ATE286052T1 - Indol-2,3-dione-3-oxim derivate - Google Patents

Indol-2,3-dione-3-oxim derivate

Info

Publication number: ATE286052T1
Authority: AT; Austria
Prior art keywords: dione; het; oxime derivatives; indole; ring
Prior art date: 1996-10-01

Application number

AT97941880T

Other languages

English (en)

Inventor

Frank Waetjen

Jorgen Drejer

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1997-10-01

Publication date

2005-01-15

1997-10-01 Application filed by Neurosearch As filed Critical Neurosearch As

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE286052T1 publication Critical patent/ATE286052T1/de

Links

LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 title abstract 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005225 alkynyloxycarbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
-1 hydroxy, carboxy Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT97941880T 1996-10-01 1997-10-01 Indol-2,3-dione-3-oxim derivate ATE286052T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK106996		1996-10-01
DK127796		1996-11-13
PCT/DK1997/000418 WO1998014447A1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives

Publications (1)

Publication Number	Publication Date
ATE286052T1 true ATE286052T1 (de)	2005-01-15

Family

ID=26065167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97941880T ATE286052T1 (de)	1996-10-01	1997-10-01	Indol-2,3-dione-3-oxim derivate

Country Status (28)

Country	Link
US (3)	USRE38200E1 (de)
EP (1)	EP0869958B1 (de)
JP (1)	JP3319762B2 (de)
KR (1)	KR100492052B1 (de)
CN (1)	CN1093859C (de)
AT (1)	ATE286052T1 (de)
AU (1)	AU716435B2 (de)
BG (1)	BG63874B1 (de)
BR (1)	BR9706765A (de)
CA (1)	CA2238410C (de)
CZ (1)	CZ297938B6 (de)
DE (1)	DE69732090T2 (de)
DK (1)	DK0869958T3 (de)
EE (1)	EE9800144A (de)
ES (1)	ES2235253T3 (de)
HU (1)	HU225145B1 (de)
IL (1)	IL124563A (de)
IS (1)	IS2123B (de)
NO (1)	NO310722B1 (de)
NZ (1)	NZ330456A (de)
PL (1)	PL193041B1 (de)
PT (1)	PT869958E (de)
RU (1)	RU2190612C2 (de)
SI (1)	SI0869958T1 (de)
SK (1)	SK282729B6 (de)
TR (1)	TR199800956T1 (de)
UA (1)	UA54403C2 (de)
WO (1)	WO1998014447A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
EP1066037B1 (de) *	1998-03-31	2004-12-29	Neurosearch A/S	Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
DK1183025T3 (da)	1999-05-19	2009-05-04	Painceptor Pharma Corp	Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser
EP1255734B1 (de) *	2000-01-24	2006-06-21	NeuroSearch A/S	Isatinderivate mit neurotropen aktivität
IT1318636B1 (it) *	2000-07-21	2003-08-27	Roberto Pellicciari	Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
US20040063742A1 (en) *	2001-02-15	2004-04-01	Dan Peters	Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
BR0211140A (pt)	2001-07-13	2005-10-25	Upjohn Co	Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht
DE60303825T2 (de) *	2002-08-22	2006-08-17	Neurosearch A/S	Verfahren zum herstellen von enantiomeren von indol-2,3-dion-3-oxim-derivaten
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
WO2007059608A1 (en) *	2005-11-23	2007-05-31	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
CA2652307A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US20080021034A1 (en) *	2006-04-10	2008-01-24	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
WO2008031831A2 (en) *	2006-09-12	2008-03-20	Neurosearch A/S	Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108603A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20080108622A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
WO2010104324A2 (ko) *	2009-03-10	2010-09-16	한국과학기술연구원	베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) *	2011-03-04	2012-09-05	爱斯医药科技(南京)有限公司	Spd-502的制备方法
ES2865330T3 (es)	2015-04-29	2021-10-15	Janssen Pharmaceutica Nv	Azabenzimidazoles y su uso como moduladores del receptor AMPA
JP6804469B2 (ja)	2015-04-29	2020-12-23	ヤンセンファーマシューティカエヌ．ベー．	ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用
KR20170141769A (ko) *	2015-04-29	2017-12-26	얀센 파마슈티카 엔.브이.	인돌론 화합물 및 ampa 수용체 조절제로서의 이의 용도
MX373652B (es)	2015-04-29	2020-04-02	Janssen Pharmaceutica Nv	Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
MX9204914A (es) *	1991-08-28	1993-07-01	Frank Watjen	Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
TW281669B (de) *	1993-02-17	1996-07-21	Chugai Pharmaceutical Co Ltd
US5721230A (en)	1993-05-10	1998-02-24	Hoffmann-La Roche Inc.	Substituted pyrroles
WO1994026747A1 (en)	1993-05-13	1994-11-24	Neurosearch A/S	Ampa antagonists and a method of treatment therewith
DK81593D0 (da) *	1993-07-07	1993-07-07	Neurosearch As	Nye isatinoximderivater, deres fremstilling og anvendelse
AU687255B2 (en) *	1994-09-14	1998-02-19	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives, their preparation and use
EE03772B1 (et) *	1994-09-14	2002-06-17	Neurosearch A/S	Kondenseeritud indooli ja kinoksaliini derivaadid, nende valmistamine ja kasutamine
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en not_active Ceased
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active Expired - Fee Related
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 EP EP97941880A patent/EP0869958B1/de not_active Expired - Lifetime
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69732090T2 (de)	2005-12-29
AU716435B2 (en)	2000-02-24
HUP9901630A2 (hu)	1999-08-30
PL327073A1 (en)	1998-11-23
KR19990071823A (ko)	1999-09-27
SI0869958T1 (en)	2005-06-30
TR199800956T1 (xx)	1998-12-21
BR9706765A (pt)	1999-09-14
EE9800144A (et)	1998-10-15
EP0869958B1 (de)	2004-12-29
DK0869958T3 (da)	2005-04-18
NO310722B1 (no)	2001-08-20
JP2000501432A (ja)	2000-02-08
JP3319762B2 (ja)	2002-09-03
DE69732090D1 (de)	2005-02-03
IS4748A (is)	1998-05-18
CZ160698A3 (cs)	1998-10-14
PL193041B1 (pl)	2007-01-31
ES2235253T3 (es)	2005-07-01
IS2123B (is)	2006-07-14
IL124563A (en)	2005-05-17
CN1207100A (zh)	1999-02-03
USRE38200E1 (en)	2003-07-22
MX9804365A (es)	1998-10-31
UA54403C2 (uk)	2003-03-17
CA2238410C (en)	2007-06-12
HUP9901630A3 (en)	2001-11-28
RU2190612C2 (ru)	2002-10-10
SK67698A3 (en)	1998-11-04
BG63874B1 (bg)	2003-04-30
CA2238410A1 (en)	1998-04-09
CN1093859C (zh)	2002-11-06
AU4376897A (en)	1998-04-24
NO982466L (no)	1998-07-31
HK1017682A1 (en)	1999-11-26
WO1998014447A1 (en)	1998-04-09
IL124563A0 (en)	1998-12-06
US6693111B1 (en)	2004-02-17
KR100492052B1 (ko)	2005-09-30
US6124285A (en)	2000-09-26
HU225145B1 (en)	2006-07-28
PT869958E (pt)	2005-05-31
BG102489A (en)	1999-04-30
NO982466D0 (no)	1998-05-29
EP0869958A1 (de)	1998-10-14
CZ297938B6 (cs)	2007-05-02
SK282729B6 (sk)	2002-11-06
NZ330456A (en)	1998-11-25

Legal Events

Date

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2005-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0869958

Country of ref document: EP

2011-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE286052T1 (de)	2005-01-15	Indol-2,3-dione-3-oxim derivate
EA200301094A1 (ru)	2004-06-24	Аминопроизводные как ингибиторы протеазы
UY25679A1 (es)	2000-03-31	Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
HUP0204418A2 (hu)	2003-04-28	NHE-1 inhibitor hatású N-[(helyettesített öttagú, di- vagy triaza-, kétszeresen telítetlen gyűrű)-karbonil]-guanidin-származékok és alkalmazásuk
ATE157355T1 (de)	1997-09-15	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
ES2162466T3 (es)	2001-12-16	Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
NZ334531A (en)	2000-09-29	Quinoxalin derivatives as Protein kinase C inhibitors
TW349098B (en)	1999-01-01	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
MY119238A (en)	2005-04-30	8-quinolinzanthine and 8-isoquinolinxanthine derivatives as pde 5 inhibitors
IL102703A (en)	1997-03-18	N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them
PT870768E (pt)	2002-09-30	Derivados azaindole-etilamina como agentes de ligacao nicotinicos aos receptores de acetilcolina
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
DK0565377T3 (da)	1998-03-16	Terapeutiske midler til behandling af Parkinsons sygdom
CY1110284T1 (el)	2015-01-14	Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο
ATE302772T1 (de)	2005-09-15	2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung
NO305287B1 (no)	1999-05-03	AMPA antagonister
DE69231546D1 (de)	2000-12-07	Endothelin Antagonisten
CO5140116A1 (es)	2002-03-22	Compuestos espiro derivados de imidazo-benzazepina con actividad antihistaminica y sus procesos de obtencion a partir de sus intermediarios de sintesis
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