- GTMDTZKPEQSFET-UHFFFAOYSA-N O=C1NC2=CC=CC=C2C1.[Cl] Chemical compound O=C1NC2=CC=CC=C2C1.[Cl] GTMDTZKPEQSFET-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/083,429 US5359068A (en) | 1993-06-28 | 1993-06-28 | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one |
| PCT/IB1994/000061 WO1995000510A1 (en) | 1993-06-28 | 1994-04-06 | Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277041T1 true ATE277041T1 (de) | 2004-10-15 |
Family
ID=22178273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94910016T ATE277041T1 (de) | 1993-06-28 | 1994-04-06 | Verfahren und zwischenprodukte für die herstellung von 5-(4-(benzisothiazol-3-yl)- piperazin-1-yl)ethyl)-6 chlor-1,3-dihydro-indol-2-one |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5359068A (de) |
| EP (1) | EP0706524B1 (de) |
| JP (1) | JP2667987B2 (de) |
| AT (1) | ATE277041T1 (de) |
| CA (1) | CA2166203C (de) |
| DE (1) | DE69434020T2 (de) |
| DK (1) | DK0706524T3 (de) |
| ES (1) | ES2227524T3 (de) |
| FI (1) | FI119372B (de) |
| PT (1) | PT706524E (de) |
| WO (1) | WO1995000510A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3701044B2 (ja) * | 1995-04-24 | 2005-09-28 | 住友精化株式会社 | シアノベンゼンスルフェニルハライドおよびそれを用いる３−置換ベンゾイソチアゾールの製造方法 |
| ATE254600T1 (de) * | 1996-02-13 | 2003-12-15 | Pfizer | Prodrogen von 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl ethyl)-6-chloro-1,3-dihydro-2h-indol- 2-on |
| IL126590A (en) * | 1996-05-07 | 2001-11-25 | Pfizer | Trihydrate salt of -5 (-2 (-4 (1 (2, 2-benzothiazole - 3yl) -1-piperazinyl) ethyl) - 6-chloro-1, 3-dihydro-2 (1H) - indole - 2On (= Ziprasidone) and pharmaceutical preparations containing it |
| TW491847B (en) * | 1996-05-07 | 2002-06-21 | Pfizer | Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one |
| IL127497A (en) * | 1997-12-18 | 2002-07-25 | Pfizer Prod Inc | Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders |
| US6150366A (en) * | 1998-06-15 | 2000-11-21 | Pfizer Inc. | Ziprasidone formulations |
| UY27668A1 (es) * | 2002-02-20 | 2003-10-31 | Pfizer Prod Inc | Composición de ziprasidona y controles sintéticos |
| US20040048876A1 (en) * | 2002-02-20 | 2004-03-11 | Pfizer Inc. | Ziprasidone composition and synthetic controls |
| AU2003260942A1 (en) * | 2002-05-24 | 2003-12-12 | Sun Pharmaceutical Industries Limited | A process for the preparation of oxindole derivatives |
| US7488729B2 (en) | 2002-12-04 | 2009-02-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof |
| WO2004050655A1 (en) * | 2002-12-04 | 2004-06-17 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride |
| EP1546146A1 (de) * | 2003-06-03 | 2005-06-29 | Teva Pharmaceutical Industries Limited | Polymorphe formen von zipradison hcl und ihr verfahren zur herstellung |
| CA2543805A1 (en) * | 2003-10-24 | 2005-05-06 | Gideon Pilarsky | Processes for preparation of ziprasidone |
| EP1687300A4 (de) * | 2003-11-28 | 2007-08-01 | Wockhardt Ltd | Verfahren zur herstellung von ziprasidonmonohydrochlorid-hydrat |
| CA2550485A1 (en) * | 2003-12-18 | 2005-07-07 | Teva Pharmaceutical Industries Ltd. | Polymorphic form b2 of ziprasidone base |
| CA2467538C (en) | 2004-05-14 | 2010-08-24 | Apotex Pharmachem Inc. | New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same |
| CA2471219A1 (en) | 2004-06-14 | 2005-12-14 | Apotex Pharmachem Inc. | Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) |
| US7777037B2 (en) * | 2004-10-27 | 2010-08-17 | Dr. Reddy's Laboratories Limited | Ziprasidone process |
| CA2593497A1 (en) * | 2005-02-11 | 2006-08-17 | Judith Aronhime | Amorphous ziprasidone mesylate |
| EP1858891A2 (de) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd. | Kristalline formen von ziprasidonmesylat |
| EP1858892A1 (de) * | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd | Wasserfreies ziprasidon-mesylat und verfahren zu seiner herstellung |
| US8097610B2 (en) * | 2005-08-26 | 2012-01-17 | Shionogi & Co., Ltd. | Derivative having PPAR agonistic activity |
| ES2383101T3 (es) | 2007-01-26 | 2012-06-18 | Basf Se | Compuestos de 3-amino-1,2-bencisotiazol para combatir plagas animales II |
| PL391810A1 (pl) | 2010-07-14 | 2012-01-16 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Nowe sole ziprasidonu oraz sposoby ich otrzymywania |
| CN104370850B (zh) * | 2013-08-14 | 2018-02-27 | 上海天慈生物谷生物工程有限公司 | 一种齐拉西酮关键中间体的制备方法 |
| JP2024177597A (ja) * | 2021-11-04 | 2024-12-20 | 日産化学株式会社 | インドール化合物の製造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721712A (en) * | 1984-06-12 | 1988-01-26 | Pfizer Inc. | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| US4690943A (en) * | 1984-09-19 | 1987-09-01 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| US4952584A (en) * | 1986-01-11 | 1990-08-28 | Beecham Group P.L.C. | 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity |
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| JPH0252042A (ja) * | 1988-08-17 | 1990-02-21 | Hitachi Plant Eng & Constr Co Ltd | 空気の浄化剤及びその製造方法 |
| US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
| US5338846A (en) | 1992-08-26 | 1994-08-16 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt |
-
1993
- 1993-06-28 US US08/083,429 patent/US5359068A/en not_active Expired - Lifetime
-
1994
- 1994-04-06 CA CA002166203A patent/CA2166203C/en not_active Expired - Fee Related
- 1994-04-06 PT PT94910016T patent/PT706524E/pt unknown
- 1994-04-06 WO PCT/IB1994/000061 patent/WO1995000510A1/en not_active Ceased
- 1994-04-06 EP EP94910016A patent/EP0706524B1/de not_active Expired - Lifetime
- 1994-04-06 DK DK94910016T patent/DK0706524T3/da active
- 1994-04-06 AT AT94910016T patent/ATE277041T1/de not_active IP Right Cessation
- 1994-04-06 ES ES94910016T patent/ES2227524T3/es not_active Expired - Lifetime
- 1994-04-06 DE DE69434020T patent/DE69434020T2/de not_active Expired - Fee Related
- 1994-04-06 JP JP7502611A patent/JP2667987B2/ja not_active Expired - Fee Related
-
1995
- 1995-12-27 FI FI956279A patent/FI119372B/fi active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08506354A (ja) | 1996-07-09 |
| US5359068A (en) | 1994-10-25 |
| DE69434020D1 (de) | 2004-10-28 |
| EP0706524A1 (de) | 1996-04-17 |
| DE69434020T2 (de) | 2005-09-29 |
| JP2667987B2 (ja) | 1997-10-27 |
| CA2166203C (en) | 2001-04-24 |
| FI119372B (fi) | 2008-10-31 |
| FI956279A0 (fi) | 1995-12-27 |
| PT706524E (pt) | 2005-03-31 |
| EP0706524B1 (de) | 2004-09-22 |
| CA2166203A1 (en) | 1995-01-05 |
| DK0706524T3 (da) | 2005-01-31 |
| ES2227524T3 (es) | 2005-04-01 |
| FI956279L (fi) | 1995-12-27 |
| WO1995000510A1 (en) | 1995-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0706524 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |