ATE285770T1 - Verfahren zur herstellung von carbapenem- antibiotika zubereitungen - Google Patents

Verfahren zur herstellung von carbapenem- antibiotika zubereitungen

Info

Publication number
ATE285770T1
ATE285770T1 AT00974020T AT00974020T ATE285770T1 AT E285770 T1 ATE285770 T1 AT E285770T1 AT 00974020 T AT00974020 T AT 00974020T AT 00974020 T AT00974020 T AT 00974020T AT E285770 T1 ATE285770 T1 AT E285770T1
Authority
AT
Austria
Prior art keywords
carbapenem
carbapenem antibiotic
antibiotic preparations
producing carbapenem
formulation
Prior art date
Application number
AT00974020T
Other languages
English (en)
Inventor
Anthony Al-Dehneh
William A Hunke
Kathleen J Illig
Anand Kanike
Hiren Patel
Scott D Reynolds
Stelios C Tsinontides
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE285770T1 publication Critical patent/ATE285770T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AT00974020T 1999-10-29 2000-10-27 Verfahren zur herstellung von carbapenem- antibiotika zubereitungen ATE285770T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16248299P 1999-10-29 1999-10-29
PCT/US2000/029869 WO2001032172A1 (en) 1999-10-29 2000-10-27 Process for formulation of carbapenem antibiotic compositions

Publications (1)

Publication Number Publication Date
ATE285770T1 true ATE285770T1 (de) 2005-01-15

Family

ID=22585803

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00974020T ATE285770T1 (de) 1999-10-29 2000-10-27 Verfahren zur herstellung von carbapenem- antibiotika zubereitungen

Country Status (8)

Country Link
EP (1) EP1244444B1 (de)
JP (1) JP4854899B2 (de)
AT (1) ATE285770T1 (de)
AU (1) AU770165B2 (de)
CA (1) CA2388163C (de)
DE (1) DE60017194T2 (de)
ES (1) ES2234689T3 (de)
WO (1) WO2001032172A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548492B1 (en) * 1999-10-29 2003-04-15 Merck & Co., Inc. Process for formulation of carbapenem antibiotic compositions
WO2003063824A2 (en) * 2002-02-01 2003-08-07 Shimoda Biotech (Pty) Ltd Pharmaceutical composition
EP2303225B1 (de) * 2008-06-11 2013-11-20 Ranbaxy Laboratories Limited Zusammensetzungen des Kohlenstoffdioxid Adduktes von Ertapenem und Polymorphe Formen des Mononatriumsalzes von Ertapenem
US8691803B2 (en) * 2011-01-24 2014-04-08 Savior Lifetec Corporation Process for the preparation of antibiotic compounds
JP6356227B2 (ja) * 2013-05-07 2018-07-11 マクマスター ユニバーシティー メタロβラクタマーゼの阻害剤
KR101587420B1 (ko) * 2014-08-20 2016-01-22 주식회사 대웅제약 에르타페넴-함유 동결건조제제의 제조방법
KR20170014842A (ko) 2015-07-31 2017-02-08 주식회사 대웅제약 개선된 에르타페넴 주사제의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP970281B1 (en) * 1996-05-28 2002-04-30 Merck & Co Inc Carbapenem antibiotic, composition and method of preparation
UA62920C2 (en) * 1996-05-28 2004-01-15 Merck & Co Inc Carbapeneme antibiotic, a composition and a method for the preparation
EP0937079A4 (de) * 1996-10-28 2001-01-24 Merck & Co Inc Stabilisierte antibiotische carbapenem-zusammensetzungen und eine methode zu ihrer herstellung
US6297231B1 (en) * 1996-10-28 2001-10-02 Merck & Co., Inc. Stabilized carbapenem antibiotic compositions and method of making
WO1998057973A1 (en) * 1997-06-16 1998-12-23 Merck & Co., Inc. Stabilized carbapenem intermediates and synthetic use

Also Published As

Publication number Publication date
AU1245601A (en) 2001-05-14
EP1244444B1 (de) 2004-12-29
WO2001032172A1 (en) 2001-05-10
DE60017194D1 (de) 2005-02-03
DE60017194T2 (de) 2005-12-22
ES2234689T3 (es) 2005-07-01
CA2388163C (en) 2009-08-25
EP1244444A4 (de) 2003-05-21
JP2003514779A (ja) 2003-04-22
CA2388163A1 (en) 2001-05-10
JP4854899B2 (ja) 2012-01-18
AU770165B2 (en) 2004-02-12
EP1244444A1 (de) 2002-10-02

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