ATE287413T1 - Verfahren zur herstellung des lna phosphoramidite - Google Patents

Verfahren zur herstellung des lna phosphoramidite

Info

Publication number
ATE287413T1
ATE287413T1 AT02764561T AT02764561T ATE287413T1 AT E287413 T1 ATE287413 T1 AT E287413T1 AT 02764561 T AT02764561 T AT 02764561T AT 02764561 T AT02764561 T AT 02764561T AT E287413 T1 ATE287413 T1 AT E287413T1
Authority
AT
Austria
Prior art keywords
producing
cyanoethyl
phosphoramidite
lna
lna phosphoramidite
Prior art date
Application number
AT02764561T
Other languages
English (en)
Inventor
Troels Koch
Christoph Rosenbohm
Daniel Sejer Pedersen
Original Assignee
Santaris Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Application granted granted Critical
Publication of ATE287413T1 publication Critical patent/ATE287413T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Luminescent Compositions (AREA)
  • Saccharide Compounds (AREA)
AT02764561T 2001-07-12 2002-07-12 Verfahren zur herstellung des lna phosphoramidite ATE287413T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101095 2001-07-12
PCT/DK2002/000488 WO2003006475A2 (en) 2001-07-12 2002-07-12 Method for preparation of lna phosphoramidites

Publications (1)

Publication Number Publication Date
ATE287413T1 true ATE287413T1 (de) 2005-02-15

Family

ID=8160624

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02764561T ATE287413T1 (de) 2001-07-12 2002-07-12 Verfahren zur herstellung des lna phosphoramidite

Country Status (7)

Country Link
EP (1) EP1409497B1 (de)
JP (1) JP4402454B2 (de)
AT (1) ATE287413T1 (de)
AU (1) AU2002328792A1 (de)
DE (1) DE60202681T2 (de)
DK (1) DK1409497T3 (de)
WO (1) WO2003006475A2 (de)

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US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
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US8470791B2 (en) 2007-03-22 2013-06-25 Santaris Pharma A/S RNA antagonist compounds for the inhibition of Apo-B100 expression
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US9211537B2 (en) 2007-11-07 2015-12-15 The University Of British Columbia Microfluidic device and method of using same
CA2717792A1 (en) 2008-03-07 2009-09-11 Santaris Pharma A/S Pharmaceutical compositions for treatment of microrna related diseases
WO2010012667A1 (en) 2008-08-01 2010-02-04 Santaris Pharma A/S Micro-rna mediated modulation of colony stimulating factors
ES2599979T3 (es) 2009-04-24 2017-02-06 Roche Innovation Center Copenhagen A/S Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón
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WO2011105901A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 9 (c9) and uses thereof
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WO2014108759A1 (en) 2013-01-14 2014-07-17 Pierfrancesco Tassone INHIBITORS OF miRNAs 221 AND 222 FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA
HUE048738T2 (hu) 2013-06-27 2020-08-28 Roche Innovation Ct Copenhagen As Antiszensz oligomerek és konjugátumok, amelyek a PCK9-t célozzák meg
WO2015075166A1 (en) 2013-11-22 2015-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of a bacterial infection
EP3099798B1 (de) 2014-01-29 2018-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Oligonukleotide und methoden zur inhibierung oder verminderung von bakteriellen biofilmen
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KR102318434B1 (ko) 2017-08-25 2021-11-01 스톡 테라퓨틱스, 인크. 병태 및 질환 치료용 안티센스 올리고머
WO2019076919A1 (en) 2017-10-17 2019-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) COMBINED TREATMENT OF CYSTIC FIBROSIS
CA3099280A1 (en) 2018-05-04 2019-11-07 Stoke Therapeutics, Inc. Methods and compositions for treatment of cholesteryl ester storage disease
AU2020227825B2 (en) 2019-02-27 2026-03-26 Stoke Therapeutics, Inc. Antisense oligomers for treatment of conditions and diseases
EP3997225A1 (de) 2019-07-10 2022-05-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur behandlung von epilepsie
IT201900017234A1 (it) 2019-09-25 2021-03-25 Int Centre For Genetic Engineering And Biotechnology Anti-miRNA per il trattamento del leiomioma
WO2021074657A1 (en) 2019-10-17 2021-04-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination treatment for cystic fibrosis
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CN117280030A (zh) 2021-02-12 2023-12-22 梅兰德制药公司 用于治疗缺氧和缺血相关病症的药剂、组合物和方法
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WO2022254021A1 (en) 2021-06-04 2022-12-08 Neumirna Therapeutics Aps Antisense oligonucleotides targeting adenosine kinase
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JP7772362B2 (ja) * 2021-12-21 2025-11-18 シンクレスト株式会社 人工核酸モノマーの製造方法
WO2023152369A1 (en) 2022-02-14 2023-08-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Nucleic acid mir-9 inhibitor for the treatment of cystic fibrosis
WO2024017990A1 (en) 2022-07-21 2024-01-25 Institut National de la Santé et de la Recherche Médicale Methods and compositions for treating chronic pain disorders
EP4332239A1 (de) 2022-08-30 2024-03-06 Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l. Mir-basierter test zur diagnose und prognose von gastro-entero-pankreatischen neuroendokrinen tumoren
EP4646478A1 (de) 2023-01-06 2025-11-12 Institut National de la Santé et de la Recherche Médicale Intravenöse verabreichung von antisense-oligonukleotiden zur behandlung von schmerzen
EP4450626A1 (de) 2023-04-21 2024-10-23 IFOM - Istituto Fondazione di Oncologia Molecolare ETS Frnip2-inhibitoren zur behandlung von ataxie telangiectasia
WO2025008406A1 (en) 2023-07-04 2025-01-09 Institut National de la Santé et de la Recherche Médicale Antisense oligonucleotides and their use for the treatment of cancer
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Also Published As

Publication number Publication date
DK1409497T3 (da) 2005-05-30
WO2003006475A3 (en) 2004-02-26
AU2002328792A1 (en) 2003-01-29
JP4402454B2 (ja) 2010-01-20
WO2003006475A2 (en) 2003-01-23
DE60202681D1 (de) 2005-02-24
EP1409497A2 (de) 2004-04-21
JP2004536125A (ja) 2004-12-02
DE60202681T2 (de) 2006-01-12
EP1409497B1 (de) 2005-01-19

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