ATE449186T1 - Zusammensetzungen und verfahren zur selektiven nukleinsäureisolierung - Google Patents
Zusammensetzungen und verfahren zur selektiven nukleinsäureisolierungInfo
- Publication number
- ATE449186T1 ATE449186T1 AT02794065T AT02794065T ATE449186T1 AT E449186 T1 ATE449186 T1 AT E449186T1 AT 02794065 T AT02794065 T AT 02794065T AT 02794065 T AT02794065 T AT 02794065T AT E449186 T1 ATE449186 T1 AT E449186T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- compositions
- nucleic acid
- acid isolation
- selective nucleic
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33402901P | 2001-11-28 | 2001-11-28 | |
| PCT/US2002/038123 WO2003046146A2 (en) | 2001-11-28 | 2002-11-27 | Compositions and methods of selective nucleic acid isolation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE449186T1 true ATE449186T1 (de) | 2009-12-15 |
Family
ID=23305266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02794065T ATE449186T1 (de) | 2001-11-28 | 2002-11-27 | Zusammensetzungen und verfahren zur selektiven nukleinsäureisolierung |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7208271B2 (de) |
| EP (1) | EP1448799B2 (de) |
| JP (3) | JP4106026B2 (de) |
| AT (1) | ATE449186T1 (de) |
| AU (1) | AU2002359522A1 (de) |
| DE (1) | DE60234464D1 (de) |
| WO (1) | WO2003046146A2 (de) |
Families Citing this family (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078224B1 (en) * | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| WO2003046146A2 (en) * | 2001-11-28 | 2003-06-05 | Applera Corporation | Compositions and methods of selective nucleic acid isolation |
| JP3644641B2 (ja) * | 2003-03-07 | 2005-05-11 | 株式会社日立ハイテクノロジーズ | 核酸回収方法 |
| JP4241183B2 (ja) * | 2003-05-19 | 2009-03-18 | 株式会社日立ハイテクノロジーズ | 核酸回収方法及び核酸回収キット |
| US20050009036A1 (en) * | 2003-07-11 | 2005-01-13 | Applera Corporation | Methods and kits for obtaining nucleic acid from biological samples |
| WO2005054466A2 (en) * | 2003-07-25 | 2005-06-16 | Ambion, Inc. | Methods and compositions for preparing rna from a fixed sample |
| US20050059024A1 (en) * | 2003-07-25 | 2005-03-17 | Ambion, Inc. | Methods and compositions for isolating small RNA molecules |
| EP2216415B2 (de) * | 2003-08-01 | 2017-01-04 | Life Technologies Corporation | Zusammensetzungen und Verfahren zur Aufreinigung kurzer RNA-Moleküle und anderer Nukleinsäuren |
| JP2005270049A (ja) * | 2004-03-26 | 2005-10-06 | Jfe Steel Kk | 核酸分子の切断方法 |
| JP2005295869A (ja) * | 2004-04-09 | 2005-10-27 | Jfe Steel Kk | 核酸分子の切断方法およびその装置 |
| KR100714988B1 (ko) * | 2005-08-09 | 2007-05-09 | 삼성전자주식회사 | 산화막이 표면에 형성된 실리콘 구조물 표면을 이용한ｄｎａ 정제 방법 및 정제장치 |
| EP1963526A4 (de) * | 2005-12-09 | 2009-11-18 | Promega Corp | Nukleinsäurereinigung mittels bindungsmatrix |
| WO2007133495A1 (en) * | 2006-05-10 | 2007-11-22 | Human Genome Sciences, Inc. | Mixture for decreasing protein interference |
| US20100216657A1 (en) * | 2006-05-16 | 2010-08-26 | Arcxis Biotechnologies, Inc. | Pcr-free sample preparation and detection systems for high speed biologic analysis and identification |
| EP3617321B1 (de) * | 2006-05-31 | 2024-10-23 | Sequenom, Inc. | Kit zur nukleinsäureextraktion und -verstärkung aus einer probe |
| DE102006031764B4 (de) * | 2006-07-06 | 2009-10-01 | Aj Innuscreen Gmbh | Verfahren zur parallelen Isolierung doppel- und einzelsträngiger Nukleinsäuren sowie zur selektiven Entfernung doppelsträngiger Nukleinsäuren aus einem Gemisch von doppel- und einzelsträngigen Nukleinsäuren |
| JP4297148B2 (ja) | 2006-09-22 | 2009-07-15 | ソニー株式会社 | 核酸回収装置及び核酸回収方法 |
| GB0719022D0 (en) * | 2007-09-28 | 2007-11-07 | Mole Genetics As | Isolation method |
| US7871764B1 (en) * | 2008-03-18 | 2011-01-18 | The United States Of America As Represented By The United States Department Of Energy | Universal nucleic acids sample preparation method for cells, spores and their mixture |
| EP3514244B1 (de) | 2009-04-03 | 2021-07-07 | Sequenom, Inc. | Verfahren für die herstellung von nukleinsäuren |
| US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| US8222397B2 (en) * | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| WO2012002887A1 (en) * | 2010-06-29 | 2012-01-05 | Sjoeblom Tobias | Method and kit for sequential isolation of nucleotide species from a sample |
| US9024008B2 (en) | 2010-07-07 | 2015-05-05 | Diagon Ltd. | Procedure for the specific isolation of total DNA content of bacterial germs and a kit for this purpose |
| EP3789500A1 (de) | 2011-08-12 | 2021-03-10 | QIAGEN GmbH | Verfahren zur isolierung von nukleinsäuren |
| FR2994184B1 (fr) | 2012-08-02 | 2017-12-08 | Biomerieux Sa | Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| AU2013334189B2 (en) | 2012-10-24 | 2018-08-02 | Genmark Diagnostics, Inc. | Integrated multiplex target analysis |
| JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス， インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| JP2017539080A (ja) | 2014-10-23 | 2017-12-28 | コーニング インコーポレイテッド | 高分子被包磁性ナノ粒子 |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| EP3218480A1 (de) | 2014-11-14 | 2017-09-20 | Corning Incorporated | Verfahren und kits zur rna-reinigung nach ivt |
| US11242518B2 (en) | 2015-09-04 | 2022-02-08 | QIAGEN Sciences, LLP | Methods for co-isolation of nucleic acids and proteins |
| MX2019007444A (es) | 2016-12-22 | 2019-08-16 | Guardant Health Inc | Metodos y sistemas para analisis de moleculas de acido nucleico. |
| EP3885445B1 (de) | 2017-04-14 | 2023-08-23 | Guardant Health, Inc. | Verfahren zur befestigung von adaptern an probennukleinsäuren |
| CA3075932A1 (en) | 2017-09-20 | 2019-03-28 | Guardant Health, Inc. | Methods and systems for differentiating somatic and germline variants |
| WO2019090147A1 (en) | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Correcting for deamination-induced sequence errors |
| WO2019090156A1 (en) | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| GB201718803D0 (en) * | 2017-11-14 | 2017-12-27 | Phoenix Molecular Pte Ltd | Method for isolation of nucleic acids |
| CN108456675A (zh) * | 2018-03-27 | 2018-08-28 | 爱默基因（厦门）生物科技有限公司 | 一种用于凝胶DNA回收的溶胶buffer、回收凝胶DNA的试剂盒及其使用方法 |
| JP7546486B2 (ja) | 2018-04-13 | 2024-09-06 | ガーダント ヘルス， インコーポレイテッド | 融合事象によって引き起こされるアライメントエラーを検出および抑制する方法 |
| EP3784796A1 (de) | 2018-04-24 | 2021-03-03 | Qiagen Sciences, LLC | Isolierung von nukleinsäuren und entfernung von inhibitoren aus komplexen proben |
| WO2019236478A1 (en) | 2018-06-04 | 2019-12-12 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free nucleic acids |
| WO2020023420A2 (en) | 2018-07-23 | 2020-01-30 | Guardant Health, Inc. | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
| KR20210052501A (ko) | 2018-08-30 | 2021-05-10 | 가던트 헬쓰, 인크. | 샘플 사이의 오염을 검출하기 위한 방법 및 시스템 |
| CN121354685A (zh) | 2018-08-31 | 2026-01-16 | 夸登特健康公司 | 无细胞dna中的微卫星不稳定性检测 |
| JP7535998B2 (ja) | 2018-08-31 | 2024-08-19 | ガーダント ヘルス， インコーポレイテッド | マージされたリードおよびマージされないリードに基づいた遺伝的変異体の検出 |
| JP7637615B2 (ja) | 2018-09-04 | 2025-02-28 | ガーダント ヘルス， インコーポレイテッド | 無細胞核酸試料におけるアレル不均衡を検出するための方法およびシステム |
| WO2020092807A1 (en) | 2018-10-31 | 2020-05-07 | Guardant Health, Inc. | Methods, compositions and systems for calibrating epigenetic partitioning assays |
| US20200232010A1 (en) | 2018-12-20 | 2020-07-23 | Guardant Health, Inc. | Methods, compositions, and systems for improving recovery of nucleic acid molecules |
| WO2020160414A1 (en) | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| WO2020176659A1 (en) | 2019-02-27 | 2020-09-03 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free dna |
| WO2020176775A1 (en) | 2019-02-27 | 2020-09-03 | Guardant Health, Inc. | Computational modeling of loss of function based on allelic frequency |
| EP3976822A1 (de) | 2019-05-31 | 2022-04-06 | Guardant Health, Inc. | Verfahren und systeme zur verbesserung der patientenüberwachung nach der operation |
| US11891653B2 (en) | 2019-09-30 | 2024-02-06 | Guardant Health, Inc. | Compositions and methods for analyzing cell-free DNA in methylation partitioning assays |
| EP4041888A4 (de) | 2019-10-11 | 2023-11-01 | Guardant Health, Inc. | Verwendung von zellfreien bakteriellen nukleinsäuren zur krebserkennung |
| EP4048812B1 (de) | 2019-10-25 | 2023-12-06 | Guardant Health, Inc. | Reparaturverfahren für 3'-überhang |
| EP4617375A3 (de) | 2019-11-26 | 2025-10-29 | Guardant Health, Inc. | Verfahren, zusammensetzungen und systeme zur verbesserung der bindung methylierter polynukleotide |
| JP7763764B2 (ja) | 2020-01-31 | 2025-11-04 | ガーダント ヘルス， インコーポレイテッド | 標的バリアントがクローンレベルで存在しないことの有意性モデリング |
| EP4118653B1 (de) | 2020-03-11 | 2024-07-17 | Guardant Health, Inc. | Verfahren zur klassifizierung von in zellfreien nukleinsäuren erkannten genetischen mutationen als tumor- oder nichttumorursprung |
| EP4143338A1 (de) | 2020-04-30 | 2023-03-08 | Guardant Health, Inc. | Verfahren zur sequenzbestimmung unter verwendung partitionierter nukleinsäuren |
| JP7842700B2 (ja) | 2020-05-14 | 2026-04-08 | ガーダント ヘルス， インコーポレイテッド | 相同組換え修復欠損の検出 |
| EP4179111B1 (de) | 2020-07-10 | 2024-04-03 | Guardant Health, Inc. | Verfahren zum nachweis von genomischen neuanordnungen unter verwendung zellfreier nukleinsäuren |
| WO2023282916A1 (en) | 2021-07-09 | 2023-01-12 | Guardant Health, Inc. | Methods of detecting genomic rearrangements using cell free nucleic acids |
| EP4585697A3 (de) | 2020-07-30 | 2025-08-06 | Guardant Health, Inc. | Verfahren zur isolierung von zellfreier dna |
| JP7588815B2 (ja) | 2020-08-17 | 2024-11-25 | 株式会社ミズホメディー | Ｒｎａろ過器及びｒｎａろ過方法 |
| EP4205126A1 (de) | 2020-08-25 | 2023-07-05 | Guardant Health, Inc. | Verfahren und systeme zur vorhersage des ursprungs einer variante |
| US20220068433A1 (en) | 2020-08-27 | 2022-03-03 | Guardant Health, Inc. | Computational detection of copy number variation at a locus in the absence of direct measurement of the locus |
| EP4222278A1 (de) | 2020-09-30 | 2023-08-09 | Guardant Health, Inc. | Zusammensetzungen und verfahren zur analyse von dna unter verwendung von partitionierung und einer methylierungsabhängigen nuklease |
| JP2023547620A (ja) | 2020-10-23 | 2023-11-13 | ガーダント ヘルス， インコーポレイテッド | 分配および塩基変換を使用してｄｎａを解析するための組成物および方法 |
| EP4251765A1 (de) | 2020-11-30 | 2023-10-04 | Guardant Health, Inc. | Zusammensetzungen und verfahren zur anreicherung methylierter polynukleotide |
| WO2022140629A1 (en) | 2020-12-23 | 2022-06-30 | Guardant Health, Inc. | Methods and systems for analyzing methylated polynucleotides |
| WO2022174109A1 (en) | 2021-02-12 | 2022-08-18 | Guardant Health, Inc. | Methods and compositions for detecting nucleic acid variants |
| JP2024513668A (ja) | 2021-03-05 | 2024-03-27 | ガーダント ヘルス， インコーポレイテッド | 分子応答を分析するための方法および関連する態様 |
| EP4305200A1 (de) | 2021-03-09 | 2024-01-17 | Guardant Health, Inc. | Nachweis des vorhandenseins eines tumors auf der basis von off-target-polynukleotidsequenzierungsdaten |
| WO2022204730A1 (en) | 2021-03-25 | 2022-09-29 | Guardant Health, Inc. | Methods and compositions for quantifying immune cell dna |
| JP2024520422A (ja) | 2021-05-28 | 2024-05-24 | ガーダント ヘルス， インコーポレイテッド | 循環分子をアッセイするための組成物および方法 |
| JP2024523401A (ja) | 2021-06-21 | 2024-06-28 | ガーダント ヘルス， インコーポレイテッド | コピー数情報に基づく組織起源分析のための方法および組成物 |
| EP4388091A2 (de) | 2021-08-20 | 2024-06-26 | Guardant Health, Inc. | Verfahren zur gleichzeitigen molekularen und probenbarcodierung |
| WO2023056065A1 (en) | 2021-09-30 | 2023-04-06 | Guardant Health, Inc. | Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements |
| JP2024540168A (ja) | 2021-11-02 | 2024-10-31 | ガーダント ヘルス， インコーポレイテッド | 品質管理方法 |
| EP4453241A1 (de) | 2021-12-21 | 2024-10-30 | Guardant Health, Inc. | Verfahren und systeme zur kombinatorischen chromatin-ip-sequenzierung |
| WO2023122740A1 (en) | 2021-12-23 | 2023-06-29 | Guardant Health, Inc. | Compositions and methods for detection of metastasis |
| EP4567129A3 (de) | 2022-02-02 | 2025-08-13 | Guardant Health, Inc. | Multifunktionelle primer für gepaarte sequenzierungsablesungen |
| WO2023197004A1 (en) | 2022-04-07 | 2023-10-12 | Guardant Health, Inc. | Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules |
| US20230360725A1 (en) | 2022-05-09 | 2023-11-09 | Guardant Health, Inc. | Detecting degradation based on strand bias |
| JP2025522763A (ja) | 2022-06-30 | 2025-07-17 | ガーダント ヘルス， インコーポレイテッド | 異常にメチル化されたｄｎａの富化 |
| CN119923475A (zh) | 2022-07-21 | 2025-05-02 | 夸登特健康公司 | 用于检测和减少样品制备诱导的甲基化人为假象的方法 |
| EP4587843A1 (de) | 2022-09-16 | 2025-07-23 | Guardant Health, Inc. | Zusammensetzungen und verfahren zur analyse löslicher proteine |
| EP4594522A2 (de) | 2022-09-27 | 2025-08-06 | Guardant Health, Inc. | Verfahren zur quantifizierung von immunzellen-dna |
| CN120188220A (zh) | 2022-11-15 | 2025-06-20 | 夸登特健康公司 | 用来自基线循环肿瘤DNA(ctDNA)水平和ctDNA水平随时间纵向变化的信号从ctDNA预测非小细胞肺癌(NSCLC)患者药物响应或直至死亡或癌症进展的时间的方法 |
| CN120226085A (zh) | 2022-11-17 | 2025-06-27 | 夸登特健康公司 | 用于在无细胞dna液体活检测定中对非肿瘤变异进行分类的生物信息学模型的验证 |
| AU2023409008A1 (en) | 2022-12-21 | 2025-06-26 | Guardant Health, Inc. | Detecting homologous recombination deficiences based on methylation status of cell-free nucleic acid molecules |
| EP4638781A2 (de) | 2022-12-22 | 2025-10-29 | Guardant Health, Inc. | Verfahren mit methylierungsbewahrender amplifikation mit fehlerkorrektur |
| WO2024138180A2 (en) | 2022-12-22 | 2024-06-27 | Guardant Health, Inc. | Integrated targeted and whole genome somatic and dna methylation sequencing workflows |
| WO2024159053A1 (en) | 2023-01-25 | 2024-08-02 | Guardant Health, Inc. | Nucleic acid methylation profiling method |
| WO2024186768A1 (en) | 2023-03-07 | 2024-09-12 | Guardant Health, Inc. | Hybrid ssdna- and dsdna-ngs library preparation methods |
| CN120898247A (zh) | 2023-04-07 | 2025-11-04 | 夸登特健康公司 | 基于无细胞核酸分子的甲基化状态检测肿瘤的存在 |
| WO2024229143A1 (en) | 2023-05-01 | 2024-11-07 | Guardant Health, Inc. | Quality control method for enzymatic conversion procedures |
| EP4705508A1 (de) | 2023-05-03 | 2026-03-11 | Guardant Health, Inc. | Verfahren zur analyse von dna-methylierung |
| WO2024233502A1 (en) | 2023-05-05 | 2024-11-14 | Guardant Health, Inc. | Cell-free dna blood-based test for cancer screening |
| CN121420358A (zh) | 2023-06-15 | 2026-01-27 | 夸登特健康公司 | 使用从头突变特征用于靶向cfDNA样品中HRD检测的方法 |
| WO2024264065A1 (en) | 2023-06-23 | 2024-12-26 | Guardant Health, Inc. | Methods and compositions for quantifying immune cell nucleic acids |
| WO2025029475A1 (en) | 2023-07-28 | 2025-02-06 | Guardant Health, Inc. | Methods to enrich nucleotide variants by negative selection |
| WO2025038399A1 (en) | 2023-08-11 | 2025-02-20 | Guardant Health, Inc. | Methylated enrichment methods for single-molecule genetic and epigenetic sequencing |
| WO2025059338A1 (en) | 2023-09-12 | 2025-03-20 | Guardant Health, Inc. | Methods for analyzing nucleic acids using sequence read family size distribution |
| WO2025064706A1 (en) | 2023-09-19 | 2025-03-27 | Guardant Health, Inc. | Detecting the presence of a tumor based on methylation status of cell-free nucleic acid molecules |
| US20250246266A1 (en) | 2023-09-29 | 2025-07-31 | Guardant Health, Inc. | Genotyping cyp2d6 |
| WO2025076452A1 (en) | 2023-10-06 | 2025-04-10 | Guardant Health, Inc. | Detecting tumor-related information based on methylation status of cell-free nucleic acid molecules |
| WO2025090956A1 (en) | 2023-10-26 | 2025-05-01 | Guardant Health, Inc. | Methods for detecting nucleic acid variants using capture probes |
| WO2025090954A1 (en) | 2023-10-26 | 2025-05-01 | Guardant Health, Inc. | Methods for detecting nucleic acid variants |
| US20250285708A1 (en) | 2023-10-27 | 2025-09-11 | Guardant Health, Inc. | Monitoring molecular response by allelic imbalance |
| WO2025137620A1 (en) | 2023-12-21 | 2025-06-26 | Guardant Health, Inc. | Methods for high quality and high accuracy methylation sequencing |
| WO2025137389A2 (en) | 2023-12-22 | 2025-06-26 | Guardant Health, Inc. | Methods for targeted single-molecule genetic and epigenetic sequencing |
| WO2025160433A1 (en) | 2024-01-24 | 2025-07-31 | Guardant Health, Inc. | Methods for analyzing sequencing reads |
| WO2025207817A1 (en) | 2024-03-26 | 2025-10-02 | Guardant Health, Inc. | Method of determining the likelihood of a disease by combining biomarkers and imaging |
| WO2025207788A1 (en) | 2024-03-27 | 2025-10-02 | Guardant Health, Inc. | Inferring cnvs from the distribution of molecules in hyper partition |
| WO2025207921A1 (en) | 2024-03-28 | 2025-10-02 | Guardant Health, Inc. | Methods for methylation enrichment using cpg-specific deamination |
| WO2025208044A1 (en) | 2024-03-28 | 2025-10-02 | Guardant Health, Inc. | Methods for cancer detection using molecular patterns |
| WO2025212664A1 (en) | 2024-04-01 | 2025-10-09 | Guardant Health, Inc. | Small variant calling with error-rate based model |
| WO2025235889A1 (en) | 2024-05-10 | 2025-11-13 | Guardant Health, Inc. | Methods involving multiplexed pooled pcr |
| WO2025250544A1 (en) | 2024-05-31 | 2025-12-04 | Guardant Health, Inc. | Methods for analyzing chromatin architecture in tissue to boost detection of cancer associated signals in cell-free dna |
| WO2026015607A1 (en) | 2024-07-09 | 2026-01-15 | Guardant Health, Inc. | Methods for partitioning hyper-, hypo-, and non-methylated dna |
| WO2026015794A1 (en) | 2024-07-12 | 2026-01-15 | Guardant Health, Inc. | Methods for modifying dna using cpg-specific deamination and uracil base excision |
| WO2026024692A1 (en) | 2024-07-24 | 2026-01-29 | Guardant Health, Inc. | Direct methylation single-base resolution sequencing of enriched unmethylated dna |
| WO2026024817A1 (en) | 2024-07-24 | 2026-01-29 | Guardant Health, Inc. | Methods and compositions for anchored multiplex ngs workflows |
| WO2026024956A1 (en) | 2024-07-24 | 2026-01-29 | Guardant Health, Inc. | Selecting low technical noise biomarkers for sensitive molecular diagnostics |
| WO2026043718A1 (en) | 2024-08-21 | 2026-02-26 | Guardant Health, Inc. | Methods to monitor patients treated with a cancer vaccine |
| WO2026043702A1 (en) | 2024-08-21 | 2026-02-26 | Guardant Health, Inc. | Methods and approaches for personalized identification and monitoring of extrachromosomal circular dna |
| WO2026050179A1 (en) | 2024-08-26 | 2026-03-05 | Guardant Health, Inc. | Tumor fraction (tf) is associated with real-world progression-free survival (rwpfs) in non-small-cell lung cancer (nsclc) patients treated with platinum-based chemotherapy (chemo) |
| WO2026050287A1 (en) | 2024-08-27 | 2026-03-05 | Guardant Health, Inc. | Methylation biomarkers for osimertinib treatment management |
| WO2026060266A1 (en) | 2024-09-13 | 2026-03-19 | Guardant Health, Inc. | Use of copy number variants for the identification of false positive tumor calls |
| WO2026064529A2 (en) | 2024-09-18 | 2026-03-26 | Guardant Health, Inc. | Methods for detecting nucleic acid variants using primers and ligation substrates |
| WO2026073140A1 (en) | 2024-09-27 | 2026-04-02 | Guardant Health, Inc. | Framework to identify genomic regions indicative of one or more biological conditions |
| WO2026076332A1 (en) | 2024-10-03 | 2026-04-09 | Guardant Health, Inc. | Methods involving multi-modal tumor variant identification and tracking of tumor molecules |
| WO2026080838A2 (en) | 2024-10-11 | 2026-04-16 | Guardant Health, Inc. | Methods for detecting nucleic acid variants |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340674A (en) * | 1980-05-05 | 1982-07-20 | The Upjohn Company | Cointegrate plasmids and their construction from plasmids of Escherichia and Streptomyces |
| US4420517A (en) | 1982-05-06 | 1983-12-13 | Becton Dickinson And Company | Methods for improving uniformity of silica films on substrates |
| US4483920A (en) | 1982-05-17 | 1984-11-20 | Hahnemann University | Immobilization of message RNA directly from cells onto filter material |
| DE3308932A1 (de) | 1983-03-12 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | Verfahren zur abtrennung von ribonukleinsaeuren aus einer loesung, die desoxyribonukleinsaeuren enthaelt |
| US5137816A (en) * | 1983-06-22 | 1992-08-11 | The Lubrizol Corporation | Rhizobial diagnostic probes and rhizobium trifolii nifH promoters |
| US4648975A (en) | 1983-08-17 | 1987-03-10 | Pedro B. Macedo | Process of using improved silica-based chromatographic supports containing additives |
| GB8519457D0 (en) * | 1985-08-02 | 1985-09-11 | Faulk Ward Page | Tumour imaging agents |
| CA1301606C (en) | 1986-05-02 | 1992-05-26 | David H. Gillespie | Chaotropic method for evaluating nucleic acids in a biological sample |
| US4900677A (en) * | 1986-09-26 | 1990-02-13 | E. I. Du Pont De Nemours And Company | Process for rapid isolation of high molecular weight DNA |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US4923978A (en) | 1987-12-28 | 1990-05-08 | E. I. Du Pont De Nemours & Company | Process for purifying nucleic acids |
| US5075430A (en) | 1988-12-12 | 1991-12-24 | Bio-Rad Laboratories, Inc. | Process for the purification of DNA on diatomaceous earth |
| NL8900725A (nl) | 1989-03-23 | 1990-10-16 | Az Univ Amsterdam | Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur. |
| US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| CA2011929A1 (en) | 1989-04-03 | 1990-10-03 | Rex M. Bitner | Metal oxide supports for nucleic acids |
| US5106966A (en) | 1989-07-10 | 1992-04-21 | University Of Kansas | Use of gel polymer for dna extraction with organic solvents |
| US5175271A (en) | 1989-07-10 | 1992-12-29 | University Of Kansas | Use of silica gel for DNA extraction with organic solvents |
| US5533888A (en) * | 1990-08-21 | 1996-07-09 | Belarde; John F. | Apparatus for forming concrete barriers |
| WO1992018514A1 (en) | 1991-04-12 | 1992-10-29 | Minnesota Mining And Manufacturing Company | Purification of nucleic acids using metal oxide supports |
| CA2067711C (en) | 1991-05-03 | 2000-08-08 | Daniel Lee Woodard | Solid phase extraction purification of dna |
| US5155018A (en) | 1991-07-10 | 1992-10-13 | Hahnemann University | Process and kit for isolating and purifying RNA from biological sources |
| US5329000A (en) | 1991-10-31 | 1994-07-12 | Becton, Dickinson And Company | Purification of DNA with silicon tetrahydrazide |
| DE4139664A1 (de) | 1991-12-02 | 1993-06-03 | Diagen Inst Molekularbio | Vorrichtung und verfahren zur isolierung und reinigung von nukleinsaeuren |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| DE69324716T2 (de) | 1992-02-13 | 1999-09-09 | Becton Dickinson And Co. | Celithydrat und Reinigung von DNS |
| AU669398B2 (en) | 1992-11-13 | 1996-06-06 | Becton Dickinson & Company | Boron silicates aluminum silicates phosphosilicates and purification of DNA |
| DE4321904B4 (de) | 1993-07-01 | 2013-05-16 | Qiagen Gmbh | Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen |
| AU7375794A (en) | 1993-07-28 | 1995-02-28 | Akzo Nobel N.V. | Process for isolating nucleic acid from gram positive microorganisms |
| CA2170604C (en) | 1993-08-30 | 2007-03-13 | Vikas V. Padhye | Nucleic acid purification compositions and methods |
| US5637687A (en) | 1993-08-31 | 1997-06-10 | Wiggins; James C. | Methods and compositions for isolating nucleic acids |
| US5503816A (en) | 1993-09-27 | 1996-04-02 | Becton Dickinson And Company | Silicate compounds for DNA purification |
| US5438129A (en) | 1993-09-27 | 1995-08-01 | Becton Dickinson And Company | DNA purification by solid phase extraction using partially fluorinated aluminum hydroxide adsorbant |
| US5438127A (en) | 1993-09-27 | 1995-08-01 | Becton Dickinson And Company | DNA purification by solid phase extraction using a PCl3 modified glass fiber membrane |
| US6180778B1 (en) | 1994-02-11 | 2001-01-30 | Qiagen Gmbh | Process for the separation of double-stranded/single-stranded nucleic acid structures |
| US5705628A (en) * | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| US5641665A (en) * | 1994-11-28 | 1997-06-24 | Vical Incorporated | Plasmids suitable for IL-2 expression |
| GB9425138D0 (en) * | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| US5576196A (en) | 1995-01-13 | 1996-11-19 | Vical Incorporated | Process for reducing RNA concentration in a mixture of biological material using diatomaceous earth |
| US5777099A (en) | 1995-02-24 | 1998-07-07 | Biotecx Laboratories, Inc. | RNA separation |
| JP2965131B2 (ja) | 1995-07-07 | 1999-10-18 | 東洋紡績株式会社 | 核酸結合用磁性担体およびそれを用いる核酸単離方法 |
| US5945515A (en) | 1995-07-31 | 1999-08-31 | Chomczynski; Piotr | Product and process for isolating DNA, RNA and proteins |
| US5804684A (en) | 1995-08-24 | 1998-09-08 | The Theobald Smith Research Institute, Inc. | Method for isolating nucleic acids |
| US5783686A (en) | 1995-09-15 | 1998-07-21 | Beckman Instruments, Inc. | Method for purifying nucleic acids from heterogenous mixtures |
| DE29601618U1 (de) | 1996-01-31 | 1996-07-04 | InViTek GmbH, 13125 Berlin | Vorrichtung zur gleichzeitigen multiplen Isolierung |
| GB9602825D0 (en) | 1996-02-12 | 1996-04-10 | Therexsys Ltd | Method of plasmid dna production and purification |
| US5973137A (en) | 1996-02-13 | 1999-10-26 | Gentra Systems, Inc. | Low pH RNA isolation reagents, method, and kit |
| ATE284891T1 (de) | 1996-02-14 | 2005-01-15 | Biomerieux Bv | Isolierung von einzelsträngigen nukleinsäuren |
| ZA973642B (en) * | 1996-04-26 | 1997-11-25 | Merck & Co Inc | DNA vaccine formulations. |
| EP0814156B1 (de) | 1996-06-18 | 2003-03-05 | The Institute Of Physical & Chemical Research | Verfahren zur Reinigung von DNS |
| DE69734263T2 (de) | 1996-07-12 | 2006-07-13 | Toyo Boseki K.K. | Verfahren zur Isolierung von Ribonucleinsäuren. |
| US5981235A (en) | 1996-07-29 | 1999-11-09 | Promega Corporation | Methods for isolating nucleic acids using alkaline protease |
| CA2214495C (en) | 1996-09-25 | 2002-02-05 | Daniel L. Woodard | Hydrated zirconium silicate composition for purification of nucleic acids |
| JP2001506005A (ja) | 1996-12-11 | 2001-05-08 | ナイコメッド・アマーシャム・ピーエルシー | 細胞の選択的溶解 |
| JP2001524820A (ja) | 1997-04-10 | 2001-12-04 | ライフ テクノロジーズ，インコーポレイテッド | Ｒｎａ単離試薬および方法 |
| EP1003908B1 (de) * | 1997-04-16 | 2006-12-06 | Applera Corporation | Nukleinsäuresammlung |
| WO1998059076A1 (en) | 1997-06-25 | 1998-12-30 | Promega Corporation | Method of isolating rna |
| US5972613A (en) | 1997-12-09 | 1999-10-26 | The Perkin-Elmer Corporation | Methods of nucleic acid isolation |
| DE19801730A1 (de) | 1998-01-19 | 1999-07-22 | Fraunhofer Ges Forschung | Verfahren zur kombinierten Analyse von Zellinhalten, insbesondere den in biologischen Zellen enthaltenen Nukleinsäuren sowie Vorrichtung zur Durchführung des Verfahrens |
| JP4616990B2 (ja) | 1998-02-02 | 2011-01-19 | キアジエン・ノース・アメリカン・ホールデイングス・インコーポレーテツド | Ｄｎａを単離し、増幅し、そして特性化するための方法 |
| WO1999040098A1 (de) | 1998-02-04 | 1999-08-12 | Merck Patent Gmbh | Verfahren zur isolierung und aufreinigung von nucleinsäuren |
| CN1299413A (zh) | 1998-04-02 | 2001-06-13 | 李璟日 | 玻璃微纤维柱及用其制备和纯化质粒dna的方法 |
| EP0969090A1 (de) * | 1998-05-27 | 2000-01-05 | QIAGEN GmbH | Schnelles und einfaches Verfahren zur Isolierung von zirkulären Nucleinsäuren |
| CA2370656A1 (en) * | 1999-04-21 | 2000-10-26 | Mitchell T. Gore | Magnetic dna extraction kit for plants |
| US6270970B1 (en) * | 1999-05-14 | 2001-08-07 | Promega Corporation | Mixed-bed solid phase and its use in the isolation of nucleic acids |
| DE60015148T2 (de) | 1999-08-20 | 2006-02-16 | Promega Corp., Madison | Simultane isolierung und quantifizierung von dna |
| US7001724B1 (en) † | 2000-11-28 | 2006-02-21 | Applera Corporation | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases |
| EP1438426A1 (de) * | 2001-10-12 | 2004-07-21 | Gentra Systems Inc. | Zusammensetzungen und verfahren für die verwendung einer festen phase bei der aufreinigung von rna |
| WO2003046146A2 (en) * | 2001-11-28 | 2003-06-05 | Applera Corporation | Compositions and methods of selective nucleic acid isolation |
-
2002
- 2002-11-27 WO PCT/US2002/038123 patent/WO2003046146A2/en not_active Ceased
- 2002-11-27 DE DE60234464T patent/DE60234464D1/de not_active Expired - Lifetime
- 2002-11-27 AU AU2002359522A patent/AU2002359522A1/en not_active Abandoned
- 2002-11-27 AT AT02794065T patent/ATE449186T1/de not_active IP Right Cessation
- 2002-11-27 US US10/306,347 patent/US7208271B2/en not_active Expired - Lifetime
- 2002-11-27 JP JP2003547581A patent/JP4106026B2/ja not_active Expired - Lifetime
- 2002-11-27 EP EP02794065.9A patent/EP1448799B2/de not_active Expired - Lifetime
-
2007
- 2007-04-23 US US11/789,352 patent/US7537898B2/en not_active Expired - Lifetime
- 2007-09-21 JP JP2007246299A patent/JP2008000146A/ja active Pending
-
2008
- 2008-10-31 JP JP2008282297A patent/JP2009039137A/ja active Pending
-
2009
- 2009-05-22 US US12/471,292 patent/US8507198B2/en not_active Expired - Fee Related
-
2013
- 2013-08-05 US US13/959,725 patent/US8865405B2/en not_active Expired - Lifetime
-
2014
- 2014-10-02 US US14/504,581 patent/US20150086988A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005510233A (ja) | 2005-04-21 |
| AU2002359522A1 (en) | 2003-06-10 |
| US20140065626A1 (en) | 2014-03-06 |
| US8507198B2 (en) | 2013-08-13 |
| JP2008000146A (ja) | 2008-01-10 |
| EP1448799B2 (de) | 2018-05-16 |
| JP4106026B2 (ja) | 2008-06-25 |
| AU2002359522A8 (en) | 2003-06-10 |
| US20100021905A1 (en) | 2010-01-28 |
| EP1448799A2 (de) | 2004-08-25 |
| WO2003046146A2 (en) | 2003-06-05 |
| US20150086988A1 (en) | 2015-03-26 |
| US7208271B2 (en) | 2007-04-24 |
| WO2003046146A3 (en) | 2004-02-26 |
| US7537898B2 (en) | 2009-05-26 |
| US20070224630A1 (en) | 2007-09-27 |
| EP1448799A4 (de) | 2006-03-08 |
| US8865405B2 (en) | 2014-10-21 |
| DE60234464D1 (de) | 2009-12-31 |
| EP1448799B1 (de) | 2009-11-18 |
| US20030138828A1 (en) | 2003-07-24 |
| JP2009039137A (ja) | 2009-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE449186T1 (de) | Zusammensetzungen und verfahren zur selektiven nukleinsäureisolierung | |
| DE60142254D1 (de) | Zusammensetzungen, methoden und reagentien zur nukleinsäureisolierung mittels oberflächenaktiven substanzen und proteasen | |
| DE50113023D1 (de) | Verfahren zur Konditionierung von organischen Pigmenten | |
| DE60230672D1 (de) | Nukleinsäureanreicherung | |
| DE69918089D1 (de) | Btk inhibitoren und verfahren zur identifizierung und verwendung | |
| DE602004032160D1 (de) | Verfahren zur Zubereitung von Getränken | |
| WO2003008623A3 (en) | Methylation analysis using nicking agents | |
| DE50213074D1 (de) | Verfahren zur Herstellung UV-vernetzter Acrylathaftklebemassen | |
| DE60210265D1 (de) | Verfahren und zwischenprodukte zur herstellung von 4-aminochinolin-cetp-inhibitoren | |
| ATA11042002A (de) | Verfahren zur simulation des fahrverhaltens von fahrzeugen | |
| DE602004030372D1 (de) | Verfahren zur Bestimmung des relativen genetischen Risikos für Autismus | |
| DE60122429D1 (de) | Verfahren zur Hydrierung von Kohlenwasserstoffschnitten | |
| ATE362530T1 (de) | Verfahren und vorrichtung zur reinigung von nukleinsäuren | |
| DE50201891D1 (de) | Verfahren zur herstellung von 1-octen | |
| DE60226766D1 (de) | Verfahren zur herstellung von phenolischen novolaken | |
| DE60223070D1 (de) | Verfahren zur herstellung von dihalogenadamantanen | |
| EP1443820A4 (de) | Zusammensetzung und verfahren zur behandlung der transplantat-wirt-reaktion | |
| DE60219193D1 (de) | Verfahren zur herstellung von silylorganomercaptanen | |
| DE60208738D1 (de) | Verfahren zur Herstellung von Chlorfluorpolyoxyalkylenolen | |
| DE602004030041D1 (de) | Verfahren und zusammensetzungen zur identifikation von rna-bindenden proteinen | |
| DE50210487D1 (de) | Verfahren zur Herstellung von 1-Amino-4-hydroxyanthrachinonen | |
| DE602005000249D1 (de) | Verfahren zur Isolierung von Bakterien aus biologischen Proben | |
| DE59905922D1 (de) | Verfahren zur Isolierung von Glykolen | |
| ATE274599T1 (de) | Verfahren zur enzymatischen racematspaltung von aminomethyl-aryl-cyclohexanol-derivaten | |
| ATE340873T1 (de) | Verfahren zur durchführung einer subtraktiven hybridisierung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |