ATE282034T1 - Verfahren zur herstellung von 1,3- oxathiolannukleoside - Google Patents

Verfahren zur herstellung von 1,3- oxathiolannukleoside

Info

Publication number: ATE282034T1
Authority: AT; Austria
Prior art keywords: oxathiolanne; nucleoside; producing; oxathiolane; preparation
Prior art date: 1998-08-12

Application number

AT99943712T

Other languages

English (en)

Inventor

George R Painter

Dennis C Liotta

Merrick Almond

Darryl Cleary

Jose Soria

Marcos Luis Sznaidman

Original Assignee

Gilead Sciences Inc

Univ Emory

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-12

Filing date

1999-08-12

Publication date

2004-11-15

1999-08-12 Application filed by Gilead Sciences Inc, Univ Emory filed Critical Gilead Sciences Inc

2004-11-15 Application granted granted Critical

2004-11-15 Publication of ATE282034T1 publication Critical patent/ATE282034T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1
238000000034 method Methods 0.000 abstract 3
WJJSZTJGFCFNKI-UHFFFAOYSA-N 1,3-oxathiolane Chemical group C1CSCO1 WJJSZTJGFCFNKI-UHFFFAOYSA-N 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

AT99943712T 1998-08-12 1999-08-12 Verfahren zur herstellung von 1,3- oxathiolannukleoside ATE282034T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9621498P	1998-08-12	1998-08-12
US12284199P	1999-03-04	1999-03-04
PCT/US1999/018584 WO2000009494A1 (en)	1998-08-12	1999-08-12	Method of manufacture of 1,3-oxathiolane nucleosides

Publications (1)

Publication Number	Publication Date
ATE282034T1 true ATE282034T1 (de)	2004-11-15

Family

ID=26791450

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03077251T ATE292631T1 (de)	1998-08-12	1999-08-12	Verfahren zu herstellung von 1,3-oxathiolane nukleosiden
AT99943712T ATE282034T1 (de)	1998-08-12	1999-08-12	Verfahren zur herstellung von 1,3- oxathiolannukleoside

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT03077251T ATE292631T1 (de)	1998-08-12	1999-08-12	Verfahren zu herstellung von 1,3-oxathiolane nukleosiden

Country Status (16)

Country	Link
US (4)	US6215004B1 (de)
EP (4)	EP1535921A1 (de)
JP (4)	JP4249393B2 (de)
KR (3)	KR100856416B1 (de)
CN (1)	CN1141305C (de)
AT (2)	ATE292631T1 (de)
AU (2)	AU771779B2 (de)
BR (1)	BR9912951B1 (de)
CA (3)	CA2714085C (de)
DE (2)	DE69924651D1 (de)
ES (2)	ES2232169T3 (de)
IL (4)	IL141359A0 (de)
MX (1)	MXPA01001552A (de)
PT (2)	PT1104415E (de)
RU (2)	RU2439069C2 (de)
WO (1)	WO2000009494A1 (de)

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CN102942563A (zh) *	2001-03-01	2013-02-27	基利得科学公司	顺-ftc的多晶型物及其它晶型
PL215267B1 (pl) *	2001-06-15	2013-11-29	Shire Canada Inc	Stereoselektywny sposób wytwarzania cis-2-hydroksymetylo-4-(cytozyn-1'-ylo)-1,3-oksatiolanu
CA2351049C (en)	2001-06-18	2007-03-13	Brantford Chemicals Inc.	Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
WO2003051298A2 (en) *	2001-12-14	2003-06-26	Pharmasset Ltd.	Preparation of intermediates useful in the synthesis of antiviral nucleosides
DE60304726T2 (de) *	2002-07-19	2007-08-09	Winston Pharmaceuticals Llc, Newport Beach	Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer
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DK1583542T3 (da)	2003-01-14	2008-09-22	Gilead Sciences Inc	Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
EP1693482A4 (de) *	2003-12-09	2008-04-30	Asahi Glass Co Ltd	Ti-oxid-film mit photokatalytischer aktivität bei bestrahlung mit sichtbarem licht und herstellungsverfahren dafür
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RU2494098C2 (ru) *	2007-09-28	2013-09-27	Авекса Лимитед	Способ хирального разделения 2,4-дизамещенных 1,3-оксатиоланов
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WO2010082128A1 (en)	2009-01-19	2010-07-22	Aurobindo Pharma Limited	Process for the preparation of cis-nucleoside derivative
EP2454244B1 (de)	2009-07-15	2013-06-26	Lupin Limited	Verbessertes verfahren zur herstellung von efavirenz
WO2011141805A2 (en)	2010-05-14	2011-11-17	Lupin Limited	An improved process for the manufacture of lamivudine
EP2739620A1 (de)	2011-08-05	2014-06-11	Lupin Limited	Stereoselektives verfahren zur herstellung von 1,3-oxathiolan-nukleosiden
CN106478618A (zh) *	2016-10-14	2017-03-08	上海礼泰医药科技有限公司	恩曲他滨氢卤酸盐的制备方法
CN109553610B (zh) *	2018-12-21	2020-10-27	江西富祥药业股份有限公司	一种恩曲他滨异构体的制备方法
CN115043823A (zh) *	2022-06-28	2022-09-13	江苏普信制药有限公司	一种恩曲他滨的合成方法
CN116444369A (zh) *	2023-04-20	2023-07-18	山东成武易信环保科技有限公司	一种高纯单丁酸甘油酯的制备方法
CN118022366A (zh) *	2024-01-03	2024-05-14	陕西延长石油（集团）有限责任公司	一种乙醇和乙缩醛的分离系统和分离方法

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1999
- 1999-08-12 AT AT03077251T patent/ATE292631T1/de not_active IP Right Cessation
- 1999-08-12 IL IL14135999A patent/IL141359A0/xx active IP Right Grant
- 1999-08-12 ES ES99943712T patent/ES2232169T3/es not_active Expired - Lifetime
- 1999-08-12 EP EP05075522A patent/EP1535921A1/de not_active Ceased
- 1999-08-12 RU RU2004125183/04A patent/RU2439069C2/ru not_active Application Discontinuation
- 1999-08-12 PT PT99943712T patent/PT1104415E/pt unknown
- 1999-08-12 KR KR1020067007631A patent/KR100856416B1/ko not_active Expired - Lifetime
- 1999-08-12 DE DE69924651T patent/DE69924651D1/de not_active Expired - Lifetime
- 1999-08-12 AU AU56752/99A patent/AU771779B2/en not_active Expired
- 1999-08-12 CA CA2714085A patent/CA2714085C/en not_active Expired - Lifetime
- 1999-08-12 EP EP10181678.3A patent/EP2322518B1/de not_active Expired - Lifetime
- 1999-08-12 ES ES10181678.3T patent/ES2537540T3/es not_active Expired - Lifetime
- 1999-08-12 KR KR1020077019476A patent/KR101208429B1/ko not_active Expired - Fee Related
- 1999-08-12 WO PCT/US1999/018584 patent/WO2000009494A1/en not_active Ceased
- 1999-08-12 AT AT99943712T patent/ATE282034T1/de active
- 1999-08-12 RU RU2001106606/04A patent/RU2244712C2/ru active
- 1999-08-12 CA CA2563022A patent/CA2563022C/en not_active Expired - Lifetime
- 1999-08-12 JP JP2000564946A patent/JP4249393B2/ja not_active Expired - Fee Related
- 1999-08-12 MX MXPA01001552A patent/MXPA01001552A/es not_active IP Right Cessation
- 1999-08-12 DE DE69921829T patent/DE69921829T2/de not_active Expired - Lifetime
- 1999-08-12 US US09/373,891 patent/US6215004B1/en not_active Expired - Lifetime
- 1999-08-12 EP EP03077251A patent/EP1361223B1/de not_active Expired - Lifetime
- 1999-08-12 EP EP99943712A patent/EP1104415B1/de not_active Expired - Lifetime
- 1999-08-12 CN CNB998099929A patent/CN1141305C/zh not_active Expired - Lifetime
- 1999-08-12 CA CA002340214A patent/CA2340214C/en not_active Expired - Lifetime
- 1999-08-12 BR BRPI9912951-5A patent/BR9912951B1/pt not_active IP Right Cessation
- 1999-08-12 PT PT101816783T patent/PT2322518E/pt unknown
- 1999-08-12 KR KR1020017001827A patent/KR100687194B1/ko not_active Expired - Fee Related
2000
- 2000-05-15 US US09/570,885 patent/US6518425B1/en not_active Expired - Lifetime
- 2000-09-26 US US09/669,806 patent/US6576776B1/en not_active Expired - Lifetime
2001
- 2001-02-09 IL IL141359A patent/IL141359A/en not_active IP Right Cessation
2003
- 2003-02-11 US US10/361,980 patent/US6939965B2/en not_active Expired - Lifetime
2004
- 2004-06-30 AU AU2004202930A patent/AU2004202930C1/en not_active Expired
2006
- 2006-02-15 IL IL173745A patent/IL173745A/en not_active IP Right Cessation
2008
- 2008-11-13 JP JP2008291234A patent/JP5203897B2/ja not_active Expired - Fee Related
2009
- 2009-10-01 IL IL201293A patent/IL201293A/en not_active IP Right Cessation
2012
- 2012-05-18 JP JP2012114415A patent/JP5547772B2/ja not_active Expired - Fee Related
2014
- 2014-03-25 JP JP2014061275A patent/JP5956492B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP5956492B2 (ja)	2016-07-27
PT1104415E (pt)	2005-03-31
US6215004B1 (en)	2001-04-10
IL201293A0 (en)	2010-05-31
KR100856416B1 (ko)	2008-09-04
EP2322518B1 (de)	2015-02-25
EP1535921A1 (de)	2005-06-01
JP4249393B2 (ja)	2009-04-02
US20030144532A1 (en)	2003-07-31
EP1361223B1 (de)	2005-04-06
IL141359A (en)	2006-07-05
AU2004202930A1 (en)	2004-07-29
ATE292631T1 (de)	2005-04-15
JP2009108080A (ja)	2009-05-21
EP1104415A1 (de)	2001-06-06
DE69921829T2 (de)	2005-10-27
CA2563022C (en)	2010-11-23
AU2004202930C1 (en)	2008-11-13
CA2340214A1 (en)	2000-02-24
KR20060063991A (ko)	2006-06-12
US6518425B1 (en)	2003-02-11
ES2232169T3 (es)	2005-05-16
JP2002522534A (ja)	2002-07-23
KR20070094667A (ko)	2007-09-20
DE69924651D1 (de)	2005-05-12
IL173745A (en)	2010-05-31
MXPA01001552A (es)	2004-08-23
EP1361223A1 (de)	2003-11-12
HK1156604A1 (en)	2012-06-15
HK1038921A1 (en)	2002-04-04
JP2014132026A (ja)	2014-07-17
EP2322518A1 (de)	2011-05-18
RU2004125183A (ru)	2006-01-27
CN1313858A (zh)	2001-09-19
WO2000009494A1 (en)	2000-02-24
CA2340214C (en)	2007-10-30
BR9912951A (pt)	2001-10-02
ES2537540T3 (es)	2015-06-09
CA2714085C (en)	2013-02-05
DE69921829D1 (de)	2004-12-16
EP1104415B1 (de)	2004-11-10
AU771779B2 (en)	2004-04-01
RU2244712C2 (ru)	2005-01-20
JP2012176974A (ja)	2012-09-13
RU2439069C2 (ru)	2012-01-10
CN1141305C (zh)	2004-03-10
CA2563022A1 (en)	2000-02-24
IL141359A0 (en)	2002-03-10
AU5675299A (en)	2000-03-06
AU2004202930B2 (en)	2008-05-08
US6939965B2 (en)	2005-09-06
JP5203897B2 (ja)	2013-06-05
JP5547772B2 (ja)	2014-07-16
KR20010072428A (ko)	2001-07-31
PT2322518E (pt)	2015-06-08
KR101208429B1 (ko)	2012-12-05
US6576776B1 (en)	2003-06-10
BR9912951B1 (pt)	2012-01-10
IL201293A (en)	2011-02-28
IL173745A0 (en)	2006-07-05
CA2714085A1 (en)	2000-02-24
KR100687194B1 (ko)	2007-02-27

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