ATE527542T1 - Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie - Google Patents

Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie

Info

Publication number
ATE527542T1
ATE527542T1 AT06751892T AT06751892T ATE527542T1 AT E527542 T1 ATE527542 T1 AT E527542T1 AT 06751892 T AT06751892 T AT 06751892T AT 06751892 T AT06751892 T AT 06751892T AT E527542 T1 ATE527542 T1 AT E527542T1
Authority
AT
Austria
Prior art keywords
imaging probe
candidate
library
click chemistry
identifying
Prior art date
Application number
AT06751892T
Other languages
English (en)
Inventor
Hartmuth Kolb
Vani Mocharla
Joseph Walsh
Original Assignee
Siemens Medical Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions filed Critical Siemens Medical Solutions
Application granted granted Critical
Publication of ATE527542T1 publication Critical patent/ATE527542T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT06751892T 2005-04-27 2006-04-27 Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie ATE527542T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67529005P 2005-04-27 2005-04-27
PCT/US2006/016428 WO2006116736A2 (en) 2005-04-27 2006-04-27 A method for the preparation of imaging probes using click chemistry

Publications (1)

Publication Number Publication Date
ATE527542T1 true ATE527542T1 (de) 2011-10-15

Family

ID=36954603

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06751892T ATE527542T1 (de) 2005-04-27 2006-04-27 Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie

Country Status (9)

Country Link
US (1) US20060269942A1 (de)
EP (1) EP1875239B1 (de)
JP (1) JP4790012B2 (de)
KR (1) KR100973156B1 (de)
AT (1) ATE527542T1 (de)
CA (1) CA2606477C (de)
DK (1) DK1875239T3 (de)
ES (1) ES2375495T3 (de)
WO (1) WO2006116736A2 (de)

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US8158590B2 (en) 2005-08-05 2012-04-17 Syntarga B.V. Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
US20090239760A1 (en) 2006-03-14 2009-09-24 University Of Basel Method for the Identification of New Leads for Drug Candidates
US20100022481A1 (en) * 2006-08-02 2010-01-28 Dong Wang Drug Carriers, Their Synthesis, and Methods of Use Thereof
KR20120003499A (ko) * 2007-04-05 2012-01-10 지멘스 메디컬 솔루션즈 유에스에이, 인크. 클릭 화학을 이용한 탄산탈수효소―ⅰⅹ에 대한 분자 영상화 프로브의 제조
US8562945B2 (en) 2008-01-09 2013-10-22 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
RU2498798C2 (ru) 2008-01-09 2013-11-20 Моликьюлар Инсайт Фармасьютикалз, Инк. Ингибиторы карбоангидразы iх
WO2009105746A2 (en) * 2008-02-22 2009-08-27 University Of South Florida Triazoles and processes for producing the same
CN102159949B (zh) * 2008-06-18 2015-03-04 加州理工学院 多配位体捕获剂及相关组合物,方法和系统
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
US8900549B2 (en) 2008-10-31 2014-12-02 The General Hospital Corporation Compositions and methods for delivering a substance to a biological target
EP2400992B1 (de) 2009-02-27 2015-07-22 Genentech, Inc. Verfahren und zusammensetzungen zur kennzeichnung von proteinen
JP2012521988A (ja) 2009-03-23 2012-09-20 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド 神経学的障害を検知するためのイメージング剤
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
AU2010260195B2 (en) 2009-06-15 2014-11-20 Molecular Insight Pharmaceuticals, Inc. Process for production of heterodimers of glutamic acid
CN106519588B (zh) * 2009-11-09 2019-08-20 华盛顿大学商业化中心 官能化发色聚合物点及其生物共轭体
WO2012074840A2 (en) 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
EP2681196B1 (de) * 2011-03-04 2015-09-09 Life Technologies Corporation Verbindungen und verfahren zur konjugation von biomolekülen
US9289516B2 (en) 2011-03-09 2016-03-22 The General Hospital Corporation Imaging beta cell mass
US10796494B2 (en) 2011-06-06 2020-10-06 Microsoft Technology Licensing, Llc Adding attributes to virtual representations of real-world objects
EP2800471A4 (de) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc Metallkomplexe von poly(carboxyl)aminhaltigen liganden mit einer affinität für carboanhydrase ix
EP2888253A4 (de) * 2012-08-24 2016-01-06 Univ Texas Heterocyclische hif-aktivitätsmodulatoren zur behandlung von krankheiten
BR112015003729A2 (pt) 2012-08-24 2018-06-05 Univ Texas composto de fórmula estrutural i; composição farmacêutica; método de tratamento de uma doença mediada por caminho do hif; método de tratamento de uma doença causada por proliferação anormal de células; e método para alcançar um efeito em um paciente
WO2014065860A1 (en) 2012-10-24 2014-05-01 The General Hospital Corporation Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
EP3939972A1 (de) 2013-01-14 2022-01-19 Molecular Insight Pharmaceuticals, Inc. Triazinbasierte radiopharmazeutika und strahlungsbildgebungsmittel
WO2014182704A2 (en) 2013-05-06 2014-11-13 The General Hospital Corporation Bioorthogonal turn-on probes
US9663504B2 (en) 2014-02-25 2017-05-30 Board Of Regents, The University Of Texas System Salts of heterocyclic modulators of HIF activity for treatment of disease
US10731202B2 (en) 2014-11-24 2020-08-04 Battelle Memorial Institute Chromatin activity precipitation method and system
CA3117914A1 (en) * 2018-10-24 2020-04-30 Apa- Advanced Technologies Ltd. Fusogenic liposomes for selective imaging of tumor cells
CN112176418B (zh) * 2019-07-05 2024-11-29 中宏鑫投资控股(深圳)有限公司 高通量的化合物库构建和筛选方法以及反应装置

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EP1110945A3 (de) * 1995-05-01 2003-05-07 University Of Pittsburgh Azoverbindungen für die Antemortem-Diagnose von Alzheimer und die in vivo Abbildung und Prävention von Amyloidenablagerung
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JP4638225B2 (ja) * 2002-05-30 2011-02-23 ザ スクリプス リサーチ インスティテュート 銅を触媒とするアジドとアセチレンのライゲーション
ATE354096T1 (de) 2002-12-23 2007-03-15 Astex Therapeutics Ltd Synthese und screening von liganden mit hilfe von röntgenkristallographie
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Also Published As

Publication number Publication date
EP1875239A2 (de) 2008-01-09
EP1875239B1 (de) 2011-10-05
JP4790012B2 (ja) 2011-10-12
DK1875239T3 (da) 2012-01-23
ES2375495T3 (es) 2012-03-01
KR20080003441A (ko) 2008-01-07
KR100973156B1 (ko) 2010-07-30
CA2606477C (en) 2013-05-28
WO2006116736A2 (en) 2006-11-02
CA2606477A1 (en) 2006-11-02
WO2006116736A3 (en) 2007-02-01
US20060269942A1 (en) 2006-11-30
JP2008541014A (ja) 2008-11-20

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