ATE277051T1 - Verfahren zur herstellung von debromohymenialdisin und deren analogen - Google Patents

Verfahren zur herstellung von debromohymenialdisin und deren analogen

Info

Publication number: ATE277051T1
Authority: AT; Austria
Prior art keywords: compound; dbh; converted; hydrogen; hymenin
Prior art date: 1999-07-20

Application number

AT00947544T

Other languages

English (en)

Inventor

David A Horne

Kenichi Yakushijin

Original Assignee

Oregon State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-20

Filing date

2000-07-19

Publication date

2004-10-15

2000-07-19 Application filed by Oregon State filed Critical Oregon State

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE277051T1 publication Critical patent/ATE277051T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
JYRJOQGKGMHTOO-VURMDHGXSA-N (4z)-4-(2-amino-4-oxo-1h-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one Chemical compound N1C(N)=NC(=O)\C1=C/1C(C=CN2)=C2C(=O)NCC\1 JYRJOQGKGMHTOO-VURMDHGXSA-N 0.000 abstract 6
JYRJOQGKGMHTOO-UHFFFAOYSA-N Debromohymenialdisine hydrochloride Natural products N1C(N)=NC(=O)C1=C1C(C=CN2)=C2C(=O)NCC1 JYRJOQGKGMHTOO-UHFFFAOYSA-N 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
LLQCRTZROWMVOL-DYDIJXKYSA-N (3as,6s,6ar,9as,9br)-6a-hydroxy-6,9a-dimethyl-3-methylidene-4,5,6,9b-tetrahydro-3ah-azuleno[8,7-b]furan-2,9-dione Chemical compound C[C@H]1CC[C@H]2C(=C)C(=O)O[C@H]2[C@]2(C)C(=O)C=C[C@]12O LLQCRTZROWMVOL-DYDIJXKYSA-N 0.000 abstract 2
WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 abstract 2
229940125773 compound 10 Drugs 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
MRMGABUTBNWSLA-UHFFFAOYSA-N hymenine Natural products N1C(N)=NC(C2C=3C(Br)=C(Br)NC=3C(=O)NCC2)=C1 MRMGABUTBNWSLA-UHFFFAOYSA-N 0.000 abstract 2
ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 abstract 2
LLQCRTZROWMVOL-UHFFFAOYSA-N parthenin Natural products CC1CCC2C(=C)C(=O)OC2C2(C)C(=O)C=CC12O LLQCRTZROWMVOL-UHFFFAOYSA-N 0.000 abstract 2
SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 abstract 1
GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 abstract 1
NPRYCHLHHVWLQZ-TURQNECASA-N 2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynylpurin-8-one Chemical compound NC1=NC=C2N(C(N(C2=N1)[C@@H]1O[C@@H]([C@H]([C@H]1O)F)CO)=O)CC#C NPRYCHLHHVWLQZ-TURQNECASA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229940125797 compound 12 Drugs 0.000 abstract 1
229940126543 compound 14 Drugs 0.000 abstract 1
150000001993 dienes Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT00947544T 1999-07-20 2000-07-19 Verfahren zur herstellung von debromohymenialdisin und deren analogen ATE277051T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/357,687 US6211361B1 (en)	1999-07-20	1999-07-20	Method for making debromohymenialdisine and analogs thereof
PCT/US2000/019704 WO2001005794A2 (en)	1999-07-20	2000-07-19	Method for making debromohymenialdisine and analogs thereof

Publications (1)

Publication Number	Publication Date
ATE277051T1 true ATE277051T1 (de)	2004-10-15

Family

ID=23406630

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00947544T ATE277051T1 (de)	1999-07-20	2000-07-19	Verfahren zur herstellung von debromohymenialdisin und deren analogen

Country Status (12)

Country	Link
US (1)	US6211361B1 (de)
EP (1)	EP1200438B1 (de)
JP (1)	JP2003505392A (de)
AT (1)	ATE277051T1 (de)
AU (1)	AU6112800A (de)
BR (1)	BR0012599A (de)
CA (1)	CA2379847A1 (de)
DE (1)	DE60014103D1 (de)
IL (1)	IL147728A0 (de)
MX (1)	MXPA02000706A (de)
WO (1)	WO2001005794A2 (de)
ZA (1)	ZA200201159B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003297431A1 (en) *	2002-12-20	2004-07-22	Pharmacia Corporation	Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds
US7423031B2 (en)	2003-05-01	2008-09-09	Irm Llc	Compounds and compositions as protein kinase inhibitors
US7385055B2 (en) *	2003-05-19	2008-06-10	Board Of Trustees Of Michigan State University	Preparation of hymenialdisine derivatives and use thereof
WO2008147713A1 (en) *	2007-05-24	2008-12-04	The Regents Of The University Of California	Wnt signaling inhibitors, and methods for making and using them
DE102017124284A1 (de) *	2016-10-19	2018-04-19	Steering Solutions Ip Holding Corporation	In eine controllerplatine integrierter drehmomentsensor und eps-system, das diese enthält

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993016703A1 (en) *	1992-02-24	1993-09-02	Smithkline Beecham Corporation	Protein kinase c inhibitor
JP3714685B2 (ja) *	1994-05-18	2005-11-09	第一サントリーファーマ株式会社	ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体
US5591740A (en) *	1995-06-07	1997-01-07	Osteoarthritis Sciences, Incorporated	Use of debromohymenialdisine for treating osteoarthritis

1999
- 1999-07-20 US US09/357,687 patent/US6211361B1/en not_active Expired - Fee Related
2000
- 2000-07-19 EP EP00947544A patent/EP1200438B1/de not_active Expired - Lifetime
- 2000-07-19 AT AT00947544T patent/ATE277051T1/de not_active IP Right Cessation
- 2000-07-19 MX MXPA02000706A patent/MXPA02000706A/es unknown
- 2000-07-19 DE DE60014103T patent/DE60014103D1/de not_active Expired - Lifetime
- 2000-07-19 WO PCT/US2000/019704 patent/WO2001005794A2/en not_active Ceased
- 2000-07-19 CA CA002379847A patent/CA2379847A1/en not_active Abandoned
- 2000-07-19 JP JP2001511453A patent/JP2003505392A/ja active Pending
- 2000-07-19 BR BR0012599-7A patent/BR0012599A/pt not_active Application Discontinuation
- 2000-07-19 IL IL14772800A patent/IL147728A0/xx unknown
- 2000-07-19 AU AU61128/00A patent/AU6112800A/en not_active Abandoned
2002
- 2002-02-11 ZA ZA200201159A patent/ZA200201159B/en unknown

Also Published As

Publication number	Publication date
ZA200201159B (en)	2003-08-27
CA2379847A1 (en)	2001-01-25
AU6112800A (en)	2001-02-05
WO2001005794A3 (en)	2001-07-19
EP1200438B1 (de)	2004-09-22
JP2003505392A (ja)	2003-02-12
EP1200438A2 (de)	2002-05-02
US6211361B1 (en)	2001-04-03
WO2001005794A2 (en)	2001-01-25
DE60014103D1 (de)	2004-10-28
BR0012599A (pt)	2002-09-17
MXPA02000706A (es)	2002-07-02
IL147728A0 (en)	2002-08-14

Legal Events

Date	Code	Title	Description
2005-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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