ATE277043T1 - Vitronectin rezeptor antagonist - Google Patents

Vitronectin rezeptor antagonist

Info

Publication number: ATE277043T1
Authority: AT; Austria
Prior art keywords: receptor antagonist; vitronectin receptor; vitronectin; antagonist; receptor
Prior art date: 1998-12-04

Application number

AT99960647T

Other languages

English (en)

Inventor

William H Miller

Peter J Manley

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-04

Filing date

1999-12-03

Publication date

2004-10-15

1999-12-03 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE277043T1 publication Critical patent/ATE277043T1/de

Links

102100022337 Integrin alpha-V Human genes 0.000 title 1
108010048673 Vitronectin Receptors Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Inorganic Chemistry (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Transplantation (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)

AT99960647T 1998-12-04 1999-12-03 Vitronectin rezeptor antagonist ATE277043T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11090398P	1998-12-04	1998-12-04
PCT/US1999/028662 WO2000033838A1 (en)	1998-12-04	1999-12-03	Vitronectin receptor antagonist

Publications (1)

Publication Number	Publication Date
ATE277043T1 true ATE277043T1 (de)	2004-10-15

Family

ID=22335565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99960647T ATE277043T1 (de)	1998-12-04	1999-12-03	Vitronectin rezeptor antagonist

Country Status (39)

Country	Link
US (1)	US6495560B1 (de)
EP (1)	EP1146874B1 (de)
JP (1)	JP4481504B2 (de)
KR (1)	KR100620485B1 (de)
CN (1)	CN1147300C (de)
AP (1)	AP1534A (de)
AR (1)	AR035006A1 (de)
AT (1)	ATE277043T1 (de)
AU (1)	AU754408B2 (de)
BG (1)	BG65118B1 (de)
BR (1)	BR9915879A (de)
CA (1)	CA2353415A1 (de)
CO (1)	CO5150166A1 (de)
CZ (1)	CZ20011963A3 (de)
DE (1)	DE69920518T2 (de)
DK (1)	DK1146874T3 (de)
DZ (1)	DZ2954A1 (de)
EA (1)	EA003254B1 (de)
EG (1)	EG24025A (de)
ES (1)	ES2229798T3 (de)
HK (1)	HK1042037B (de)
HU (1)	HUP0104804A3 (de)
ID (1)	ID28811A (de)
IL (2)	IL143390A0 (de)
MA (1)	MA25265A1 (de)
NO (1)	NO318895B1 (de)
NZ (1)	NZ511876A (de)
OA (1)	OA11724A (de)
PE (1)	PE20001563A1 (de)
PL (1)	PL195973B1 (de)
PT (1)	PT1146874E (de)
SI (1)	SI1146874T1 (de)
SK (1)	SK7452001A3 (de)
TR (1)	TR200101654T2 (de)
TW (1)	TW482673B (de)
UA (1)	UA71586C2 (de)
UY (1)	UY25824A1 (de)
WO (1)	WO2000033838A1 (de)
ZA (1)	ZA200104398B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY26780A1 (es) *	2000-06-15	2002-01-31	Pharmacia Corp	Cicloalquil avb3 antagonistas
JP2004513953A (ja) *	2000-10-24	2004-05-13	メルク　エンド　カムパニー　インコーポレーテッド	ジベンズオキサゼピンαＶインテグリン受容体アンタゴニスト
WO2002060438A1 (en)	2001-01-29	2002-08-08	3-Dimensional Pharmaceuticals, Inc.	Substituted indoles and their use as integrin antagonists
US6872730B2 (en)	2001-04-27	2005-03-29	3-Dimensional Pharmaceuticals, Inc.	Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
US20040224986A1 (en)	2002-08-16	2004-11-11	Bart De Corte	Piperidinyl targeting compounds that selectively bind integrins
BR0316876A (pt)	2002-12-20	2005-10-25	Pharmacia Corp	Compostos de tiazol e composição farmacêutica compreendendo o mesmo
GB0319069D0 (en) *	2003-08-14	2003-09-17	Glaxo Group Ltd	Therapeutically useful compounds
TW200635902A (en) *	2004-12-21	2006-10-16	Smithkline Beecham Corp	Methods and formulations
BR112013000946B1 (pt)	2010-07-14	2020-09-08	Novartis Ag	Compostos heterocíclicos agonistas de receptor de ip, seus usos, composição e combinação farmacêuticas
AR089698A1 (es)	2012-01-13	2014-09-10	Novartis Ag	Compuestos heterociclicos antagonistas del receptor ip
ES2637719T3 (es)	2013-02-13	2017-10-16	Novartis Ag	Compuestos heterocíclicos agonistas del receptor IP
DK3929196T3 (da)	2013-09-24	2023-09-25	Fujifilm Corp	Farmaceutisk sammensætning af en nitrogenholdig forbindelse eller salt deraf, eller metalkompleks deraf

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2687154B1 (fr)	1992-02-07	1995-05-12	Rhone Poulenc Rorer Sa	Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
SI0910563T1 (en) *	1995-06-29	2003-10-31	Smithkline Beecham Corporation	Integrin receptor antagonists
AU4109297A (en) *	1996-09-27	1998-04-17	Merkler, H.	Tank for liquids, particularly for chemically aggressive liquids
EP0946180A4 (de) *	1996-10-07	2003-07-23	Smithkline Beecham Corp	Methoden zur stimulierung der knochenbildung
UY24949A1 (es)	1997-04-08	2001-04-30	Smithkline Beecham Corp	Compuestos calcilíticos

1999
- 1999-03-12 UA UA2001063754A patent/UA71586C2/uk unknown
- 1999-11-29 TW TW088120752A patent/TW482673B/zh not_active IP Right Cessation
- 1999-11-29 UY UY25824A patent/UY25824A1/es unknown
- 1999-11-30 CO CO99075061A patent/CO5150166A1/es unknown
- 1999-11-30 PE PE1999001197A patent/PE20001563A1/es not_active Application Discontinuation
- 1999-12-01 DZ DZ990254A patent/DZ2954A1/xx active
- 1999-12-02 AR ARP990106128A patent/AR035006A1/es unknown
- 1999-12-02 EG EG154299A patent/EG24025A/xx active
- 1999-12-03 AU AU17502/00A patent/AU754408B2/en not_active Ceased
- 1999-12-03 ID IDW00200101183A patent/ID28811A/id unknown
- 1999-12-03 CZ CZ20011963A patent/CZ20011963A3/cs unknown
- 1999-12-03 PL PL99348702A patent/PL195973B1/pl not_active IP Right Cessation
- 1999-12-03 KR KR1020017006937A patent/KR100620485B1/ko not_active Expired - Fee Related
- 1999-12-03 JP JP2000586330A patent/JP4481504B2/ja not_active Expired - Fee Related
- 1999-12-03 CA CA002353415A patent/CA2353415A1/en not_active Abandoned
- 1999-12-03 SI SI9930700T patent/SI1146874T1/xx unknown
- 1999-12-03 PT PT99960647T patent/PT1146874E/pt unknown
- 1999-12-03 CN CNB998159735A patent/CN1147300C/zh not_active Expired - Fee Related
- 1999-12-03 AT AT99960647T patent/ATE277043T1/de not_active IP Right Cessation
- 1999-12-03 WO PCT/US1999/028662 patent/WO2000033838A1/en not_active Ceased
- 1999-12-03 OA OA1200100139A patent/OA11724A/en unknown
- 1999-12-03 AP APAP/P/2001/002156A patent/AP1534A/en active
- 1999-12-03 HU HU0104804A patent/HUP0104804A3/hu unknown
- 1999-12-03 DE DE69920518T patent/DE69920518T2/de not_active Expired - Lifetime
- 1999-12-03 SK SK745-2001A patent/SK7452001A3/sk unknown
- 1999-12-03 US US09/857,316 patent/US6495560B1/en not_active Expired - Lifetime
- 1999-12-03 EA EA200100618A patent/EA003254B1/ru not_active IP Right Cessation
- 1999-12-03 ES ES99960647T patent/ES2229798T3/es not_active Expired - Lifetime
- 1999-12-03 HK HK02101522.3A patent/HK1042037B/en not_active IP Right Cessation
- 1999-12-03 DK DK99960647T patent/DK1146874T3/da active
- 1999-12-03 NZ NZ511876A patent/NZ511876A/xx unknown
- 1999-12-03 BR BR9915879-5A patent/BR9915879A/pt not_active Application Discontinuation
- 1999-12-03 IL IL14339099A patent/IL143390A0/xx active IP Right Grant
- 1999-12-03 TR TR2001/01654T patent/TR200101654T2/xx unknown
- 1999-12-03 EP EP99960647A patent/EP1146874B1/de not_active Expired - Lifetime
2001
- 2001-05-24 IL IL143390A patent/IL143390A/en not_active IP Right Cessation
- 2001-05-29 ZA ZA200104398A patent/ZA200104398B/en unknown
- 2001-06-01 NO NO20012732A patent/NO318895B1/no not_active IP Right Cessation
- 2001-06-01 MA MA26218A patent/MA25265A1/fr unknown
- 2001-06-26 BG BG105651A patent/BG65118B1/bg unknown

Also Published As

Publication number	Publication date
CA2353415A1 (en)	2000-06-15
UY25824A1 (es)	2001-07-31
BG105651A (en)	2002-02-28
IL143390A (en)	2006-07-05
PE20001563A1 (es)	2001-02-09
DK1146874T3 (da)	2005-01-31
ZA200104398B (en)	2002-05-29
ID28811A (id)	2001-07-05
EG24025A (en)	2008-03-26
HK1042037A1 (en)	2002-08-02
CZ20011963A3 (cs)	2001-11-14
SK7452001A3 (en)	2001-12-03
NO20012732D0 (no)	2001-06-01
ES2229798T3 (es)	2005-04-16
JP2003523931A (ja)	2003-08-12
AU754408B2 (en)	2002-11-14
EP1146874B1 (de)	2004-09-22
CN1147300C (zh)	2004-04-28
DZ2954A1 (fr)	2004-06-20
NO318895B1 (no)	2005-05-18
HK1042037B (en)	2005-07-29
KR20010080669A (ko)	2001-08-22
BG65118B1 (bg)	2007-03-30
OA11724A (en)	2005-01-26
PT1146874E (pt)	2005-02-28
JP4481504B2 (ja)	2010-06-16
EP1146874A4 (de)	2002-06-05
AP1534A (en)	2006-01-09
TR200101654T2 (tr)	2002-03-21
CO5150166A1 (es)	2002-04-29
HUP0104804A2 (hu)	2002-05-29
IL143390A0 (en)	2002-04-21
SI1146874T1 (en)	2005-04-30
HUP0104804A3 (en)	2002-12-28
DE69920518T2 (de)	2005-09-22
MA25265A1 (fr)	2001-10-01
DE69920518D1 (de)	2004-10-28
UA71586C2 (en)	2004-12-15
PL348702A1 (en)	2002-06-03
CN1334730A (zh)	2002-02-06
AU1750200A (en)	2000-06-26
TW482673B (en)	2002-04-11
PL195973B1 (pl)	2007-11-30
BR9915879A (pt)	2002-02-13
NZ511876A (en)	2004-02-27
WO2000033838A1 (en)	2000-06-15
NO20012732L (no)	2001-08-01
KR100620485B1 (ko)	2006-09-13
EP1146874A1 (de)	2001-10-24
EA200100618A1 (ru)	2001-12-24
AR035006A1 (es)	2004-04-14
EA003254B1 (ru)	2003-02-27
US6495560B1 (en)	2002-12-17

Legal Events

Date

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Title

Description

2005-05-15

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Publication of translation of european patent specification

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2010-09-15

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Publication	Publication Date	Title
BR9712248A (pt)	1999-08-24	Antagonista receptores de vitronectina
IS5706A (is)	2000-11-07	Adenosín A3 viðtakastillar
NO993350D0 (no)	1999-07-07	Vitronectin-reseptor-antagonister
NO965608D0 (no)	1996-12-27	Vitronectin-reseptor-antagonister
DE69921351D1 (de)	2004-11-25	4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii
NO20004503D0 (no)	2000-09-08	Vitronectin-reseptor-antagonister
NO20001514D0 (no)	2000-03-23	Vitronectin-reseptor-antagonist
NO20001515D0 (no)	2000-03-23	Vitronektin reseptor-antagonist
NO20001407D0 (no)	2000-03-17	Vitronectin-reseptor-antagonister
NO20016053D0 (no)	2001-12-11	IL-8 reseptor-antagonister
DE69920518D1 (de)	2004-10-28	Vitronectin rezeptor antagonist
NO20016052L (no)	2001-12-11	IL-8-reseptor-antagonister
ATE352299T1 (de)	2007-02-15	Il-8 rezeptorantagonist
NO20021113D0 (no)	2002-03-06	Vitronectin-reseptor-antagonister
NO20015774D0 (no)	2001-11-27	IL-8 reseptorantagonister
NO20010620D0 (no)	2001-02-06	Vitronektinreseptor-antagonister
NO20010353L (no)	2001-01-22	IL-8 reseptor-antagonist
DK1218005T3 (da)	2005-04-11	Vitronectinreptorantagonister
NO20016102D0 (no)	2001-12-14	IL-8 reseptorantagonister
NO20016065L (no)	2001-12-12	IL-8-reseptor-antagonister
DE69830671D1 (de)	2005-07-28	Integrin-rezeptor-antagonisten
SE0003996D0 (sv)	2000-11-01	Receptorantagonister