ATE277899T1 - 8-8,6-6 und 6-8 catechin und epicatechin dimere und verfahren zu ihrer herstellung - Google Patents

8-8,6-6 und 6-8 catechin und epicatechin dimere und verfahren zu ihrer herstellung

Info

Publication number
ATE277899T1
ATE277899T1 AT00919756T AT00919756T ATE277899T1 AT E277899 T1 ATE277899 T1 AT E277899T1 AT 00919756 T AT00919756 T AT 00919756T AT 00919756 T AT00919756 T AT 00919756T AT E277899 T1 ATE277899 T1 AT E277899T1
Authority
AT
Austria
Prior art keywords
catechin
production
dimers
epicatechin
epicatechin dimers
Prior art date
Application number
AT00919756T
Other languages
English (en)
Inventor
Werner Tuckmantel
Alan P Kozikowski
Leo J Romanczyk
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc filed Critical Mars Inc
Application granted granted Critical
Publication of ATE277899T1 publication Critical patent/ATE277899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
AT00919756T 1999-04-09 2000-03-29 8-8,6-6 und 6-8 catechin und epicatechin dimere und verfahren zu ihrer herstellung ATE277899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/289,565 US6156912A (en) 1999-04-09 1999-04-09 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation
PCT/US2000/008234 WO2000061547A1 (en) 1999-04-09 2000-03-29 8-8, 6-6 and 6-8 catechin and epicatechin dimers and methods for their preparation

Publications (1)

Publication Number Publication Date
ATE277899T1 true ATE277899T1 (de) 2004-10-15

Family

ID=23112085

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00919756T ATE277899T1 (de) 1999-04-09 2000-03-29 8-8,6-6 und 6-8 catechin und epicatechin dimere und verfahren zu ihrer herstellung

Country Status (12)

Country Link
US (1) US6156912A (de)
EP (1) EP1169304B1 (de)
JP (1) JP2002541241A (de)
CN (1) CN1354743A (de)
AT (1) ATE277899T1 (de)
AU (1) AU782592B2 (de)
CA (1) CA2369399A1 (de)
DE (1) DE60014344T2 (de)
ES (1) ES2230089T3 (de)
IL (1) IL145788A (de)
RU (1) RU2293081C2 (de)
WO (1) WO2000061547A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207842B1 (en) 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
WO1999022728A1 (en) 1997-10-31 1999-05-14 Arch Development Corporation Methods and compositions for regulation of 5-alpha reductase activity
US6696484B2 (en) 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
US7015338B1 (en) * 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US7048941B2 (en) 2001-03-30 2006-05-23 New World Enterprizes, Inc. Chocolate composition as delivery system for nutrients and medications
US7067679B2 (en) * 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest
EP1670455A4 (de) * 2003-10-10 2008-10-15 Mars Inc Behandlung von erkrankungen mit erbb2-kinase-überexpression
CA2559272C (en) 2004-03-12 2015-12-01 University Of Georgia Research Foundation, Inc. Novel peanut skin extract as a vaccine adjuvant
RU2007101288A (ru) * 2004-06-14 2008-07-20 Марс Композиции и способы применения димерных дигаллатов
CA2611856C (en) 2005-06-29 2018-02-27 Mars, Incorporated Inducing peripheral blood vessel vasodilation using polyphenols provided as cocoa
US20070004796A1 (en) * 2005-06-29 2007-01-04 Romanczyk Leo Jr Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates
EP1896443A1 (de) * 2005-06-29 2008-03-12 Mars, Incorporated Herstellung von (+)-catechin, (-)-epicatechin, (-)-catechin, (+)-epicatechin und deren 5,7,3',4'-tetra-o-benzyl-analoga
CN100353940C (zh) * 2005-08-30 2007-12-12 华南师范大学 一种茶叶活性单体组合物
CA2634127C (en) 2005-12-23 2016-06-07 Mars, Incorporated Skin protection and improvement
EP3744324A1 (de) 2006-06-15 2020-12-02 Mars Incorporated Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion
EP2068941A4 (de) * 2006-07-21 2009-09-30 Mars Inc Verbesserung von arginase-spiegeln und -aktivität
TWI469779B (zh) * 2008-08-29 2015-01-21 Suntory Holdings Ltd Novel epigallocatechin gallate 4, and its vascular endothelial function enhancer
JP5295744B2 (ja) * 2008-12-11 2013-09-18 三井農林株式会社 テアシネンシンの製造方法
KR101472120B1 (ko) * 2011-03-25 2014-12-11 대한민국 알파-글루코시데이즈 억제활성을 갖는 좀돌팥 유래 화합물, 및 이를 포함하는 알파-글루코시데이즈 관련 질환의 예방 또는 치료용 약학적 조성물 및 개선용 식품 조성물
CN104311542A (zh) * 2014-09-30 2015-01-28 浙江大学 3-四氢吡喃基儿茶素选择性制备方法及产品
WO2016049966A1 (zh) * 2014-09-30 2016-04-07 浙江大学 取代儿茶素的选择性制备方法及产品

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493976C3 (de) * 1964-01-18 1973-09-13 Merck Patent Gmbh, 6100 Darmstadt Substituierte Flavandenvate sowie Verfahren zu ihrer Herstellung
US4255336A (en) * 1977-11-25 1981-03-10 Ciba-Geigy Corporation Process for the preparation of O-substituted derivatives of (+)-cyanidan-3-01
JPS58154571A (ja) * 1982-03-08 1983-09-14 Nippon Shinyaku Co Ltd 新規タンニン
GB2122608B (en) * 1982-06-01 1985-10-02 Zyma Sa (+)-cyanidan-3-ol derivatives
JPS61205272A (ja) * 1985-03-08 1986-09-11 Tsumura Juntendo Inc 新規なタンニン
JPH0231074B2 (ja) * 1986-08-26 1990-07-11 Nippon Shinyaku Co Ltd Shintannin
CA2057023A1 (fr) * 1989-05-12 1990-11-13 Leon Cariel Composition a base de proanthocyanidols, leur application pharmacologique
JP2857646B2 (ja) * 1990-11-26 1999-02-17 キッコーマン株式会社 抗変異原性剤
US5605929A (en) * 1992-05-27 1997-02-25 Arch Development Corp. Methods and compositions for inhibiting 5α-reductase activity
US5554645A (en) * 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
WO1997036597A1 (en) * 1996-04-02 1997-10-09 Mars, Incorporated Cocoa extract compounds and methods for making and using the same
US5912363A (en) * 1997-08-29 1999-06-15 Interhealth Nutraceuticals Method for extraction of proanthocyanidins from plant material

Also Published As

Publication number Publication date
CA2369399A1 (en) 2000-10-19
US6156912A (en) 2000-12-05
AU782592B2 (en) 2005-08-11
CN1354743A (zh) 2002-06-19
DE60014344D1 (de) 2004-11-04
IL145788A (en) 2005-11-20
DE60014344T2 (de) 2006-03-09
AU4038900A (en) 2000-11-14
RU2293081C2 (ru) 2007-02-10
ES2230089T3 (es) 2005-05-01
EP1169304B1 (de) 2004-09-29
IL145788A0 (en) 2002-07-25
JP2002541241A (ja) 2002-12-03
EP1169304A4 (de) 2002-05-22
WO2000061547A1 (en) 2000-10-19
EP1169304A1 (de) 2002-01-09

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