ATE284399T1 - Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe - Google Patents

Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe

Info

Publication number
ATE284399T1
ATE284399T1 AT00962637T AT00962637T ATE284399T1 AT E284399 T1 ATE284399 T1 AT E284399T1 AT 00962637 T AT00962637 T AT 00962637T AT 00962637 T AT00962637 T AT 00962637T AT E284399 T1 ATE284399 T1 AT E284399T1
Authority
AT
Austria
Prior art keywords
quinolinepropyl
active ingredients
piperidine derivatives
antibacterial active
antibacterial
Prior art date
Application number
AT00962637T
Other languages
English (en)
Inventor
Jean-Luc Malleron
Michel Tabart
Jean-Christophe Carry
Michel Evers
Ahmad Youssef El
Serge Mignani
Fabrice Viviani
Michel Cheve
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE284399T1 publication Critical patent/ATE284399T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT00962637T 1999-09-17 2000-09-14 Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe ATE284399T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9911679A FR2798656B1 (fr) 1999-09-17 1999-09-17 Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
PCT/FR2000/002541 WO2001025227A2 (fr) 1999-09-17 2000-09-14 Derives de la quinolyl propyl piperidine et leur utilisation en tant que antibacteriens

Publications (1)

Publication Number Publication Date
ATE284399T1 true ATE284399T1 (de) 2004-12-15

Family

ID=9549990

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00962637T ATE284399T1 (de) 1999-09-17 2000-09-14 Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe

Country Status (30)

Country Link
EP (2) EP1218370B1 (de)
JP (1) JP2004527448A (de)
KR (1) KR20020038757A (de)
CN (1) CN1374959A (de)
AP (1) AP2002002459A0 (de)
AT (1) ATE284399T1 (de)
AU (1) AU7429500A (de)
BG (1) BG106524A (de)
BR (1) BR0014060A (de)
CA (1) CA2383836A1 (de)
CZ (1) CZ2002940A3 (de)
DE (2) DE60016611T2 (de)
DZ (1) DZ3195A1 (de)
EA (1) EA005183B1 (de)
EE (1) EE200200138A (de)
FR (1) FR2798656B1 (de)
GE (1) GEP20043223B (de)
HR (1) HRP20020214A2 (de)
HU (1) HUP0204283A3 (de)
IL (1) IL148720A0 (de)
MA (1) MA26820A1 (de)
MX (1) MXPA02001979A (de)
NO (1) NO20021253L (de)
OA (1) OA12022A (de)
PL (1) PL354809A1 (de)
SK (1) SK3632002A3 (de)
TN (1) TNSN00184A1 (de)
WO (1) WO2001025227A2 (de)
YU (1) YU19002A (de)
ZA (1) ZA200202073B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
EP1305308B1 (de) 2000-07-26 2006-12-20 Smithkline Beecham Plc Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US7312212B2 (en) 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
EP1470131A2 (de) 2002-01-29 2004-10-27 Glaxo Group Limited "aminopiperidinverbindugen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen "
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
FR2842807A1 (fr) * 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
EP1551829B1 (de) * 2002-10-10 2010-04-07 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
US7232832B2 (en) 2002-11-05 2007-06-19 Smithkline Beecham Corporation Antibacterial agents
EP1560488B1 (de) 2002-11-05 2010-09-01 Glaxo Group Limited Antibakterielle mittel
WO2004050036A2 (en) 2002-12-04 2004-06-17 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
DE602005021133D1 (de) * 2004-10-05 2010-06-17 Actelion Pharmaceuticals Ltd Neue piperidin-antibiotika
EP1799674B1 (de) * 2004-10-05 2010-05-05 Actelion Pharmaceuticals Ltd. Neue piperidin-antibiotika
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528586A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006081182A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1845995A4 (de) 2005-01-25 2010-03-03 Glaxo Group Ltd Antibakterielle wirkstoffe
ATE536351T1 (de) 2006-01-26 2011-12-15 Actelion Pharmaceuticals Ltd Tetrahydropyran-antibiotika
EP2001887B1 (de) 2006-04-06 2010-09-15 Glaxo Group Limited Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (de) 2007-05-18 2008-11-19 Glaxo Group Limited Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen
CN101679357A (zh) * 2007-05-09 2010-03-24 辉瑞大药厂 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
EP2080761A1 (de) 2008-01-18 2009-07-22 Glaxo Group Limited Verbindungen
EP2352734A1 (de) 2008-10-17 2011-08-10 Glaxo Group Limited Als antibakterielle mittel verwendete tricyclische stickstoffverbindungen
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
ES2670550T3 (es) * 2013-10-14 2018-05-30 Eisai R&D Management Co., Ltd. Derivados de quinolina selectivamente sustituidos
US10702521B2 (en) 2014-08-22 2020-07-07 Glaxosmithkline Intellectual Property Development Limited Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
PT3889145T (pt) 2015-12-17 2024-04-02 Merck Patent Gmbh 8-ciano-5-piperidino-quinolinas como antagonistas de tlr7/8 e suas utilizações para tratamento de distúrbios imunitários
EP4198031A1 (de) 2016-08-08 2023-06-21 Merck Patent GmbH Tlr7/8-antagonisten und verwendungen davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2318842A1 (en) * 1998-01-26 1999-07-29 Julie Dorothy Warrack Quinoline derivatives as antibacterials
JP2002535323A (ja) * 1999-01-20 2002-10-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー プロテインキナーゼ阻害剤としてのピペリジニルキノリン

Also Published As

Publication number Publication date
EA005183B1 (ru) 2004-12-30
AU7429500A (en) 2001-05-10
DE60016611T2 (de) 2005-12-22
EE200200138A (et) 2003-06-16
FR2798656B1 (fr) 2004-12-17
NO20021253D0 (no) 2002-03-13
YU19002A (sh) 2005-06-10
WO2001025227A2 (fr) 2001-04-12
EA200200374A1 (ru) 2002-10-31
JP2004527448A (ja) 2004-09-09
IL148720A0 (en) 2002-09-12
MXPA02001979A (es) 2002-08-20
AP2002002459A0 (en) 2002-06-30
BG106524A (en) 2003-01-31
DE60034713D1 (de) 2007-06-14
ZA200202073B (en) 2003-08-27
MA26820A1 (fr) 2004-12-20
EP1218370A2 (de) 2002-07-03
HUP0204283A2 (hu) 2003-04-28
EP1218370B1 (de) 2004-12-08
EP1484328A1 (de) 2004-12-08
PL354809A1 (en) 2004-02-23
GEP20043223B (en) 2004-04-26
CA2383836A1 (fr) 2001-04-12
CN1374959A (zh) 2002-10-16
FR2798656A1 (fr) 2001-03-23
HRP20020214A2 (en) 2005-04-30
HUP0204283A3 (en) 2004-07-28
CZ2002940A3 (cs) 2002-07-17
DZ3195A1 (fr) 2001-04-12
TNSN00184A1 (fr) 2005-11-10
DE60016611D1 (de) 2005-01-13
WO2001025227A3 (fr) 2001-11-22
EP1484328B1 (de) 2007-05-02
BR0014060A (pt) 2002-05-21
SK3632002A3 (en) 2003-04-01
DE60034713T2 (de) 2008-01-17
OA12022A (fr) 2006-04-19
KR20020038757A (ko) 2002-05-23
NO20021253L (no) 2002-04-24

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties