ATE286976T1 - Menschliche calcium-kanale und verwendungen davon - Google Patents

Menschliche calcium-kanale und verwendungen davon

Info

Publication number
ATE286976T1
ATE286976T1 AT99119092T AT99119092T ATE286976T1 AT E286976 T1 ATE286976 T1 AT E286976T1 AT 99119092 T AT99119092 T AT 99119092T AT 99119092 T AT99119092 T AT 99119092T AT E286976 T1 ATE286976 T1 AT E286976T1
Authority
AT
Austria
Prior art keywords
human calcium
calcium channels
subunit
modulate
arise
Prior art date
Application number
AT99119092T
Other languages
English (en)
Inventor
Michael M Harpold
Steven B Ellis
Mark E Williams
Ann F Mccue
Daniel H Feldman
Robert Brenner
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/745,206 external-priority patent/US5429921A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE286976T1 publication Critical patent/ATE286976T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
AT99119092T 1991-08-15 1992-08-14 Menschliche calcium-kanale und verwendungen davon ATE286976T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/745,206 US5429921A (en) 1988-04-04 1991-08-15 Assays for agonists and antagonists of recombinant human calcium channels
US86835492A 1992-04-10 1992-04-10

Publications (1)

Publication Number Publication Date
ATE286976T1 true ATE286976T1 (de) 2005-01-15

Family

ID=27114421

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99119092T ATE286976T1 (de) 1991-08-15 1992-08-14 Menschliche calcium-kanale und verwendungen davon
AT92918611T ATE191920T1 (de) 1991-08-15 1992-08-14 Menschliche kalziumkanäle und verwendungen davon

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT92918611T ATE191920T1 (de) 1991-08-15 1992-08-14 Menschliche kalziumkanäle und verwendungen davon

Country Status (10)

Country Link
EP (3) EP1469074B1 (de)
JP (1) JPH06509717A (de)
AT (2) ATE286976T1 (de)
AU (1) AU677571B2 (de)
CA (1) CA2113203C (de)
DE (2) DE69233469T2 (de)
DK (1) DK0598840T3 (de)
ES (2) ES2147184T3 (de)
GR (1) GR3033961T3 (de)
WO (1) WO1993004083A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
US5876958A (en) * 1988-04-04 1999-03-02 Sibia Neurosciences, Inc. Assays of cells expressing human calcium channels containing α1 β subunits
US6387696B1 (en) * 1988-04-04 2002-05-14 Merck & Co., Inc. Human calcium channel compositions and methods
US5874236A (en) * 1988-04-04 1999-02-23 Sibia Neurosciences. Inc. DNA encoding human calcium channel α-1A, β1, β-2, and β-4 subunits, and assays using cells that express the subunits
US5912122A (en) 1993-06-04 1999-06-15 Sibia Neurosciences, Inc. Nucleic acids encoding and method for detecting nucleic acid encoding human metabotropic glutamate receptor subtype mGluR6
US5623051A (en) * 1994-11-10 1997-04-22 University Of Washington Methods and compositions for screening for presynaptic calcium channel blockers
US5712158A (en) * 1995-06-06 1998-01-27 Warner-Lambert Company Cell line for the rapid expression of functional calcium channels
US6040436A (en) * 1996-09-16 2000-03-21 American Home Products Corporation Nucleic acid encoding human neuronal calcium channel subunits
CA2312195A1 (en) * 1997-12-03 1999-06-10 Merck & Co., Inc. Low-voltage activated calcium channel compositions and methods
EP1036170A1 (de) * 1997-12-05 2000-09-20 Loyola University Of Chicago T-type voltage-gated kalciumkanäle und deren verfahren zur anwendung
ES2378977T3 (es) 1998-03-13 2012-04-19 Brown University Research Foundation Isoforma del canal de calcio del tipo N humano y usos de la misma
WO1999063078A2 (en) 1998-06-02 1999-12-09 University Technologies International Inc. Retinal calcium channel (alpha)1f-subunit gene
EP1173571A2 (de) * 1999-05-05 2002-01-23 Lexicon Genetics Incorporated Menschliche ionenkanalproteinen
JP2003512602A (ja) 1999-09-16 2003-04-02 ワーナー−ランバート・カンパニー α２δ−１サブユニット結合リガンドのスクリーニング方法
US6962973B1 (en) 1999-09-16 2005-11-08 Warner-Lambert Company Porcine α2δ-1 calcium channel subunit cDNA and soluble secreted α2δ-1 subunit polypeptides
US6783952B1 (en) 1999-09-16 2004-08-31 Warner-Lambert Company Secreted soluble α2δ-2, α2δ-3 or α2δ-4 calcium channel subunit polypeptides and screening assays using same
WO2001030137A1 (en) * 1999-10-26 2001-05-03 Eisai Co. Ltd. N-calcium channel knockout animal
US7067714B1 (en) 1999-10-26 2006-06-27 Eisai Research Institute N-calcium channel knockout animal
US7294691B1 (en) 2000-09-18 2007-11-13 Warner Lambert Company Soluble secreted α2δ-2calcium channel subunit polypeptide
EP1488231A2 (de) 2002-03-19 2004-12-22 Novartis AG Nachweismethode für verbindungen die wirksam gegen chronische neuropathie-schmerzen sind und diesbezügliche zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4950739A (en) * 1988-02-10 1990-08-21 New York University Membrane calcium channels and factors and methods for blocking, isolating and purifying calcium channels
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
ATE139542T1 (de) * 1988-04-04 1996-07-15 Salk Inst Biotech Ind Calciumkanal-zusammensetzungen und verfahren
DE4110785A1 (de) * 1991-04-04 1992-10-08 Bayer Ag Gewebe-spezifische humane neuronale calcium-kanal-subtypen und deren verwendung

Also Published As

Publication number Publication date
EP0598840A1 (de) 1994-06-01
WO1993004083A1 (en) 1993-03-04
DE69230938D1 (de) 2000-05-25
EP1469074A1 (de) 2004-10-20
GR3033961T3 (en) 2000-11-30
CA2113203C (en) 2001-01-02
ES2147184T3 (es) 2000-09-01
DK0598840T3 (da) 2000-10-02
EP0598840B1 (de) 2000-04-19
DE69233469T2 (de) 2005-12-22
AU2495792A (en) 1993-03-16
ES2235417T3 (es) 2005-07-01
DE69233469D1 (de) 2005-02-17
EP1469074B1 (de) 2008-11-26
DE69230938T2 (de) 2000-10-12
EP0992585A3 (de) 2000-11-15
EP0992585A2 (de) 2000-04-12
JPH06509717A (ja) 1994-11-02
CA2113203A1 (en) 1993-03-04
EP0992585B1 (de) 2005-01-12
ATE191920T1 (de) 2000-05-15
AU677571B2 (en) 1997-05-01

Similar Documents

Publication Publication Date Title
DE68926713D1 (de) Calciumkanal-zusammensetzungen und verfahren
ATE286976T1 (de) Menschliche calcium-kanale und verwendungen davon
DE69432794D1 (de) Menschliche kalziumkanale und verwendungen davon
ATE342973T1 (de) Zusammensetzungen von durch niedervolt aktivierten kalziumkanälen und verfahren
MX9302932A (es) Nuevas 4-aza-5&-androstan-3-onas 7b-substituidas como inhibidores de la5&-reductasa.
DK130387D0 (da) Transglutaminase inhibitorer
NO944406D0 (no) Nye 7 se inhibitorer
ATE247114T1 (de) Serotonergische modulatoren
NO165108C (no) Analogifremgangsmaate for fremstilling av teraputisk aktive beta-laktamantibiotika.
DE3689099D1 (de) Verwendung von angiotensin-converting-enzym-inhibitoren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit.
ES2179254T3 (es) 1-poliarilpirazoles plaguicidas.
ES553033A0 (es) Procedimiento para la obtencion de compuestos de b-lactama
FR2524996B1 (fr) Source de courants regules/generateur de tensions asservies
DE3481167D1 (de) Sebosuppressive kosmetische mittel, enthaltend alkoxyaryl-alkanole.
IT8647880A0 (it) Apparecchio per la stabilizzazione di zone magnetiche
DK0668872T3 (da) Calciumkanalblokerende polypeptider fra Theraphosidaeaphonopelma
ATE90562T1 (de) Antiepileptisch wirkende pyrazolopyridine.
UA10769A (uk) Лікарський засіб для профілактики передчасhого старіhhя та лікуваhhя вікових патологій
ES2038638T3 (es) Sustancias moduladoras del canal del calcio.
DK625386D0 (da) Fremgangsmaade til behandling af instrumenter
ES286693Y (es) Nuevo gorro impermeable con orificios para el tratamiento demechones de cabello

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties