ATE282036T1 - Trizyklische antitumor verbindungen mit farnesyl protein transferase inhibierender wirkung - Google Patents

Trizyklische antitumor verbindungen mit farnesyl protein transferase inhibierender wirkung

Info

Publication number: ATE282036T1
Authority: AT; Austria
Prior art keywords: protein transferase; farnesyl protein; inhibiting effect; antitumor compounds; transferase inhibiting
Prior art date: 1996-09-13

Application number

AT97910710T

Other languages

English (en)

Inventor

F George Njoroge

Ronald J Doll

Stacy W Remiszewski

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-13

Filing date

1997-09-11

Publication date

2004-11-15

1997-09-11 Application filed by Schering Corp filed Critical Schering Corp

2004-11-15 Application granted granted Critical

2004-11-15 Publication of ATE282036T1 publication Critical patent/ATE282036T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
230000002401 inhibitory effect Effects 0.000 title abstract 2
JXBSHSBNOVLGHF-BUJBXKITSA-N (6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene Chemical compound C\C=C(/C)CC\C=C(/C)CCC=C(C)C JXBSHSBNOVLGHF-BUJBXKITSA-N 0.000 title 1
102000004357 Transferases Human genes 0.000 title 1
108090000992 Transferases Proteins 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 abstract 1
230000004614 tumor growth Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT97910710T 1996-09-13 1997-09-11 Trizyklische antitumor verbindungen mit farnesyl protein transferase inhibierender wirkung ATE282036T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US71298996A	1996-09-13	1996-09-13
US87740097A	1997-06-17	1997-06-17
PCT/US1997/015899 WO1998011092A1 (en)	1996-09-13	1997-09-11	Tricyclic antitumor compounds being farnesyl protein transferase inhibitors

Publications (1)

Publication Number	Publication Date
ATE282036T1 true ATE282036T1 (de)	2004-11-15

Family

ID=27108923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97910710T ATE282036T1 (de)	1996-09-13	1997-09-11	Trizyklische antitumor verbindungen mit farnesyl protein transferase inhibierender wirkung

Country Status (12)

Country	Link
EP (1)	EP0929544B1 (de)
JP (1)	JP2001521489A (de)
KR (1)	KR20000036111A (de)
CN (1)	CN1238770A (de)
AT (1)	ATE282036T1 (de)
AU (1)	AU4801197A (de)
CA (1)	CA2266015C (de)
DE (1)	DE69731544T2 (de)
ES (1)	ES2229340T3 (de)
HU (1)	HUP0001109A2 (de)
IL (1)	IL128931A0 (de)
WO (1)	WO1998011092A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5852034A (en) *	1997-06-17	1998-12-22	Schering Corporation	Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
NZ501617A (en) *	1997-06-17	2001-09-28	Schering Corp	4-(5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine derivatives useful for inhibition of farnesyl protein transferase
US6218401B1 (en)	1997-06-17	2001-04-17	Schering Corporation	Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
IL133392A0 (en) *	1997-06-17	2001-04-30	Schering Corp	Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase
US6211193B1 (en)	1997-06-17	2001-04-03	Schering Corporation	Compounds useful for inhibition of farnesyl protein transferase
US6228865B1 (en)	1997-06-17	2001-05-08	Schering Corporation	Compounds useful for inhibition of farnesyl protein transferase
US5925639A (en) *	1997-06-17	1999-07-20	Schering Corporation	Keto amide derivatives useful as farnesyl protein transferase inhibitors
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
WO1999037619A1 (en)	1998-01-21	1999-07-29	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
DK1049700T3 (da)	1998-01-21	2006-02-20	Millennium Pharm Inc	Kemokinreceptorantagonister og fremgangsmåder til anvendelse deraf
WO2000005215A1 (en) *	1998-07-24	2000-02-03	Russinsky Limited	A process for preparing benzocycloheptapyridin-11-ones
US7271176B2 (en)	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US6503926B2 (en)	1998-09-04	2003-01-07	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en)	1998-09-04	2001-09-11	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6262216B1 (en)	1998-10-13	2001-07-17	Affymetrix, Inc.	Functionalized silicon compounds and methods for their synthesis and use
AU2001268607A1 (en)	2000-06-21	2002-01-02	Bristol-Myers Squibb Company	Piperidine amides as modulators of chemokine receptor activity
US7342016B2 (en)	2000-08-30	2008-03-11	Schering Corporation	Farnesyl protein transferase inhibitors as antitumor agents
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
PT1556358E (pt) *	2002-10-03	2007-09-25	Schering Corp	''alquilação enantiosselectiva de compostos tricíclicos''
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor
ES2345146T3 (es) *	2002-11-18	2010-09-16	Schering Corporation	Inhibidores de 17beta-hidroxiesteroides deshidrogenasa de tipo 3 para el tratamiento de enfermedades dependientes de androgenos.
WO2005017160A2 (en)	2003-08-13	2005-02-24	Children's Hospital Medical Center	Mobilization of hematopoietic cells
WO2005058823A1 (ja) *	2003-12-17	2005-06-30	Takeda Pharmaceutical Company Limited	ウレア誘導体、その製造法及び用途
US20050288298A1 (en) *	2004-03-18	2005-12-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
CN113549072B (zh) *	2020-04-23	2024-12-06	鲁南制药集团股份有限公司	一种托法替布杂质ⅰ的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5089496A (en) *	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) *	1986-10-31	1989-05-02	Schering Corporation	6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
KR920014799A (ko) *	1991-01-18	1992-08-25	나오가따 다이도	신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
US5719148A (en) *	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5721236A (en) *	1993-10-15	1998-02-24	Schering Corporation	Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
JP2875393B2 (ja) *	1993-10-15	1999-03-31	シェーリングコーポレイション	Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5700806A (en) *	1995-03-24	1997-12-23	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) *	1995-04-07	2001-11-25	Schering Plough Corp	Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
US5712280A (en) *	1995-04-07	1998-01-27	Schering Corporation	Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
SK86198A3 (en) *	1995-12-22	1999-02-11	Schering Corp	Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

1997
- 1997-09-11 ES ES97910710T patent/ES2229340T3/es not_active Expired - Lifetime
- 1997-09-11 JP JP51375898A patent/JP2001521489A/ja not_active Ceased
- 1997-09-11 EP EP97910710A patent/EP0929544B1/de not_active Expired - Lifetime
- 1997-09-11 IL IL12893197A patent/IL128931A0/xx unknown
- 1997-09-11 CA CA002266015A patent/CA2266015C/en not_active Expired - Fee Related
- 1997-09-11 HU HU0001109A patent/HUP0001109A2/hu unknown
- 1997-09-11 WO PCT/US1997/015899 patent/WO1998011092A1/en not_active Ceased
- 1997-09-11 AT AT97910710T patent/ATE282036T1/de not_active IP Right Cessation
- 1997-09-11 KR KR1019997002134A patent/KR20000036111A/ko not_active Withdrawn
- 1997-09-11 DE DE69731544T patent/DE69731544T2/de not_active Expired - Fee Related
- 1997-09-11 CN CN97199602A patent/CN1238770A/zh active Pending
- 1997-09-11 AU AU48011/97A patent/AU4801197A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1998011092A1 (en)	1998-03-19
HUP0001109A2 (hu)	2001-04-28
EP0929544B1 (de)	2004-11-10
IL128931A0 (en)	2000-02-17
ES2229340T3 (es)	2005-04-16
EP0929544A1 (de)	1999-07-21
JP2001521489A (ja)	2001-11-06
AU4801197A (en)	1998-04-02
CA2266015C (en)	2003-12-30
KR20000036111A (ko)	2000-06-26
DE69731544T2 (de)	2005-10-27
CA2266015A1 (en)	1998-03-19
DE69731544D1 (de)	2004-12-16
CN1238770A (zh)	1999-12-15
HK1018446A1 (en)	1999-12-24

Legal Events

Date	Code	Title	Description
2005-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69731544D1 (de)	2004-12-16	Trizyklische antitumor verbindungen mit farnesyl protein transferase inhibierender wirkung
DE69732120D1 (de)	2005-02-03	Trizyklische inhibitoren der farnesyl protein transferase
MY114792A (en)	2003-01-31	Farnesyl transferase inhibitors,their preparation and pharmaceutical compositions comprising them
PT904274E (pt)	2005-10-31	Inibidores da farnesil transferase
DE69738373D1 (de)	2008-01-24	Prenyl-transferase inhibitoren
PL332240A1 (en)	1999-08-30	Tricyclic compounds useful in inhibiting g-proteinic function and in treating proliferative diseases
DE69732123D1 (de)	2005-02-03	Trizyklische verbindungen mit farnesyl protein transferase inhibierender wirkung
NO991229D0 (no)	1999-03-12	Substituerte benzosykloheptapyridinderivater for inhibering av farnesylproteintransferase
IL127575A0 (en)	1999-10-28	Prenyl transferase inhibitors
MX9801792A (es)	1998-07-31	Inhibidores cicloantihelminticos.
NO991231D0 (no)	1999-03-12	Forbindelser for inhibering av farnesylproteintransferase
NO991232D0 (no)	1999-03-12	Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferase