ATE283050T1 - Zusammensetzungen mit verzögerter wirkstoffabgabe zur behandlung der hyperlipidämie - Google Patents
Zusammensetzungen mit verzögerter wirkstoffabgabe zur behandlung der hyperlipidämieInfo
- Publication number
- ATE283050T1 ATE283050T1 AT98941662T AT98941662T ATE283050T1 AT E283050 T1 ATE283050 T1 AT E283050T1 AT 98941662 T AT98941662 T AT 98941662T AT 98941662 T AT98941662 T AT 98941662T AT E283050 T1 ATE283050 T1 AT E283050T1
- Authority
- AT
- Austria
- Prior art keywords
- hyperlipidemia
- treatment
- delayed release
- release compositions
- component
- Prior art date
Links
- 208000031226 Hyperlipidaemia Diseases 0.000 title 1
- 230000003111 delayed effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE19970731A IE970731A1 (en) | 1997-10-07 | 1997-10-07 | Product and method for the treatment of hyperlipidemia |
| PCT/IB1998/001489 WO1999017774A1 (en) | 1997-10-07 | 1998-07-20 | Product and method for the treatment of hyperlipidemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283050T1 true ATE283050T1 (de) | 2004-12-15 |
Family
ID=11041609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98941662T ATE283050T1 (de) | 1997-10-07 | 1998-07-20 | Zusammensetzungen mit verzögerter wirkstoffabgabe zur behandlung der hyperlipidämie |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6090830A (de) |
| EP (1) | EP0969838B2 (de) |
| AT (1) | ATE283050T1 (de) |
| AU (1) | AU8995598A (de) |
| CA (1) | CA2273298C (de) |
| DE (1) | DE69827777T9 (de) |
| ES (1) | ES2235357T5 (de) |
| IE (1) | IE970731A1 (de) |
| WO (1) | WO1999017774A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
| US20080213378A1 (en) * | 1998-10-01 | 2008-09-04 | Elan Pharma International, Ltd. | Nanoparticulate statin formulations and novel statin combinations |
| US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
| EP1117384A1 (de) * | 1998-10-01 | 2001-07-25 | Elan Pharma International Limited | Nanopartikelformulierungen mit kontrollierter wirkstofffreisetzung |
| US20040141925A1 (en) * | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
| US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
| US20040115134A1 (en) * | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
| US7503493B2 (en) * | 1999-10-25 | 2009-03-17 | Silverbrook Research Pty Ltd | Method and system for digitizing freehand graphics with user-selected properties |
| WO2001032162A1 (en) * | 1999-11-03 | 2001-05-10 | Howard J. Smith & Associates Pty Ltd | Liver selective therapy |
| US20040156872A1 (en) * | 2000-05-18 | 2004-08-12 | Elan Pharma International Ltd. | Novel nimesulide compositions |
| US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| ES2274013T3 (es) | 2001-01-26 | 2007-05-16 | Schering Corporation | Combinaciones de activador(es) del receptor activado por el proliferador de los peroxisomas (ppar) e inhibidor(es)m de la absorcion de estelores y tratamientos para trastornos vasculares. |
| PT1355644E (pt) | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| GB2380937A (en) * | 2001-10-18 | 2003-04-23 | David Ian Slovick | Method of dispensing a plurality of medical substances into capsules |
| US20040101566A1 (en) * | 2002-02-04 | 2004-05-27 | Elan Pharma International Limited | Novel benzoyl peroxide compositions |
| DK1471887T3 (da) * | 2002-02-04 | 2010-06-07 | Elan Pharma Int Ltd | Nanopartikelkompositioner der har lysozym som overfladestabiliseringsmiddel |
| US20040067918A1 (en) * | 2002-03-18 | 2004-04-08 | Keller Bradley T. | Combination of an aldosterone receptor antagonist and nicotinic acid or a nicotinic acid derivative |
| AU2003241478A1 (en) * | 2002-06-10 | 2003-12-22 | Elan Pharma International, Ltd. | Nanoparticulate sterol formulations and sterol combinations |
| AU2003261167A1 (en) * | 2002-07-16 | 2004-02-02 | Elan Pharma International, Ltd | Liquid dosage compositions of stable nanoparticulate active agents |
| US7560449B2 (en) | 2002-11-06 | 2009-07-14 | Schering Corporation | Methods and therapeutic combinations for the treatment of demyelination |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| EP1606287B1 (de) | 2003-03-07 | 2013-10-02 | Merck Sharp & Dohme Corp. | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| WO2004081003A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholeterolemia |
| ES2311806T3 (es) * | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| BRPI0417348A (pt) * | 2003-12-04 | 2007-03-13 | Pfizer Prod Inc | processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo |
| WO2005053639A2 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Controlled release multiparticulates formed with dissolution enhancers |
| CA2547597A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate compositions with improved stability |
| RU2331410C2 (ru) * | 2003-12-04 | 2008-08-20 | Пфайзер Продактс Инк. | Способ получения фармацевтических мультичастиц |
| KR20060109481A (ko) * | 2003-12-04 | 2006-10-20 | 화이자 프로덕츠 인코포레이티드 | 바람직하게는 폴록사머와 글리세라이드를 함유하는다미립자 아지트로마이신 조성물의 제조를 위해 압출기를사용하는 분무응결 방법 |
| US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
| WO2005053652A1 (en) | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride |
| MXPA06005913A (es) * | 2003-12-04 | 2006-06-27 | Pfizer Prod Inc | Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos. |
| PL364348A1 (en) | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Application of quaternary pyridine salts as vessel protection agent |
| KR101356335B1 (ko) * | 2004-12-06 | 2014-02-06 | 릴라이언트 파마슈티컬스 인코퍼레이티드 | 지질 치료를 위한 오메가-3 지방산 및 이상지질혈증 제제 |
| WO2007074406A2 (en) | 2005-07-11 | 2007-07-05 | Pharmena North America Inc. | Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative |
| EP1825847A3 (de) * | 2006-02-24 | 2008-01-23 | Teva Pharmaceutical Industries Ltd | Pharmazeutische Zusammensetzungen mit Fluvastatin-Natrium |
| CA2657606A1 (en) * | 2006-03-08 | 2007-09-13 | Cortria Corporation | Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries |
| US20100305074A1 (en) * | 2007-04-04 | 2010-12-02 | Hight H Thomas | Niacin-based pharmaceutical compositions |
| US20100178341A1 (en) * | 2008-06-11 | 2010-07-15 | Ranbaxy Laboratories Limited | BILAYERED TABLET COMPRISING NIACIN AND HMG-CoA REDUCTASE INHIBITOR |
| US20110123609A1 (en) * | 2008-07-19 | 2011-05-26 | Sunil Shantwan Borude | Multiple unit dosage form of niacin |
| CN101836987B (zh) * | 2009-03-19 | 2013-03-27 | 西安万隆制药股份有限公司 | 一种复方烟酸缓释片 |
| US20190111064A1 (en) * | 2017-10-18 | 2019-04-18 | Interstice Therapeutics, LLC | Statin + vitamin d combination drug and method of use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1255805A (en) * | 1967-12-16 | 1971-12-01 | Albert Ag Chem Werke | Improvements in delayed release pharmaceutical preparations and stabilisation of vitamins |
| US5260305A (en) * | 1988-12-12 | 1993-11-09 | E. R. Squibb & Sons, Inc. | Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination |
| CA2016467A1 (en) * | 1989-06-05 | 1990-12-05 | Martin Eisman | Method for treating peripheral atherosclerotic disease employing an hmg coa reductase inhibitor and/or a squalene synthetase inhibitor |
| US5157025A (en) * | 1991-04-01 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug |
| US5445769A (en) * | 1994-06-27 | 1995-08-29 | Fuisz Technologies Ltd. | Spinner head for flash flow processing |
| US5458823A (en) * | 1994-10-28 | 1995-10-17 | Fuisz Technologies Ltd. | Method and apparatus for spinning feedstock material |
| US5683720A (en) * | 1994-10-28 | 1997-11-04 | Fuisz Technologies Ltd. | Liquiflash particles and method of making same |
| DK1017390T3 (da) † | 1997-07-31 | 2007-06-11 | Kos Life Sciences Inc | Coated tablet, der omfatter nikotinsyre eller en forbindelse, der metaboliseres til nikotinsyre, i en form med langvarig frigivelse og en HMG-CoA-reduktaseinhibitor i en form med öjeblikkelig frigivelse |
-
1997
- 1997-10-07 IE IE19970731A patent/IE970731A1/en not_active IP Right Cessation
-
1998
- 1998-07-20 ES ES98941662T patent/ES2235357T5/es not_active Expired - Lifetime
- 1998-07-20 AU AU89955/98A patent/AU8995598A/en not_active Abandoned
- 1998-07-20 US US09/119,225 patent/US6090830A/en not_active Expired - Lifetime
- 1998-07-20 WO PCT/IB1998/001489 patent/WO1999017774A1/en not_active Ceased
- 1998-07-20 DE DE69827777T patent/DE69827777T9/de active Active
- 1998-07-20 AT AT98941662T patent/ATE283050T1/de not_active IP Right Cessation
- 1998-07-20 EP EP98941662A patent/EP0969838B2/de not_active Expired - Lifetime
- 1998-07-20 CA CA002273298A patent/CA2273298C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2273298C (en) | 2008-04-08 |
| DE69827777T9 (de) | 2010-11-11 |
| EP0969838B1 (de) | 2004-11-24 |
| DE69827777T2 (de) | 2005-12-22 |
| IE970731A1 (en) | 2000-10-04 |
| DE69827777T3 (de) | 2010-07-29 |
| DE69827777D1 (de) | 2004-12-30 |
| ES2235357T3 (es) | 2005-07-01 |
| WO1999017774A1 (en) | 1999-04-15 |
| US6090830A (en) | 2000-07-18 |
| EP0969838A1 (de) | 2000-01-12 |
| CA2273298A1 (en) | 1999-04-15 |
| EP0969838B2 (de) | 2010-01-13 |
| ES2235357T5 (es) | 2010-03-30 |
| AU8995598A (en) | 1999-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |