ATE284433T1 - Fluorescierende cyaninlabels mit einem sulphamidobrückenglied - Google Patents
Fluorescierende cyaninlabels mit einem sulphamidobrückengliedInfo
- Publication number
- ATE284433T1 ATE284433T1 AT99112696T AT99112696T ATE284433T1 AT E284433 T1 ATE284433 T1 AT E284433T1 AT 99112696 T AT99112696 T AT 99112696T AT 99112696 T AT99112696 T AT 99112696T AT E284433 T1 ATE284433 T1 AT E284433T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- group
- indipendently
- alkylensulfonic
- alkylensulfonate
- Prior art date
Links
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 title abstract 2
- 239000012038 nucleophile Substances 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052755 nonmetal Inorganic materials 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 238000006862 quantum yield reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99112696A EP1065250B1 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE284433T1 true ATE284433T1 (de) | 2004-12-15 |
Family
ID=8238492
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99112696T ATE284433T1 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende cyaninlabels mit einem sulphamidobrückenglied |
| AT04023147T ATE435262T1 (de) | 1999-07-02 | 1999-07-02 | Fluoreszierende cyaninlabels mit einem sulphamidobrückenglied |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04023147T ATE435262T1 (de) | 1999-07-02 | 1999-07-02 | Fluoreszierende cyaninlabels mit einem sulphamidobrückenglied |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6448008B1 (de) |
| EP (2) | EP1065250B1 (de) |
| AT (2) | ATE284433T1 (de) |
| AU (1) | AU776841B2 (de) |
| BR (1) | BR0005843A (de) |
| CA (1) | CA2312099C (de) |
| DE (2) | DE69941067D1 (de) |
| ES (1) | ES2329572T3 (de) |
Families Citing this family (79)
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| JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
| US7597878B2 (en) | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
| DE20122672U1 (de) | 2000-09-29 | 2007-04-05 | Molecular Probes, Inc., Eugene | Modifizierte Carbocyaninfarbstoffe und deren Konjugate |
| CA2423806C (en) | 2000-09-29 | 2009-12-22 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
| US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
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| US20030231984A1 (en) * | 2002-05-07 | 2003-12-18 | Bright Frank V. | Method to rapidly prepare and screen formulations and compositions containing same |
| US7172907B2 (en) * | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
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| US8357801B2 (en) | 2005-05-24 | 2013-01-22 | Enzo Life Sciences, Inc. | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits |
| US7737281B2 (en) * | 2005-05-24 | 2010-06-15 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Purine based fluorescent dyes |
| EP1934202B1 (de) | 2005-09-02 | 2019-01-09 | Visen Medical, Inc. | Nah-infrarot-fluorophore, die sich von nicotinsäure und picolinsäure ableiten |
| US7947256B2 (en) | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
| CA2621137C (en) * | 2005-09-02 | 2014-07-29 | Visen Medical, Inc. | Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels |
| EP1934607B1 (de) | 2005-10-13 | 2013-08-28 | Fundação D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Multiplex in situ immunochemische analyse |
| WO2007111669A2 (en) | 2005-12-22 | 2007-10-04 | Visen Medical, Inc. | Combined x-ray and optical tomographic imaging system |
| WO2007136413A2 (en) | 2005-12-22 | 2007-11-29 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| USD580285S1 (en) | 2006-01-13 | 2008-11-11 | Invitrogen Corporation | Fluorometer |
| ITSV20060002A1 (it) * | 2006-01-19 | 2007-07-20 | Ferrania Technologies Spa | Colorante fluorescente di tipo cianinico |
| US8551408B2 (en) | 2006-01-24 | 2013-10-08 | Life Technologies Corporation | Device and methods for quantifying analytes |
| DK3438131T3 (da) | 2006-02-10 | 2022-04-11 | Life Technologies Corp | Oligosaccharidmodifikation og mærkning af proteiner |
| US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
| US8562802B1 (en) | 2006-02-13 | 2013-10-22 | Life Technologies Corporation | Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems |
| JP2009536150A (ja) | 2006-03-23 | 2009-10-08 | アブソルバー， アーベー | 診断および治療適用のための異なる型の血液型抗原 |
| AU2007240316A1 (en) | 2006-04-20 | 2007-11-01 | Becton, Dickinson And Company | Thermostable proteins and methods of making and using thereof |
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| US8906354B2 (en) | 2007-02-28 | 2014-12-09 | Bruker Biospin Corporation | Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes |
| US8017104B2 (en) | 2007-02-28 | 2011-09-13 | Carestream Health, Inc. | Large stoke shift dye used for optical imaging |
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| US8309059B2 (en) | 2009-08-31 | 2012-11-13 | Promega Corporation | Reactive cyanine compounds |
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| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
| CN103687854A (zh) | 2011-05-09 | 2014-03-26 | 文森医学公司 | 碳酸酐酶靶向剂及其使用方法 |
| US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| CN104955484B (zh) | 2012-08-15 | 2019-01-15 | 文森医学公司 | 用于前列腺癌成像的前列腺特异性抗原药剂及其使用方法 |
| US10743768B2 (en) | 2012-10-15 | 2020-08-18 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
| WO2014066733A2 (en) | 2012-10-25 | 2014-05-01 | Life Technologies Corporation | Methods and compositions for enzyme-mediated site-specific radiolabeling of glycoproteins |
| ES2620423T3 (es) * | 2013-03-08 | 2017-06-28 | Illumina Cambridge Limited | Compuestos de polimetina y su uso como marcadores fluorescentes |
| US9763577B2 (en) | 2013-03-14 | 2017-09-19 | Lumicell, Inc. | Imaging agent for detection of diseased cells |
| WO2014144702A2 (en) | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
| SI3052192T1 (sl) | 2013-10-02 | 2020-11-30 | Medimmune, Llc | Nevtralizarijoča protitelesa proti-influenci A in njihove uporabe |
| US9636034B2 (en) | 2013-10-23 | 2017-05-02 | Verily Life Sciences Llc | Non-invasive analyte detection system with modulation source |
| US10542918B2 (en) | 2013-10-23 | 2020-01-28 | Verily Life Sciences Llc | Modulation of a response signal to distinguish between analyte and background signals |
| JP5824729B2 (ja) * | 2013-12-18 | 2015-11-25 | 東洋インキＳｃホールディングス株式会社 | カラーフィルタ用着色組成物、およびカラーフィルタ |
| US10986997B2 (en) | 2013-12-31 | 2021-04-27 | Memorial Sloan Kettering Cancer Center | Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time |
| MX392761B (es) | 2014-07-15 | 2025-03-21 | Medimmune Llc | Anticuerpos anti-influenza b neutralizantes y usos de los mismos. |
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| US10028659B2 (en) | 2015-03-26 | 2018-07-24 | Verily Life Sciences Llc | Aptamer-based sensors, implantable devices and detection system |
| GB201516987D0 (en) | 2015-09-25 | 2015-11-11 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
| CA3007062A1 (en) * | 2015-12-01 | 2017-06-08 | Dishman Pharmaceuticals And Chemicals Limited | An improved process for the preparation of indocyanine green |
| BR112018011868A2 (pt) | 2015-12-15 | 2018-12-04 | Univ Cornell | sistemas de imagem e métodos para diferenciação de tecidos, por exemplo, para visualização intraoperatória |
| WO2017181176A1 (en) | 2016-04-15 | 2017-10-19 | Lcahn School Of Medicine At Mount Sinai | Tissue profiling using multiplexed immunohistochemical consecutive staining |
| RU2637310C1 (ru) * | 2016-06-08 | 2017-12-04 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Флуоресцентно-меченые дезоксиуридинтрифосфаты |
| WO2018031448A1 (en) | 2016-08-11 | 2018-02-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near-ir light-cleavable conjugates and conjugate precursors |
| US11660354B2 (en) | 2016-11-30 | 2023-05-30 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
| US20210108253A1 (en) | 2017-03-30 | 2021-04-15 | Life Technologies Corporation | Quantification of ngs dna by adapter sequence |
| WO2019190549A1 (en) | 2018-03-30 | 2019-10-03 | Perkinelmer Health Sciences, Inc. | Systems and methods for 3d reconstruction of anatomical organs and inclusions using short-wave infrared (swir) projection tomography |
| KR20230034333A (ko) | 2020-07-02 | 2023-03-09 | 라이프 테크놀로지스 코포레이션 | 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도 |
| EP4015004A1 (de) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglykanspezifische verzweigte peptide |
| JP2026505989A (ja) | 2023-02-17 | 2026-02-20 | デンマークス テクニスケ ユニバーシテト | 腫瘍の治療のためのコポリマー薬物複合体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1287000A (fr) * | 1961-03-07 | 1962-03-09 | Gevaert Photo Prod Nv | Procédé pour la sensibilisation d'émulsions photographiques |
| US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
| US5556959A (en) * | 1993-01-22 | 1996-09-17 | Pharmacia P-L Biochemicals Inc. | Indocarbocyanine-linked phosphoramidites |
| US5714386A (en) * | 1996-01-11 | 1998-02-03 | Board Of Trustees Of The Leland Stanford Junior University | Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays |
-
1999
- 1999-07-02 AT AT99112696T patent/ATE284433T1/de not_active IP Right Cessation
- 1999-07-02 DE DE69941067T patent/DE69941067D1/de not_active Expired - Lifetime
- 1999-07-02 AT AT04023147T patent/ATE435262T1/de not_active IP Right Cessation
- 1999-07-02 DE DE69922498T patent/DE69922498T2/de not_active Expired - Lifetime
- 1999-07-02 EP EP99112696A patent/EP1065250B1/de not_active Expired - Lifetime
- 1999-07-02 ES ES04023147T patent/ES2329572T3/es not_active Expired - Lifetime
- 1999-07-02 EP EP04023147A patent/EP1491591B1/de not_active Expired - Lifetime
-
2000
- 2000-06-21 AU AU42581/00A patent/AU776841B2/en not_active Expired
- 2000-06-22 CA CA002312099A patent/CA2312099C/en not_active Expired - Lifetime
- 2000-06-30 US US09/609,035 patent/US6448008B1/en not_active Expired - Lifetime
- 2000-07-03 BR BR0005843-2A patent/BR0005843A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0005843A (pt) | 2002-01-02 |
| EP1065250B1 (de) | 2004-12-08 |
| DE69941067D1 (de) | 2009-08-13 |
| EP1491591A1 (de) | 2004-12-29 |
| CA2312099C (en) | 2009-05-12 |
| DE69922498T2 (de) | 2005-12-08 |
| DE69922498D1 (de) | 2005-01-13 |
| EP1491591B1 (de) | 2009-07-01 |
| US6448008B1 (en) | 2002-09-10 |
| ATE435262T1 (de) | 2009-07-15 |
| EP1065250A1 (de) | 2001-01-03 |
| AU4258100A (en) | 2001-01-11 |
| AU776841B2 (en) | 2004-09-23 |
| ES2329572T3 (es) | 2009-11-27 |
| CA2312099A1 (en) | 2001-01-02 |
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