ATE287291T1 - Prozessoptimierungsreaktor mit parallelem durchfluss - Google Patents

Prozessoptimierungsreaktor mit parallelem durchfluss

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Publication number
ATE287291T1
ATE287291T1 AT01914751T AT01914751T ATE287291T1 AT E287291 T1 ATE287291 T1 AT E287291T1 AT 01914751 T AT01914751 T AT 01914751T AT 01914751 T AT01914751 T AT 01914751T AT E287291 T1 ATE287291 T1 AT E287291T1
Authority
AT
Austria
Prior art keywords
feed
parallel flow
process optimization
flow
systems
Prior art date
Application number
AT01914751T
Other languages
English (en)
Inventor
H Sam Bergh
James R Engstrom
Shenheng Guan
Daniel Meron Pinkas
Kyle W Self
Original Assignee
Symyx Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26883153&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE287291(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Symyx Technologies Inc filed Critical Symyx Technologies Inc
Application granted granted Critical
Publication of ATE287291T1 publication Critical patent/ATE287291T1/de

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    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Organic Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
  • Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01914751T 2000-03-07 2001-03-07 Prozessoptimierungsreaktor mit parallelem durchfluss ATE287291T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18756600P 2000-03-07 2000-03-07
US22998400P 2000-09-02 2000-09-02
PCT/US2001/007372 WO2001066245A2 (en) 2000-03-07 2001-03-07 Parallel flow process optimization reactor

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ATE287291T1 true ATE287291T1 (de) 2005-02-15

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Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7150994B2 (en) * 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US6975924B2 (en) * 1999-12-03 2005-12-13 Baxter International Inc. Method and apparatus for controlling the strategy of compounding pharmaceutical admixtures
US7435392B2 (en) 2000-02-03 2008-10-14 Acclavis, Llc Scalable continuous production system
ATE287291T1 (de) 2000-03-07 2005-02-15 Symyx Technologies Inc Prozessoptimierungsreaktor mit parallelem durchfluss
AU2001273331A1 (en) 2000-07-07 2002-01-21 Symyx Technologies, Inc. Methods and apparatus for mechanical treatment of materials such as catalysts
US7413714B1 (en) 2000-07-16 2008-08-19 Ymc Co. Ltd. Sequential reaction system
DE10036602A1 (de) 2000-07-27 2002-02-14 Cpc Cellular Process Chemistry Mikroreaktor für Reaktionen zwischen Gasen und Flüssigkeiten
US6436720B1 (en) * 2000-09-15 2002-08-20 Cellular Process Chemistry, Inc. Residence time providing module/apparatus
US7118917B2 (en) 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
DE10115474A1 (de) * 2001-03-29 2002-10-10 Infineon Technologies Ag Mikrofluidkanalstruktur und Verfahren zur Herstellung einer derartigen Mikrofluidkanalstruktur
WO2003008981A1 (en) * 2001-07-10 2003-01-30 Kanagawa Academy Of Science And Technology Integrated structure of multilayer flow microchannel and method for operating multilayer flow usigng it
US20030012700A1 (en) * 2001-07-11 2003-01-16 Carnahan James Claude Systems and methods for parallel testing of catalyst performance
GB2380528B (en) * 2001-10-05 2003-09-10 Minebea Co Ltd A bearing assembly and method of manufacturing a bearing assembly
US6901334B2 (en) * 2001-12-17 2005-05-31 Rohm And Haas Company Methods and systems for high throughput analysis
ES2209588B1 (es) * 2002-01-14 2005-04-01 Universidad Politecnica De Valencia Sistema de control de flujos para pruebas multiples de materiales solidos y dispositivo para ensayos cataliticos multiples que comprende el sistema.
JP3740528B2 (ja) * 2002-02-05 2006-02-01 独立行政法人産業技術総合研究所 微細粒子製造方法
GB0217993D0 (en) * 2002-08-02 2002-09-11 Imp College Innovations Ltd Powder mixing microchip system and method
JP2004069498A (ja) * 2002-08-06 2004-03-04 Canon Inc 液体搬送装置及び液体搬送方法
US7250151B2 (en) * 2002-08-15 2007-07-31 Velocys Methods of conducting simultaneous endothermic and exothermic reactions
WO2004026460A1 (en) * 2002-09-20 2004-04-01 Avantium International B.V. Method and apparatus for performing chemical experiments
US7139595B2 (en) * 2002-10-24 2006-11-21 The Rail Network, Inc. Transit vehicle wireless transmission broadcast system
EP1419818B1 (de) * 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
EP2206552A3 (de) 2002-12-20 2011-03-09 Honda Giken Kogyo Kabushiki Kaisha Herstellung von Katalysatoren zum erzeugen eines Wasserstoffreichen Gases
US7267987B2 (en) * 2003-01-06 2007-09-11 Uop Llc Process and assembly for simultaneously evaluating a plurality of catalysts
TW571101B (en) * 2003-01-21 2004-01-11 Ind Tech Res Inst Fluid analysis apparatus
US7311882B1 (en) * 2003-01-24 2007-12-25 Sandia National Laboratories Capillary interconnect device
EP1618372A2 (de) * 2003-04-14 2006-01-25 Cellular Process Chemistry, Inc. System und verfahren zur bestimmung der optimalen reaktionsparameter unter verwendung eines kontinuierlich laufenden prozesses
EP1622715A1 (de) * 2003-05-09 2006-02-08 MERCK PATENT GmbH Mikroverfahrenschnischer baustein
US7134459B2 (en) * 2003-06-12 2006-11-14 Symyx Technologies, Inc. Methods and apparatus for mixing powdered samples
JP4578867B2 (ja) * 2003-09-30 2010-11-10 株式会社日立製作所 水素貯蔵・供給装置とそのシステム及びそれを用いた分散電源並びに自動車
DE10361003B3 (de) * 2003-12-23 2005-07-28 Hte Ag The High Throughput Experimentation Company Vorrichtung und Verfahren zur Druck- und Flusskontrolle in Parallelreaktoren
SE527130C2 (sv) * 2004-01-13 2005-12-27 Delaval Holding Ab Anordning och förfarande för utfodring av djur
US7507380B2 (en) * 2004-03-19 2009-03-24 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microchemical nanofactories
EP1793187B1 (de) * 2004-09-21 2011-11-23 Vives Joan Iglesias Verfahren und maschine zum sintern und/oder trocknen von pulvermaterialien unter verwendung von infrarotstrahlung
US7955504B1 (en) 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
GB0422378D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd A method
US8518346B1 (en) * 2005-02-02 2013-08-27 Sandia Corporation Multidimensional bioseparation with modular microfluidics
US20060171852A1 (en) * 2005-02-02 2006-08-03 Sandia National Laboratories Microfluidics prototyping platform and components
BRPI0520513B1 (pt) 2005-04-04 2015-12-08 Avantium Int Bv sistema e método para realização de experimentos químicos paralelos
US20060280651A1 (en) * 2005-04-18 2006-12-14 Louis Bellafiore Industrial biosynthesizer system and method
GB0509742D0 (en) * 2005-05-13 2005-06-22 Ashe Morris Ltd Variable heat flux heat exchangers
US7846489B2 (en) 2005-07-22 2010-12-07 State of Oregon acting by and though the State Board of Higher Education on behalf of Oregon State University Method and apparatus for chemical deposition
SE529516C2 (sv) * 2005-10-24 2007-09-04 Alfa Laval Corp Ab Universell flödesmodul
DE102006001327A1 (de) * 2005-11-14 2007-05-16 Saltigo Gmbh Vorrichtung zur Dosierung von Reaktivgasen
US8679587B2 (en) * 2005-11-29 2014-03-25 State of Oregon acting by and through the State Board of Higher Education action on Behalf of Oregon State University Solution deposition of inorganic materials and electronic devices made comprising the inorganic materials
US7278308B2 (en) * 2005-12-08 2007-10-09 Honeywell International Inc. Thermal isolation between heating and sensing for flow sensors
US20080092969A1 (en) * 2006-08-07 2008-04-24 Diperna Paul Mario Variable flow reshapable flow restrictor apparatus and related methods
US20070246106A1 (en) 2006-04-25 2007-10-25 Velocys Inc. Flow Distribution Channels To Control Flow in Process Channels
US20080029173A1 (en) * 2006-08-07 2008-02-07 Diperna Paul Mario Variable flow reshapable flow restrictor apparatus and related methods
US20080108122A1 (en) * 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
FR2907228B1 (fr) * 2006-10-13 2009-07-24 Rhodia Recherches & Tech Dispositif d'ecoulement fluidique,ensemble de determination d'au moins une caracteristique d'un systeme physico-chimique comprenant un tel dispositif,procede de determination et procede de criblage correspondants
WO2008052168A2 (en) * 2006-10-26 2008-05-02 Symyx Technologies, Inc. High pressure parallel fixed bed reactor and method
SE530902C2 (sv) * 2006-12-19 2008-10-14 Alfa Laval Corp Ab Sektionerad flödesanordning och förfarande för att reglera temperaturen i denna
US20080175765A1 (en) * 2006-12-27 2008-07-24 Guang Cao High throughput, microwave energy heated continuous hydrothermal synthesis apparatus
US20100324157A1 (en) * 2006-12-29 2010-12-23 Bauman Richard F High throughput fischer-tropsch catalytic process development method
CN101274254A (zh) * 2006-12-29 2008-10-01 亚申科技研发中心(上海)有限公司 一种加氢处理洁净原料的研究方法
CN101274260A (zh) * 2006-12-29 2008-10-01 亚申科技研发中心(上海)有限公司 一种催化加氢处理不洁原料的研究方法
US9308530B2 (en) * 2007-03-02 2016-04-12 Shimadzu Corporation Reaction container plate and reaction treatment apparatus
DE102007031680A1 (de) * 2007-07-06 2009-01-08 Thermo Fisher Scientific (Bremen) Gmbh Einrichtung zur Bereitstellung von Gasen, insbesondere für die Isotopenverhältnisanalyse
EP2042232A1 (de) 2007-07-25 2009-04-01 Symyx Technologies, Inc. Systeme und Verfahren zur Materialvermischung
TW200909338A (en) * 2007-08-23 2009-03-01 Ind Tech Res Inst Autonomous microfluidic apparatus
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US20090211977A1 (en) * 2008-02-27 2009-08-27 Oregon State University Through-plate microchannel transfer devices
NL2002365C2 (en) * 2008-05-26 2011-04-05 Avantium Holding B V Flow splitter and reaction assembly.
DE102008032097A1 (de) * 2008-07-08 2010-01-14 Hte Ag The High Throughput Experimentation Company Teststand mit Gruppen von Restriktoren
US8056582B2 (en) * 2008-08-08 2011-11-15 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
JP4722977B2 (ja) * 2008-08-27 2011-07-13 シャープ株式会社 検出器具、分析装置、検出方法および検出器具の制御方法
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
CA2737461A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
KR100971914B1 (ko) * 2008-10-14 2010-07-22 한국원자력연구원 초고온 가스로의 동심축 이중관형 고온가스관의 설계방법
US8236599B2 (en) 2009-04-09 2012-08-07 State of Oregon acting by and through the State Board of Higher Education Solution-based process for making inorganic materials
JP2012531256A (ja) * 2009-06-24 2012-12-10 ステイト オブ オレゴン アクティング バイ アンド スルー ザ ステイト ボード オブ ハイヤー エデュケーション オン ビハーフ オブ オレゴン ステイト ユニバーシティー 透析用マイクロ流体デバイス
US8801922B2 (en) * 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
EP2724739B1 (de) 2009-07-30 2015-07-01 Tandem Diabetes Care, Inc. Tragbares Infusionspumpensystem
DE102010050599B4 (de) 2009-11-07 2014-11-13 Hte Gmbh The High Throughput Experimentation Company Vorrichtung und Verfahren zur Testung von Katalysatoren mit verbesserter Prozessdruckeinstellung
WO2011069110A1 (en) * 2009-12-05 2011-06-09 Home Dialysis Plus, Ltd. Modular dialysis system
US8753515B2 (en) 2009-12-05 2014-06-17 Home Dialysis Plus, Ltd. Dialysis system with ultrafiltration control
US8580161B2 (en) 2010-05-04 2013-11-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluidic devices comprising photocontrollable units
US8501009B2 (en) 2010-06-07 2013-08-06 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluid purification system
EP2458358B1 (de) * 2010-11-29 2017-09-27 Corning Incorporated Kontaktlose Inline-Drucksensoren und Verfahren zur Druckmessung
GB201117064D0 (en) 2011-10-04 2011-11-16 Univ Brunel A modular flow reactor
CN103957960B (zh) 2011-10-07 2016-04-13 霍姆透析普拉斯有限公司 用于透析系统的热交换流体净化
US20130196053A1 (en) * 2012-01-10 2013-08-01 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Stat Flow cell design for uniform residence time fluid flow
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
DE102012014504A1 (de) 2012-07-20 2014-01-23 Dräger Safety AG & Co. KGaA Gasmesssystem
NL2009659C2 (en) * 2012-10-18 2014-04-22 Avantium Technologies B V System and method for operating parallel reactors.
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
DE102013006544B4 (de) * 2013-04-16 2017-04-27 Dräger Safety AG & Co. KGaA Messvorrichtung, Reaktionsträger und Messverfahren
US10086537B2 (en) * 2013-05-08 2018-10-02 Minipumps, Llc Flexible manufacture of polymeric tubing
US20140335626A1 (en) * 2013-05-10 2014-11-13 Cdti Test Bench Gas Flow Control System and Method
NL2011856C2 (en) * 2013-11-28 2014-09-25 Avantium Technologies B V Reactor system for high throughput applications.
US20150224502A1 (en) * 2014-02-12 2015-08-13 Monterey Bay Aquarium Research Institute Flow-through cartridge-based system for collecting and processing samples from water
EP3838308A1 (de) 2014-04-29 2021-06-23 Outset Medical, Inc. Dialysesysteme und -verfahren
CN104190340B (zh) * 2014-08-29 2016-04-06 高剑峰 一种微管式反应装置及利用该装置制备氢化丁腈橡胶的工艺
US20160102283A1 (en) * 2014-10-09 2016-04-14 The United States Of America As Represented By The Secretary Department Of Health And Human Services Microfluidic device and system for precisely controlling and analyzing shear forces in blast-induced traumatic brain injuries
GB2533386B (en) * 2014-12-18 2019-09-11 Smiths Detection Watford Ltd A detection apparatus with pneumatic interface
TW201634738A (zh) * 2015-01-22 2016-10-01 應用材料股份有限公司 用於在空間上分離之原子層沉積腔室的經改良注射器
JP2018506718A (ja) * 2015-01-30 2018-03-08 ヒューレット−パッカード デベロップメント カンパニー エル.ピー.Hewlett‐Packard Development Company, L.P. 診断装置
US10957561B2 (en) * 2015-07-30 2021-03-23 Lam Research Corporation Gas delivery system
US10825659B2 (en) 2016-01-07 2020-11-03 Lam Research Corporation Substrate processing chamber including multiple gas injection points and dual injector
EP3192583A1 (de) * 2016-01-12 2017-07-19 ETH Zurich Vorrichtung und verfahren zur automatisierten chemischen synthese von verbindungen
US10699878B2 (en) 2016-02-12 2020-06-30 Lam Research Corporation Chamber member of a plasma source and pedestal with radially outward positioned lift pins for translation of a substrate c-ring
US10651015B2 (en) 2016-02-12 2020-05-12 Lam Research Corporation Variable depth edge ring for etch uniformity control
US10438833B2 (en) 2016-02-16 2019-10-08 Lam Research Corporation Wafer lift ring system for wafer transfer
KR102378100B1 (ko) * 2016-04-06 2022-03-23 플루이딕 애널리틱스 리미티드 유동 균형의 향상 또는 이와 관련된 향상
CN105738638B (zh) * 2016-05-12 2019-06-04 利多(香港)有限公司 用于分析仪的保温壳
US10410832B2 (en) 2016-08-19 2019-09-10 Lam Research Corporation Control of on-wafer CD uniformity with movable edge ring and gas injection adjustment
ES2908601T3 (es) 2016-08-19 2022-05-03 Outset Medical Inc Sistema y métodos de diálisis peritoneal
GB201704763D0 (de) 2017-01-05 2017-05-10 Illumina Inc
US11154855B2 (en) 2017-05-08 2021-10-26 Custom Sensors And Technology Automated liquid handling and testing systems and methods
EP3645166B1 (de) * 2017-06-30 2025-03-26 SRI International Vorrichtungen für reaktionsscreening und optimierung und verfahren dafür
CN107335395B (zh) * 2017-09-05 2023-11-03 山东豪迈化工技术有限公司 微反应器
CN118380374A (zh) 2017-11-21 2024-07-23 朗姆研究公司 底部边缘环和中部边缘环
SG11202005577PA (en) * 2017-12-15 2020-07-29 Richard Nordman Automated liquid handling and testing systems and methods
JP6859426B2 (ja) 2018-08-13 2021-04-14 ラム リサーチ コーポレーションLam Research Corporation エッジリングの位置決めおよびセンタリング機構を組み込んだプラズマシース調整のための交換可能および/または折りたたみ式エッジリングアセンブリ
JP2021533881A (ja) 2018-08-23 2021-12-09 アウトセット・メディカル・インコーポレイテッドOutset Medical, Inc. 透析システム及び方法
BR112021021836A2 (pt) 2019-04-30 2022-01-04 Outset Medical Inc Métodos para calcular a pressão arterial, para criar dialisato em um sistema de diálise, para medir a porcentagem de rejeição em um sistema de diálise, para coletar e analisar plasma sanguíneo, para remover gás de um circuito extracorpóreo de um sistema de diálise, para inferir uma pressão de linha em um circuito extracorpóreo de um sistema de diálise, para prover terapia de diálise extracorpórea e intracorpórea, para montar um conjunto de tubos de paciente no estilo cartucho em uma máquina de diálise e para preparar uma máquina de diálise para terapia de diálise, câmaras de fluxo e de remoção de ar, sistema de diálise, subsistema de dispensação de dialisato, filtro de micróbio/endotoxina de uso único, dialisador, dispositivo para medir pressão de um sistema de diálise, e, conjunto de tubos de sangue
KR20260010464A (ko) 2020-03-23 2026-01-20 램 리써치 코포레이션 기판 프로세싱 시스템들에서의 중간-링 부식 보상
DE102020109887B4 (de) 2020-04-08 2023-07-20 Opus Inspection, Inc. Gasmessgerät mit einer kompakten Bauform
CN111530515A (zh) * 2020-05-08 2020-08-14 北京森美希克玛生物科技有限公司 一种微流控芯片
US12440836B2 (en) 2021-06-02 2025-10-14 Interface Fluidics Ltd. Manifolds for microfluidic chips, microfluidic chips, and related methods and assemblies
EP4464408A1 (de) * 2023-05-15 2024-11-20 Sanofi Verfahren der flüssigkeitszirkulation und -interaktion in einem aufbau zur implementierung eines mehrstufigen chemischen prozesses
EP4464409A1 (de) * 2023-05-15 2024-11-20 Sanofi Aufbau für die implementierung eines mehrstufigen chemischen prozesses
DE102023121365A1 (de) 2023-08-10 2025-02-13 Ineratec Gmbh Regulierung der Kühlmittelzufuhr bei Mikroreaktoren
WO2025140948A1 (en) * 2023-12-28 2025-07-03 Avantium Technologies B.V Measuring compositional changes in the effluent of multiple parallel packed columns to which is fed a liquid mixture of components
DE102024118229A1 (de) 2024-06-27 2025-12-31 Ineratec Gmbh Vorrichtung und Verfahren zur verbesserten Kühlmittelzirkulierung bei (mikro-)strukturierten Reaktoren

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1164381B (de) * 1961-03-18 1964-03-05 Bayer Ag Reaktorsystem
US3536452A (en) 1965-04-21 1970-10-27 Marathon Oil Co Multiple reactor apparatus
US3431077A (en) 1966-07-18 1969-03-04 Joseph D Danforth Analytical apparatus
US4099923A (en) 1977-01-17 1978-07-11 The Standard Oil Company Automatic catalytic screening unit
DE2714939C3 (de) 1977-04-02 1980-08-14 Hoechst Ag, 6000 Frankfurt Verfahren und Vorrichtung zur Untersuchung der Wirksamkeit von festen Katalysatoren
DD234941A1 (de) 1985-02-28 1986-04-16 Leuna Werke Veb Verfahren und anordnung zur katalysatoraktivitaetsbestimmung
JPH0619311B2 (ja) 1985-10-19 1994-03-16 株式会社堀場製作所 多成分同時測定用ガス分析装置
US5252294A (en) 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
EP0396650B2 (de) 1988-09-02 1995-04-12 GebràœDer Sulzer Aktiengesellschaft Vorrichtung zur durchführung katalysierter reaktionen
US4869282A (en) 1988-12-09 1989-09-26 Rosemount Inc. Micromachined valve with polyimide film diaphragm
DE3902402C1 (de) 1989-01-27 1990-06-13 Draegerwerk Ag, 2400 Luebeck, De
US4996387A (en) 1989-07-20 1991-02-26 Phillips Petroleum Company Dehydrogenation process
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
US5204270A (en) * 1991-04-29 1993-04-20 Lacount Robert B Multiple sample characterization of coals and other substances by controlled-atmosphere programmed temperature oxidation
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5324483B1 (en) 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5534328A (en) 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
BR9405989A (pt) 1993-03-19 1995-12-26 Du Pont Estruturas integrais para manufatura e processamento químico processo de preparação de uma estrutura integral aparelho e método de processamento químico e de manufatura
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5595712A (en) 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
US5611214A (en) 1994-07-29 1997-03-18 Battelle Memorial Institute Microcomponent sheet architecture
US5811062A (en) 1994-07-29 1998-09-22 Battelle Memorial Institute Microcomponent chemical process sheet architecture
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6004617A (en) 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6030917A (en) 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
DE4438785C2 (de) 1994-10-24 1996-11-07 Wita Gmbh Wittmann Inst Of Tec Mikrochemische Reaktions- und Analyseeinheit
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5846396A (en) * 1994-11-10 1998-12-08 Sarnoff Corporation Liquid distribution system
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5658537A (en) 1995-07-18 1997-08-19 Basf Corporation Plate-type chemical reactor
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5750906A (en) 1995-11-02 1998-05-12 Chiron Diagnostics Corporation Multifunction valve
US6063633A (en) 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
CA2198433A1 (en) 1996-03-22 1997-09-23 Sheila Helen Hobbs Dewitt Information management system for automated multiple simultaneous synthesis
US6033544A (en) * 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
CA2258489C (en) 1996-06-28 2004-01-27 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
JPH11514012A (ja) 1996-07-23 1999-11-30 サイミックス・テクノロジーズ 有機金属化合物及び触媒の組み合わせ合成並びに分析
DE19632779A1 (de) 1996-08-15 1998-02-19 Hoechst Ag Verfahren und Vorrichtung zum Untersuchen von chemischen Reaktionen in parallel geschalteten, miniaturisierten Reaktoren
US5866342A (en) 1996-09-27 1999-02-02 Glaxo Group Limited Systems and methods for the synthesis of organic compounds
US5865417A (en) 1996-09-27 1999-02-02 Redwood Microsystems, Inc. Integrated electrically operable normally closed valve
CA2267897C (en) 1996-10-09 2005-12-06 Symyx Technologies Infrared spectroscopy and imaging of libraries
DE19642261A1 (de) 1996-10-11 1998-04-16 Hoechst Ag Verfahren und Vorrichtung zum Erkennen der katalytischen Aktivität von Feststoffen
US5927325A (en) 1996-10-25 1999-07-27 Inpod, Inc. Microelectromechanical machined array valve
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
US5780748A (en) 1997-01-29 1998-07-14 Hewlett-Packard Company Flow device having parallel flow surfaces which move toward and away from one another to adjust the flow channel in proportion to applied force
US5865147A (en) 1997-03-25 1999-02-02 Rubin; Ellice L. Animal exercise toy containing animal meal
EP0981710A4 (de) 1997-05-21 2003-08-13 Redwood Microsystems Inc Thermopneumatisches mikroventil mit gerigem energieverbrauch
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DE19805719A1 (de) 1998-02-12 1999-08-19 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
DE19855894A1 (de) 1998-12-03 2000-06-08 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
DE19806848A1 (de) 1998-02-18 1999-08-19 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
JP2002502697A (ja) 1998-02-12 2002-01-29 ビーエーエスエフ アクチェンゲゼルシャフト 不均一系触媒のコンビナトリアル製造法および評価法
DE19809477C2 (de) 1998-03-06 2002-04-11 Hte Ag High Throughput Experim Anordnung zum Testen der katalytischen Aktivität von einem Reaktionsgas ausgesetzten Feststoffen
US6087181A (en) 1998-03-16 2000-07-11 Symyx Technologies Sampling and detection of trace gas species by optical spectroscopy
US6054047A (en) * 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
US6175409B1 (en) 1999-04-02 2001-01-16 Symyx Technologies, Inc. Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers
US6149882A (en) * 1998-06-09 2000-11-21 Symyx Technologies, Inc. Parallel fixed bed reactor and fluid contacting apparatus
US6306658B1 (en) 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
US6410332B1 (en) 1998-09-08 2002-06-25 Symyx Technologies, Inc. Sampling and analysis of reactions by trapping reaction components on a sorbent
AU6255299A (en) 1998-09-18 2000-04-10 Symyx Technologies, Inc. Formation of combinatorial arrays of materials using solution-based methodologies
US20020042140A1 (en) 1999-03-03 2002-04-11 Alfred Hagemeyer Methods for analysis of heterogeneous catalysts in a multi-variable screening reactor
WO2000051720A2 (en) 1999-03-03 2000-09-08 Symyx Technologies, Inc. Chemical processing microsystems and methods for preparing and using same
US7150994B2 (en) 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
EP1200185A2 (de) 1999-06-25 2002-05-02 Avantium International B.V. Reaktionsbehälterreihe
ATE287291T1 (de) 2000-03-07 2005-02-15 Symyx Technologies Inc Prozessoptimierungsreaktor mit parallelem durchfluss
US6701774B2 (en) 2000-08-02 2004-03-09 Symyx Technologies, Inc. Parallel gas chromatograph with microdetector array

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DE60108482T2 (de) 2006-02-16
WO2001066245A3 (en) 2002-04-25
DE60108482D1 (de) 2005-02-24
EP1265700A2 (de) 2002-12-18
US20020045265A1 (en) 2002-04-18
AU2001240104A1 (en) 2001-09-17
US7122156B2 (en) 2006-10-17
WO2001066245A2 (en) 2001-09-13

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