ATE285232T1 - N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie - Google Patents

N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie

Info

Publication number: ATE285232T1
Authority: AT; Austria
Prior art keywords: hydroxybenzyl; ethylenediamine; bis; diacetic acid; sodium salts
Prior art date: 1998-02-04

Application number

AT99905716T

Other languages

English (en)

Inventor

Raymond J Bergeron Jr

Original Assignee

Univ Florida

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-04

Filing date

1999-02-03

Publication date

2005-01-15

1999-02-03 Application filed by Univ Florida filed Critical Univ Florida

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE285232T1 publication Critical patent/ATE285232T1/de

Links

GRUVVLWKPGIYEG-UHFFFAOYSA-N 2-[2-[carboxymethyl-[(2-hydroxyphenyl)methyl]amino]ethyl-[(2-hydroxyphenyl)methyl]amino]acetic acid Chemical compound C=1C=CC=C(O)C=1CN(CC(=O)O)CCN(CC(O)=O)CC1=CC=CC=C1O GRUVVLWKPGIYEG-UHFFFAOYSA-N 0.000 title abstract 4
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 4
229910052742 iron Inorganic materials 0.000 title abstract 2
238000002560 therapeutic procedure Methods 0.000 title abstract 2
159000000000 sodium salts Chemical class 0.000 title 1
206010065973 Iron Overload Diseases 0.000 abstract 2
125000002091 cationic group Chemical group 0.000 abstract 1
OEUUFNIKLCFNLN-LLVKDONJSA-N chembl432481 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC(O)=CC=2)O)=N1 OEUUFNIKLCFNLN-LLVKDONJSA-N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
-1 iron overload Chemical compound 0.000 abstract 1
238000007920 subcutaneous administration Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT99905716T 1998-02-04 1999-02-03 N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie ATE285232T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7360398P	1998-02-04	1998-02-04
PCT/US1999/002388 WO1999039706A1 (en)	1998-02-04	1999-02-03	Pharmaceuticals comprising n,n'-bis(2- hydroxybenzyl) ethylenediamine-n, n'-diacetic acid for iron chelating therapy

Publications (1)

Publication Number	Publication Date
ATE285232T1 true ATE285232T1 (de)	2005-01-15

Family

ID=22114691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99905716T ATE285232T1 (de)	1998-02-04	1999-02-03	N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie

Country Status (13)

Country	Link
US (2)	US6242492B1 (de)
EP (1)	EP1052985B1 (de)
JP (1)	JP2002502816A (de)
CN (1)	CN1227006C (de)
AT (1)	ATE285232T1 (de)
AU (1)	AU752383B2 (de)
CA (1)	CA2319255C (de)
DE (1)	DE69922787T2 (de)
ES (1)	ES2235461T3 (de)
NZ (1)	NZ506528A (de)
PT (1)	PT1052985E (de)
TR (1)	TR200002256T2 (de)
WO (1)	WO1999039706A1 (de)

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* Cited by examiner, † Cited by third party
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US7232830B2 (en) *	1998-06-26	2007-06-19	Elaine A Delack	Method for treatment of neurodegenerative diseases and effects of aging
JP5349722B2 (ja)	1999-10-01	2013-11-20	ディーエムアイバイオサイエンシズインコーポレイテッド	金属結合化合物およびその使用方法
US7592304B2 (en)	1999-10-01	2009-09-22	Dmi Life Sciences, Inc.	Metal-binding compounds and uses therefor
US7632803B2 (en)	1999-10-01	2009-12-15	Dmi Life Sciences, Inc.	Metal-binding compounds and uses therefor
EP1246618A1 (de) *	1999-12-21	2002-10-09	University Of Florida Research Foundation, Inc.	N,N'-Bis(2-hydroxybenzyl)ethylendiamin-N,N'-diessigsäure zur Behandlung mit Eisenchelatoren
US7160855B2 (en) *	2002-03-14	2007-01-09	Children's Hospital & Research Center At Oakland	Enhancement of iron chelation therapy
PL1866296T3 (pl) *	2005-04-04	2017-05-31	University Of Florida Research Foundation, Inc.	Polieterowe analogi desferritiocyny
JPWO2010032489A1 (ja)	2008-09-22	2012-02-09	国立大学法人旭川医科大学	鉄キレート剤及びその製造方法、並びに鉄イオンの定量・捕捉方法
WO2010133907A1 (en) *	2009-05-18	2010-11-25	Carlo Ghisalberti	Hexadentate chelators in inflammatory bowel disease
US20110077396A1 (en) *	2009-09-30	2011-03-31	General Electric Company	Intermediates for hydroxylated contrast enhancement agents
US20110077417A1 (en) *	2009-09-30	2011-03-31	General Electric Company	Intermediates for Hydroxylated Contrast Enhancement Agents
US8378134B2 (en) *	2009-09-30	2013-02-19	General Electric Company	Hydroxylated contrast enhancement agents
WO2012096183A1 (ja)	2011-01-14	2012-07-19	株式会社ダステック	高分子鉄キレート剤
WO2012104204A1 (en)	2011-01-31	2012-08-09	Vifor (International) Ag	Iron-carbohydrate complex compounds for the intravenous therapy of malaria
CN104706631A (zh) *	2013-12-14	2015-06-17	于莹莹	一种铁螯合剂作为制备抗癌药物的应用
US10472320B2 (en)	2015-06-25	2019-11-12	Nouryon Chemicals International B.V.	Process to prepare phenolic ethylenediamine diacetic acid compounds
US10093612B2 (en)	2015-06-25	2018-10-09	Akzo Nobel Chemicals International B.V.	Process to prepare phenolic ethylenediamine diacetic acid compounds

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Publication number	Priority date	Publication date	Assignee	Title
US3005848A (en)	1957-09-09	1961-10-24	Geigy Chem Corp	Ethylenediamine derivatives containing aromatic rings
US3758540A (en)	1968-02-13	1973-09-11	A Martell	Ferric chelates of n-(2-hydroxybenzyl) substituted aminopoly carboxylic acids
BE786946A (fr)	1971-07-29	1973-01-29	Ciba Geigy	Chelates pour combattre des symptomes de carences en metaux dans des systemes biologiques
GB1439048A (en)	1973-09-11	1976-06-09	Ciba Geigy Ag	Metal complexes of bis-azomethines and processes for their manufacture
FR2267308B1 (de)	1974-04-12	1976-10-08	Protex Manuf Prod Chimiq
CH602857A5 (de)	1976-12-10	1978-08-15	Ciba Geigy Ag
US4130582A (en)	1977-04-19	1978-12-19	Ciba-Geigy Corporation	Preparation of phenolic ethylenediaminepolycarboxylic acids
US4352751A (en)	1979-09-10	1982-10-05	Analytical Radiation Corporation	Species-linked diamine triacetic acids and their chelates
US4528196A (en) *	1981-02-23	1985-07-09	The United States Of America As Represented By The Department Of Health And Human Services	Chelating agents for the treatment of iron overload
US4647447A (en)	1981-07-24	1987-03-03	Schering Aktiengesellschaft	Diagnostic media
US4454106A (en)	1982-06-07	1984-06-12	Gansow Otto A	Use of metal chelate conjugated monoclonal antibodies
US4909257A (en)	1986-05-01	1990-03-20	The Regents Of The University Of California	Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging
US5227474A (en) *	1987-02-13	1993-07-13	Abbott Laboratories	Bifunctional chelating agents
US5057302A (en) *	1987-02-13	1991-10-15	Abbott Laboratories	Bifunctional chelating agents
NZ231180A (en)	1988-10-31	1994-11-25	Dow Chemical Co	Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof
US5376154A (en)	1991-05-13	1994-12-27	The Lubrizol Corporation	Low-sulfur diesel fuels containing organometallic complexes
US5840739A (en) *	1992-11-16	1998-11-24	University Of Florida Research Foundation, Inc.	Thiazoline acid derivatives
US5534241A (en) *	1993-07-23	1996-07-09	Torchilin; Vladimir P.	Amphipathic polychelating compounds and methods of use
AU1033495A (en) *	1993-12-16	1995-07-03	Ciba-Geigy Ag	N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid derivatives as chelating agents
US5539138A (en)	1994-07-28	1996-07-23	Merck Frosst Canada, Inc.	High affinity chelates containing isothiocyanate groups, useful for coupling with peptides and proteins
AU2958397A (en)	1996-05-21	1997-12-09	Novartis Ag	N,n'-di(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid derivatives

1999
- 1999-02-03 AT AT99905716T patent/ATE285232T1/de not_active IP Right Cessation
- 1999-02-03 CA CA2319255A patent/CA2319255C/en not_active Expired - Fee Related
- 1999-02-03 PT PT99905716T patent/PT1052985E/pt unknown
- 1999-02-03 JP JP2000530205A patent/JP2002502816A/ja active Pending
- 1999-02-03 WO PCT/US1999/002388 patent/WO1999039706A1/en not_active Ceased
- 1999-02-03 TR TR2000/02256T patent/TR200002256T2/xx unknown
- 1999-02-03 NZ NZ506528A patent/NZ506528A/xx not_active IP Right Cessation
- 1999-02-03 CN CNB998027219A patent/CN1227006C/zh not_active Expired - Fee Related
- 1999-02-03 EP EP99905716A patent/EP1052985B1/de not_active Expired - Lifetime
- 1999-02-03 ES ES99905716T patent/ES2235461T3/es not_active Expired - Lifetime
- 1999-02-03 DE DE69922787T patent/DE69922787T2/de not_active Expired - Lifetime
- 1999-02-03 AU AU25814/99A patent/AU752383B2/en not_active Ceased
- 1999-12-21 US US09/467,943 patent/US6242492B1/en not_active Expired - Lifetime
2000
- 2000-11-28 US US09/724,823 patent/US6531510B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2319255C (en)	2010-01-26
PT1052985E (pt)	2005-04-29
DE69922787D1 (de)	2005-01-27
DE69922787T2 (de)	2005-12-15
NZ506528A (en)	2002-11-26
EP1052985A1 (de)	2000-11-22
CN1227006C (zh)	2005-11-16
CA2319255A1 (en)	1999-08-12
JP2002502816A (ja)	2002-01-29
US6531510B1 (en)	2003-03-11
TR200002256T2 (tr)	2001-03-21
CN1290163A (zh)	2001-04-04
WO1999039706A9 (en)	2000-09-21
AU752383B2 (en)	2002-09-19
US6242492B1 (en)	2001-06-05
WO1999039706A1 (en)	1999-08-12
AU2581499A (en)	1999-08-23
EP1052985B1 (de)	2004-12-22
ES2235461T3 (es)	2005-07-01

Legal Events

Date	Code	Title	Description
2005-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69922787D1 (de)	2005-01-27	N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'-diessigsäure und natriumsalze davon zur eisenchelatierungstherapie
AU2001252958A1 (en)	2001-10-03	Compounds and methods to treat alzheimer's disease
WO2002002518A3 (en)	2002-08-08	Compounds to treat alzheimer's disease
TR200200706T2 (tr)	2002-10-21	Nöropatik ağrı tedavisi için retigabin kullanımı.
AU5584901A (en)	2001-10-30	Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
EA200201247A1 (ru)	2003-10-30	Соединения для лечения болезни альцгеймера
BRPI0316438C1 (pt)	2021-05-25	uso de eritropoietina em doenças cardíacas
DE60126980D1 (de)	2007-04-12	Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
GB0225474D0 (en)	2002-12-11	Therapeutic agents
GB0005251D0 (en)	2000-04-26	Therapeutic compounds
DK0694545T3 (da)	2000-09-18	Substituerede dibenzoxazepinforbindelser, farmaceutiske sammensætninger og anvendelsesmetoder
DE60322121D1 (de)	2008-08-21	Zusammensetzung zur verabreichung von eisen für die behandlung des unruhigen beinsyndroms
IL162384A0 (en)	2005-11-20	Composition inhibiting matrix-metallproteinases for the treatment of neoplastic diseases
UA66856C2 (uk)	2004-06-15	Тієнопіримідини, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
WO2002096362A3 (en)	2003-05-22	Method for treating fibrotic diseases or other indications vi
NZ512659A (en)	2002-11-26	Use of growth hormone secretagogues for treatment of physical performance decline
AU2456201A (en)	2001-07-03	N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid in iron chelating therapy
MY118244A (en)	2004-09-30	Alfa-amino acid amides, preparation thereof and the therapeutical use thereof
EP1038524A4 (de)	2002-08-07	L-threonat-eisen, pharmazeutische zusammensetzung und verwendung zur verbesserung und behandlung von anämie bei menschen
MXPA03005903A (es)	2003-09-10	DISEnO Y USO DE PEPTIDOS QUELATANTES DE ZINC AVANZADOR PARA REGULAR LAS METALOPROTEINASAS DE MATRIZ.
MY144204A (en)	2011-08-15	Aquoues olanexidine solution, method of preparing the same, and disinfectant
DE60204818D1 (de)	2005-08-04	Zusammensetzungen enthaltend Eisenerz zur topischen Behandlung von bioenergetischen und elektromagnetischen Erkrankungen
DE60108775T8 (de)	2006-08-24	Methode zur behandlung von schlaganfall
ATE288755T1 (de)	2005-02-15	Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel
MY122576A (en)	2006-04-29	Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect