ATE281521T1 - Von filaggrin abgeleitete antigene und deren anwendung in der diagnose von rheumatischer polyarthritis - Google Patents
Von filaggrin abgeleitete antigene und deren anwendung in der diagnose von rheumatischer polyarthritisInfo
- Publication number
- ATE281521T1 ATE281521T1 AT97938965T AT97938965T ATE281521T1 AT E281521 T1 ATE281521 T1 AT E281521T1 AT 97938965 T AT97938965 T AT 97938965T AT 97938965 T AT97938965 T AT 97938965T AT E281521 T1 ATE281521 T1 AT E281521T1
- Authority
- AT
- Austria
- Prior art keywords
- filaggrin
- diagnosis
- application
- derived antigens
- polyarthritis
- Prior art date
Links
- 206010036030 Polyarthritis Diseases 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 206010003246 arthritis Diseases 0.000 title abstract 2
- 208000030428 polyarticular arthritis Diseases 0.000 title abstract 2
- 208000025747 Rheumatic disease Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 230000000552 rheumatic effect Effects 0.000 title 1
- 102100028314 Filaggrin Human genes 0.000 abstract 1
- 101710088660 Filaggrin Proteins 0.000 abstract 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- 229960002173 citrulline Drugs 0.000 abstract 1
- 235000013477 citrulline Nutrition 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Rehabilitation Therapy (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Navigation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9610651A FR2752842B1 (fr) | 1996-08-30 | 1996-08-30 | Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide |
| PCT/FR1997/001541 WO1998008946A1 (fr) | 1996-08-30 | 1997-09-01 | Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE281521T1 true ATE281521T1 (de) | 2004-11-15 |
Family
ID=9495335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97938965T ATE281521T1 (de) | 1996-08-30 | 1997-09-01 | Von filaggrin abgeleitete antigene und deren anwendung in der diagnose von rheumatischer polyarthritis |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6890720B1 (de) |
| EP (2) | EP1475438A1 (de) |
| AT (1) | ATE281521T1 (de) |
| CA (1) | CA2264019C (de) |
| DE (1) | DE69731479T2 (de) |
| ES (1) | ES2227711T3 (de) |
| FR (1) | FR2752842B1 (de) |
| PT (1) | PT929669E (de) |
| WO (1) | WO1998008946A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1004539C2 (nl) * | 1996-11-15 | 1998-05-20 | Stichting Tech Wetenschapp | Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen. |
| EP1034186A2 (de) * | 1997-11-28 | 2000-09-13 | Innogenetics N.V. | Citrullin-enthaltende synthetische peptide, reaktiv mit seren von patienten mit rheumatische arthritis, zur diagnose und behandlung |
| EP0949270A1 (de) * | 1998-04-09 | 1999-10-13 | Innogenetics N.V. | Citrullin-enthaltende synthetische Peptide, reaktiv mit Seren von Patienten mit rheumatische Arthritis, zur Diagnose und Behandlung |
| FR2773157B1 (fr) * | 1997-12-30 | 2001-10-05 | Bio Merieux | Epitopes peptidiques reconnus par des auto-anticorps antifilaggrine presents dans le serum des patients atteints de polyarthrite rhumatoide |
| FR2773078B1 (fr) * | 1997-12-30 | 2000-05-26 | Univ Toulouse | Utilisation de peptides citrullines derives de la filaggrine pour le traitement de la polyarthrite rhumatoide |
| DE1240180T1 (de) * | 1999-12-21 | 2003-08-14 | Innogenetics N.V., Gent | Peptide zur diagnose und behandlung rheumatischer arthritis |
| FR2826124B1 (fr) * | 2001-06-13 | 2004-01-02 | Bio Merieux | Procede de detection d'auto-anticorps specifiques de la polyarthrite rhumatoide |
| NL1019540C2 (nl) * | 2001-12-11 | 2003-07-01 | Stichting Tech Wetenschapp | Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit. |
| EP1882946B1 (de) | 2003-12-23 | 2010-02-17 | Roche Diagnostics GmbH | Methode zur Beurteilung von rheumatoider Arthritis durch Bestimmung von Anti-CCP und Interleukin 6 |
| SI1721162T1 (sl) | 2004-02-27 | 2009-02-28 | Roche Diagnostics Gmbh | Postopek za ugotavljanje revmatoidnega artritisa z merjenjem anti-CCP in serumskega amiloida A |
| US20060141547A1 (en) * | 2004-11-16 | 2006-06-29 | Das Hasi R | Novel diagnostic marker, a diagnostic kit and a method for diagnosis of rheumatoid arthritis |
| EP2270226B1 (de) * | 2005-03-31 | 2016-05-18 | Two Cells Co., Ltd | Verfahren zur Unterscheidung mesenchymaler Stammzellen mittels molekularem Marker und Nutzung dieses Marker |
| US7362443B2 (en) * | 2005-11-17 | 2008-04-22 | Honeywell International Inc. | Optical gyro with free space resonator and method for sensing inertial rotation rate |
| ES2545688T3 (es) | 2006-09-29 | 2015-09-15 | F. Hoffmann-La Roche Ag | Método de evaluación del riesgo de progresión de enfermedad de pacientes con artritis reumatoide |
| RU2386609C2 (ru) * | 2008-01-22 | 2010-04-20 | Общество с ограниченной ответственностью "Филагр" | Иммунореактивный пептид и способ диагностики ревматоидного артрита с его использованием |
| EP2325195A1 (de) | 2009-11-23 | 2011-05-25 | Toscana Biomarkers S.r.l. | Virale citrullinierte Peptide und Verwendungen dafür |
| EP2336769A1 (de) | 2009-12-18 | 2011-06-22 | F. Hoffmann-La Roche AG | Assay zur Unterscheidung zwischen rheumatischen und nicht rheumatischen Leiden |
| EP2402368A1 (de) | 2010-07-02 | 2012-01-04 | Toscana Biomarkers S.r.l. | Histoncitrullinierte Peptide und deren Verwendungen |
| EP2527841A1 (de) | 2011-05-25 | 2012-11-28 | Toscana Biomarkers S.r.l. | Verfahren zur Diagnose rheumatoider Arthritis |
| EP3056903A1 (de) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-Casp8 |
| EP3056904A1 (de) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-MCM3 |
| CN107484423A (zh) | 2015-02-13 | 2017-12-15 | 豪夫迈·罗氏有限公司 | 通过测量抗ccp和抗pik3cd来评估类风湿性关节炎的方法 |
| CN118255862B (zh) * | 2024-05-30 | 2024-08-09 | 湖南中科极美生物科技有限公司 | 一种重组人源化丝聚蛋白及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATA38988A (de) * | 1988-02-18 | 1993-11-15 | Josef Dr Smolen | Verfahren zur untersuchung menschlicher oder tierischer körperflüssigkeiten sowie reagens hierfür |
| WO1992019649A1 (fr) * | 1991-04-26 | 1992-11-12 | Clonatec | Antigenes reconnus par des anticorps de la polyarthrite rhumatoide, leur preparation et leurs applications |
-
1996
- 1996-08-30 FR FR9610651A patent/FR2752842B1/fr not_active Expired - Lifetime
-
1997
- 1997-09-01 CA CA2264019A patent/CA2264019C/fr not_active Expired - Lifetime
- 1997-09-01 AT AT97938965T patent/ATE281521T1/de not_active IP Right Cessation
- 1997-09-01 DE DE69731479T patent/DE69731479T2/de not_active Expired - Lifetime
- 1997-09-01 ES ES97938965T patent/ES2227711T3/es not_active Expired - Lifetime
- 1997-09-01 EP EP04014969A patent/EP1475438A1/de not_active Withdrawn
- 1997-09-01 PT PT97938965T patent/PT929669E/pt unknown
- 1997-09-01 EP EP97938965A patent/EP0929669B1/de not_active Expired - Lifetime
- 1997-09-01 US US09/254,032 patent/US6890720B1/en not_active Expired - Lifetime
- 1997-09-01 WO PCT/FR1997/001541 patent/WO1998008946A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69731479T2 (de) | 2006-02-02 |
| WO1998008946A1 (fr) | 1998-03-05 |
| EP0929669B1 (de) | 2004-11-03 |
| CA2264019A1 (fr) | 1998-03-05 |
| FR2752842A1 (fr) | 1998-03-06 |
| EP0929669A1 (de) | 1999-07-21 |
| US6890720B1 (en) | 2005-05-10 |
| PT929669E (pt) | 2005-01-31 |
| DE69731479D1 (de) | 2004-12-09 |
| ES2227711T3 (es) | 2005-04-01 |
| CA2264019C (fr) | 2012-04-10 |
| EP1475438A1 (de) | 2004-11-10 |
| FR2752842B1 (fr) | 1998-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |