ATE284399T1 - Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe - Google Patents

Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe

Info

Publication number
ATE284399T1
ATE284399T1 AT00962637T AT00962637T ATE284399T1 AT E284399 T1 ATE284399 T1 AT E284399T1 AT 00962637 T AT00962637 T AT 00962637T AT 00962637 T AT00962637 T AT 00962637T AT E284399 T1 ATE284399 T1 AT E284399T1
Authority
AT
Austria
Prior art keywords
quinolinepropyl
active ingredients
piperidine derivatives
antibacterial active
antibacterial
Prior art date
Application number
AT00962637T
Other languages
English (en)
Inventor
Jean-Luc Malleron
Michel Tabart
Jean-Christophe Carry
Michel Evers
Ahmad Youssef El
Serge Mignani
Fabrice Viviani
Michel Cheve
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE284399T1 publication Critical patent/ATE284399T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT00962637T 1999-09-17 2000-09-14 Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe ATE284399T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9911679A FR2798656B1 (fr) 1999-09-17 1999-09-17 Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
PCT/FR2000/002541 WO2001025227A2 (fr) 1999-09-17 2000-09-14 Derives de la quinolyl propyl piperidine et leur utilisation en tant que antibacteriens

Publications (1)

Publication Number Publication Date
ATE284399T1 true ATE284399T1 (de) 2004-12-15

Family

ID=9549990

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00962637T ATE284399T1 (de) 1999-09-17 2000-09-14 Chinolinpropyl-piperidinderivate und deren verwendung als antibakterielle wirkstoffe

Country Status (30)

Country Link
EP (2) EP1218370B1 (de)
JP (1) JP2004527448A (de)
KR (1) KR20020038757A (de)
CN (1) CN1374959A (de)
AP (1) AP2002002459A0 (de)
AT (1) ATE284399T1 (de)
AU (1) AU7429500A (de)
BG (1) BG106524A (de)
BR (1) BR0014060A (de)
CA (1) CA2383836A1 (de)
CZ (1) CZ2002940A3 (de)
DE (2) DE60016611T2 (de)
DZ (1) DZ3195A1 (de)
EA (1) EA005183B1 (de)
EE (1) EE200200138A (de)
FR (1) FR2798656B1 (de)
GE (1) GEP20043223B (de)
HR (1) HRP20020214A2 (de)
HU (1) HUP0204283A3 (de)
IL (1) IL148720A0 (de)
MA (1) MA26820A1 (de)
MX (1) MXPA02001979A (de)
NO (1) NO20021253L (de)
OA (1) OA12022A (de)
PL (1) PL354809A1 (de)
SK (1) SK3632002A3 (de)
TN (1) TNSN00184A1 (de)
WO (1) WO2001025227A2 (de)
YU (1) YU19002A (de)
ZA (1) ZA200202073B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
CN1452619A (zh) 2000-07-26 2003-10-29 史密斯克莱·比奇曼公司 具有抗细菌活性的氨基哌啶喹啉和它们的氮杂等排的类似物
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
JP4445753B2 (ja) 2002-01-29 2010-04-07 グラクソ グループ リミテッド アミノピペリジン誘導体
US7109213B2 (en) 2002-01-29 2006-09-19 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
FR2842807A1 (fr) * 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
JP4602903B2 (ja) * 2002-10-10 2010-12-22 モルフォケム アクチェンゲゼルシャフト フュア コンビナトリシェ ヘミー 抗菌活性を有する新規化合物
AU2003303956A1 (en) 2002-11-05 2004-11-23 Smithkline Beecham Corporation Antibacterial agents
ES2350977T3 (es) 2002-11-05 2011-01-28 Glaxo Group Limited Agentes antibacterianos.
DE60324179D1 (de) 2002-12-04 2008-11-27 Glaxo Group Ltd Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
EP1799674B1 (de) * 2004-10-05 2010-05-05 Actelion Pharmaceuticals Ltd. Neue piperidin-antibiotika
CA2581057A1 (en) * 2004-10-05 2006-04-13 Actelion Pharmaceuticals Ltd New piperidine antibiotics
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528586A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
EP1845995A4 (de) 2005-01-25 2010-03-03 Glaxo Group Ltd Antibakterielle wirkstoffe
WO2006081182A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
JP2009524643A (ja) 2006-01-26 2009-07-02 アクテリオン ファーマシューティカルズ リミテッド テトラヒドロピラン抗生物質
ATE481406T1 (de) 2006-04-06 2010-10-15 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (de) 2007-05-18 2008-11-19 Glaxo Group Limited Derivate und Analoge von N-Ethylquinolonen und N-Ethylazaquinolonen
EP2481735A1 (de) * 2007-05-09 2012-08-01 Pfizer Inc. Substituierte heterocyclische Derivate und Zusammensetzungen und ihre pharmazeutische Verwendung als antibakterielle Mittel
EP2080761A1 (de) 2008-01-18 2009-07-22 Glaxo Group Limited Verbindungen
JP2012505866A (ja) 2008-10-17 2012-03-08 グラクソ グループ リミテッド 抗菌剤として使用される三環式窒素化合物
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
ES2670550T3 (es) * 2013-10-14 2018-05-30 Eisai R&D Management Co., Ltd. Derivados de quinolina selectivamente sustituidos
AR101674A1 (es) 2014-08-22 2017-01-04 Glaxosmithkline Ip Dev Ltd Uso de un compuesto tricíclico que contiene nitrógeno
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
MX2021006804A (es) 2015-12-17 2023-01-13 Merck Patent Gmbh Antagonistas policiclicos del receptor 7/8 tipo toll (tlr7/8) y uso de los mismos en el tratamiento de trastornos inmunitarios.
AU2017311047B2 (en) 2016-08-08 2021-07-22 Merck Patent Gmbh TLR7/8 antagonists and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2717899A (en) * 1998-01-26 1999-08-09 Smithkline Beecham Plc Quinoline derivatives as antibacterials
JP2002535323A (ja) * 1999-01-20 2002-10-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー プロテインキナーゼ阻害剤としてのピペリジニルキノリン

Also Published As

Publication number Publication date
MXPA02001979A (es) 2002-08-20
HUP0204283A2 (hu) 2003-04-28
KR20020038757A (ko) 2002-05-23
WO2001025227A2 (fr) 2001-04-12
GEP20043223B (en) 2004-04-26
HUP0204283A3 (en) 2004-07-28
WO2001025227A3 (fr) 2001-11-22
DE60034713D1 (de) 2007-06-14
CZ2002940A3 (cs) 2002-07-17
DZ3195A1 (fr) 2001-04-12
CN1374959A (zh) 2002-10-16
EP1484328B1 (de) 2007-05-02
DE60016611D1 (de) 2005-01-13
BR0014060A (pt) 2002-05-21
EP1218370B1 (de) 2004-12-08
PL354809A1 (en) 2004-02-23
NO20021253D0 (no) 2002-03-13
HRP20020214A2 (en) 2005-04-30
EA005183B1 (ru) 2004-12-30
EE200200138A (et) 2003-06-16
DE60016611T2 (de) 2005-12-22
DE60034713T2 (de) 2008-01-17
OA12022A (fr) 2006-04-19
JP2004527448A (ja) 2004-09-09
FR2798656B1 (fr) 2004-12-17
EP1484328A1 (de) 2004-12-08
AP2002002459A0 (en) 2002-06-30
EP1218370A2 (de) 2002-07-03
SK3632002A3 (en) 2003-04-01
CA2383836A1 (fr) 2001-04-12
AU7429500A (en) 2001-05-10
IL148720A0 (en) 2002-09-12
TNSN00184A1 (fr) 2005-11-10
ZA200202073B (en) 2003-08-27
EA200200374A1 (ru) 2002-10-31
BG106524A (en) 2003-01-31
FR2798656A1 (fr) 2001-03-23
MA26820A1 (fr) 2004-12-20
YU19002A (sh) 2005-06-10
NO20021253L (no) 2002-04-24

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties