YU19002A - Derivati hinolil-propil-piperidina, njihovo dobivanje i smeše koje ih sadrže - Google Patents
Derivati hinolil-propil-piperidina, njihovo dobivanje i smeše koje ih sadržeInfo
- Publication number
- YU19002A YU19002A YU19002A YUP19002A YU19002A YU 19002 A YU19002 A YU 19002A YU 19002 A YU19002 A YU 19002A YU P19002 A YUP19002 A YU P19002A YU 19002 A YU19002 A YU 19002A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compositions
- contain
- preparation
- piperidine derivatives
- propyl piperidine
- Prior art date
Links
- -1 Quinolyl propyl piperidine derivatives Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Derivati hinolil-propil-piperidina opste formule (I) u kojoj R1 oznacava H ili halogen, ili OH, R'1 je H, ili moze oznacavati halogen kada R1 takodje oznacava halogen, i R0 oznacava H, ili R1 i R0 zajedno formiraju vezu i R'1 oznacava H, R2 oznacava radikal karboksi, karboksimetil ili 2-karboksietil, i R3 oznacava alkil (1-6 C-atoma) koji je supstituisan sa 1-3 supstituenta odabrana izmedju OH, halogena, =O, COOH, alkiloksikarbonila, alkiloksi, alkiltio ili izmedju radikala fenila, feniltio ili fenilalkiltio koji sami mogu nositi 1-4 supstituenta [odabrana izmedju halogena, OH, alkila, alkiloksi, trifluormetila, trifluormetoksi, COOH, alkiloksikarbonila, CN, acetamido ili NH2] ili izmedju cikloalkila ili cikloalkiltio (3-7 clanova), ili izmedju aromaticnog heterociklila ili heterocikliltio (5-6 clanova) koji obuvhata 1-4 heteroatoma odabrana izmedju N, O ili S i koji su u datom slucaju sami supstituisani [halogenom, OH, alkilom, alkiloksi, CF3, OCF3, =OCOOH, alkiloksikarbonila, CN ili NH2], ili R3 oznacava propargil koji je supstituisan fenilom koji sam moze nositi 1-3 supstituenta [odabrana izmedju halogena, OH, alkila, alkiloksi, CF3, OCF3, COOH, alkiloksikarbonila, CN ili NH2], ili koji je supstituisan radikalom cikloalkilom koji sadrzi 3-7 clanova ili koji je supstituisan aromaticnim heterociklilom (5-6 clanova) koji obuhvata 1-4 heteroatoma odabrana izmedju N, O ili S i koji je u datom slucaju sam supstituisan [halogenom, OH, alkilo, alkiloksi, CF3, OCF3, =O, COOH, alkiloksikarbonilom, CN ili NH2], ili R3 oznacava cinamil ili 4-fenilbuten-3-il, ili R2 oznacava -CH2OH, alkiloksikarbonil, alkiloksikarbonil-metil ili alkiloksikarbonil-2-etil i R3 oznacava alkil (1-6 C-atoma) koji je supstituisan sa feniltio koji sam moze nositi 1-3 supstituenta [odabrana izmedju halogena, OH, alkila, alkiloksi, CF3, OCF3, COOH, alkiloksikarbonilom, CN ili NH2], sa cikloalkiltio (3-7 clanova) ili sa aromaticnim heterocikliltio (5-6 clanova) koji obuhvata 1-4 heteroatoma odabrana izmedju N, O ili S i koji je u datom slucaju sam supstituisan [halogenom, OH, alkilom, alkiloksi, CF3, OCF3, =O, COOH, alkiloksikarbonilom, CN ili NH2] ili R3 oznacava propargil koji je supstituisan fenilom koji sam moze nositi 1-3 supstituenta [odabrana izmedju halogena, OH, alkila, alkiloksi, CF3, OCF3, COOH, alkiloksikarbonila, CN ili NH2] ili koji je supstituisan cikloalkiom koji sadrzi 3-7 clanova ili koji je supstituisan aromaticnim heterociklilom sa 5-6 clanova koji obuhvata 1-4 heteroatoma odabrana izmedju N, O ili S i koji je u datom slucaju sam supstituisan [halogenom, OH, alkilom, alkiloksi, CF3, OCF3, =O, COOH, alkiloksikarbonilom, CN ili NH2], i R4 oznacava radikal alkil (1-6 C-atoma), alkenil-CH2- ili alkinil-CH2- (3-7 C-atoma), u obliku svojih diastereoizomera ili njihovih smesa, kao i u obliku svojih soli. Ovi novi derivati su narocito prikladni antimikrobni agensi.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9911679A FR2798656B1 (fr) | 1999-09-17 | 1999-09-17 | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU19002A true YU19002A (sh) | 2005-06-10 |
Family
ID=9549990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU19002A YU19002A (sh) | 1999-09-17 | 2000-09-14 | Derivati hinolil-propil-piperidina, njihovo dobivanje i smeše koje ih sadrže |
Country Status (30)
| Country | Link |
|---|---|
| EP (2) | EP1218370B1 (sh) |
| JP (1) | JP2004527448A (sh) |
| KR (1) | KR20020038757A (sh) |
| CN (1) | CN1374959A (sh) |
| AP (1) | AP2002002459A0 (sh) |
| AT (1) | ATE284399T1 (sh) |
| AU (1) | AU7429500A (sh) |
| BG (1) | BG106524A (sh) |
| BR (1) | BR0014060A (sh) |
| CA (1) | CA2383836A1 (sh) |
| CZ (1) | CZ2002940A3 (sh) |
| DE (2) | DE60016611T2 (sh) |
| DZ (1) | DZ3195A1 (sh) |
| EA (1) | EA005183B1 (sh) |
| EE (1) | EE200200138A (sh) |
| FR (1) | FR2798656B1 (sh) |
| GE (1) | GEP20043223B (sh) |
| HR (1) | HRP20020214A2 (sh) |
| HU (1) | HUP0204283A3 (sh) |
| IL (1) | IL148720A0 (sh) |
| MA (1) | MA26820A1 (sh) |
| MX (1) | MXPA02001979A (sh) |
| NO (1) | NO20021253L (sh) |
| OA (1) | OA12022A (sh) |
| PL (1) | PL354809A1 (sh) |
| SK (1) | SK3632002A3 (sh) |
| TN (1) | TNSN00184A1 (sh) |
| WO (1) | WO2001025227A2 (sh) |
| YU (1) | YU19002A (sh) |
| ZA (1) | ZA200202073B (sh) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9822440D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| GB9917408D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| IL154107A0 (en) | 2000-07-26 | 2003-07-31 | Smithkline Beecham Plc | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
| GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| AU2003239302A1 (en) | 2002-01-29 | 2003-09-02 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| WO2003064421A1 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine derivatives |
| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| FR2842807A1 (fr) * | 2002-07-23 | 2004-01-30 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| FR2844270B1 (fr) * | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| BR0315221A (pt) * | 2002-10-10 | 2005-08-23 | Morphochem Ag Komb Chemie | Compostos com atividade antibacteriana |
| AU2003303956A1 (en) | 2002-11-05 | 2004-11-23 | Smithkline Beecham Corporation | Antibacterial agents |
| AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
| WO2004050036A2 (en) | 2002-12-04 | 2004-06-17 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
| EP1799674B1 (en) * | 2004-10-05 | 2010-05-05 | Actelion Pharmaceuticals Ltd. | New piperidine antibiotics |
| CA2581057A1 (en) * | 2004-10-05 | 2006-04-13 | Actelion Pharmaceuticals Ltd | New piperidine antibiotics |
| JP2008528586A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| US7709472B2 (en) | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
| JP2008528588A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| WO2006081264A1 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| WO2007086016A1 (en) | 2006-01-26 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Tetrahydropyrane antibiotics |
| ATE481406T1 (de) | 2006-04-06 | 2010-10-15 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| AU2008249745B2 (en) * | 2007-05-09 | 2012-01-12 | Pfizer Inc. | Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| EP2352734A1 (en) | 2008-10-17 | 2011-08-10 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| JP5653935B2 (ja) | 2009-01-15 | 2015-01-14 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物 |
| EP3057948B1 (en) * | 2013-10-14 | 2018-03-14 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline derivatives |
| EP3639824A1 (en) | 2014-08-22 | 2020-04-22 | GlaxoSmithKline Intellectual Property Development Limited | Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| SG11201804170RA (en) | 2015-12-17 | 2018-06-28 | Merck Patent Gmbh | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders |
| EP3497094B1 (en) | 2016-08-08 | 2023-02-15 | Merck Patent GmbH | Tlr7/8 antagonists and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1051413B1 (en) * | 1998-01-26 | 2003-06-04 | SmithKline Beecham plc | Quinoline derivatives as antibacterials |
| EP1144404A1 (en) * | 1999-01-20 | 2001-10-17 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
-
1999
- 1999-09-17 FR FR9911679A patent/FR2798656B1/fr not_active Expired - Fee Related
-
2000
- 2000-09-14 EA EA200200374A patent/EA005183B1/ru not_active IP Right Cessation
- 2000-09-14 EE EEP200200138A patent/EE200200138A/xx unknown
- 2000-09-14 HU HU0204283A patent/HUP0204283A3/hu unknown
- 2000-09-14 EP EP00962637A patent/EP1218370B1/fr not_active Expired - Lifetime
- 2000-09-14 CZ CZ2002940A patent/CZ2002940A3/cs unknown
- 2000-09-14 MX MXPA02001979A patent/MXPA02001979A/es unknown
- 2000-09-14 PL PL00354809A patent/PL354809A1/xx not_active Application Discontinuation
- 2000-09-14 DE DE60016611T patent/DE60016611T2/de not_active Expired - Fee Related
- 2000-09-14 SK SK363-2002A patent/SK3632002A3/sk unknown
- 2000-09-14 HR HR20020214A patent/HRP20020214A2/hr not_active Application Discontinuation
- 2000-09-14 BR BR0014060-0A patent/BR0014060A/pt not_active IP Right Cessation
- 2000-09-14 KR KR1020027003547A patent/KR20020038757A/ko not_active Ceased
- 2000-09-14 WO PCT/FR2000/002541 patent/WO2001025227A2/fr not_active Ceased
- 2000-09-14 DZ DZ003195A patent/DZ3195A1/xx active
- 2000-09-14 CA CA002383836A patent/CA2383836A1/fr not_active Abandoned
- 2000-09-14 AP APAP/P/2002/002459A patent/AP2002002459A0/en unknown
- 2000-09-14 AU AU74295/00A patent/AU7429500A/en not_active Abandoned
- 2000-09-14 CN CN00813020A patent/CN1374959A/zh active Pending
- 2000-09-14 IL IL14872000A patent/IL148720A0/xx unknown
- 2000-09-14 GE GEAP20006413A patent/GEP20043223B/en unknown
- 2000-09-14 AT AT00962637T patent/ATE284399T1/de not_active IP Right Cessation
- 2000-09-14 YU YU19002A patent/YU19002A/sh unknown
- 2000-09-14 JP JP2001528171A patent/JP2004527448A/ja active Pending
- 2000-09-14 OA OA1200200074A patent/OA12022A/fr unknown
- 2000-09-14 DE DE60034713T patent/DE60034713T2/de not_active Expired - Fee Related
- 2000-09-14 EP EP04019136A patent/EP1484328B1/fr not_active Expired - Lifetime
- 2000-09-15 TN TNTNSN00184A patent/TNSN00184A1/fr unknown
-
2002
- 2002-03-13 ZA ZA200202073A patent/ZA200202073B/en unknown
- 2002-03-13 NO NO20021253A patent/NO20021253L/no not_active Application Discontinuation
- 2002-03-14 MA MA26554A patent/MA26820A1/fr unknown
- 2002-03-15 BG BG106524A patent/BG106524A/xx unknown
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