ATE280756T1 - Substituierte benzolverbindungen als antiproliferative mittel - Google Patents

Substituierte benzolverbindungen als antiproliferative mittel

Info

Publication number
ATE280756T1
ATE280756T1 AT98939384T AT98939384T ATE280756T1 AT E280756 T1 ATE280756 T1 AT E280756T1 AT 98939384 T AT98939384 T AT 98939384T AT 98939384 T AT98939384 T AT 98939384T AT E280756 T1 ATE280756 T1 AT E280756T1
Authority
AT
Austria
Prior art keywords
agents
substituted benzene
antiproliferative agents
compositions
benzene compounds
Prior art date
Application number
AT98939384T
Other languages
English (en)
Inventor
Julio Cesar Medina
David Louis Clark
John A Flygare
Terry J Rosen
Bei Shan
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Application granted granted Critical
Publication of ATE280756T1 publication Critical patent/ATE280756T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98939384T 1997-08-22 1998-08-13 Substituierte benzolverbindungen als antiproliferative mittel ATE280756T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/917,025 US6284923B1 (en) 1997-08-22 1997-08-22 Substituted benzene compounds as antiproliferative and cholesterol lowering action
PCT/US1998/016781 WO1999010320A1 (en) 1997-08-22 1998-08-13 Substituted benzene compounds as antiproliferative and cholesterol lowering agents

Publications (1)

Publication Number Publication Date
ATE280756T1 true ATE280756T1 (de) 2004-11-15

Family

ID=25438246

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98939384T ATE280756T1 (de) 1997-08-22 1998-08-13 Substituierte benzolverbindungen als antiproliferative mittel

Country Status (10)

Country Link
US (2) US6284923B1 (de)
EP (1) EP1005453B1 (de)
JP (1) JP4309041B2 (de)
AT (1) ATE280756T1 (de)
AU (1) AU748826B2 (de)
CA (1) CA2301842C (de)
DE (1) DE69827267T2 (de)
ES (1) ES2245803T3 (de)
PT (1) PT1005453E (de)
WO (1) WO1999010320A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3421349B2 (ja) * 1996-02-22 2003-06-30 テュラリク インコーポレイテッド ペンタフルオロベンゼンスルホンアミドおよび類縁体
CA2260777C (en) * 1996-07-19 2006-06-13 Tularik, Inc. Pentafluorobenzenesulfonamides and analogs
EP1053227B1 (de) 1998-01-29 2008-11-05 Amgen Inc. Ppar-gamma modulatoren
US6583157B2 (en) 1998-01-29 2003-06-24 Tularik Inc. Quinolinyl and benzothiazolyl modulators
AU763687B2 (en) * 1998-06-25 2003-07-31 Tularik Inc. Arylsulfonanilide phosphates
TR200101549T2 (tr) * 1998-12-02 2001-11-21 Pfizer Products Inc. p53-Familyasından bir proteinin yapısal kararlılığının canlandırılmasına yönelik metotlar.
CN1171872C (zh) * 1999-06-30 2004-10-20 图拉列克股份有限公司 调节PPARγ活性的化合物
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
US6306615B1 (en) 1999-08-19 2001-10-23 Tularik Inc. Detection method for monitoring β tubulin isotype specific modification
WO2001082916A2 (en) 2000-05-03 2001-11-08 Tularik Inc. Combination therapeutic compositions and methods of use
US20030171399A1 (en) 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US6822001B2 (en) 2000-11-03 2004-11-23 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US7547716B2 (en) * 2001-06-08 2009-06-16 Institute Of Medicinal Molecular Design, Inc. Sulfonamide derivatives
JP2003081937A (ja) * 2001-09-07 2003-03-19 Bayer Ag ベンゼンスルホンアミド誘導体
US7833734B2 (en) * 2002-11-26 2010-11-16 Institute Of Virology Of The Slovak Academy Of Sciences CA IX-specific inhibitors
AU2003295950B2 (en) * 2002-11-26 2007-06-28 Institute Of Virology CA IX-specific inhibitors
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
FI20055498A0 (fi) * 2005-09-16 2005-09-16 Biotie Therapies Corp Sulfonamidijohdannaisia
GB0526252D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
US9096558B2 (en) 2010-07-09 2015-08-04 Pfizer Limited N-sulfonylbenzamide compounds
EP2632920A1 (de) 2010-10-27 2013-09-04 Dynamix Pharmaceuticals Ltd. Sulfonamide zur modulation von pkm2
WO2014083384A1 (en) * 2012-11-28 2014-06-05 Stichting Dienst Landbouwkundig Onderzoek Benzenesulfonamide compounds for somatic embryogenesis iν plants
CN105452745B (zh) * 2013-08-28 2019-03-19 博格华纳公司 高温阀轴密封
GB201514021D0 (en) 2015-08-07 2015-09-23 Arner Elias Set Jeno Novel Pyridines and their use in the treatment of cancer
BR112019016223A2 (pt) 2017-02-07 2020-04-07 Oblique Therapeutics Ab piridinas substituídas por heteroarilsulfonila e uso das mesmas no tratamento de câncer
MX389800B (es) 2017-02-07 2025-03-20 Oblique Therapeutics Ab Piridinas sustituidas con heterociclilsulfonilo y su uso en el tratamiento del cancer
RU2019128063A (ru) 2017-02-07 2021-03-09 Облик Терапьютикс Аб Углеводородсульфонилзамещенные пиридины и их применение при лечении рака
AU2018218518B2 (en) 2017-02-07 2022-03-17 Oblique Therapeutics Ab Sulfinylpyridines and their use in the treatment of cancer
WO2020097408A1 (en) * 2018-11-09 2020-05-14 Nimbus Artemis, Inc. Acly inhibitors and uses thereof
AU2020315192A1 (en) * 2019-07-17 2022-02-24 2692372 Ontario, Inc. Benzenesulfonamide derivatives and uses thereof
MX2024011428A (es) * 2022-03-21 2024-09-24 Chemocentryx Inc Compuestos de sulfonamida para cxcr6.
WO2024175999A2 (en) * 2023-02-23 2024-08-29 Dunad Therapeutics Ltd. Benzenesulfonamide derivatives and uses thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1955207A (en) 1931-09-16 1934-04-17 Ig Farbenindustrie Ag Mothproofing agent
DE622494C (de) 1932-01-03 1935-11-29 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Mono- bzw. Polynitropolysulfonen und deren Reduktionsprodukten
US2358365A (en) 1940-08-03 1944-09-19 Parke Davis & Co Sulphonamide derivatives and process for obtaining the same
US2450863A (en) 1946-03-07 1948-10-05 Socony Vacuum Oil Co Inc Amides from sulfonyl fluorides
CH362688A (de) 1957-09-10 1962-06-30 Geigy Ag J R Verfahren zur Herstellung von neuen Arylsulfonarylamiden
US2937202A (en) 1958-05-19 1960-05-17 Dow Chemical Co Substituted benzenesulfonanilides
GB938890A (en) 1961-02-03 1963-10-09 Boots Pure Drug Co Ltd New fungicidal compositions and compounds
NL301745A (de) 1962-12-17
CH504416A (de) * 1966-12-05 1971-03-15 Ciba Geigy Ag Verfahren zur Herstellung von aromatischen Sulfamoylverbindungen
US3505455A (en) 1966-12-15 1970-04-07 Ansul Co Nematocidal method
NL174644C (nl) 1970-04-13 1984-07-16 Minnesota Mining & Mfg Werkwijze ter bereiding van een herbicide verbinding; tevens werkwijze voor de bereiding van een preparaat met herbicide werking.
US3951910A (en) * 1973-12-28 1976-04-20 General Electric Company Flame retardant polycarbonate composition
US4013621A (en) 1975-04-29 1977-03-22 Ciba-Geigy Corporation Substituted sulfonamide derivatives of hindered phenols and stabilized compositions
DE2528697C2 (de) 1975-06-27 1986-02-20 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Salicylaldehyden
US4034110A (en) 1976-09-20 1977-07-05 Hoffmann-La Roche Inc. Anthelmintics effective against liver flukes
US4239699A (en) 1978-05-24 1980-12-16 Henkel Corporation Sulfonamidophenols, metal complexes thereof, and solutions containing such compounds for use in extraction of metal values
US4373017A (en) 1980-03-05 1983-02-08 Konishiroku Photo Industry Co., Ltd. Photosensitive compound and photosensitive material containing it
US4483986A (en) 1982-05-03 1984-11-20 Eli Lilly And Company 4-Nitrobenzophenone compounds
NZ215272A (en) 1985-02-27 1989-08-29 Mitsui Toatsu Chemicals Fungicidal n-(2-chloro-4-nitrophenyl)-benzenesulphonamide derivatives and compositions thereof
US4692466A (en) 1985-02-28 1987-09-08 Mitsui Toatsu Chemicals, Incorporated N-(2-chloro-4-trifluoromethylphenyl)-3-trifluoromethylbenzenesulfonamide derivative and agricultural fungicide containing same
US5280043A (en) 1988-10-10 1994-01-18 Smith Kline & French Laboratories Ltd. Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists
DE3905075A1 (de) 1989-02-18 1990-08-30 Hoechst Ag Benzolsulfonamide und verfahren zu ihrer herstellung
ATE167473T1 (de) 1990-08-20 1998-07-15 Eisai Co Ltd Sulfonamid-derivate
WO1996040629A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders

Also Published As

Publication number Publication date
AU748826B2 (en) 2002-06-13
US20020013496A1 (en) 2002-01-31
JP2001514167A (ja) 2001-09-11
PT1005453E (pt) 2005-02-28
WO1999010320A8 (en) 1999-09-23
JP4309041B2 (ja) 2009-08-05
CA2301842A1 (en) 1999-03-04
DE69827267D1 (de) 2004-12-02
CA2301842C (en) 2010-04-27
DE69827267T2 (de) 2006-02-02
WO1999010320A1 (en) 1999-03-04
AU8782498A (en) 1999-03-16
ES2245803T3 (es) 2006-01-16
EP1005453B1 (de) 2004-10-27
US6284923B1 (en) 2001-09-04
EP1005453A1 (de) 2000-06-07
US6388131B2 (en) 2002-05-14

Similar Documents

Publication Publication Date Title
ATE280756T1 (de) Substituierte benzolverbindungen als antiproliferative mittel
PT1115701E (pt) Ureias de arilsulfonanilida
BR9710737A (pt) Pentafluorobenzenosulfonamidas e análogos.
PT896533E (pt) Pentafluorobenzenosulfonamidas e analogos
DE69928952D1 (de) Chinolin-derivate und ihre verwendung als antibakterielle wirkstoffe
ATE403430T1 (de) Neue carbamate- und harnstoffderivate als mittel gegen multidrugresistenz
DE69811363D1 (de) Piperazin-derivate und ihre verwendung als entzündungshemmende mittel
ATE555789T1 (de) Pyridazinderivate und deren verwendung als therapeutische mittel
ECSP066311A (es) Derivados de la piperazina y su uso como agentes terapéuticos
ATE391715T1 (de) Heterozyklische mutilinester und deren verwendung als bakterizide
DE69911017D1 (en) Arylsulfonanilid-phosphate
ATE241640T1 (de) Fusidinsäure-derivate
IT1314274B1 (it) Composizione dermatologica per il trattamento topico di malattiecutanee.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1005453

Country of ref document: EP

EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee