ATE280778T1 - Verfahren zur behandlung von mikrobiellen infektionen mittles entkupplung des phosphotransferase-systems und dazu geeingnete wirkstoffe - Google Patents
Verfahren zur behandlung von mikrobiellen infektionen mittles entkupplung des phosphotransferase-systems und dazu geeingnete wirkstoffeInfo
- Publication number
- ATE280778T1 ATE280778T1 AT98101704T AT98101704T ATE280778T1 AT E280778 T1 ATE280778 T1 AT E280778T1 AT 98101704 T AT98101704 T AT 98101704T AT 98101704 T AT98101704 T AT 98101704T AT E280778 T1 ATE280778 T1 AT E280778T1
- Authority
- AT
- Austria
- Prior art keywords
- pts
- uncoupling
- phosphoenolpyruvate
- phosphotransferase system
- compounds
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 2
- 102000020233 phosphotransferase Human genes 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 235000014633 carbohydrates Nutrition 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000206602 Eukaryota Species 0.000 abstract 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 abstract 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 abstract 1
- 230000008848 allosteric regulation Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000035605 chemotaxis Effects 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 239000003596 drug target Substances 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 229930029653 phosphoenolpyruvate Natural products 0.000 abstract 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 230000004983 pleiotropic effect Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000001018 virulence Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97102616 | 1997-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE280778T1 true ATE280778T1 (de) | 2004-11-15 |
Family
ID=8226491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98101704T ATE280778T1 (de) | 1997-02-19 | 1998-02-02 | Verfahren zur behandlung von mikrobiellen infektionen mittles entkupplung des phosphotransferase-systems und dazu geeingnete wirkstoffe |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6245502B1 (de) |
| JP (1) | JPH10327894A (de) |
| AT (1) | ATE280778T1 (de) |
| DE (1) | DE69827179T2 (de) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5518911A (en) * | 1995-01-06 | 1996-05-21 | Onyx Pharmaceuticals, Inc. | Human PAK65 |
| US5700675A (en) * | 1995-12-13 | 1997-12-23 | Regents Of The University Of California | Protein kinase required for Ras signal transduction |
-
1998
- 1998-02-02 AT AT98101704T patent/ATE280778T1/de not_active IP Right Cessation
- 1998-02-02 DE DE69827179T patent/DE69827179T2/de not_active Expired - Fee Related
- 1998-02-18 JP JP10052878A patent/JPH10327894A/ja active Pending
- 1998-02-19 US US09/026,904 patent/US6245502B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10327894A (ja) | 1998-12-15 |
| DE69827179D1 (de) | 2004-12-02 |
| DE69827179T2 (de) | 2005-03-10 |
| US6245502B1 (en) | 2001-06-12 |
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| DE69827179D1 (de) | Verfahren zur Behandlung von mikrobiellen Infektionen mittles Entkupplung des Phosphotransferase-Systems und dazu geeingnete Wirkstoffe | |
| EP0866075A3 (de) | Verfahren zur Behandlung von mikrobiellen Infektionen mittles Entkupplung des Phosphotransferase-Systems und dazu geeingnete Wirkstoffe |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |