ATE279461T1 - Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung - Google Patents

Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung

Info

Publication number
ATE279461T1
ATE279461T1 AT98915208T AT98915208T ATE279461T1 AT E279461 T1 ATE279461 T1 AT E279461T1 AT 98915208 T AT98915208 T AT 98915208T AT 98915208 T AT98915208 T AT 98915208T AT E279461 T1 ATE279461 T1 AT E279461T1
Authority
AT
Austria
Prior art keywords
polymers
compositions
methods
articles
production
Prior art date
Application number
AT98915208T
Other languages
English (en)
Inventor
Hai-Quan Mao
Kam W Leong
Wenbin Dang
Hungnan Lo
Zhong Zhao
David P Nowotnik
James P English
Original Assignee
Guilford Pharm Inc
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc, Univ Johns Hopkins Med filed Critical Guilford Pharm Inc
Application granted granted Critical
Publication of ATE279461T1 publication Critical patent/ATE279461T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/692Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/692Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
    • C08G63/6924Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/6926Dicarboxylic acids and dihydroxy compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06At least partially resorbable materials
    • A61L17/10At least partially resorbable materials containing macromolecular materials
    • A61L17/12Homopolymers or copolymers of glycolic acid or lactic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L85/00Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
    • C08L85/02Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers containing phosphorus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2913Rod, strand, filament or fiber
    • Y10T428/2933Coated or with bond, impregnation or core
    • Y10T428/2938Coating on discrete and individual rods, strands or filaments
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/30Woven fabric [i.e., woven strand or strip material]
    • Y10T442/3472Woven fabric including an additional woven fabric layer
    • Y10T442/3528Three or more fabric layers
    • Y10T442/3545Woven fabric layers impregnated with a blend of thermosetting and thermoplastic resins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
AT98915208T 1997-04-03 1998-04-02 Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung ATE279461T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83221597A 1997-04-03 1997-04-03
PCT/US1998/006381 WO1998044021A1 (en) 1997-04-03 1998-04-02 Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same

Publications (1)

Publication Number Publication Date
ATE279461T1 true ATE279461T1 (de) 2004-10-15

Family

ID=25261011

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98915208T ATE279461T1 (de) 1997-04-03 1998-04-02 Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung

Country Status (16)

Country Link
US (2) US6322797B1 (de)
EP (1) EP0973818B1 (de)
JP (1) JP4496316B2 (de)
KR (1) KR20010006026A (de)
CN (1) CN1256700A (de)
AT (1) ATE279461T1 (de)
AU (1) AU741145B2 (de)
BR (1) BR9809064A (de)
CA (1) CA2285903A1 (de)
DE (1) DE69826994T2 (de)
HU (1) HUP0001256A3 (de)
IL (1) IL132120A0 (de)
NO (1) NO994802L (de)
NZ (1) NZ500649A (de)
TW (1) TW534915B (de)
WO (1) WO1998044021A1 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033608B1 (en) * 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6322797B1 (en) * 1997-04-03 2001-11-27 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same
US6828357B1 (en) * 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US5959066A (en) 1998-04-23 1999-09-28 Hna Holdings, Inc. Polyesters including isosorbide as a comonomer and methods for making same
US6063465A (en) 1998-04-23 2000-05-16 Hna Holdings, Inc. Polyester container and method for making same
US6063464A (en) 1998-04-23 2000-05-16 Hna Holdings, Inc. Isosorbide containing polyesters and methods for making same
US5958581A (en) 1998-04-23 1999-09-28 Hna Holdings, Inc. Polyester film and methods for making same
US6025061A (en) 1998-04-23 2000-02-15 Hna Holdings, Inc. Sheets formed from polyesters including isosorbide
US6548302B1 (en) 1998-06-18 2003-04-15 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
JP2002526396A (ja) * 1998-10-02 2002-08-20 ギルフォード ファーマシュウティカルズ インコーポレイテッド 生分解性テレフタレートポリエステル−ポリホスホネートとポリエステル−ポリホスファイトの組成物、物品、及びそれらの使用方法
US6153212A (en) 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6350464B1 (en) * 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
PT1163019E (pt) * 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
US6537585B1 (en) * 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
AU4230900A (en) * 1999-04-08 2000-10-23 General Hospital Corporation, The Purposeful movement of human migratory cells away from an agent source
KR20010081686A (ko) * 2000-02-18 2001-08-29 윤여생 생분해성 일회용 주사기
WO2002004544A2 (en) 2000-07-06 2002-01-17 Guilford Pharmaceuticals Polymers and polymerization processes
US20020045668A1 (en) * 2000-07-17 2002-04-18 Wenbin Dang Compositions for sustained release of analgesic agents, and methods of making and using the same
AU2002215333A1 (en) * 2000-10-12 2002-04-22 Guilford Pharmaceuticals Inc. Compositions for release of radiosensitizers, and methods of making and using the same
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
SG125885A1 (en) * 2000-12-05 2006-10-30 Univ Singapore A polymer and nerve guide conduits formed thereof
US7345138B2 (en) * 2001-05-14 2008-03-18 Johns Hopkins Singapore Pte Ltd. Biodegradable polyphosphates for controlled release of bioactive substances
ES2312593T3 (es) 2001-07-09 2009-03-01 Repros Therapeutics Inc. Procedimientos y materiales para el tratamiento de la deficiencia de testosterona en hombres.
US7737185B2 (en) * 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
WO2003007915A2 (en) * 2001-07-19 2003-01-30 Guilford Pharmaceuticals, Inc. Compositions for treatment of head and neck cancers, and methods of making and using the same
US20030133903A1 (en) * 2001-07-19 2003-07-17 Wenbin Dang Compositions for treatment of prostate cancers and methods of making and using the same
WO2003060799A2 (en) * 2002-01-09 2003-07-24 Guilford Pharmaceuticals, Inc. Compositions for treatment of central nervous system neoplasms, and methods of making and using the same
KR20100110378A (ko) 2002-05-24 2010-10-12 안지오테크 인터내셔날 아게 의료용 임플란트를 피복하기 위한 조성물 및 방법
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
US20040043067A1 (en) * 2002-06-19 2004-03-04 Salamone Joseph C. Fluorosiloxane matrix controlled diffusion drug delivery systems
PT1638615E (pt) * 2003-05-08 2015-02-04 Tepha Inc Fibras e tecidos médicos de polihidroxialcanoato
US20040253293A1 (en) * 2003-06-16 2004-12-16 Afshin Shafiee Rate controlled release of a pharmaceutical agent in a biodegradable device
CA2531833C (en) * 2003-07-08 2009-10-20 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US7785512B1 (en) 2003-07-31 2010-08-31 Advanced Cardiovascular Systems, Inc. Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
WO2005013810A2 (en) * 2003-08-07 2005-02-17 University Of Florida Biodegradable embolic agents
WO2005020825A1 (en) * 2003-08-22 2005-03-10 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
US20050209664A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Electrical devices and anti-scarring agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
EP1687041A2 (de) * 2003-11-20 2006-08-09 Angiotech International AG Weichteilimplantate und anti-narbenmittel
WO2005057165A2 (en) * 2003-12-05 2005-06-23 The Regents Of The University Of Michigan Biodegradable/bioresorbable tissue augmentation/reconstruction device
US7435788B2 (en) 2003-12-19 2008-10-14 Advanced Cardiovascular Systems, Inc. Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
EP2633853A1 (de) * 2004-01-12 2013-09-04 The Trustees of The University of Pennsylvania Langzeitabgabe von Lieferungsformulierungen und Verwendungsverfahren dafür
EP1735024A1 (de) * 2004-03-26 2006-12-27 SurModics, Inc. Verfahren und systeme für biokompatible oberflächen
CA2560507C (en) * 2004-03-26 2011-08-16 Surmodics, Inc. Composition and method for preparing biocompatible surfaces
US7820732B2 (en) 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US20050288481A1 (en) 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
WO2006002399A2 (en) * 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable implantable medical devices, methods and systems
BRPI0513129A (pt) * 2004-07-14 2008-04-29 Repros Therapeutics Inc método de tratamento de condição selecionada do grupo que consiste em hipertrofia benigna de próstata, cáncer de próstata, trigliceridos elevados, colesterol alto e hipogonadismo
PT1778305E (pt) * 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
WO2006023130A2 (en) * 2004-08-12 2006-03-02 Surmodics, Inc. Biodegradable controlled release bioactive agent delivery device
US20100297248A1 (en) * 2004-09-01 2010-11-25 Board Of Regents, The University Of Texas System Encapsulated particles for amorphous stability enhancement
US20060045822A1 (en) 2004-09-01 2006-03-02 Board Of Regents, The University Of Texas System Plasma polymerization for encapsulating particles
US7166680B2 (en) 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
WO2006050493A2 (en) 2004-11-03 2006-05-11 The Regents Of The University Of Michigan Biodegradable implant for intertransverse process fusion
JP2008519052A (ja) 2004-11-05 2008-06-05 ザ ジェネラル ホスピタル コーポレイション 薬剤によるヒト遊走性細胞の合目的的挙動
US20060134174A1 (en) * 2004-12-22 2006-06-22 Bausch & Lomb Incorporated Pharmaceutical delivery system and method of use
US20060147491A1 (en) * 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
US20060198868A1 (en) * 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
CN100408037C (zh) * 2005-02-03 2008-08-06 武汉大学 一种治疗骨髓炎的药物及制备方法
US20090215906A1 (en) * 2005-02-04 2009-08-27 Repros Therapeutics Inc. Methods and materials with trans-clomiphene for the treatment of male infertility
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
KR20070114187A (ko) * 2005-03-22 2007-11-29 레프로스 쎄라피우틱스 아이엔씨. 트랜스-클로미펜의 투약 방법
US9603941B2 (en) * 2006-01-24 2017-03-28 Minghui Chai Method of preparing dendritic drugs
US7910152B2 (en) * 2006-02-28 2011-03-22 Advanced Cardiovascular Systems, Inc. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology
WO2008030958A2 (en) * 2006-09-06 2008-03-13 Innfocus, Llc Apparatus, methods and devices for treatment of ocular disorders
WO2008030939A2 (en) * 2006-09-06 2008-03-13 Innovia, Llc Porous polymeric material particularly suited for medical implant applications
US7914819B1 (en) 2006-10-19 2011-03-29 Clemson University Research Foundation Polysaccharide-based biomaterials
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
WO2008073295A2 (en) * 2006-12-07 2008-06-19 Surmodics, Inc. Latent stabilization of bioactive agents releasable from implantable medical articles
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
BRPI0818637A2 (pt) 2007-10-16 2015-04-07 Repros Therapeutics Inc Métodos de tratamento de sintoma da síndrome metabólica, de glicose em jejum prejudicada, da síndrome metabólica e de redução de níveis de glicose em, jejum em sujeito com hipogonadismo hipogonadotrófico secundário ou idiopático
EP2262851B1 (de) 2008-03-13 2017-09-27 Board of Regents, The University of Texas System Kovalent funktionalisierte teilchen zur synthese neuer verbundwerkstoffe
JP5667559B2 (ja) 2008-03-28 2015-02-12 サーモディクス,インコーポレイティド 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法
WO2010006046A1 (en) * 2008-07-10 2010-01-14 Tyrx Pharma, Inc. Nsaid delivery from polyarylates
US9414864B2 (en) 2009-04-15 2016-08-16 Warsaw Orthopedic, Inc. Anterior spinal plate with preformed drug-eluting device affixed thereto
US9078712B2 (en) 2009-04-15 2015-07-14 Warsaw Orthopedic, Inc. Preformed drug-eluting device to be affixed to an anterior spinal plate
US9174000B2 (en) * 2009-10-08 2015-11-03 Sanofi-Aventis Deutschland Gmbh Drug delivery device with biodegradable plastic components
CA2791716C (en) 2010-03-03 2020-08-18 Novabone Products, Llc Devices and methods for the regeneration of bony defects
US9144629B2 (en) 2010-03-03 2015-09-29 Novabone Products, Llc Ionically crosslinked materials and methods for production
WO2015147923A1 (en) 2010-03-03 2015-10-01 Novabone Products, Llc Kit for delivering bone grafting materials
CA2796274A1 (en) 2010-04-16 2011-10-20 Apatech Limited Biomaterial
WO2011146078A1 (en) * 2010-05-21 2011-11-24 Board Of Regents, The University Of Texas System Encapsulated particles for enteric release
AU2012284097B2 (en) 2011-07-18 2017-08-03 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
CA2889770A1 (en) 2012-11-02 2014-05-08 Repros Therapeutics Inc. Trans-clomiphene for use in cancer therapy
WO2014190040A1 (en) 2013-05-21 2014-11-27 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
EP3083658B1 (de) 2013-12-18 2019-05-08 President and Fellows of Harvard College Detektion gram-positiver bakterien mit crp
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
EP3191593A4 (de) 2014-09-08 2018-01-24 University of Iowa Research Foundation Mikrorna-hemmersystem und verfahren zur verwendung davon
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
EP3763378A1 (de) 2015-08-06 2021-01-13 President and Fellows of Harvard College Verbesserte mikrobenbindende moleküle und verwendungen davon
US10273476B2 (en) 2016-04-30 2019-04-30 University Of Iowa Research Foundation MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
CN106039386A (zh) * 2016-06-16 2016-10-26 湖州科达化工燃料有限公司 一种抗感染的手术缝合线
CN109053440A (zh) * 2018-08-20 2018-12-21 苏州市湘园特种精细化工有限公司 一种对苯二甲酸双酯的制备方法
CN112642412A (zh) * 2020-12-18 2021-04-13 江苏大学 一步双乳液模板法制备冠醚功能化多孔微球吸附剂的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA597473A (en) 1960-05-03 Starck Werner Process for the manufacture of phosphorus-containing polyesters and copolymers thereof
US2891915A (en) 1954-07-02 1959-06-23 Du Pont Organophosphorus polymers
US3271329A (en) 1958-09-19 1966-09-06 Eastman Kodak Co Method for producing polymers derived from phosphites and glycols
SU203231A1 (ru) * 1963-05-09 1983-07-15 Akutin M S Способ получени полиарилатов
US3442982A (en) 1965-10-15 1969-05-06 Weston Chemical Corp Polyphosphites of 2,2-dimethyl-3-hydroxypropyl - 2 - dimethyl - 3-hydroxypropionate
FR2219193B1 (de) 1973-02-28 1976-05-21 Rhone Poulenc Sa
US3932566A (en) 1974-09-16 1976-01-13 Celanese Corporation Phosphonate polymers
US4100354A (en) 1976-08-05 1978-07-11 Owens-Corning Fiberglass Corporation Terephthalate ester polyols
US4259222A (en) 1978-08-16 1981-03-31 Basf Wyandotte Corporation Linear saturated polyesters of phosphoric acid and halogenated diols as flame-retardant additives and coatings
DE2925206A1 (de) 1979-06-22 1981-01-29 Bayer Ag Aromatische polyesterphosphonate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung thermoplastischer formkoerper
FR2498612A1 (fr) * 1981-01-26 1982-07-30 Peters Ligatures Nouveaux polymeres insolubles a biodegradabilite reglable a volonte, leurs procedes de preparation et leur application en tant que biomateriaux
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4474937A (en) 1983-10-03 1984-10-02 The Dow Chemical Company Phosphorus-modified polyestercarbonate resins
US4481353A (en) 1983-10-07 1984-11-06 The Children's Medical Center Corporation Bioresorbable polyesters and polyester composites
US4746462A (en) 1985-02-21 1988-05-24 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Phosphoric ester compound
GB8618334D0 (en) 1986-07-28 1986-09-03 Biocompatibles Ltd Polyesters
US4789724A (en) 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US4978332A (en) 1987-09-28 1990-12-18 Matrix Pharmaceutical, Inc. Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas
US5194581A (en) 1989-03-09 1993-03-16 Leong Kam W Biodegradable poly(phosphoesters)
US5256765A (en) 1989-03-09 1993-10-26 The Johns Hopkins University School Of Medicine Biodegradable poly(phosphate esters)
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
NZ240214A (en) 1990-10-16 1993-02-25 Takeda Chemical Industries Ltd Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
AU681231B2 (en) 1993-12-29 1997-08-21 Intarcia Therapeutics, Inc. Methods and compositions for the treatment of a host with a cellular proliferative disease
DE4404365A1 (de) 1994-02-11 1995-08-17 Cassella Ag Phosphin- und phosphonsäuregruppenhaltige Polykondensate
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
DE4440837A1 (de) 1994-11-15 1996-05-23 Basf Ag Biologisch abbaubare Polymere, Verfahren zu deren Herstellung sowie deren Verwendung zur Herstellung bioabbaubarer Formkörper
EP0895517B1 (de) 1996-04-23 2004-11-17 Ipsen Manufacturing Ireland Limited Saure Polymilchsäure Polymere
US6322797B1 (en) * 1997-04-03 2001-11-27 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same
CA2295209A1 (en) 1997-06-18 1998-12-23 Zhong Zhao Two-stage solution polymerization of high molecular weight poly(phosphoesters)
US6028163A (en) 1997-06-27 2000-02-22 Guilford Pharmaceuticals Inc. Solution polymerization of high molecular weight poly(phosphoesters) in toluene

Also Published As

Publication number Publication date
CN1256700A (zh) 2000-06-14
KR20010006026A (ko) 2001-01-15
US6322797B1 (en) 2001-11-27
JP2001519842A (ja) 2001-10-23
HUP0001256A2 (hu) 2002-01-28
WO1998044021A9 (en) 1999-04-22
NZ500649A (en) 2001-05-25
BR9809064A (pt) 2002-01-02
AU741145B2 (en) 2001-11-22
NO994802D0 (no) 1999-10-01
EP0973818B1 (de) 2004-10-13
HUP0001256A3 (en) 2002-12-28
AU6945098A (en) 1998-10-22
NO994802L (no) 1999-12-03
WO1998044021A1 (en) 1998-10-08
CA2285903A1 (en) 1998-10-08
JP4496316B2 (ja) 2010-07-07
DE69826994T2 (de) 2005-12-08
EP0973818A1 (de) 2000-01-26
IL132120A0 (en) 2001-03-19
US20020091230A1 (en) 2002-07-11
US6600010B2 (en) 2003-07-29
DE69826994D1 (de) 2004-11-18
TW534915B (en) 2003-06-01

Similar Documents

Publication Publication Date Title
ATE279461T1 (de) Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung
CA2285909A1 (en) Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
Guan et al. Synthesis, characterization, and cytocompatibility of elastomeric, biodegradable poly (ester‐urethane) ureas based on poly (caprolactone) and putrescine
NO995301L (no) Bionedbrytbare sammensetninger omfattende poly(cykloalifatisk fosfoester) forbindelser, artikler og fremgangsmåte for anvendelse derav
ATE218896T1 (de) Vorrichtung zur knochenbehandlung bestehend aus abbaubarem thermoplastischen copolyester und kultivierten zellen
DE69831300D1 (de) Biokompatible Polymerbeschichtungen
SI0866816T1 (de)
EP1033383A4 (de) Biologisch abbaubare folie und verfahren zu deren herstellung
EP0295055A3 (de) Biodegradierbare polymere Materialien auf der Basis von Polyetherglycolen, Verfahren zu ihrer Herstellung und chirurgische Gegenstände daraus
EP1114839A4 (de) Polyesterdiol, daraus hergestelltes polyurethan und spandexfaser, ein neues dialkylaminoenthaltendes acrylpolymer, polyurethanzusammensetzung und spandexzusammensetzung
DE69129770D1 (de) Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung
DE60108651D1 (de) Wärmegellierende bioabbaubare wässrige polymerlösung
Mohapatra et al. Biomedical application of polymeric biomaterial: polyhydroxybutyrate
ATE290564T1 (de) Funktionsfähige poly-alpha-aminosäurederivate zur modifizierung von biologisch wirksamen stoffen und deren herstellung
WO2000019976A3 (en) Biodegradable terephthalate polyester-poly(phosphonate) and polyester-poly(phosphite) compositions, articles, and methods of using them
ATE263835T1 (de) Verfahren zur herstellung eines hautimplantats und nach dem verfahren hergestelltes implantat
DE69713477D1 (de) Verfahren zur Herstellung von Polyhydroxycarbonsäure
Skarja The development and characterization of degradable, segmented polyurethanes containing amino acid-based chain extenders
van Bochove et al. In Vitro and In Vivo Degradation of Photo-Crosslinked Poly (Trimethylene Carbonate-co-𝝐-Caprolactone) Networks
Ponsart et al. Mechanical Properties and Lipase-Catalyzed Biodegradation of α-Methyl, ε-Caprolactone/ε-Caprolactone Copolymers Obtained by Chemical Modification of Poly (ε-caprolactone)
Sariri et al. Biodegradable Polyglycol Succinates Used as Disposables
Ponsart et al. Mechanical Properties and Lipase-Catalyzed Biodegradation of a-Methyl, e-Caprolactone/ e-Caprolactone Copolymers Obtained by Chemical Modification of Poly (e-caprolactone)

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties