ATE277042T1 - Antimikrobielle 4-oxochinolizine mit 2- pyridongerüsten als teilstruktur - Google Patents

Antimikrobielle 4-oxochinolizine mit 2- pyridongerüsten als teilstruktur

Info

Publication number
ATE277042T1
ATE277042T1 AT00969876T AT00969876T ATE277042T1 AT E277042 T1 ATE277042 T1 AT E277042T1 AT 00969876 T AT00969876 T AT 00969876T AT 00969876 T AT00969876 T AT 00969876T AT E277042 T1 ATE277042 T1 AT E277042T1
Authority
AT
Austria
Prior art keywords
group
hydrogen atom
amino
oxochinolizine
pyridone
Prior art date
Application number
AT00969876T
Other languages
English (en)
Inventor
Ryoichi Fukumoto
Hiroyuki Kusakabe
Chong Chu
Hiroaki Kimura
Satoshi Yanagihara
Masatoshi Kato
Chisato Hirosawa
Seiji Ishiduka
Fusae Shizume
Original Assignee
Sato Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sato Pharma filed Critical Sato Pharma
Application granted granted Critical
Publication of ATE277042T1 publication Critical patent/ATE277042T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00969876T 1999-10-19 2000-10-19 Antimikrobielle 4-oxochinolizine mit 2- pyridongerüsten als teilstruktur ATE277042T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29638399 1999-10-19
PCT/JP2000/007256 WO2001029035A1 (en) 1999-10-19 2000-10-19 4-oxoquinolizine antimicrobials having 2-pyridone skeletons as the partial structure

Publications (1)

Publication Number Publication Date
ATE277042T1 true ATE277042T1 (de) 2004-10-15

Family

ID=17832846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00969876T ATE277042T1 (de) 1999-10-19 2000-10-19 Antimikrobielle 4-oxochinolizine mit 2- pyridongerüsten als teilstruktur

Country Status (8)

Country Link
US (1) US6525066B2 (de)
EP (1) EP1227096B1 (de)
JP (1) JP4328049B2 (de)
AT (1) ATE277042T1 (de)
AU (1) AU7948900A (de)
DE (1) DE60014143T2 (de)
ES (1) ES2225237T3 (de)
WO (1) WO2001029035A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230030B1 (hu) 1999-10-08 2015-05-28 Debiopharm International Sa Fab I inhibitorok
AU2001286191A1 (en) * 2000-09-12 2002-03-26 Sankyo Company, Limited Quinolizine derivatives
EP1560584B1 (de) * 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab-i-inhibitoren
EP1437354B1 (de) * 2001-09-28 2008-08-13 Sato Pharmaceutical Co. Ltd. Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen
EP1575951B1 (de) * 2002-12-06 2014-06-25 Debiopharm International SA Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel
WO2004082586A2 (en) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
WO2005019224A2 (en) * 2003-06-06 2005-03-03 Cadila Healthcare Limited Novel antiinfective compounds
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
EP2125802A4 (de) 2007-02-16 2014-08-20 Debiopharm Int Sa Salze, prodrugs und polymorphe von fab-i-inhibitoren
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
WO2012047487A1 (en) * 2010-09-27 2012-04-12 Evolva Sa 2-pyridone antimicrobial compositions
ES2658346T3 (es) 2011-02-01 2018-03-09 Emergent Product Development Gaithersburg Inc. 4-Oxoquinolizinas antimicrobianas
AU2013279021C1 (en) 2012-06-19 2017-03-16 Debiopharm International Sa Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
TN2021000159A1 (en) 2019-02-14 2023-04-04 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
SG11202113174SA (en) 2019-06-14 2021-12-30 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm
CN110938028B (zh) * 2019-12-09 2022-03-04 南京杰运医药科技有限公司 一种(1r)-5-溴-2,3-二氢-1-甲基-1h-异吲哚的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0723545B1 (de) * 1993-10-14 2002-05-08 Abbott Laboratories Verbindungen des chinolizinon-typs
EP0775702B1 (de) 1994-08-12 2003-07-23 Toyama Chemical Co., Ltd. Neue chinolon- oder naphthyridoncarbonsäurederivate oder deren salze
JP3833738B2 (ja) 1995-11-15 2006-10-18 第一製薬株式会社 置換アミノメチルピロリジン誘導体
AU2001286191A1 (en) * 2000-09-12 2002-03-26 Sankyo Company, Limited Quinolizine derivatives

Also Published As

Publication number Publication date
AU7948900A (en) 2001-04-30
DE60014143T2 (de) 2006-03-02
EP1227096A4 (de) 2003-04-02
US6525066B2 (en) 2003-02-25
DE60014143D1 (de) 2004-10-28
WO2001029035A1 (en) 2001-04-26
ES2225237T3 (es) 2005-03-16
EP1227096B1 (de) 2004-09-22
US20020173517A1 (en) 2002-11-21
EP1227096A1 (de) 2002-07-31
JP4328049B2 (ja) 2009-09-09

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