ATE496054T1 - Verfahren zur herstellung von 1,3-dioxolan- nucleosiden - Google Patents
Verfahren zur herstellung von 1,3-dioxolan- nucleosidenInfo
- Publication number
- ATE496054T1 ATE496054T1 AT03789692T AT03789692T ATE496054T1 AT E496054 T1 ATE496054 T1 AT E496054T1 AT 03789692 T AT03789692 T AT 03789692T AT 03789692 T AT03789692 T AT 03789692T AT E496054 T1 ATE496054 T1 AT E496054T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- dioxolane nucleosides
- nucleosides
- dioxolane
- purine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40165502P | 2002-08-06 | 2002-08-06 | |
| PCT/US2003/024986 WO2004028445A2 (en) | 2002-08-06 | 2003-08-06 | Processes for preparing 1,3-dioxolane nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE496054T1 true ATE496054T1 (de) | 2011-02-15 |
Family
ID=32043165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03789692T ATE496054T1 (de) | 2002-08-06 | 2003-08-06 | Verfahren zur herstellung von 1,3-dioxolan- nucleosiden |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6855821B2 (de) |
| EP (1) | EP1534255B1 (de) |
| JP (1) | JP4560407B2 (de) |
| KR (1) | KR101108115B1 (de) |
| AT (1) | ATE496054T1 (de) |
| AU (1) | AU2003294212B2 (de) |
| BR (1) | BR0313302A (de) |
| CA (1) | CA2494183C (de) |
| DE (1) | DE60335805D1 (de) |
| ES (1) | ES2360096T3 (de) |
| IL (2) | IL166682A0 (de) |
| MX (1) | MXPA05001451A (de) |
| WO (1) | WO2004028445A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100406017C (zh) * | 2002-12-09 | 2008-07-30 | 佐治亚大学研究基金会 | 用于对抗hiv抗性株的二氧戊环基胸腺嘧啶及其组合物 |
| RU2358979C2 (ru) | 2003-05-30 | 2009-06-20 | Фармассет, Инк. | Модифицированные фторированные аналоги нуклеозида |
| KR101157468B1 (ko) | 2004-02-03 | 2012-07-06 | 에모리 유니버시티 | 1,3-디옥솔란 뉴클레오시드 제조방법 |
| US7956087B2 (en) * | 2005-04-21 | 2011-06-07 | Kao Corporation | Cosmetic composition for skin and wrinkle improver |
| WO2009114080A2 (en) * | 2008-03-03 | 2009-09-17 | Stiefel Laboratories, Inc. | Processes for preparing enantiomerically pure diol and dioxolane compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3028519A1 (de) * | 1980-07-28 | 1982-02-25 | Dynamit Nobel Ag, 5210 Troisdorf | Substituierte 2,5,7-trioxan-bicyclo (2.2.2) octan-6-one und 3,6,8-trioxa-bicyclo (3.2.1) octan-4-one und verfahren zu deren herstellung |
| US5047407A (en) | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
| US5276151A (en) | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| US5925643A (en) * | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
| IT1244501B (it) | 1991-03-22 | 1994-07-15 | Sigma Tau Ind Farmaceuti | Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono |
| ZA923641B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| GB9525606D0 (en) | 1995-12-14 | 1996-02-14 | Iaf Biochem Int | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
| US5792773A (en) | 1996-11-15 | 1998-08-11 | Yale University | L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection |
| IT1301977B1 (it) * | 1998-07-31 | 2000-07-20 | Sigma Tau Ind Farmaceuti | Procedimento per la preparazione di r-(-)-carnitina |
| CA2340214C (en) | 1998-08-12 | 2007-10-30 | Triangle Pharmaceuticals, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
| IL143867A0 (en) | 1998-12-23 | 2002-04-21 | Shire Biochem Inc | Antiviral nucleoside analogues |
-
2003
- 2003-08-06 MX MXPA05001451A patent/MXPA05001451A/es active IP Right Grant
- 2003-08-06 WO PCT/US2003/024986 patent/WO2004028445A2/en not_active Ceased
- 2003-08-06 JP JP2004539827A patent/JP4560407B2/ja not_active Expired - Fee Related
- 2003-08-06 IL IL16668203A patent/IL166682A0/xx unknown
- 2003-08-06 EP EP03789692A patent/EP1534255B1/de not_active Expired - Lifetime
- 2003-08-06 AT AT03789692T patent/ATE496054T1/de not_active IP Right Cessation
- 2003-08-06 US US10/635,971 patent/US6855821B2/en not_active Expired - Fee Related
- 2003-08-06 CA CA2494183A patent/CA2494183C/en not_active Expired - Fee Related
- 2003-08-06 DE DE60335805T patent/DE60335805D1/de not_active Expired - Lifetime
- 2003-08-06 KR KR1020057002178A patent/KR101108115B1/ko not_active Expired - Fee Related
- 2003-08-06 BR BR0313302-8A patent/BR0313302A/pt not_active IP Right Cessation
- 2003-08-06 AU AU2003294212A patent/AU2003294212B2/en not_active Ceased
- 2003-08-06 ES ES03789692T patent/ES2360096T3/es not_active Expired - Lifetime
-
2005
- 2005-02-03 IL IL166682A patent/IL166682A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1534255A4 (de) | 2006-10-18 |
| HK1078781A1 (en) | 2006-03-24 |
| KR20050052461A (ko) | 2005-06-02 |
| ES2360096T3 (es) | 2011-05-31 |
| AU2003294212B2 (en) | 2010-01-07 |
| BR0313302A (pt) | 2005-06-28 |
| WO2004028445A2 (en) | 2004-04-08 |
| US20040087806A1 (en) | 2004-05-06 |
| IL166682A0 (en) | 2006-01-15 |
| KR101108115B1 (ko) | 2012-01-31 |
| CA2494183A1 (en) | 2004-04-08 |
| AU2003294212A1 (en) | 2004-04-19 |
| WO2004028445A3 (en) | 2004-06-10 |
| US6855821B2 (en) | 2005-02-15 |
| MXPA05001451A (es) | 2005-09-30 |
| DE60335805D1 (de) | 2011-03-03 |
| IL166682A (en) | 2011-06-30 |
| EP1534255B1 (de) | 2011-01-19 |
| JP4560407B2 (ja) | 2010-10-13 |
| EP1534255A2 (de) | 2005-06-01 |
| JP2006504703A (ja) | 2006-02-09 |
| CA2494183C (en) | 2012-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |