ATE284891T1 - Isolierung von einzelsträngigen nukleinsäuren - Google Patents
Isolierung von einzelsträngigen nukleinsäurenInfo
- Publication number
- ATE284891T1 ATE284891T1 AT97902751T AT97902751T ATE284891T1 AT E284891 T1 ATE284891 T1 AT E284891T1 AT 97902751 T AT97902751 T AT 97902751T AT 97902751 T AT97902751 T AT 97902751T AT E284891 T1 ATE284891 T1 AT E284891T1
- Authority
- AT
- Austria
- Prior art keywords
- single stranded
- nucleic acid
- stranded nucleic
- methods
- silica particles
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 5
- 102000039446 nucleic acids Human genes 0.000 title abstract 5
- 108020004707 nucleic acids Proteins 0.000 title abstract 5
- 238000002955 isolation Methods 0.000 title 1
- 239000000463 material Substances 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 3
- 230000003321 amplification Effects 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 239000007790 solid phase Substances 0.000 abstract 2
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002357 guanidines Chemical class 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200354 | 1996-02-14 | ||
| PCT/NL1997/000063 WO1997030062A1 (en) | 1996-02-14 | 1997-02-14 | Isolation and amplification of nucleic acid materials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE284891T1 true ATE284891T1 (de) | 2005-01-15 |
Family
ID=8223661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97902751T ATE284891T1 (de) | 1996-02-14 | 1997-02-14 | Isolierung von einzelsträngigen nukleinsäuren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7238530B2 (de) |
| EP (1) | EP0880537B1 (de) |
| JP (1) | JP3943597B2 (de) |
| KR (1) | KR100483498B1 (de) |
| AT (1) | ATE284891T1 (de) |
| AU (1) | AU723900B2 (de) |
| CA (1) | CA2245888C (de) |
| DE (1) | DE69731939T2 (de) |
| ES (1) | ES2235225T3 (de) |
| WO (1) | WO1997030062A1 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2965131B2 (ja) | 1995-07-07 | 1999-10-18 | 東洋紡績株式会社 | 核酸結合用磁性担体およびそれを用いる核酸単離方法 |
| US6423536B1 (en) * | 1999-08-02 | 2002-07-23 | Molecular Dynamics, Inc. | Low volume chemical and biochemical reaction system |
| AU2001232485A1 (en) | 2000-01-13 | 2001-07-24 | Amsterdam Support Diagnostics B.V. | A universal nucleic acid amplification system for nucleic acids in a sample |
| WO2002059353A2 (en) * | 2001-01-26 | 2002-08-01 | Bio S & T | Two-step amplification using a program primer followed by specific primers |
| WO2003046146A2 (en) | 2001-11-28 | 2003-06-05 | Applera Corporation | Compositions and methods of selective nucleic acid isolation |
| EP1560926B2 (de) † | 2002-11-08 | 2013-08-21 | STRATEC Molecular GmbH | Neuartige pufferformulierungen zur isolierung, reinigung und rückgewinnung lang- und kurzkettiger nukleinsäuren |
| EP1418241A1 (de) * | 2002-11-08 | 2004-05-12 | PrimaGen Holding B.V. | Methode zur Quantifizierung des Verhältnisses zweier Nukleinsäuresequenzen |
| US7718403B2 (en) | 2003-03-07 | 2010-05-18 | Rubicon Genomics, Inc. | Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process |
| US8206913B1 (en) | 2003-03-07 | 2012-06-26 | Rubicon Genomics, Inc. | Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process |
| JP4241183B2 (ja) | 2003-05-19 | 2009-03-18 | 株式会社日立ハイテクノロジーズ | 核酸回収方法及び核酸回収キット |
| DE10358137A1 (de) * | 2003-12-12 | 2005-07-07 | Merck Patent Gmbh | Verfahren und Kit zur Isolierung von RNA |
| JP2005218385A (ja) * | 2004-02-06 | 2005-08-18 | Dnaform:Kk | １本鎖ｄｎａを調製するための方法 |
| JP4690656B2 (ja) * | 2004-02-12 | 2011-06-01 | ジーエルサイエンス株式会社 | 核酸の分離精製方法及び分離吸着体 |
| AU2005200670B2 (en) * | 2004-02-20 | 2007-05-03 | F. Hoffmann-La Roche Ag | Adsorption of nucleic acids to a solid phase |
| WO2005090607A1 (en) | 2004-03-08 | 2005-09-29 | Rubicon Genomics, Inc. | Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation |
| WO2005100611A2 (en) * | 2004-04-19 | 2005-10-27 | Academisch Medisch Centrum | Detection of viral nucleic acid and method for reverse transcribing rna |
| EP1589119A1 (de) * | 2004-04-19 | 2005-10-26 | Academisch Medisch Centrum | Detektion von enterovirales RNS und Methode für reverse Transkription von RNS |
| US20080146790A1 (en) * | 2004-08-18 | 2008-06-19 | Daniel Grolz | Additive, Method, and Article For Dna Collection, Stabilization, and Purification |
| AU2011253981B2 (en) * | 2004-09-02 | 2015-03-26 | Lifeind Ehf. | Two-dimensional strandness- and length-dependent separation of nucleic acid fragments |
| ATE498682T1 (de) | 2004-09-02 | 2011-03-15 | Lifeind Ehf | Zweidimensionale strangform- und längenabhängige trennung von nukleinsäurefragmenten |
| DE102004045332B3 (de) * | 2004-09-16 | 2006-03-09 | Macherey, Nagel Gmbh & Co. Handelsgesellschaft | Verfahren zur Isolierung und Trennung von einzel- und doppelsträngigen Nucleinsäuren aus einer diese Nucleinsäuren enthaltenden Probe sowie Trennsäule zur Durchführung dieses Verfahrens |
| US20060166223A1 (en) * | 2005-01-26 | 2006-07-27 | Reed Michael W | DNA purification and analysis on nanoengineered surfaces |
| ATE510930T1 (de) | 2005-08-02 | 2011-06-15 | Rubicon Genomics Inc | Zusammensetzungen und verfahren zur bearbeitung und amplifikation von dna mit verwendung mehrerer enzyme in einer einzigen reaktion |
| US8409804B2 (en) | 2005-08-02 | 2013-04-02 | Rubicon Genomics, Inc. | Isolation of CpG islands by thermal segregation and enzymatic selection-amplification method |
| JP4699868B2 (ja) | 2005-11-04 | 2011-06-15 | 株式会社日立ハイテクノロジーズ | 核酸精製方法及び核酸精製器具 |
| US8163535B2 (en) * | 2006-06-26 | 2012-04-24 | Blood Cell Storage, Inc. | Devices and processes for nucleic acid extraction |
| US7608399B2 (en) * | 2006-06-26 | 2009-10-27 | Blood Cell Storage, Inc. | Device and method for extraction and analysis of nucleic acids from biological samples |
| EP2247753B1 (de) * | 2008-02-01 | 2014-06-25 | Siemens Healthcare Diagnostics Inc. | Urintransportmittel |
| EP2271756A4 (de) * | 2008-04-30 | 2011-08-24 | Ge Healthcare Bio Sciences | Verfahren zur trennung doppelsträngiger und einzelsträngiger nukleinsäuren |
| DE102008026058A1 (de) | 2008-05-30 | 2009-12-03 | Qiagen Gmbh | Lyse, Binde- und/oder Waschreagenz verwendbar zur Isolierung und/oder Reinigung von Nukleinsäuren |
| CN102264899A (zh) * | 2008-11-04 | 2011-11-30 | 血细胞保存公司 | 弯曲的玻璃表面上的核酸提取 |
| EP2345719A1 (de) | 2010-01-18 | 2011-07-20 | Qiagen GmbH | Verfahren zur Isolierung kleiner RNA |
| EP2407540A1 (de) | 2010-07-15 | 2012-01-18 | Qiagen GmbH | Verfahren zur Reinigung von Nukleinsäure |
| JP6096660B2 (ja) | 2010-09-02 | 2017-03-15 | キアゲン ゲーエムベーハー | 低分子標的核酸を含む標的核酸を高収量で単離するための方法 |
| US8629264B2 (en) | 2011-05-19 | 2014-01-14 | Blood Cell Storage, Inc. | Gravity flow fluidic device for nucleic acid extraction |
| DK2742152T3 (en) | 2011-08-12 | 2017-07-31 | Qiagen Gmbh | PROCEDURE FOR ISOLATING NUCLEIC ACIDS |
| CN103827301A (zh) | 2011-09-13 | 2014-05-28 | 恰根有限公司 | 从兽医学全血样品中分离核酸的方法 |
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| CN103827303B (zh) | 2011-09-26 | 2021-10-22 | 普瑞阿那利提克斯有限公司 | 细胞外核酸的稳定化和分离 |
| EP3412773B1 (de) | 2011-09-26 | 2022-11-16 | QIAGEN GmbH | Schnellverfahren zur isolierung extrazellulärer nukleinsäuren |
| US20140227688A1 (en) | 2011-09-26 | 2014-08-14 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| US10233508B2 (en) | 2012-08-21 | 2019-03-19 | Qiagen Gmbh | Virus particle stabilisation and method for isolating viral nucleic acids |
| US20150225712A1 (en) | 2012-08-21 | 2015-08-13 | Qiagen Gmbh | Method for isolating nucleic acids from a formaldehyde releaser stabilized sample |
| WO2014033326A1 (en) | 2012-09-03 | 2014-03-06 | Qiagen Gmbh | Method for isolating rna including small rna with high yield |
| EP2898090B1 (de) | 2012-09-18 | 2017-11-08 | Qiagen GmbH | Verfahren und kit zur herstellung einer ziel-rna-verringerten zusammensetzung |
| EP2900834B1 (de) | 2012-09-25 | 2016-11-09 | Qiagen GmbH | Stabilisierung von biologischen proben |
| JP6255034B2 (ja) | 2012-12-11 | 2017-12-27 | キアゲン ゲーエムベーハー | シリカ粒子の調製 |
| WO2014146780A1 (en) | 2013-03-18 | 2014-09-25 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| EP2976424B1 (de) | 2013-03-18 | 2018-10-03 | Qiagen GmbH | Stabilisierung von biologischen proben |
| EP3119197A1 (de) | 2014-03-18 | 2017-01-25 | Qiagen GmbH | Stabilisierung und isolierung extrazellulärer nukleinsäuren |
| EP2940136A1 (de) | 2014-04-30 | 2015-11-04 | QIAGEN GmbH | Verfahren zur Isolierung von Poly(A)-Nukleinsäuren |
| NZ727020A (en) | 2014-06-26 | 2022-02-25 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| CN106715714B (zh) * | 2014-10-17 | 2021-11-09 | 深圳华大智造科技股份有限公司 | 一种用于核酸随机片段化的引物及核酸随机片段化方法 |
| AU2016277476B2 (en) | 2015-06-10 | 2022-07-21 | Qiagen Gmbh | Method for isolating extracellular nucleic acids using anion exchange particles |
| US10214739B2 (en) * | 2015-10-30 | 2019-02-26 | Axagarius Gmbh & Co. Kg | RNA binding solution |
| EP3377645B1 (de) | 2015-11-20 | 2023-10-04 | Qiagen GmbH | Verfahren zur herstellung sterilisierter zusammensetzungen zur stabilisierung von extrazellulären nukleinsäuren |
| CN111148834B (zh) | 2017-09-27 | 2024-06-11 | 凯杰有限公司 | 以高收率分离rna的方法 |
| JP7548904B2 (ja) | 2019-01-04 | 2024-09-10 | キアゲン ゲーエムベーハー | 尿安定化 |
| WO2021211849A1 (en) * | 2020-04-16 | 2021-10-21 | Chhalliyil Pradheep | Rapid extraction and purification of rna |
| WO2025203643A1 (ja) * | 2024-03-29 | 2025-10-02 | 株式会社日立ハイテク | 一本鎖核酸の検出方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU82089A1 (fr) * | 1980-01-16 | 1981-09-10 | Sipac | Procede de preparation d'un echangeur de cations et procede d'utilisation de cet echangeur pour l'extraction de metaux de liquides |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5075430A (en) * | 1988-12-12 | 1991-12-24 | Bio-Rad Laboratories, Inc. | Process for the purification of DNA on diatomaceous earth |
| NL8900725A (nl) * | 1989-03-23 | 1990-10-16 | Az Univ Amsterdam | Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur. |
| US5043272A (en) * | 1989-04-27 | 1991-08-27 | Life Technologies, Incorporated | Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers |
| CA2063855C (en) * | 1991-04-03 | 1997-08-26 | Will Bloch | Precision and accuracy of anion-exchange separation of nucleic acids |
| US5155018A (en) * | 1991-07-10 | 1992-10-13 | Hahnemann University | Process and kit for isolating and purifying RNA from biological sources |
| WO1995004140A1 (en) * | 1993-07-28 | 1995-02-09 | Akzo Nobel N.V. | Process for isolating nucleic acid from gram positive microorganisms |
| DE69433425T2 (de) * | 1993-08-30 | 2004-10-07 | Promega Corp | Zusammensetzungen und verfahren zur reinigung von nukleinsäuren |
| JP3256238B2 (ja) * | 1994-02-11 | 2002-02-12 | クイアジェン・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 二本鎖／単鎖核酸構造物の分離方法 |
| DE69534886T2 (de) | 1994-04-14 | 2006-10-26 | The Rockefeller University | Verfahren zur Isolierung von Zellkomponenten |
| WO1995034569A1 (de) * | 1994-06-14 | 1995-12-21 | Invitek Gmbh | Universelles verfahren zur isolierung und reinigung von nukleinsäuren aus extrem geringen mengen sowie sehr stark verunreinigten unterschiedlichsten ausgangsmaterialien |
| US6037465A (en) * | 1994-06-14 | 2000-03-14 | Invitek Gmbh | Universal process for isolating and purifying nucleic acids from extremely small amounts of highly contaminated various starting materials |
-
1997
- 1997-02-14 KR KR10-1998-0706258A patent/KR100483498B1/ko not_active Expired - Lifetime
- 1997-02-14 ES ES97902751T patent/ES2235225T3/es not_active Expired - Lifetime
- 1997-02-14 CA CA002245888A patent/CA2245888C/en not_active Expired - Lifetime
- 1997-02-14 EP EP97902751A patent/EP0880537B1/de not_active Expired - Lifetime
- 1997-02-14 JP JP52922197A patent/JP3943597B2/ja not_active Expired - Lifetime
- 1997-02-14 DE DE69731939T patent/DE69731939T2/de not_active Expired - Lifetime
- 1997-02-14 AU AU16766/97A patent/AU723900B2/en not_active Expired
- 1997-02-14 WO PCT/NL1997/000063 patent/WO1997030062A1/en not_active Ceased
- 1997-02-14 AT AT97902751T patent/ATE284891T1/de not_active IP Right Cessation
-
2001
- 2001-01-12 US US09/760,085 patent/US7238530B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997030062A1 (en) | 1997-08-21 |
| EP0880537A1 (de) | 1998-12-02 |
| US20010021518A1 (en) | 2001-09-13 |
| CA2245888A1 (en) | 1997-08-21 |
| ES2235225T3 (es) | 2005-07-01 |
| KR100483498B1 (ko) | 2005-07-18 |
| AU723900B2 (en) | 2000-09-07 |
| US7238530B2 (en) | 2007-07-03 |
| DE69731939T2 (de) | 2005-12-22 |
| JP3943597B2 (ja) | 2007-07-11 |
| AU1676697A (en) | 1997-09-02 |
| EP0880537B1 (de) | 2004-12-15 |
| JP2000505295A (ja) | 2000-05-09 |
| CA2245888C (en) | 2008-12-23 |
| KR19990082522A (ko) | 1999-11-25 |
| DE69731939D1 (de) | 2005-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |