ATE168391T1 - Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung - Google Patents

Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung

Info

Publication number
ATE168391T1
ATE168391T1 AT91303163T AT91303163T ATE168391T1 AT E168391 T1 ATE168391 T1 AT E168391T1 AT 91303163 T AT91303163 T AT 91303163T AT 91303163 T AT91303163 T AT 91303163T AT E168391 T1 ATE168391 T1 AT E168391T1
Authority
AT
Austria
Prior art keywords
production
high molecular
biodegradable
low
molecular polymers
Prior art date
Application number
AT91303163T
Other languages
English (en)
Inventor
Minoru Yamada
Toshiro Heya
Yasuaki Ogawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE168391T1 publication Critical patent/ATE168391T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91303163T 1990-04-13 1991-04-10 Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung ATE168391T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9851090 1990-04-13

Publications (1)

Publication Number Publication Date
ATE168391T1 true ATE168391T1 (de) 1998-08-15

Family

ID=14221647

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91303163T ATE168391T1 (de) 1990-04-13 1991-04-10 Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung

Country Status (6)

Country Link
US (1) US5585460A (de)
EP (1) EP0452111B1 (de)
AT (1) ATE168391T1 (de)
CA (1) CA2040141C (de)
DE (1) DE69129770T2 (de)
HU (1) HUT59943A (de)

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US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
ATE288270T1 (de) * 1993-11-19 2005-02-15 Janssen Pharmaceutica Nv Mikroverkapselte 1,2-benzazole
US5942597A (en) * 1995-08-21 1999-08-24 The Procter & Gamble Company Solvent extraction of polyhydroxyalkanoates from biomass
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
US5821299A (en) * 1996-02-16 1998-10-13 The Proctor & Gamble Company Solvent extraction of polyhydroxy-alkanoates from biomass facilitated by the use of marginal nonsolvent
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
WO1998046782A1 (en) * 1997-04-15 1998-10-22 Monsanto Company Methods of pha extraction and recovery using non-halogenated solvents
AU6974398A (en) * 1997-04-15 1998-11-11 Monsanto Company High temperature pha extraction using pha-poor solvents
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
EP1042388B1 (de) 1997-12-22 2006-11-15 Metabolix, Inc. Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
DE60036863T2 (de) 1999-03-25 2008-07-31 Metabolix, Inc., Cambridge Medizinische vorrichtungen und verwendungen von polyhydroxyalkanoatpolymeren
ES2256276T5 (es) * 2000-08-07 2011-02-22 Wako Pure Chemical Industries, Ltd. Polímero de ácido láctico y procedimiento para su producción.
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
TWI225416B (en) 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
TW200526267A (en) * 2001-06-29 2005-08-16 Takeda Chemical Industries Ltd Controlled release composition and method of producing the same
CN1620285A (zh) * 2001-12-26 2005-05-25 武田药品工业株式会社 新微球和其生产方法
PT2561860T (pt) 2002-05-31 2018-05-08 Titan Pharmaceuticals Inc Dispositivo polimérico implantável para a libertação prolongada de buprenorfina
KR100709015B1 (ko) * 2002-11-13 2007-04-18 (주)아모레퍼시픽 지속적 약물방출이 가능한 고분자 미립구 및 그 제조방법
SI1610791T1 (sl) 2003-03-31 2011-05-31 Titan Pharmaceuticals Inc Implantibilna polimerna naprava za zadržano sproščanje dopaminskega agonista
EP1638615B1 (de) 2003-05-08 2014-10-29 Tepha, Inc. Medizinische polyhydroxyalkanoat-textilien und fasern
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
ES2362217T3 (es) 2004-08-03 2011-06-29 Tepha, Inc. Suturas de polihidroxialcanoato no rizadas.
US7342048B2 (en) * 2005-04-28 2008-03-11 Nipro Corporation Bioabsorbable pharmaceutical formulation
CA2637569C (en) 2006-01-18 2013-01-08 Yuhua Li Pharmaceutical compositions with enhanced stability
US20070179276A1 (en) * 2006-01-31 2007-08-02 Purac Biochem Bv Method for the purification of resorbable polymers from residual monomers
US8076448B2 (en) 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8414424B2 (en) * 2006-12-12 2013-04-09 Acushnet Company Anti-counterfeiting system using compound additives
MY148370A (en) 2006-12-18 2013-04-15 Takeda Pharmaceutical Sustained-release composition and method for producing the same
EP3202814B1 (de) 2007-02-15 2019-10-16 Tolmar Therapeutics, Inc. Poly-(lactid/glycolid) mit geringen burst-eigenschaften und verfahren zur herstellung von polymeren
DE102007020951A1 (de) * 2007-05-04 2008-11-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren und Vorrichtung zur Reinigung eines resorbierbaren Polyesters
CA2742361C (en) * 2008-11-07 2013-07-30 Samyang Corporation Highly purified polylactic acid or a derivative thereof, a salt of the same, and purification method thereof
WO2010111238A2 (en) * 2009-03-23 2010-09-30 Micell Technologies, Inc. Improved biodegradable polymers
US8293444B2 (en) 2009-06-24 2012-10-23 Xerox Corporation Purified polyester resins for toner performance improvement
WO2014168134A1 (ja) 2013-04-11 2014-10-16 三井化学株式会社 乳酸―グリコール酸共重合体の製造法またはその塩の製造法
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US20160106804A1 (en) 2014-10-15 2016-04-21 Yuhua Li Pharmaceutical composition with improved stability
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE61935T1 (de) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
US5182258A (en) * 1989-03-20 1993-01-26 Orbon Corporation Systemic delivery of polypeptides through the eye

Also Published As

Publication number Publication date
CA2040141A1 (en) 1991-10-14
US5585460A (en) 1996-12-17
HUT59943A (en) 1992-07-28
EP0452111B1 (de) 1998-07-15
DE69129770D1 (de) 1998-08-20
HU911222D0 (en) 1991-10-28
EP0452111A2 (de) 1991-10-16
DE69129770T2 (de) 1998-11-19
EP0452111A3 (en) 1992-08-05
CA2040141C (en) 2002-05-14

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