ATE527542T1 - Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie - Google Patents

Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie

Info

Publication number
ATE527542T1
ATE527542T1 AT06751892T AT06751892T ATE527542T1 AT E527542 T1 ATE527542 T1 AT E527542T1 AT 06751892 T AT06751892 T AT 06751892T AT 06751892 T AT06751892 T AT 06751892T AT E527542 T1 ATE527542 T1 AT E527542T1
Authority
AT
Austria
Prior art keywords
imaging probe
candidate
library
click chemistry
identifying
Prior art date
Application number
AT06751892T
Other languages
English (en)
Inventor
Hartmuth Kolb
Vani Mocharla
Joseph Walsh
Original Assignee
Siemens Medical Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions filed Critical Siemens Medical Solutions
Application granted granted Critical
Publication of ATE527542T1 publication Critical patent/ATE527542T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT06751892T 2005-04-27 2006-04-27 Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie ATE527542T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67529005P 2005-04-27 2005-04-27
PCT/US2006/016428 WO2006116736A2 (en) 2005-04-27 2006-04-27 A method for the preparation of imaging probes using click chemistry

Publications (1)

Publication Number Publication Date
ATE527542T1 true ATE527542T1 (de) 2011-10-15

Family

ID=36954603

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06751892T ATE527542T1 (de) 2005-04-27 2006-04-27 Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie

Country Status (9)

Country Link
US (1) US20060269942A1 (de)
EP (1) EP1875239B1 (de)
JP (1) JP4790012B2 (de)
KR (1) KR100973156B1 (de)
AT (1) ATE527542T1 (de)
CA (1) CA2606477C (de)
DK (1) DK1875239T3 (de)
ES (1) ES2375495T3 (de)
WO (1) WO2006116736A2 (de)

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US8071718B2 (en) 2004-12-22 2011-12-06 General Electric Company Selective radiolabeling of biomolecules
US8158590B2 (en) 2005-08-05 2012-04-17 Syntarga B.V. Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
WO2007105094A1 (en) 2006-03-14 2007-09-20 Universität Basel Method for the identification of new leads for drug candidates
US20100022481A1 (en) * 2006-08-02 2010-01-28 Dong Wang Drug Carriers, Their Synthesis, and Methods of Use Thereof
CA2683434A1 (en) * 2007-04-05 2008-10-16 Siemens Medical Solutions Usa, Inc. Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry
AU2009204133B2 (en) * 2008-01-09 2014-04-10 Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase IX
US8562945B2 (en) 2008-01-09 2013-10-22 Molecular Insight Pharmaceuticals, Inc. Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
WO2009105746A2 (en) * 2008-02-22 2009-08-27 University Of South Florida Triazoles and processes for producing the same
AU2009259987B2 (en) * 2008-06-18 2015-08-27 California Institute Of Technology Multi-ligand capture agents and related compositions, methods and systems
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
WO2010051530A2 (en) 2008-10-31 2010-05-06 The General Hospital Corporation Compositions and methods for delivering a substance to a biological target
SG173812A1 (en) 2009-02-27 2011-09-29 Genentech Inc Methods and compositions for protein labelling
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
EP2411057B1 (de) 2009-03-23 2020-05-06 Eli Lilly and Company Bildgebungsmittel zum nachweis von neurologischen erkrankungen
BR112012000209B8 (pt) 2009-06-15 2021-07-27 Molecular Insight Pharm Inc heterodímeros de ácido glutâmico e seus processos de preparação
CN102791827B (zh) * 2009-11-09 2016-11-16 华盛顿大学商业化中心 官能化发色聚合物点及其生物共轭体
WO2012074840A2 (en) 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
EP2681196B1 (de) * 2011-03-04 2015-09-09 Life Technologies Corporation Verbindungen und verfahren zur konjugation von biomolekülen
WO2012121746A2 (en) 2011-03-09 2012-09-13 The General Hospital Corporation Imaging beta cell mass
US10796494B2 (en) 2011-06-06 2020-10-06 Microsoft Technology Licensing, Llc Adding attributes to virtual representations of real-world objects
EP2800471A4 (de) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc Metallkomplexe von poly(carboxyl)aminhaltigen liganden mit einer affinität für carboanhydrase ix
WO2014031933A2 (en) * 2012-08-24 2014-02-27 Philip Jones Heterocyclic modulators of hif activity for treatment of disease
US9018380B2 (en) 2012-08-24 2015-04-28 Boar of Regents, The University of Texas System Heterocyclic modulators of HIF activity for treatment of disease
WO2014065860A1 (en) 2012-10-24 2014-05-01 The General Hospital Corporation Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
CA2897437C (en) 2013-01-14 2021-12-14 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents
US10517965B2 (en) 2013-05-06 2019-12-31 The General Hospital Corporation Bioorthogonal turn-on probes
US9663504B2 (en) 2014-02-25 2017-05-30 Board Of Regents, The University Of Texas System Salts of heterocyclic modulators of HIF activity for treatment of disease
WO2016085659A1 (en) * 2014-11-24 2016-06-02 Battelle Memorial Institute Chromatin activity precipitation method and system
CA3117914A1 (en) * 2018-10-24 2020-04-30 Apa- Advanced Technologies Ltd. Fusogenic liposomes for selective imaging of tumor cells
CN112176418B (zh) * 2019-07-05 2024-11-29 中宏鑫投资控股(深圳)有限公司 高通量的化合物库构建和筛选方法以及反应装置

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DE3424525A1 (de) * 1984-07-04 1986-01-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
US5519931A (en) * 1994-03-16 1996-05-28 Syncor International Corporation Container and method for transporting a syringe containing radioactive material
CA2219880A1 (en) * 1995-05-01 1996-11-07 University Of Pittsburgh Azocompounds for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6210655B1 (en) * 1997-06-18 2001-04-03 University Of Medicine & Dentistry Of Nj Site-specific 13C-enriched reagents for diagnostic medicine by magnetic resonance imaging
US6558903B1 (en) * 1999-06-30 2003-05-06 Millennium Pharmaceuticals, Inc. Kinases and uses thereof
US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
US6808308B2 (en) * 2001-05-25 2004-10-26 Scanwell Systems Removable shielding for use during neurological examinations on a whole body pet scanner
JP2005534286A (ja) * 2002-03-21 2005-11-17 サネシス ファーマシューティカルズ， インコーポレイテッド キナーゼインヒビターの同定
WO2003101972A1 (en) * 2002-05-30 2003-12-11 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
US7149280B2 (en) 2002-12-23 2006-12-12 Astex Therapeutics Limited Synthesis and screening of ligands using X-ray crystallography
US20060067879A1 (en) * 2004-09-27 2006-03-30 Schuller Hildegard M Diagnosis of diseases associated with COX-2 expression

Also Published As

Publication number Publication date
WO2006116736A2 (en) 2006-11-02
CA2606477C (en) 2013-05-28
ES2375495T3 (es) 2012-03-01
EP1875239A2 (de) 2008-01-09
JP4790012B2 (ja) 2011-10-12
DK1875239T3 (da) 2012-01-23
WO2006116736A3 (en) 2007-02-01
JP2008541014A (ja) 2008-11-20
EP1875239B1 (de) 2011-10-05
CA2606477A1 (en) 2006-11-02
KR20080003441A (ko) 2008-01-07
KR100973156B1 (ko) 2010-07-30
US20060269942A1 (en) 2006-11-30

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