ATE282433T1 - Kationische kopolymere von vinylamine und vinylalkohol zur verabreichung von oligonukleotiden - Google Patents

Kationische kopolymere von vinylamine und vinylalkohol zur verabreichung von oligonukleotiden

Info

Publication number
ATE282433T1
ATE282433T1 AT96902128T AT96902128T ATE282433T1 AT E282433 T1 ATE282433 T1 AT E282433T1 AT 96902128 T AT96902128 T AT 96902128T AT 96902128 T AT96902128 T AT 96902128T AT E282433 T1 ATE282433 T1 AT E282433T1
Authority
AT
Austria
Prior art keywords
oligonucleotides
vinyl alcohol
vinylamine
administration
cationic copolymers
Prior art date
Application number
AT96902128T
Other languages
English (en)
Inventor
Merrill S Goldenberg
Alice C Beekman
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE282433T1 publication Critical patent/ATE282433T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT96902128T 1995-01-25 1996-01-11 Kationische kopolymere von vinylamine und vinylalkohol zur verabreichung von oligonukleotiden ATE282433T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/378,301 US5629184A (en) 1995-01-25 1995-01-25 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
PCT/US1996/000354 WO1996022792A1 (en) 1995-01-25 1996-01-11 Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides

Publications (1)

Publication Number Publication Date
ATE282433T1 true ATE282433T1 (de) 2004-12-15

Family

ID=23492568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96902128T ATE282433T1 (de) 1995-01-25 1996-01-11 Kationische kopolymere von vinylamine und vinylalkohol zur verabreichung von oligonukleotiden

Country Status (16)

Country Link
US (1) US5629184A (de)
EP (1) EP0806966B1 (de)
JP (1) JPH11503407A (de)
AT (1) ATE282433T1 (de)
AU (1) AU701543B2 (de)
BR (1) BR9606783A (de)
CA (1) CA2210875C (de)
DE (1) DE69633852T2 (de)
DK (1) DK0806966T3 (de)
ES (1) ES2233960T3 (de)
IL (1) IL116887A0 (de)
MX (1) MX9705536A (de)
PT (1) PT806966E (de)
SI (1) SI0806966T1 (de)
WO (1) WO1996022792A1 (de)
ZA (1) ZA96401B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US8217015B2 (en) * 2003-04-04 2012-07-10 Arrowhead Madison Inc. Endosomolytic polymers
CA2256900A1 (en) * 1996-05-29 1997-12-04 Xiao-Ying Meng Cationic polymer/lipid nucleic acid delivery vehicles
US6656508B2 (en) 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
FR2766195A1 (fr) * 1997-07-21 1999-01-22 Transgene Sa Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique
WO1999042091A2 (en) * 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
EP0987029B1 (de) * 1998-08-28 2003-01-22 Transgene S.A. Verwendung eines kationischen Polymer zur Herstellung von Nukleinsäure-Komplexe und verwandte Zusammensetzungen
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
KR100482774B1 (ko) * 2002-09-05 2005-04-14 주식회사 마이진 폴리비닐이미다졸계 화합물을 포함하는 유전자 전달체
US20050025741A1 (en) 2003-05-15 2005-02-03 Lau Aldrich N.K. Poly and copoly(N-vinylamide)s and their use in capillary electrophoresis
CA2791853C (en) 2010-02-12 2018-03-06 Rhodia Operations Rheology modifier compositions and methods of use
FI20115664A0 (fi) * 2011-06-23 2011-06-23 Kemira Oyj Polymeerituote ja sen käyttö dispergointiaineena
ES2907486T3 (es) 2015-09-24 2022-04-25 Univ North Carolina Chapel Hill Métodos y composiciones para reducir metástasis
US11186858B1 (en) 2016-03-15 2021-11-30 Fresenius Kabi Deutschland Gmbh Methods for increasing biosimilarity
US11254964B1 (en) * 2016-03-15 2022-02-22 Fresenius Kabi Deutschland Gmbh Cell culture methods for increased cell viability
KR102432637B1 (ko) * 2022-03-15 2022-08-17 주식회사 한솔케미칼 공중합체 조성물을 포함하는 바인더, 상기 바인더를 포함하는 이차전지용 음극 및 상기 음극을 포함하는 이차전지

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE751299A (en) * 1970-06-01 1970-11-16 Kakenyaku Kako Kk Dna polyamine compositions for treating - lesions caused by radiation
US4713236A (en) * 1981-12-07 1987-12-15 Morton Thiokol, Inc. Polymeric amine conditioning additives for hair care products
US5300566A (en) * 1988-04-15 1994-04-05 Air Products And Chemicals, Inc. Method for preparing poly(vinyl alcohol)-co-poly(vinylamine) via a two-phase process
US5194492A (en) * 1988-04-15 1993-03-16 Air Products And Chemicals, Inc. Two-phase process for preparing poly(vinyl alcohol)-co-poly(vinylamine)
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5281307A (en) * 1993-01-13 1994-01-25 Air Products And Chemicals, Inc. Crosslinked vinyl alcohol/vinylamine copolymers for dry end paper addition
WO1994018834A1 (en) * 1993-02-16 1994-09-01 Virginia Tech Intellectual Properties, Inc. Polyelectrolyte dna conjugation and genetic transformation of an animal
US5387641A (en) * 1993-05-25 1995-02-07 Yeung; Dominic W. K. Aqueous polymer emulsions useful as wallcovering prepaste adhesives

Also Published As

Publication number Publication date
BR9606783A (pt) 1997-12-30
AU701543B2 (en) 1999-01-28
SI0806966T1 (en) 2005-06-30
PT806966E (pt) 2005-03-31
JPH11503407A (ja) 1999-03-26
US5629184A (en) 1997-05-13
DK0806966T3 (da) 2005-01-03
AU4655496A (en) 1996-08-14
MX9705536A (es) 1997-10-31
CA2210875A1 (en) 1996-08-01
ZA96401B (en) 1996-08-14
DE69633852T2 (de) 2005-11-03
IL116887A0 (en) 1996-05-14
ES2233960T3 (es) 2005-06-16
EP0806966B1 (de) 2004-11-17
EP0806966A1 (de) 1997-11-19
CA2210875C (en) 2001-05-01
DE69633852D1 (de) 2004-12-23
WO1996022792A1 (en) 1996-08-01

Similar Documents

Publication Publication Date Title
DE69633852D1 (de) Kationische kopolymere von vinylamine und vinylalkohol zur verabreichung von oligonukleotiden
DK0839026T3 (da) Micellære polyether-blokcopolymerkompositioner til målretning af biologiske midler
ATE393831T1 (de) Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
AU3438900A (en) Use of trehalose for stabilising a liquid vaccine
BR0207775A (pt) Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização
NO971192L (no) Fremgangsmåter for avlevering av materialer inn i huden, og sammensetninger som blir anvendt
MX9707021A (es) Receptor de il-7.
JP2001506668A5 (de)
ATE383169T1 (de) Komponente und zusammensetzungen zur verabreichung von wirkstoffen
TR200003513T2 (tr) Pirolo[2,3d]Pirimidin kompozisyonları ve kullanımları
BRPI0412845A (pt) herpes-vìrus, uso de um vìrus, composição farmacêutica, e, método de tratamento de um tumor em um indivìduo em necessidade do mesmo
TR200100054T2 (tr) Paroksetin metansülfonat
DE69732273D1 (de) Öl-Gel-Zusammensetzungen, enthaltend hydrierte (Styrol-Butadien-Styrol)-Blockcopolymere mit hohem Vinylgehalt
MX9708401A (es) Genes reguladores de la cromatina.
MX9603607A (es) Matriz insecticida y su proceso de preparacion.
DE60336059D1 (de) Verfahren zu deren verwendung
MX9801987A (es) Nuevos derivados de aminoacido, su obtencion y su uso.
DE69510162D1 (de) Hydrierte Polybutadien-Blockcopolymer enthaltende Polymermischungen
FR2776188B1 (fr) Oleamide de glycylglycine en dermo-cosmetologie
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
IL149810A0 (en) Method of enhancing immune responses to herpes simplex virus vaccine
ATE319830T1 (de) Mutanten von streptococcaltoxin c und verfahren zu deren anwendung
TR200000291T2 (tr) Taşikinin reseptör antagonistleri olarak 2-asilaminopropanaminler.
UA48245C2 (uk) ЗАМІЩЕНІ 1,2,3,4-ТЕТРАГІДРО-2-ДИБЕНЗОФУРАНАМІНИ ТА 2-АМІНОЦИКЛОГЕПТА[B]БЕНЗОФУРАНИ, ФАРМАЦЕВТИЧНА ЛІКАРСЬКА ФОРМА ТА СПОСІБ ПІДВИЩЕННЯ АКТИВАЦІЇ 5-НТ<sub>1F</sub> РЕЦЕПТОРА У ССАВЦЯ
BR9914722A (pt) Derivados de anticonvulsivo úteis no tratamento de dependência, vìcio e abuso do álcool

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0806966

Country of ref document: EP

REN Ceased due to non-payment of the annual fee