ATE287417T1 - Kombinatorische bibliotheken von substrat- gebundenen zyklischen organischen verbindungen - Google Patents

Kombinatorische bibliotheken von substrat- gebundenen zyklischen organischen verbindungen

Info

Publication number
ATE287417T1
ATE287417T1 AT96916633T AT96916633T ATE287417T1 AT E287417 T1 ATE287417 T1 AT E287417T1 AT 96916633 T AT96916633 T AT 96916633T AT 96916633 T AT96916633 T AT 96916633T AT E287417 T1 ATE287417 T1 AT E287417T1
Authority
AT
Austria
Prior art keywords
compounds
cyclic organic
reacted
libraries
resin
Prior art date
Application number
AT96916633T
Other languages
English (en)
Inventor
Manoj C Desai
John M Nuss
Kerry L Spear
Rajinder Singh
Paul A Renhowe
Edward G Brown
Lutz Richter
Barbara O Scott
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE287417T1 publication Critical patent/ATE287417T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Structural Engineering (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
AT96916633T 1995-06-07 1996-05-23 Kombinatorische bibliotheken von substrat- gebundenen zyklischen organischen verbindungen ATE287417T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/485,006 US5958792A (en) 1995-06-07 1995-06-07 Combinatorial libraries of substrate-bound cyclic organic compounds
PCT/US1996/007684 WO1996040201A1 (en) 1995-06-07 1996-05-23 Combinatorial libraries of substrate-bound cyclic organic compounds

Publications (1)

Publication Number Publication Date
ATE287417T1 true ATE287417T1 (de) 2005-02-15

Family

ID=23926558

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916633T ATE287417T1 (de) 1995-06-07 1996-05-23 Kombinatorische bibliotheken von substrat- gebundenen zyklischen organischen verbindungen

Country Status (10)

Country Link
US (1) US5958792A (de)
EP (1) EP0777492B1 (de)
JP (2) JP2001518053A (de)
KR (1) KR100445564B1 (de)
CN (1) CN1192154A (de)
AT (1) ATE287417T1 (de)
AU (1) AU5932096A (de)
CA (1) CA2221508A1 (de)
DE (1) DE69634191T2 (de)
WO (1) WO1996040201A1 (de)

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AU754599B2 (en) * 1998-08-21 2002-11-21 Applera Corporation Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
US6783929B1 (en) * 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
EP1326892A2 (de) 2000-10-12 2003-07-16 University of Rochester Zusammensetzungen die die proliferation von krebszellen hemmen
FR2818662B1 (fr) * 2000-12-22 2003-09-19 Commissariat Energie Atomique Procede d'immobilisation de sondes, en particulier pour realiser des puces biologiques
ES2300379T3 (es) 2000-12-23 2008-06-16 Novartis Vaccines And Diagnostics, Inc. Procedimiento de deteccion selectiva de transfeccion de oligonucleotidos.
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
GB0229931D0 (en) 2002-12-21 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0314079D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
SE0104334D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
WO2003065997A2 (en) 2002-02-06 2003-08-14 Vicor Technologies, Inc. Anti-infarction molecules
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
EP1539980B1 (de) 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
EP1575992A4 (de) 2002-08-05 2007-02-21 Univ Rochester Chimäre proteine aus proteintransduzierender domäne/deaminase, verwandte verbindungen und deren verwendungen
EP2348124B1 (de) 2002-10-30 2013-12-11 Nuevolution A/S Synthese bifunktioneller Komplexe
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US7244751B2 (en) * 2003-02-14 2007-07-17 Shenzhen Chipscreen Biosciences Ltd. Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
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AU2005332058B2 (en) 2005-05-19 2011-12-01 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Functional epitopes of Streptococcus pneumoniae PsaA antigen and uses thereof
WO2007019410A2 (en) * 2005-08-05 2007-02-15 The Board Of Trustees Of The Leland Stanford Junior University Mammalian obestatin receptors
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2392645A1 (de) 2005-10-14 2011-12-07 MUSC Foundation For Research Development Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
EP2032987B1 (de) 2006-05-22 2016-02-24 The Board of Trustees of The Leland Stanford Junior University Pharmakologische behandlung einer kognitiven beeinträchtigung
WO2008020334A2 (en) 2006-06-22 2008-02-21 Hannah Monyer Serotonin 5-ht3a receptors in treatment of neurological and psychiatric disorders
EP2560001B1 (de) 2006-09-21 2016-04-13 University of Rochester Zusammensetzungen und Verfahren für eine Proteinverlagerungstherapie für myotone Dystrophie
US8999317B2 (en) 2006-11-01 2015-04-07 University Of Rochester Methods and compositions related to the structure and function of APOBEC3G
JP2010514839A (ja) * 2007-01-03 2010-05-06 バーナム インスティテュート フォー メディカル リサーチ クロット結合化合物に関連する方法および組成物
WO2008098182A1 (en) 2007-02-08 2008-08-14 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
WO2009029173A1 (en) * 2007-08-23 2009-03-05 The Board Of Trustees Of The Leland Stanford Junior University Modulation of synaptogenesis
WO2010019963A2 (en) * 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
US20120070443A1 (en) 2008-12-02 2012-03-22 University Of Utah Research Foundation Pde1 as a target therapeutic in heart disease
EP3623374B1 (de) 2008-12-03 2021-09-08 The Scripps Research Institute Stammzellkulturen
WO2011022502A1 (en) 2009-08-18 2011-02-24 Georgetown University Boronic acid compositions and methods related to cancer
US8865901B2 (en) 2009-10-02 2014-10-21 Fred Hutchinson Cancer Research Center Gain-of-function Bcl-2 inhibitors
WO2011041731A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Method of inhibiting bcl-2-related survival proteins
JP2013507365A (ja) 2009-10-07 2013-03-04 サンフォード−バーナム メディカル リサーチ インスティテュート 血餅結合脂質化合物に関する方法および組成物
CA2784145A1 (en) 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
EP3540059A1 (de) 2010-04-16 2019-09-18 Nuevolution A/S Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe
US20130130317A1 (en) 2010-08-02 2013-05-23 Kyowa Hakko Kirin Co., Ltd Method for producing substance
CA2868735C (en) 2011-03-28 2020-02-25 University Of Utah Research Foundation D-peptide conjugates comprising a membrane localizing potency-enhancing cargo molecule for inhibiting hiv entry
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
US12038430B2 (en) 2018-04-27 2024-07-16 The Regents Of The University Of California Methods for high-content drug screening
EP3875595A4 (de) 2018-11-02 2022-07-13 Kyowa Kirin Co., Ltd. Verfahren zur herstellung eines flüssigen mediums
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer

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DE2447305C3 (de) * 1973-10-05 1979-09-13 Miyoshi Yushi K.K., Tokio Verfahren zur Herstellung chelatbildender Polymerisate
DE3586772T2 (de) * 1984-07-24 1993-03-04 Coselco Mimotopes Pty Ltd Verfahren zur bestimmung von mimotopen.
NZ215865A (en) * 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
WO1986006487A1 (en) * 1985-04-22 1986-11-06 Commonwealth Serum Laboratories Commission Method for determining mimotopes
US5266684A (en) * 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5225533A (en) * 1988-05-02 1993-07-06 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
ATE123780T1 (de) * 1989-02-17 1995-06-15 Chiron Mimotopes Pty Ltd Verfahren zur verwendung und herstellung von peptiden.
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Also Published As

Publication number Publication date
US5958792A (en) 1999-09-28
KR19990022719A (ko) 1999-03-25
JP2001518053A (ja) 2001-10-09
EP0777492A1 (de) 1997-06-11
EP0777492A4 (de) 2002-11-27
CA2221508A1 (en) 1996-12-19
DE69634191D1 (de) 2005-03-03
CN1192154A (zh) 1998-09-02
DE69634191T2 (de) 2006-01-05
WO1996040201A1 (en) 1996-12-19
KR100445564B1 (ko) 2004-11-16
JP2008050360A (ja) 2008-03-06
EP0777492B1 (de) 2005-01-19
AU5932096A (en) 1996-12-30

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