ATE278952T1 - Leptin vermittelte geninduktion - Google Patents

Leptin vermittelte geninduktion

Info

Publication number: ATE278952T1
Authority: AT; Austria
Prior art keywords: leptin; induced; genes; adenylate cyclase; protein
Prior art date: 1998-07-28

Application number

AT99941484T

Other languages

English (en)

Inventor

Dani L Broekaert

Jo L Stefaan Vandekerckhove

Annick Verhee

Wim Waelput

Jan Tavernier

Original Assignee

Vlaams Interuniv Inst Biotech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-28

Filing date

1999-07-27

Publication date

2004-10-15

1999-07-27 Application filed by Vlaams Interuniv Inst Biotech filed Critical Vlaams Interuniv Inst Biotech

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE278952T1 publication Critical patent/ATE278952T1/de

Links

108090000623 proteins and genes Proteins 0.000 title abstract 6
230000006698 induction Effects 0.000 title 1
OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 abstract 4
102000016267 Leptin Human genes 0.000 abstract 4
108010092277 Leptin Proteins 0.000 abstract 4
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 abstract 4
229940039781 leptin Drugs 0.000 abstract 4
102000030621 adenylate cyclase Human genes 0.000 abstract 3
108060000200 adenylate cyclase Proteins 0.000 abstract 3
SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 abstract 2
102000008080 Pancreatitis-Associated Proteins Human genes 0.000 abstract 2
108010074467 Pancreatitis-Associated Proteins Proteins 0.000 abstract 2
OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 abstract 2
101150067958 plk-3 gene Proteins 0.000 abstract 2
JDKLPDJLXHXHNV-MFVUMRCOSA-N (3s,6s,9r,12s,15s,23s)-15-[[(2s)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1h-imidazol-5-ylmethyl)-3-(1h-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide Chemical compound C([C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCNC(=O)C[C@@H](C(N[C@@H](CC=2NC=NC=2)C(=O)N1)=O)NC(=O)[C@@H](NC(C)=O)CCCC)C(N)=O)C1=CC=CC=C1 JDKLPDJLXHXHNV-MFVUMRCOSA-N 0.000 abstract 1
102100030834 AT-rich interactive domain-containing protein 5A Human genes 0.000 abstract 1
102000000412 Annexin Human genes 0.000 abstract 1
108050008874 Annexin Proteins 0.000 abstract 1
102100034613 Annexin A2 Human genes 0.000 abstract 1
108090000668 Annexin A2 Proteins 0.000 abstract 1
108090000669 Annexin A4 Proteins 0.000 abstract 1
102100034612 Annexin A4 Human genes 0.000 abstract 1
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
102000016354 Glucuronosyltransferase Human genes 0.000 abstract 1
108010092364 Glucuronosyltransferase Proteins 0.000 abstract 1
101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 1
102000003792 Metallothionein Human genes 0.000 abstract 1
108090000157 Metallothionein Proteins 0.000 abstract 1
101710201349 Metallothionein B Proteins 0.000 abstract 1
102100031347 Metallothionein-2 Human genes 0.000 abstract 1
101710094505 Metallothionein-2 Proteins 0.000 abstract 1
101710202670 Peptide chain release factor 1, mitochondrial Proteins 0.000 abstract 1
102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 1
102000005782 Squalene Monooxygenase Human genes 0.000 abstract 1
108020003891 Squalene monooxygenase Proteins 0.000 abstract 1
108700027337 Suppressor of Cytokine Signaling 3 Proteins 0.000 abstract 1
102100024283 Suppressor of cytokine signaling 3 Human genes 0.000 abstract 1
XCCTYIAWTASOJW-XVFCMESISA-N Uridine-5'-Diphosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 XCCTYIAWTASOJW-XVFCMESISA-N 0.000 abstract 1
230000003213 activating effect Effects 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940126513 cyclase activator Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000000955 neuroendocrine Effects 0.000 abstract 1
210000004412 neuroendocrine cell Anatomy 0.000 abstract 1
230000004044 response Effects 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Immunology (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Biophysics (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT99941484T 1998-07-28 1999-07-27 Leptin vermittelte geninduktion ATE278952T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98202524		1998-07-28
PCT/EP1999/005489 WO2000007014A2 (en)	1998-07-28	1999-07-27	Leptin-mediated gene-induction

Publications (1)

Publication Number	Publication Date
ATE278952T1 true ATE278952T1 (de)	2004-10-15

Family

ID=8233981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99941484T ATE278952T1 (de)	1998-07-28	1999-07-27	Leptin vermittelte geninduktion

Country Status (8)

Country	Link
US (1)	US7291458B2 (de)
EP (1)	EP1101112B1 (de)
JP (1)	JP2002521496A (de)
AT (1)	ATE278952T1 (de)
AU (1)	AU756617B2 (de)
CA (1)	CA2335107C (de)
DE (1)	DE69920921T2 (de)
WO (1)	WO2000007014A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1101112B1 (de)	1998-07-28	2004-10-06	Vlaams Interuniversitair Instituut voor Biotechnologie vzw.	Leptin vermittelte geninduktion
US7803765B2 (en)	1999-05-05	2010-09-28	Phylogica Limited	Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom
EP1283878B1 (de)	2000-05-22	2005-07-27	Vlaams Interuniversitair Instituut voor Biotechnologie vzw.	Auf rezeptorgrundlage arbeitende screening-verfahren für protein wechselwirkungen
WO2003004643A2 (en) *	2001-07-03	2003-01-16	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw	Reversed mammalian protein-protein interaction trap
WO2002101034A1 (en) *	2001-06-08	2002-12-19	Zoegene Corporation	Leptin-induced gene
EP1754052B1 (de) *	2004-06-03	2015-07-22	Phylogica Limited	Modulatoren biochemischer eigenschaften
EP1812038A1 (de)	2004-11-18	2007-08-01	VIB vzw	Fibronectin iii domäne als leptin-rezeptor-antagonisten
US8716220B2 (en) *	2005-09-07	2014-05-06	Nikolaos Tezapsidis	Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta
US8227408B2 (en) *	2005-09-07	2012-07-24	Neurotez, Inc.	Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
CA2663545A1 (en)	2006-09-19	2008-03-27	Phylogica Limited	Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof
US8822409B2 (en)	2007-06-20	2014-09-02	Phylogica Limited	Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith
CA2725143A1 (en) *	2008-05-21	2009-11-26	Neurotez, Inc.	Methods for treating progressive cognitive disorders related to neurofibrillary tangles
GB201504859D0 (en)	2015-03-23	2015-05-06	Vib Vzw	Viral particle based small molecule-protein interaction trap
JP2023507172A (ja)	2019-12-17	2023-02-21	オリオニスバイオサイエンシズ，インコーポレイテッド	タンパク質分解の調節

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US5521066A (en)	1993-09-13	1996-05-28	Bristol-Myers Squibb Company	Periplasmic membrane-bound system for detecting protein-protein interactions
US5716622A (en) *	1995-01-06	1998-02-10	The Rockefeller University	Functionally active regions of signal transducer and activators of transcription
US5712149A (en) *	1995-02-03	1998-01-27	Cell Genesys, Inc.	Chimeric receptor molecules for delivery of co-stimulatory signals
GB9511935D0 (en)	1995-06-13	1995-08-09	Smithkline Beecham Plc	Novel compound
US5972621A (en) *	1995-11-27	1999-10-26	Millennium Pharmaceuticals, Inc.	Methods of identifying compounds that modulate body weight using the OB receptor
AU1406497A (en)	1995-12-06	1997-06-27	Schering Corporation	Mutational variants of mammalian ob gene proteins
US7063958B1 (en)	1996-01-16	2006-06-20	The Rockefeller University	Nucleic acids db, the receptor for leptin
AU2053197A (en)	1996-02-23	1997-09-10	Ariad Pharmaceuticals, Inc.	Cell-based assay
EP0914611A4 (de) *	1996-04-22	2002-10-16	Merck & Co Inc	Transaktivierung von leptin
KR20000016402A (ko)	1996-06-06	2000-03-25	피터 기딩스	렙틴(ob단백질)의 프레그먼트
US6001816A (en) *	1996-06-20	1999-12-14	Merck & Co., Inc.	Gene therapy for leptin deficiency
EP0954579A1 (de) *	1996-06-20	1999-11-10	Merck & Co., Inc.	Gentherapie gegen Fettleibigkeit
EP0921820A4 (de) *	1996-06-20	2003-01-15	Merck & Co Inc	Genterapie für die fettleibigkeit
US5843697A (en) *	1996-07-17	1998-12-01	University Of Medicine And Dentistry Of New Jersey	Cells expressing IL-10 receptor and the CRFB4 gene product, an IL-10 receptor accessory protein
US5776689A (en) *	1996-07-19	1998-07-07	The Regents Of The University Of California	Protein recruitment system
WO1998012224A1 (en) *	1996-09-20	1998-03-26	Hoechst Aktiengesellschaft	Use of leptin antagonists for treating insulin resistance in type ii diabetes
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US5885779A (en) *	1997-09-09	1999-03-23	University Of British Columbia	Repressed trans-activator system for characterization of protein-protein interactions
EP1053007A2 (de)	1998-02-11	2000-11-22	Beth Israel Deaconess Medical Center	Methoden und zusammensetzungen zur modulierung der leptinaktivität
EP1101112B1 (de)	1998-07-28	2004-10-06	Vlaams Interuniversitair Instituut voor Biotechnologie vzw.	Leptin vermittelte geninduktion
WO2000006722A1 (en)	1998-07-28	2000-02-10	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw	Eukaryotic cell-based gene interaction cloning
EP1027608B1 (de)	1998-07-30	2010-01-20	Odyssey Thera, Inc.	Eiweisbruchstückergänzungstests
DE60133896D1 (de) *	2000-06-13	2008-06-19	Bayer Healthcare Ag	Regulierung einer humanen transmembran-serinprotease
EP1363949B1 (de)	2000-11-14	2007-09-26	Vlaams Interuniversitair Instituut voor Biotechnologie vzw.	Funktionelles fragment des leptinrezeptors
CN1491232A (zh)	2001-02-06	2004-04-21	Ĭ��ר��޹�˾	免疫原性减弱的经修饰肥胖蛋白

1999
- 1999-07-27 EP EP99941484A patent/EP1101112B1/de not_active Expired - Lifetime
- 1999-07-27 CA CA002335107A patent/CA2335107C/en not_active Expired - Lifetime
- 1999-07-27 WO PCT/EP1999/005489 patent/WO2000007014A2/en not_active Ceased
- 1999-07-27 AU AU55084/99A patent/AU756617B2/en not_active Expired
- 1999-07-27 JP JP2000562753A patent/JP2002521496A/ja active Pending
- 1999-07-27 DE DE69920921T patent/DE69920921T2/de not_active Expired - Lifetime
- 1999-07-27 AT AT99941484T patent/ATE278952T1/de not_active IP Right Cessation
2002
- 2002-09-04 US US10/235,264 patent/US7291458B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20030036526A1 (en)	2003-02-20
WO2000007014A2 (en)	2000-02-10
JP2002521496A (ja)	2002-07-16
US7291458B2 (en)	2007-11-06
AU756617B2 (en)	2003-01-16
DE69920921T2 (de)	2006-03-09
DE69920921D1 (de)	2004-11-11
AU5508499A (en)	2000-02-21
EP1101112B1 (de)	2004-10-06
CA2335107A1 (en)	2000-02-10
EP1101112A2 (de)	2001-05-23
CA2335107C (en)	2010-01-19
WO2000007014A3 (en)	2000-04-27

Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE278952T1 (de)	2004-10-15	Leptin vermittelte geninduktion
Jinushi et al.	2003	Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid
BR9812540A (pt)	2001-12-26	Expressão de genes endógenos por recombinaçãonão homóloga de uma construção de vetor comdna celular
BR9407512A (pt)	1997-01-07	Sequência de ácidos nucléicos vírus recombinante defectivo vetor notadamente virale composição farmaceutica e utilização de uma sequencia de ácidos nucléicos
PT633941E (pt)	2002-10-31	Promotores eurocarioticos sinteticos contendo dois elementos indutiveis
Araki et al.	1998	Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin
FI961202A0 (fi)	1996-03-14	Grb3-3-geeni, sen variantteja ja niiden käyttöjä
KR930701610A (ko)	1993-06-12	미생물의 세포, 조직 또는 숙주 지향성을 변화시키는 방법, 이 방법으로 수득된 재조합 미생물, 및 의학 및 수의학분야에서 이들을 사용하는 방법
Neel et al.	2000	The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis
ATE221124T1 (de)	2002-08-15	Kombinationsvektoren zum austragen von genmaterial
HU9401604D0 (en)	1994-09-28	Production of proteins using fb2 protein
DE69223237D1 (de)	1998-01-02	Zusammensetzungen von zerspanbaren messing
ATE302215T1 (de)	2005-09-15	Modulatoren von intrazellulären entzündungs-, zelltod- und zellüberlebenswegen, die card- und kinase-domänen enthalten
CA2220012A1 (en)	1996-11-07	Methods for modulating t cell survival by modulating bcl-xl protein level
ATE120209T1 (de)	1995-04-15	Isolierung von einkettigen proteinen mit fsh unter- drückender aktivität aus follikularflüssigkeit.
GB9203821D0 (en)	1992-04-08	Improvements in or relating to malaria vaccine
Scott	1984	The role of cytoskeletal integrity in cellular transformation
DE69619530D1 (de)	2002-04-04	Zyklische somatostatinanaloge mit wachstumhormon inhibierender aktivität
Terashima et al.	1999	Introduction of NAD decreases fMLP‐induced actin polymerization in chicken polymorphonuclear leukocytes‐The role of intracellular ADP‐ribosylation of actin for cytoskeletal organization
ATE362531T1 (de)	2007-06-15	Interne ribosom eintrittstelle (ires), vektor der diesen enthaltet und dessen therapeutische verwendung
USD166021S (en)	1952-02-26	birkestol
Vrtis et al.	1991	405 Influenza a virus enhances eosinophil (EOS) generation of superoxide (O2−)
Reddigari et al.	1991	406 Connective tissue activating peptide-III and neutrophil activating peptide-2 both release histamine from human basophils
Hiwasaa et al.	1998	Down-regulation of protein kinase CK and Q and enhanced TPA-induced neurite formation in DAN-transfected neuroblastoma cells
Reddy et al.	1985	Pattern of protein profiles of reproductive organs after induced bilateral cryptorchidism in albino rats