ATE283700T1 - Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges - Google Patents

Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges

Info

Publication number
ATE283700T1
ATE283700T1 AT00935413T AT00935413T ATE283700T1 AT E283700 T1 ATE283700 T1 AT E283700T1 AT 00935413 T AT00935413 T AT 00935413T AT 00935413 T AT00935413 T AT 00935413T AT E283700 T1 ATE283700 T1 AT E283700T1
Authority
AT
Austria
Prior art keywords
signal transmission
therapeutic use
pathway inhibitor
transmission pathway
hedgehog signal
Prior art date
Application number
AT00935413T
Other languages
English (en)
Inventor
Jonathan Robert Lamb
Gerard Francis Hoyne
Margaret Jane Dallman
Original Assignee
Lorantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26315650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE283700(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9913350.6A external-priority patent/GB9913350D0/en
Priority claimed from GBGB9921953.7A external-priority patent/GB9921953D0/en
Application filed by Lorantis Ltd filed Critical Lorantis Ltd
Application granted granted Critical
Publication of ATE283700T1 publication Critical patent/ATE283700T1/de

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00935413T 1999-06-08 2000-06-05 Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges ATE283700T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9913350.6A GB9913350D0 (en) 1999-06-08 1999-06-08 Therapeutic use
GBGB9921953.7A GB9921953D0 (en) 1999-09-16 1999-09-16 Therapeutic use
PCT/GB2000/002191 WO2000074706A1 (en) 1999-06-08 2000-06-05 Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway

Publications (1)

Publication Number Publication Date
ATE283700T1 true ATE283700T1 (de) 2004-12-15

Family

ID=26315650

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00935413T ATE283700T1 (de) 1999-06-08 2000-06-05 Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges

Country Status (10)

Country Link
US (1) US20020192216A1 (de)
EP (1) EP1183040B1 (de)
JP (1) JP2003501395A (de)
AT (1) ATE283700T1 (de)
AU (1) AU780358B2 (de)
CA (1) CA2376210A1 (de)
DE (1) DE60016402T2 (de)
ES (1) ES2233383T3 (de)
GB (1) GB0013674D0 (de)
WO (1) WO2000074706A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69841320D1 (de) 1997-02-10 2010-01-07 Harvard College Verfahren zur modulation von hämatopoese und vaskulärem wachstum
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
EP1235851B1 (de) 1999-10-13 2006-05-31 Johns Hopkins University School of Medicine Verbindungen zur regulierung des hedgehog-signalwegs, zusammensetzungen und verwendungen davon
ATE324876T1 (de) * 1999-10-14 2006-06-15 Curis Inc VERMITTLER VON ßHEDGEHOGß ÜBERMITTELNDEN BAHNEN, DAZUGEHÖRIGE ZUSAMMENETZUNGEN UND VERWENDUNGEN
US6552016B1 (en) 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
EP1646395B8 (de) * 1999-11-30 2014-12-17 Curis, Inc. Verfahren und zusammensetzungen zur regulierung der lymphozytenaktivität
US6951839B1 (en) 1999-11-30 2005-10-04 Curis, Inc. Methods and compositions for regulating lymphocyte activity
US8168178B2 (en) 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
AU7549501A (en) * 2000-06-16 2002-01-02 Biogen Inc Angiogenesis-modulating compositions and uses
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US20040060568A1 (en) 2000-10-13 2004-04-01 Henryk Dudek Hedgehog antagonists, methods and uses related thereto
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
EP1401469A2 (de) * 2001-04-09 2004-03-31 Lorantis Limited Therapeutische verwendung und identifikation von modulatoren des hedgehog-signalübertragungsweges oder eines seiner zielübertragungswege
EP1411938B1 (de) 2001-07-02 2005-07-06 Tas, Sinan Verwendung von cyclopamine zur Herstellung eines Arzneimittels zur Behandlung von Psoriasis
EP1561464A3 (de) * 2001-07-02 2007-04-25 Sinan Tas Verwendung des Cyclopamins zur Behandlung des basalen Zellkarzinoms und anderer Tumoren
WO2004032838A2 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
FR2850022B1 (fr) * 2003-01-22 2006-09-08 Centre Nat Rech Scient Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications
WO2005032578A1 (en) * 2003-10-06 2005-04-14 Monash University Therapeutic method
WO2005097207A2 (en) 2004-03-26 2005-10-20 Curis, Inc. Rna interference modulators of hedgehog signaling and uses thereof
CA2566498A1 (en) * 2004-05-14 2005-12-08 The Regents Of The University Of California Methods for treating cancer using anti-wnt2 monoclonal antibodies and sirna
US7618936B2 (en) 2004-05-21 2009-11-17 The Regents Of The University Of California Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
US8257438B2 (en) * 2005-04-12 2012-09-04 Warsaw Orthopedic, Inc. Methods and devices for preserving motion in an articulating prosthetic disc
WO2007033063A2 (en) * 2005-09-12 2007-03-22 The Board Of Regents Of The University Of Texas System Regulation of the hedgehog signaling pathway and uses thereof
GB0610242D0 (en) * 2006-05-23 2006-07-05 Novartis Ag Organic compounds
US20110044991A1 (en) * 2006-09-27 2011-02-24 Irm Llc Methods and compositions for treating lymphoma and myeloma
CA2681162C (en) * 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
GB0707349D0 (en) * 2007-04-17 2007-05-23 Renovo Ltd Medicaments and methods for accelerating wound healing
WO2009132032A2 (en) * 2008-04-21 2009-10-29 President And Fellows Of Harvard College Sonic hedgehog modulators
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP2177208A1 (de) * 2008-10-17 2010-04-21 Ferrer Internacional, S.A. Pharmazeutische topische Zusammensetzungen
MX2011004683A (es) 2008-11-03 2011-06-20 Lilly Co Eli Antagonistas de la via hedgehog de ftalazina disustituida.
BRPI0921777A2 (pt) 2008-11-17 2016-01-12 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
KR101342184B1 (ko) 2008-11-17 2013-12-19 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
DE102010052941A1 (de) * 2010-11-18 2012-05-24 Eberhard-Karls-Universität Tübingen Universitätsklinikum Therapeutisches Protein
CA2853187A1 (en) * 2011-10-28 2013-05-02 Paranta Biosciences Limited A method of treating mucus hypersecretion
GB201204201D0 (en) * 2012-03-09 2012-04-25 Ucl Business Plc Erythropoiesis
GB201204645D0 (en) * 2012-03-16 2012-05-02 Ucl Business Plc Treatment of disease
WO2014046624A1 (en) * 2012-09-21 2014-03-27 Agency For Science, Technology And Research A method for treating a disease or disorder of the lung by inhibition of the hedgehog pathway
JP5804389B2 (ja) * 2013-01-11 2015-11-04 国立大学法人東北大学 運動に応答して筋肉細胞において発現変動するタンパク質及びそれらの受容体、それらをコードする遺伝子、並びにそれらを用いたスクリーニング方法
EP2945623B1 (de) 2013-01-15 2018-09-05 Suzhou Kintor Pharmaceuticals, Inc. Signalhemmer des hedgehog-signmalwegs und therapeutische anwendungen davon
AU2017294208B2 (en) 2016-07-04 2019-08-29 Suzhou Kintor Pharmaceuticals, Inc. Chiral heterocyclic compound with hedgehog pathway antagonist activity, method and use thereof
JP2023546536A (ja) 2020-10-13 2023-11-02 エンデバー バイオメディシンズ, インコーポレイテッド 線維症を処置する方法
US12605377B2 (en) 2020-10-13 2026-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function
CN118311175B (zh) * 2024-05-06 2025-12-12 四川新绿色药业科技发展有限公司 一种刺猬皮药材、饮片、标准汤剂及其配方颗粒hplc特征图谱的构建方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011862A1 (en) * 1988-05-31 1989-12-14 Biotechnology Australia Pty. Ltd. Actions of hormones
IL128999A0 (en) * 1996-09-20 2000-02-17 Harvard College Hedgehog interacting proteins and uses related thereto
US5989909A (en) * 1997-09-26 1999-11-23 Millennium Biotherapeutics, Inc. Huchordin and uses thereof
JPH114695A (ja) * 1997-04-25 1999-01-12 Hayashibara Biochem Lab Inc ヘッジホッグ蛋白質
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
DE19747418C1 (de) * 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP5067986B2 (ja) * 1998-04-09 2012-11-07 ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
WO1999063052A2 (en) * 1998-06-03 1999-12-09 The President And Fellows Of Harvard College Bigenic mouse models and assays to identify proliferation and differentiation regulators
AU773044B2 (en) * 1998-09-11 2004-05-13 Curis, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
JP2002524528A (ja) * 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
WO2000025725A2 (en) * 1998-11-02 2000-05-11 Biogen, Inc. Functional antagonists of hedgehog activity
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
PT1173201E (pt) * 1999-04-22 2005-08-31 Biogen Idec Inc Metodo para o tratamento de fibrose utilizando um antagonista da subunidade alfa 4 de integrina
US6743613B2 (en) * 1999-04-23 2004-06-01 Human Genome Sciences, Inc. Lysyl-oxidase HOHEC84 polynucleotides

Also Published As

Publication number Publication date
ES2233383T3 (es) 2005-06-16
EP1183040B1 (de) 2004-12-01
WO2000074706A1 (en) 2000-12-14
EP1183040A1 (de) 2002-03-06
GB0013674D0 (en) 2000-07-26
AU5095500A (en) 2000-12-28
DE60016402D1 (de) 2005-01-05
CA2376210A1 (en) 2000-12-14
DE60016402T2 (de) 2005-10-27
US20020192216A1 (en) 2002-12-19
JP2003501395A (ja) 2003-01-14
AU780358B2 (en) 2005-03-17

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