ATE309007T1 - Transplantate für die wiederherstellung von osteochondralen schäden - Google Patents

Transplantate für die wiederherstellung von osteochondralen schäden

Info

Publication number: ATE309007T1
Authority: AT; Austria
Prior art keywords: transplants; restoration; dimensional matrix; osteochondral damage; constituted
Prior art date: 2001-02-09

Application number

AT02726105T

Other languages

English (en)

Inventor

Alessandra Pavesio

Lanfranco Callegaro

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-09

Filing date

2002-02-06

Publication date

2005-11-15

2002-02-06 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

2005-11-15 Application granted granted Critical

2005-11-15 Publication of ATE309007T1 publication Critical patent/ATE309007T1/de

Links

239000011159 matrix material Substances 0.000 abstract 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
229910010293 ceramic material Inorganic materials 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Oral & Maxillofacial Surgery (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cell Biology (AREA)
Botany (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Zoology (AREA)
Composite Materials (AREA)
Materials Engineering (AREA)
Developmental Biology & Embryology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Materials For Medical Uses (AREA)
Prostheses (AREA)
Cosmetics (AREA)
Dental Preparations (AREA)
Earth Drilling (AREA)
Excavating Of Shafts Or Tunnels (AREA)
Cultivation Of Seaweed (AREA)
Medicines Containing Plant Substances (AREA)
Pretreatment Of Seeds And Plants (AREA)

AT02726105T 2001-02-09 2002-02-06 Transplantate für die wiederherstellung von osteochondralen schäden ATE309007T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001PD000032A ITPD20010032A1 (it)	2001-02-09	2001-02-09	Innesti ingegnerizzati per la riparazione di difetti osteocondrali
PCT/EP2002/001224 WO2002070030A1 (en)	2001-02-09	2002-02-06	Grafts for the repair of osteochondral defects

Publications (1)

Publication Number	Publication Date
ATE309007T1 true ATE309007T1 (de)	2005-11-15

Family

ID=11452207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02726105T ATE309007T1 (de)	2001-02-09	2002-02-06	Transplantate für die wiederherstellung von osteochondralen schäden

Country Status (11)

Country	Link
US (1)	US7968111B2 (de)
EP (1)	EP1357953B1 (de)
JP (1)	JP2004524904A (de)
AT (1)	ATE309007T1 (de)
AU (1)	AU2002256617B8 (de)
CA (1)	CA2437440C (de)
DE (1)	DE60207198T2 (de)
DK (1)	DK1357953T3 (de)
ES (1)	ES2250642T3 (de)
IT (1)	ITPD20010032A1 (de)
WO (1)	WO2002070030A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10260958A1 (de) *	2002-12-20	2004-07-08	Sustech Gmbh & Co. Kg	Kompositmaterialien aus Calciumverbindungen und Glucuronsäure- und/oder Iduronsäurehaltigen Polysacchariden
ES2405080T3 (es) *	2003-02-26	2013-05-30	Zimmer Orthobiologics, Inc.	Preparado para la reparación de un tejido cartilaginoso, en particular de defectos de cartílagos articulares
US20050074877A1 (en) *	2003-07-28	2005-04-07	Mao Jeremy Jian	Biological engineering of articular structures containing both cartilage and bone
ITPD20030286A1 (it)	2003-11-27	2005-05-28	Fidia Advanced Biopolymers Srl	Strutture composite multistrato contenenti acido ialuronico
US7666230B2 (en)	2003-12-08	2010-02-23	Depuy Products, Inc.	Implant device for cartilage regeneration in load bearing articulation regions
ITPD20040053A1 (it)	2004-02-27	2004-05-27	Fidia Advanced Biopolymers Srl	Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
WO2006026725A2 (en)	2004-08-31	2006-03-09	C.R. Bard, Inc.	Self-sealing ptfe graft with kink resistance
US20110076315A1 (en) *	2005-06-08	2011-03-31	C.R Bard, Inc.	Grafts and Stents Having Inorganic Bio-Compatible Calcium Salt
US8066758B2 (en)	2005-06-17	2011-11-29	C. R. Bard, Inc.	Vascular graft with kink resistance after clamping
DE102005030614B4 (de) *	2005-06-30	2014-05-08	Biotissue Ag	Zellfreies Transplantat, dessen Verwendung, Verfahren zu dessen Herstellung, dabei hergestellte Matrix mit Gel und Verfahren zur Herstellung dieser Matrix mit Gel
WO2007007062A2 (en) *	2005-07-08	2007-01-18	Depuy International Limited	Cartilage repair implant
EP1764117A1 (de)	2005-09-20	2007-03-21	Zimmer GmbH	Implantat zur Wiederherstellung von Knorpeldefekten und Verfahren zu seiner Herstellung
US8636794B2 (en)	2005-11-09	2014-01-28	C. R. Bard, Inc.	Grafts and stent grafts having a radiopaque marker
CN100398496C (zh) *	2005-12-29	2008-07-02	武汉理工大学	层状多孔磷酸钙生物陶瓷的制备方法及其应用
JP5173199B2 (ja) *	2006-01-16	2013-03-27	株式会社アイ・ティー・オー	創傷治癒用高分子組成物
JP5538493B2 (ja) *	2006-01-16	2014-07-02	株式会社アイ・ティー・オー	生体内組織用創傷治癒用フィルム及び生体内接着用フィルム
DE102006047346A1 (de) *	2006-10-06	2008-04-10	Transtissue Technologies Gmbh	Matrix-Gel-Transplantat ohne Zellen
EP2079575B1 (de)	2006-10-12	2021-06-02	C.R. Bard, Inc.	Herstellungsverfahren für gefässtransplantate mit mehreren kanälen
WO2008049281A1 (en) *	2006-10-27	2008-05-02	Beijing Institute Of Transfusion Medicine	Construction method of hepatic tissue engineering construct and the hepatic tissue engineering construct
US9381216B2 (en)	2007-08-06	2016-07-05	Mesoblast, Inc.	Methods of generating, repairing and/or maintaining connective tissue in vivo
AU2013203054B2 (en) *	2007-08-06	2017-05-18	Mesoblast, Inc.	Methods of generating, repairing and/or maintaining connective tissue in vivo
US8524494B2 (en)	2008-01-30	2013-09-03	Histogen, Inc.	Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
SG10201500237TA (en) *	2008-01-30	2015-04-29	Histogen Inc	Extracellular matrix compositions
US8530415B2 (en) *	2008-01-30	2013-09-10	Histogen, Inc.	Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
US8535913B2 (en) *	2008-01-30	2013-09-17	Histogen, Inc.	Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
EP2303290B1 (de)	2008-06-25	2018-07-25	Mesoblast, Inc.	Reparatur und/oder rekonstitution von bandscheiben
DK2451964T3 (en) *	2009-07-10	2018-04-30	Histogen Inc	Conditioned medium and extracellular matrix compositions from cells grown under hypoxic conditions
WO2012051420A2 (en)	2010-10-13	2012-04-19	Cibor, Inc.	Synthetic bone grafts constructed from carbon foam materials
WO2012099852A1 (en)	2011-01-17	2012-07-26	Cibor, Inc.	Reinforced carbon fiber/carbon foam intervertebral spine fusion device
KR101306748B1 (ko) *	2012-03-29	2013-09-10	주식회사 바이오알파	성장인자 전달속도 조절이 가능한 히알루론산-인산칼슘 복합체 및 그 제조방법
WO2014041516A1 (en)	2012-09-14	2014-03-20	Ecole Polytechnique Federale De Lausanne (Epfl)	Biocompatible multi-layered structure comprising foam layers and a functional interface
ES2751398T3 (es)	2013-01-15	2020-03-31	Tepha Inc	Implantes para regeneración de tejido blando y tejido duro
JPWO2018097198A1 (ja) *	2016-11-28	2019-10-17	株式会社バイオ未来工房	間葉系幹細胞の分離方法及びリン酸カルシウム類を含有する不織布の使用
EP3735204B1 (de)	2018-01-02	2023-09-06	Cartiheal (2009) Ltd.	Implantationswerkzeug für optimierte solide substrate zur förderung von zell- und gewebewachstum
CN112552035A (zh) *	2020-12-11	2021-03-26	湖北联结生物材料有限公司	一种可诱导生物活性3d打印陶瓷及其制备方法
CN115317672B (zh) *	2022-08-27	2023-11-14	四川大学	仿生骨软骨一体化修复植入体及其制备方法与应用
EP4732856A1 (de) *	2023-06-21	2026-04-29	Kagoshima University	Komplex zur knochenregeneration oder -verstärkung und verfahren zur herstellung davon

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9101853D0 (sv) *	1991-06-17	1991-06-17	Jonas Wadstroem	Improved tissue ashesive
IT1259090B (it) *	1992-04-17	1996-03-11	Fidia Spa	Biomaterialli per protesi d'osso
IT1263316B (it)	1993-02-12	1996-08-05	Fidia Advanced Biopolymers Srl	Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
EP0907721A1 (de) *	1996-05-28	1999-04-14	Brown University Research Foundation	Biologisch abbaubarer träger auf basis von hyaluronan für die gewebewiederherstellung
DE19803673A1 (de) *	1998-01-30	1999-08-05	Norbert M Dr Meenen	Biohybrider Gelenkflächenersatz
US6872819B1 (en)	1998-05-27	2005-03-29	Fidia Advanced Biopolymers S.R.L.	Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
ITPD980149A1 (it) *	1998-06-17	1999-12-17	Fidia Advanced Biopolymers Srl	Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
ITPD980169A1 (it) *	1998-07-06	2000-01-06	Fidia Advanced Biopolymers Srl	Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
IT1302534B1 (it)	1998-12-21	2000-09-05	Fidia Advanced Biopolymers Srl	Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6656489B1 (en) *	1999-02-10	2003-12-02	Isotis N.V.	Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
IT1306644B1 (it) *	1999-04-08	2001-10-02	Fidia Advanced Biopolymers Srl	Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.

2001
- 2001-02-09 IT IT2001PD000032A patent/ITPD20010032A1/it unknown
2002
- 2002-02-06 US US10/467,142 patent/US7968111B2/en not_active Expired - Lifetime
- 2002-02-06 WO PCT/EP2002/001224 patent/WO2002070030A1/en not_active Ceased
- 2002-02-06 AT AT02726105T patent/ATE309007T1/de active
- 2002-02-06 AU AU2002256617A patent/AU2002256617B8/en not_active Ceased
- 2002-02-06 DE DE60207198T patent/DE60207198T2/de not_active Expired - Lifetime
- 2002-02-06 EP EP02726105A patent/EP1357953B1/de not_active Expired - Lifetime
- 2002-02-06 DK DK02726105T patent/DK1357953T3/da active
- 2002-02-06 CA CA2437440A patent/CA2437440C/en not_active Expired - Lifetime
- 2002-02-06 JP JP2002569201A patent/JP2004524904A/ja active Pending
- 2002-02-06 ES ES02726105T patent/ES2250642T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60207198T2 (de)	2006-06-01
DE60207198D1 (de)	2005-12-15
WO2002070030A1 (en)	2002-09-12
AU2002256617B2 (en)	2007-02-08
ES2250642T3 (es)	2006-04-16
WO2002070030A8 (en)	2002-12-05
CA2437440A1 (en)	2002-09-12
AU2002256617B8 (en)	2007-02-15
JP2004524904A (ja)	2004-08-19
US20040076656A1 (en)	2004-04-22
EP1357953A1 (de)	2003-11-05
ITPD20010032A1 (it)	2002-08-09
DK1357953T3 (da)	2006-01-16
US7968111B2 (en)	2011-06-28
EP1357953B1 (de)	2005-11-09
CA2437440C (en)	2012-04-03

Legal Events

Date

Code

Title

Description

2006-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1357953

Country of ref document: EP

Publication	Publication Date	Title
ATE309007T1 (de)	2005-11-15	Transplantate für die wiederherstellung von osteochondralen schäden
AU8178601A (en)	2001-12-03	Sustained release pharmaceutical compositions for the parenteral administration of biologically active hydrophilic compounds
PT1401501E (pt)	2005-10-31	Composicoes farmaceuticas orais com libertacao modificada do ingrediente activo
IL143706A0 (en)	2002-04-21	Polyol/oil suspensions for the sustained release of proteins
AU2845599A (en)	1999-09-20	Pharmaceutical compositions and their use
ZA200307161B (en)	2005-01-26	Medical aerosol formulations
BR0112962B1 (pt)	2013-12-31	Composições farmacêuticas compreendendo ácido hialurônico, ácido glicirretínico e polivinilpirrolidona, e uso desses compostos na preparação de medicamentos
ID28510A (id)	2001-05-31	Formulasi oral yang baru untuk agonis atau antagonis 5-ht4
ATE464878T1 (de)	2010-05-15	Pharmazeutische zusammensetzung zur nasalen anwendung von fentanyl
ES2167939T3 (es)	2002-05-16	Nuevas poliaminas, su preparacion y usos.
UY27373A1 (es)	2003-02-28	Formulaciones de interferón beta-humano
HRP20020071B1 (hr)	2011-01-31	Farmaceutske kompozicije i pripravljanje istih
YU87501A (sh)	2004-05-12	Farmaceutski kompleksi
PL361732A1 (en)	2004-10-04	Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy
ATE228300T1 (de)	2002-12-15	Wirkstoffhaltige polyetherblockamide
AP2003002897A0 (en)	2003-12-31	Processes and intermediates for preparing benzyl epoxides
PT1150716E (pt)	2004-08-31	Composicao farmaceutica de proteinas hedgehog hidrofobicamente modificadas e sua utilizacao
DE60000877D1 (de)	2003-01-09	Material für knochentransplantate aus calciumphosphat-keramik und knochengewebe
SE0004780D0 (sv)	2000-12-22	Novel compunds
AP2001002320A0 (en)	2001-12-31	(7-(3-Carboxyphenyl)-4-Chloroisoquinolin-1-yl)Guanide.
IT1307866B1 (it)	2001-11-19	Composizioni farmaceutiche contenenti inibitori dell'ormone dellacrescita o loro frammenti biologicamente attivi per il trattamento
SE9304065D0 (sv)	1993-12-06	New compound