ATE284674T1 - Hybride matrizen und gemische davon - Google Patents

Hybride matrizen und gemische davon

Info

Publication number: ATE284674T1
Authority: AT; Austria
Prior art keywords: microcarriers; polypeptide; animal; mixtures; vertebrate cells
Prior art date: 1999-10-05

Application number

AT00968669T

Other languages

English (en)

Inventor

Rochelle Mineau-Hanschke

Justin Chace Lamsa

Deborah Abalos-Coyle

Original Assignee

Transkaryotic Therapies Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-05

Filing date

2000-10-04

Publication date

2005-01-15

1999-10-05 Priority claimed from US09/413,715 external-priority patent/US6419920B1/en

2000-10-04 Application filed by Transkaryotic Therapies Inc filed Critical Transkaryotic Therapies Inc

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE284674T1 publication Critical patent/ATE284674T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 2
241000251539 Vertebrata <Metazoa> Species 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
102000008186 Collagen Human genes 0.000 abstract 1
108010035532 Collagen Proteins 0.000 abstract 1
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229920001436 collagen Polymers 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/438—Antigens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Botany (AREA)
Zoology (AREA)
Cell Biology (AREA)
Composite Materials (AREA)
Materials Engineering (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Polyurethanes Or Polyureas (AREA)
Dental Preparations (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT00968669T 1999-10-05 2000-10-04 Hybride matrizen und gemische davon ATE284674T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US09/413,715 US6419920B1 (en)	1995-10-25	1999-10-05	Hybrid matrix implants and explants
US66203700A	2000-09-14	2000-09-14
PCT/US2000/027362 WO2001024842A2 (en)	1999-10-05	2000-10-04	Hybrid matrices and hybrid matrix mixtures

Publications (1)

Publication Number	Publication Date
ATE284674T1 true ATE284674T1 (de)	2005-01-15

Family

ID=27022280

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00968669T ATE284674T1 (de)	1999-10-05	2000-10-04	Hybride matrizen und gemische davon

Country Status (14)

Country	Link
EP (1)	EP1221937B1 (de)
JP (1)	JP2003511100A (de)
CN (1)	CN1214781C (de)
AT (1)	ATE284674T1 (de)
AU (1)	AU777833B2 (de)
BR (1)	BR0014503A (de)
CA (1)	CA2379971A1 (de)
DE (1)	DE60016775D1 (de)
HK (1)	HK1047240B (de)
IL (1)	IL148962A0 (de)
MX (1)	MXPA02001450A (de)
NZ (1)	NZ518759A (de)
TR (1)	TR200200897T2 (de)
WO (1)	WO2001024842A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8858981B2 (en)	1997-10-10	2014-10-14	Ed. Geistlich Soehne Fuer Chemistrie Industrie	Bone healing material comprising matrix carrying bone-forming cells
US20050186283A1 (en)	1997-10-10	2005-08-25	Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie	Collagen carrier of therapeutic genetic material, and method
US9034315B2 (en)	1997-10-10	2015-05-19	Ed. Geistlich Soehne Ag Fuer Chemische Industrie	Cell-charged multi-layer collagen membrane
US7144729B2 (en) *	2000-09-01	2006-12-05	Dfb Pharmaceuticals, Inc.	Methods and compositions for tissue regeneration
US6673603B2 (en) *	2000-09-01	2004-01-06	Modex Therapeutiques, S.A.	Cell paste comprising keratinocytes and fibroblasts
AR034262A1 (es) *	2000-09-14	2004-02-18	Transkaryotic Therapies Inc	Una composicion para proporcionar una mezcla fluida inyectable, un equipo, un metodo para preparacion de una mezcla de dicho equipo, un aparato para la introduccion de una mezcla en un paciente
TWI221421B (en) *	2001-05-17	2004-10-01	Gejyo Fumitake	Artificial kidney having function of metabolizing protein and method of constructing the same
AU2002300450B2 (en) *	2001-08-10	2007-04-05	Ed. Geistlich Soehne Ag Fuer Chemische Industrie	Collagen Carrier of Therapeutic Genetic Material, and Method
US8383158B2 (en) *	2003-04-15	2013-02-26	Abbott Cardiovascular Systems Inc.	Methods and compositions to treat myocardial conditions
CN1294994C (zh) *	2004-07-05	2007-01-17	暨南大学	可注射型胶原基软组织填充材料及其制备方法
CN103055350B (zh) *	2004-12-08	2014-12-10	夏尔再生医学公司	含细胞的可流动组合物的最小侵入性给药的材料和方法
US20080125745A1 (en)	2005-04-19	2008-05-29	Shubhayu Basu	Methods and compositions for treating post-cardial infarction damage
US9539410B2 (en)	2005-04-19	2017-01-10	Abbott Cardiovascular Systems Inc.	Methods and compositions for treating post-cardial infarction damage
GB0524103D0 (en)	2005-11-26	2006-01-04	Medical Res Council	Healing
US7671014B2 (en)	2006-08-14	2010-03-02	Warsaw Orthopedic, Inc.	Flowable carrier matrix and methods for delivering to a patient
US9242005B1 (en)	2006-08-21	2016-01-26	Abbott Cardiovascular Systems Inc.	Pro-healing agent formulation compositions, methods and treatments
US9005672B2 (en)	2006-11-17	2015-04-14	Abbott Cardiovascular Systems Inc.	Methods of modifying myocardial infarction expansion
US9616153B2 (en)	2008-04-17	2017-04-11	Warsaw Orthopedic, Inc.	Rigid bone graft substitute
US9889230B2 (en) *	2008-10-17	2018-02-13	Covidien Lp	Hemostatic implant
US8034363B2 (en)	2008-12-11	2011-10-11	Advanced Technologies And Regenerative Medicine, Llc.	Sustained release systems of ascorbic acid phosphate
EP2512516B1 (de)	2009-12-18	2016-02-17	The Governing Council Of The University Of Toronto	Injizierbare polymerzusammensetzung zur verwendung als ein zellfreisetzungsträger
KR101776675B1 (ko) *	2010-04-06	2017-09-20	동국대학교 산학협력단	콜라겐 하이드로겔 제조용 멀티 시린지
FR2960783B1 (fr) *	2010-06-04	2012-07-27	Ass Pour Les Transferts De Technologies Du Mans	Membrane fonctionnalisee pour chambre d'encapsulation de cellules produisant au moins une substance d'interet therapeutique et organe bioartificiel comprenant une telle membrane
DE102011011092A1 (de) *	2011-02-09	2012-08-23	Amedrix Gmbh	Gelierendes Kollagen und Mittel zu dessen Bereitstellung
KR101266652B1 (ko) *	2011-10-19	2013-05-22	국립대학법인 울산과학기술대학교 산학협력단	하이드로젤을 이용한 세포 패터닝 및 전달 방법 및 이를 이용한 세포 기반 바이오센서
DE102012213496A1 (de) *	2012-07-31	2014-05-15	Amedrix Gmbh	Kit, dessen Verwendung und Verfahren zum Auffüllen von Bindegewebe der Haut
CN105274049B (zh) *	2015-11-03	2018-01-09	中山大学中山眼科中心	一种诱导人iPSc源性的3D视网膜定向分化为视网膜神经节细胞的方法
WO2018165565A1 (en) *	2017-03-09	2018-09-13	Georgia Tech Research Corporation	Synthetic hydrogel carriers for cellular structures, generation of organoids, and treatment of tissue injury
EP3666298A1 (de) *	2018-12-13	2020-06-17	Global Stem Cell Technology	Zur injektion geeignete kollagenformulierung
US20230040919A1 (en) *	2019-12-26	2023-02-09	Allergan, Inc.	Crosslinked ha-collagen hydrogels as dermal fillers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69431295T2 (de) *	1993-04-21	2003-05-15	Institut Pasteur, Paris	Biokompatibles implantat zur in vivo expression und sekretion von therapeutischer verbindung
CA2235581A1 (en) *	1995-10-25	1997-05-01	Kubota Corporation	Process for producing entomopathogenic nematode preparation and entomopathogenic nematode insecticide
US5965125A (en) *	1995-10-25	1999-10-12	Transkaryotic Therapies, Inc.	Hybrid matrix implants and explants

2000
- 2000-10-04 EP EP00968669A patent/EP1221937B1/de not_active Expired - Lifetime
- 2000-10-04 CN CNB008136998A patent/CN1214781C/zh not_active Expired - Fee Related
- 2000-10-04 HK HK02108845.8A patent/HK1047240B/en not_active IP Right Cessation
- 2000-10-04 TR TR2002/00897T patent/TR200200897T2/xx unknown
- 2000-10-04 IL IL14896200A patent/IL148962A0/xx unknown
- 2000-10-04 MX MXPA02001450A patent/MXPA02001450A/es active IP Right Grant
- 2000-10-04 JP JP2001527841A patent/JP2003511100A/ja active Pending
- 2000-10-04 BR BR0014503-3A patent/BR0014503A/pt not_active Application Discontinuation
- 2000-10-04 AT AT00968669T patent/ATE284674T1/de not_active IP Right Cessation
- 2000-10-04 DE DE60016775T patent/DE60016775D1/de not_active Expired - Lifetime
- 2000-10-04 CA CA002379971A patent/CA2379971A1/en not_active Abandoned
- 2000-10-04 AU AU78545/00A patent/AU777833B2/en not_active Ceased
- 2000-10-04 WO PCT/US2000/027362 patent/WO2001024842A2/en not_active Ceased
- 2000-10-04 NZ NZ518759A patent/NZ518759A/en unknown

Also Published As

Publication number	Publication date
CN1214781C (zh)	2005-08-17
CA2379971A1 (en)	2001-04-12
AU7854500A (en)	2001-05-10
JP2003511100A (ja)	2003-03-25
EP1221937B1 (de)	2004-12-15
CN1377257A (zh)	2002-10-30
AU777833B2 (en)	2004-11-04
NZ518759A (en)	2004-10-29
WO2001024842A3 (en)	2001-08-30
BR0014503A (pt)	2002-06-11
TR200200897T2 (tr)	2002-08-21
EP1221937A2 (de)	2002-07-17
IL148962A0 (en)	2002-11-10
MXPA02001450A (es)	2002-08-30
HK1047240A1 (en)	2003-02-14
HK1047240B (en)	2005-06-24
DE60016775D1 (de)	2005-01-20
WO2001024842A2 (en)	2001-04-12

Legal Events

Date	Code	Title	Description
2005-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60016775D1 (de)	2005-01-20	Hybride matrizen und gemische davon
Lombaert et al.	2017	Concise review: salivary gland regeneration: therapeutic approaches from stem cells to tissue organoids
Hilkens et al.	2017	The angiogenic potential of DPSCs and SCAPs in an in vivo model of dental pulp regeneration
Ting et al.	1998	In vitro prefabrication of human cartilage shapes using fibrin glue and human chondrocytes
Seliktar	2005	Extracellular stimulation in tissue engineering
Dunn et al.	1995	Development of fibroblast‐seeded ligament analogs for ACL reconstruction
Hashemi et al.	2015	Application of encapsulation technology in stem cell therapy
Nakahara	2006	A review of new developments in tissue engineering therapy for periodontitis
NZ321417A (en)	2000-03-27	An implantable device having a body matrix made of insoluble collagen fibrils and disposed in vertebrate cells and microspheres
CY1107121T1 (el)	2012-10-24	Ρυθμιση διαφοροποιησης αιματοποιητικων βλαστικων κυτταρων με τη χρηση ανθρωπινων μεσυγχυματικων βλαστικων κυτταρων
HRP20040347B1 (en)	2012-07-31	Keratynocites which may be used as biologically active substances for the treatment of wounds
DE69922933D1 (de)	2005-02-03	Anwendungen für humane nicht autologe, mesenchymale stammzellen
ATE393831T1 (de)	2008-05-15	Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
ATE309007T1 (de)	2005-11-15	Transplantate für die wiederherstellung von osteochondralen schäden
BR0009562A (pt)	2007-05-29	arpe- 19 como uma linhagem de célula de plataforma para liberação com base em célula encapsulada
ES2152992T3 (es)	2001-02-16	Metodo para obtener un material bioerosionable para la liberacion sostenida de un medicamento, y el material obtenido del metodo.
CA2339182A1 (en)	2000-02-10	Improvement of cardiac function by mesenchymal stem cell transplantation
IL133428A0 (en)	2001-04-30	Hyaluronic acid derivative based cell culture and biodegradable three-dimensional matrix
Martin et al.	2013	The effects of fibrin and fibrin‐agarose on the extracellular matrix profile of bioengineered oral mucosa
Coutu et al.	2011	Hierarchical scaffold design for mesenchymal stem cell-based gene therapy of hemophilia B
Maori et al.	1987	Acceleration of cartilage and bone differentiation on collagenous substrata
Wang et al.	2024	Research progress in cell therapy for oral diseases: focus on cell sources and strategies to optimize cell function
DE69817180D1 (de)	2003-09-18	Zns neuroregenerative zusammensetzungen und deren verwendungen
EP1331264B1 (de)	2008-11-12	Verfahren zur kultivierung humaner chondrozyten
IL134593A0 (en)	2001-04-30	A cell system for in-vivo expression of an interferon beta protein, pharmaceutical compositions containing the same and methods for the preparation thereof