ATE168391T1 - Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung - Google Patents

Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung

Info

Publication number
ATE168391T1
ATE168391T1 AT91303163T AT91303163T ATE168391T1 AT E168391 T1 ATE168391 T1 AT E168391T1 AT 91303163 T AT91303163 T AT 91303163T AT 91303163 T AT91303163 T AT 91303163T AT E168391 T1 ATE168391 T1 AT E168391T1
Authority
AT
Austria
Prior art keywords
production
high molecular
biodegradable
low
molecular polymers
Prior art date
Application number
AT91303163T
Other languages
English (en)
Inventor
Minoru Yamada
Toshiro Heya
Yasuaki Ogawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE168391T1 publication Critical patent/ATE168391T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91303163T 1990-04-13 1991-04-10 Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung ATE168391T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9851090 1990-04-13

Publications (1)

Publication Number Publication Date
ATE168391T1 true ATE168391T1 (de) 1998-08-15

Family

ID=14221647

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91303163T ATE168391T1 (de) 1990-04-13 1991-04-10 Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung

Country Status (6)

Country Link
US (1) US5585460A (de)
EP (1) EP0452111B1 (de)
AT (1) ATE168391T1 (de)
CA (1) CA2040141C (de)
DE (1) DE69129770T2 (de)
HU (1) HUT59943A (de)

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MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
CN1074923C (zh) 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
US5942597A (en) * 1995-08-21 1999-08-24 The Procter & Gamble Company Solvent extraction of polyhydroxyalkanoates from biomass
TW448055B (en) * 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
US5821299A (en) * 1996-02-16 1998-10-13 The Proctor & Gamble Company Solvent extraction of polyhydroxy-alkanoates from biomass facilitated by the use of marginal nonsolvent
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
DE69837914T2 (de) * 1997-04-15 2008-02-21 Metabolix, Inc., Cambridge Hochtemperatur-PHA Extraktion mit schlecht-lösenden Lösungsmittel für PHA
AU6971598A (en) * 1997-04-15 1998-11-11 Monsanto Company Methods of pha extraction and recovery using non-halogenated solvents
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
ATE345359T1 (de) 1997-12-22 2006-12-15 Metabolix Inc Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
PT1163019E (pt) 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
DK1310517T4 (da) * 2000-08-07 2011-01-17 Wako Pure Chem Ind Ltd Mælkesyrepolymer og fremgangsmåde til fremstilling af denne
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
TWI332407B (en) * 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
TWI225416B (en) 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
US20050064039A1 (en) * 2001-12-26 2005-03-24 Tomomichi Futo Novel microsphere and method for production thereof
AU2003240493B2 (en) 2002-05-31 2008-06-12 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Implantable polymeric device for sustained release of buprenorphine
KR100709015B1 (ko) * 2002-11-13 2007-04-18 (주)아모레퍼시픽 지속적 약물방출이 가능한 고분자 미립구 및 그 제조방법
DE602004031512D1 (de) 2003-03-31 2011-04-07 Titan Pharmaceuticals Inc Polymeres implantat zur verzögerten freisetzung von dopamin antagonisten
PT1638615E (pt) 2003-05-08 2015-02-04 Tepha Inc Fibras e tecidos médicos de polihidroxialcanoato
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
PT1778305E (pt) 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
ATE382337T1 (de) * 2005-04-28 2008-01-15 Nipro Corp Bioabsorbierbare pharmazeutische zusammensetzung enthaltend einen plga-copolymer
MX2008009125A (es) 2006-01-18 2008-10-23 Qps Llc Composiciones farmaceuticas con estabilidad mejorada.
US20070179276A1 (en) * 2006-01-31 2007-08-02 Purac Biochem Bv Method for the purification of resorbable polymers from residual monomers
US8076448B2 (en) 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8414424B2 (en) * 2006-12-12 2013-04-09 Acushnet Company Anti-counterfeiting system using compound additives
TWI481424B (zh) 2006-12-18 2015-04-21 Takeda Pharmaceutical 緩釋性組成物及其製法
US9187593B2 (en) 2007-02-15 2015-11-17 Tolmar Therapeutics, Inc. Low burst polymers and methods to produce polymer
DE102007020951A1 (de) * 2007-05-04 2008-11-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren und Vorrichtung zur Reinigung eines resorbierbaren Polyesters
JP5567581B2 (ja) * 2008-11-07 2014-08-06 サムヤン バイオファーマシューティカルズ コーポレイション 高純度ポリ乳酸、その塩またはその誘導体、及びその精製方法
US20100256746A1 (en) * 2009-03-23 2010-10-07 Micell Technologies, Inc. Biodegradable polymers
US8293444B2 (en) 2009-06-24 2012-10-23 Xerox Corporation Purified polyester resins for toner performance improvement
US10011681B2 (en) 2013-04-11 2018-07-03 Mitsui Chemicals, Inc. Process for producing a lactic acid-glycolic acid copolymer or a salt thereof
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US20160106804A1 (en) 2014-10-15 2016-04-21 Yuhua Li Pharmaceutical composition with improved stability
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE61935T1 (de) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
US5182258A (en) * 1989-03-20 1993-01-26 Orbon Corporation Systemic delivery of polypeptides through the eye

Also Published As

Publication number Publication date
EP0452111B1 (de) 1998-07-15
DE69129770D1 (de) 1998-08-20
HU911222D0 (en) 1991-10-28
US5585460A (en) 1996-12-17
EP0452111A2 (de) 1991-10-16
CA2040141C (en) 2002-05-14
HUT59943A (en) 1992-07-28
CA2040141A1 (en) 1991-10-14
DE69129770T2 (de) 1998-11-19
EP0452111A3 (en) 1992-08-05

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