ATE286052T1 - Indol-2,3-dione-3-oxim derivate - Google Patents

Indol-2,3-dione-3-oxim derivate

Info

Publication number: ATE286052T1
Authority: AT; Austria
Prior art keywords: dione; het; oxime derivatives; indole; ring
Prior art date: 1996-10-01

Application number

AT97941880T

Other languages

English (en)

Inventor

Frank Waetjen

Jorgen Drejer

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1997-10-01

Publication date

2005-01-15

1997-10-01 Application filed by Neurosearch As filed Critical Neurosearch As

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE286052T1 publication Critical patent/ATE286052T1/de

Links

LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 title abstract 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005225 alkynyloxycarbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
-1 hydroxy, carboxy Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT97941880T 1996-10-01 1997-10-01 Indol-2,3-dione-3-oxim derivate ATE286052T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK106996		1996-10-01
DK127796		1996-11-13
PCT/DK1997/000418 WO1998014447A1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives

Publications (1)

Publication Number	Publication Date
ATE286052T1 true ATE286052T1 (de)	2005-01-15

Family

ID=26065167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97941880T ATE286052T1 (de)	1996-10-01	1997-10-01	Indol-2,3-dione-3-oxim derivate

Country Status (28)

Country	Link
US (3)	USRE38200E1 (de)
EP (1)	EP0869958B1 (de)
JP (1)	JP3319762B2 (de)
KR (1)	KR100492052B1 (de)
CN (1)	CN1093859C (de)
AT (1)	ATE286052T1 (de)
AU (1)	AU716435B2 (de)
BG (1)	BG63874B1 (de)
BR (1)	BR9706765A (de)
CA (1)	CA2238410C (de)
CZ (1)	CZ297938B6 (de)
DE (1)	DE69732090T2 (de)
DK (1)	DK0869958T3 (de)
EE (1)	EE9800144A (de)
ES (1)	ES2235253T3 (de)
HU (1)	HU225145B1 (de)
IL (1)	IL124563A (de)
IS (1)	IS2123B (de)
NO (1)	NO310722B1 (de)
NZ (1)	NZ330456A (de)
PL (1)	PL193041B1 (de)
PT (1)	PT869958E (de)
RU (1)	RU2190612C2 (de)
SI (1)	SI0869958T1 (de)
SK (1)	SK282729B6 (de)
TR (1)	TR199800956T1 (de)
UA (1)	UA54403C2 (de)
WO (1)	WO1998014447A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
WO1999049864A1 (en) *	1998-03-31	1999-10-07	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives for therapeutic use
WO2000071102A2 (en) *	1999-05-19	2000-11-30	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (de) *	2000-01-24	2007-01-03	NeuroSearch A/S	Isatinderivate mit neurotropischer Aktivität geeignet zur Behandlung von NGF-bedingten Krankheiten
IT1318636B1 (it) *	2000-07-21	2003-08-27	Roberto Pellicciari	Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
JP2004523543A (ja) *	2001-02-15	2004-08-05	ニューロサーチ、アクティーゼルスカブ	神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法
MXPA04000358A (es)	2001-07-13	2004-05-04	Pharmacia & Up John Company	Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht.
CA2493244A1 (en)	2002-08-22	2004-03-04	Neurosearch A/S	A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
KR20080070749A (ko) *	2005-11-23	2008-07-30	페인셉터 파마 코포레이션	개폐 이온 통로를 조절하기 위한 조성물 및 방법
US20080004282A1 (en) *	2006-04-10	2008-01-03	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
WO2007115403A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
EP2066323A2 (de) *	2006-09-12	2009-06-10	NeuroSearch AS	Pharmazeutische zusammensetzungen mit kombinationen aus einer antagonistischen ampa-/kainat-verbindung und einem hemmer eines multdrug-resistenzproteins
US20080108603A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20080108622A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
WO2010104324A2 (ko) *	2009-03-10	2010-09-16	한국과학기술연구원	베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) *	2011-03-04	2012-09-05	爱斯医药科技(南京)有限公司	Spd-502的制备方法
HRP20210403T1 (hr)	2015-04-29	2021-10-29	Janssen Pharmaceutica Nv	Azabenzimidazoli i njihova uporaba kao modulatora ampa receptora
WO2016176449A1 (en)	2015-04-29	2016-11-03	Janssen Pharmaceutica Nv	Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators
ES2767707T3 (es) *	2015-04-29	2020-06-18	Janssen Pharmaceutica Nv	Compuestos de indolona y su uso como moduladores de receptor AMPA
AU2016255431B2 (en)	2015-04-29	2020-05-07	Janssen Pharmaceutica Nv	Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
MX9204914A (es) *	1991-08-28	1993-07-01	Frank Watjen	Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
TW281669B (de) *	1993-02-17	1996-07-21	Chugai Pharmaceutical Co Ltd
US5721230A (en)	1993-05-10	1998-02-24	Hoffmann-La Roche Inc.	Substituted pyrroles
NZ267081A (en) *	1993-05-13	1997-11-24	Neurosearch As	Hetero-fused indole and quinoxaline compounds and medicaments thereof
DK81593D0 (da) *	1993-07-07	1993-07-07	Neurosearch As	Nye isatinoximderivater, deres fremstilling og anvendelse
AU686888B2 (en) *	1994-09-14	1998-02-12	Neurosearch A/S	Fused indole and quinoxaline derivatives, their preparation and use
NZ293265A (en) *	1994-09-14	1998-01-26	Neurosearch As	5-aryl-isoquinoline-2-one-3-acyloxime derivatives fused with a n-heterocyclic ring
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active Expired - Fee Related
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 EP EP97941880A patent/EP0869958B1/de not_active Expired - Lifetime
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en not_active Ceased
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SI0869958T1 (en)	2005-06-30
CA2238410C (en)	2007-06-12
IS2123B (is)	2006-07-14
HUP9901630A3 (en)	2001-11-28
SK67698A3 (en)	1998-11-04
NO982466D0 (no)	1998-05-29
MX9804365A (es)	1998-10-31
KR100492052B1 (ko)	2005-09-30
PL327073A1 (en)	1998-11-23
RU2190612C2 (ru)	2002-10-10
JP3319762B2 (ja)	2002-09-03
DE69732090T2 (de)	2005-12-29
HU225145B1 (en)	2006-07-28
USRE38200E1 (en)	2003-07-22
IS4748A (is)	1998-05-18
EE9800144A (et)	1998-10-15
PT869958E (pt)	2005-05-31
IL124563A (en)	2005-05-17
DK0869958T3 (da)	2005-04-18
EP0869958B1 (de)	2004-12-29
SK282729B6 (sk)	2002-11-06
BR9706765A (pt)	1999-09-14
AU716435B2 (en)	2000-02-24
BG102489A (en)	1999-04-30
CN1093859C (zh)	2002-11-06
US6124285A (en)	2000-09-26
IL124563A0 (en)	1998-12-06
TR199800956T1 (xx)	1998-12-21
JP2000501432A (ja)	2000-02-08
NZ330456A (en)	1998-11-25
UA54403C2 (uk)	2003-03-17
CN1207100A (zh)	1999-02-03
DE69732090D1 (de)	2005-02-03
CZ160698A3 (cs)	1998-10-14
EP0869958A1 (de)	1998-10-14
NO310722B1 (no)	2001-08-20
BG63874B1 (bg)	2003-04-30
CA2238410A1 (en)	1998-04-09
HUP9901630A2 (hu)	1999-08-30
US6693111B1 (en)	2004-02-17
PL193041B1 (pl)	2007-01-31
KR19990071823A (ko)	1999-09-27
WO1998014447A1 (en)	1998-04-09
HK1017682A1 (en)	1999-11-26
NO982466L (no)	1998-07-31
AU4376897A (en)	1998-04-24
ES2235253T3 (es)	2005-07-01
CZ297938B6 (cs)	2007-05-02

Legal Events

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2005-06-15

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Publication of translation of european patent specification

Ref document number: 0869958

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2011-07-15

REN

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Publication	Publication Date	Title
DE69732090D1 (de)	2005-02-03	Indol-2,3-dione-3-oxim derivate
EA200100970A1 (ru)	2002-04-25	Аминопроизводные как ингибиторы протеазы
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ATE157355T1 (de)	1997-09-15	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
ES2162466T3 (es)	2001-12-16	Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
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PT870768E (pt)	2002-09-30	Derivados azaindole-etilamina como agentes de ligacao nicotinicos aos receptores de acetilcolina
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