ATE281520T1 - E2f ubiquitinierungsdomäne, und nachweismethoden für inhibitoren von e2f ubiquitinierung - Google Patents
E2f ubiquitinierungsdomäne, und nachweismethoden für inhibitoren von e2f ubiquitinierungInfo
- Publication number
- ATE281520T1 ATE281520T1 AT97936814T AT97936814T ATE281520T1 AT E281520 T1 ATE281520 T1 AT E281520T1 AT 97936814 T AT97936814 T AT 97936814T AT 97936814 T AT97936814 T AT 97936814T AT E281520 T1 ATE281520 T1 AT E281520T1
- Authority
- AT
- Austria
- Prior art keywords
- ubiquitination
- domain
- inhibitors
- polypeptide
- candidate
- Prior art date
Links
- 230000034512 ubiquitination Effects 0.000 title abstract 7
- 238000010798 ubiquitination Methods 0.000 title abstract 7
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 238000001514 detection method Methods 0.000 title 1
- 239000003623 enhancer Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000001388 E2F Transcription Factors Human genes 0.000 abstract 3
- 108010093502 E2F Transcription Factors Proteins 0.000 abstract 3
- 238000003556 assay Methods 0.000 abstract 3
- 102400000757 Ubiquitin Human genes 0.000 abstract 2
- 108090000848 Ubiquitin Proteins 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617697.9A GB9617697D0 (en) | 1996-08-23 | 1996-08-23 | Assay |
| PCT/GB1997/002293 WO1998007852A1 (en) | 1996-08-23 | 1997-08-22 | E2f ubiquitination domain, and assays for inhibitors of e2f ubiquitination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE281520T1 true ATE281520T1 (de) | 2004-11-15 |
Family
ID=10798859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97936814T ATE281520T1 (de) | 1996-08-23 | 1997-08-22 | E2f ubiquitinierungsdomäne, und nachweismethoden für inhibitoren von e2f ubiquitinierung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6368809B1 (de) |
| EP (1) | EP0927249B1 (de) |
| JP (1) | JP2000517178A (de) |
| AT (1) | ATE281520T1 (de) |
| AU (1) | AU3951097A (de) |
| CA (1) | CA2263803A1 (de) |
| DE (1) | DE69731478T2 (de) |
| DK (1) | DK0927249T3 (de) |
| ES (1) | ES2232880T3 (de) |
| GB (1) | GB9617697D0 (de) |
| PT (1) | PT927249E (de) |
| WO (1) | WO1998007852A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713449B1 (en) * | 1996-09-30 | 2004-03-30 | Kyowa Hakko Kogyo Co., Ltd. | E2F activity inhibitory compounds |
| EP1282815A2 (de) * | 2000-05-12 | 2003-02-12 | Prolifix Limited | Assay für zell-zyklus modulatoren |
| WO2004033483A2 (en) * | 2002-10-04 | 2004-04-22 | Sloan-Kettering Institute For Cancer Research | Liposomal system and method of using same |
| US7052843B2 (en) * | 2002-10-08 | 2006-05-30 | New York University | Transcription-based assay for identification of post-translational modification and its application in proteomics |
| CN119751591B (zh) * | 2025-03-06 | 2025-05-16 | 中南大学 | 一种靶向增稳brd7抑瘤蛋白的多肽及其在制备治疗实体肿瘤药物中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6045999A (en) | 1994-11-15 | 2000-04-04 | Prolifix Limited | Transcription factor E2F-4 |
-
1996
- 1996-08-23 GB GBGB9617697.9A patent/GB9617697D0/en active Pending
-
1997
- 1997-08-22 AU AU39510/97A patent/AU3951097A/en not_active Abandoned
- 1997-08-22 DK DK97936814T patent/DK0927249T3/da active
- 1997-08-22 AT AT97936814T patent/ATE281520T1/de not_active IP Right Cessation
- 1997-08-22 CA CA002263803A patent/CA2263803A1/en not_active Abandoned
- 1997-08-22 EP EP97936814A patent/EP0927249B1/de not_active Expired - Lifetime
- 1997-08-22 US US09/242,737 patent/US6368809B1/en not_active Expired - Fee Related
- 1997-08-22 DE DE69731478T patent/DE69731478T2/de not_active Expired - Lifetime
- 1997-08-22 ES ES97936814T patent/ES2232880T3/es not_active Expired - Lifetime
- 1997-08-22 PT PT97936814T patent/PT927249E/pt unknown
- 1997-08-22 WO PCT/GB1997/002293 patent/WO1998007852A1/en not_active Ceased
- 1997-08-22 JP JP10510527A patent/JP2000517178A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0927249A1 (de) | 1999-07-07 |
| US6368809B1 (en) | 2002-04-09 |
| DE69731478D1 (de) | 2004-12-09 |
| PT927249E (pt) | 2005-03-31 |
| DE69731478T2 (de) | 2005-10-27 |
| EP0927249B1 (de) | 2004-11-03 |
| WO1998007852A1 (en) | 1998-02-26 |
| AU3951097A (en) | 1998-03-06 |
| CA2263803A1 (en) | 1998-02-26 |
| JP2000517178A (ja) | 2000-12-26 |
| ES2232880T3 (es) | 2005-06-01 |
| DK0927249T3 (da) | 2005-03-14 |
| GB9617697D0 (en) | 1996-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0927249 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |