ATE287873T1 - Vitamin d3-derivate - Google Patents

Vitamin d3-derivate

Info

Publication number: ATE287873T1
Authority: AT; Austria
Prior art keywords: hydroxy; ethylene; formula; ortho; para
Prior art date: 1996-12-04

Application number

AT97945802T

Other languages

English (en)

Inventor

Daehne Welf Von

Original Assignee

Leo Pharma As With Secondary N

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-04

Filing date

1997-11-28

Publication date

2005-02-15

1997-11-28 Application filed by Leo Pharma As With Secondary N filed Critical Leo Pharma As With Secondary N

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE287873T1 publication Critical patent/ATE287873T1/de

Links

150000003704 vitamin D3 derivatives Chemical class 0.000 title 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 2
239000005977 Ethylene Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Cardiology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97945802T 1996-12-04 1997-11-28 Vitamin d3-derivate ATE287873T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9625271.3A GB9625271D0 (en)	1996-12-04	1996-12-04	Chemical compounds
PCT/DK1997/000546 WO1998024762A1 (en)	1996-12-04	1997-11-28	Vitamin d3 derivatives

Publications (1)

Publication Number	Publication Date
ATE287873T1 true ATE287873T1 (de)	2005-02-15

Family

ID=10803970

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97945802T ATE287873T1 (de)	1996-12-04	1997-11-28	Vitamin d3-derivate

Country Status (18)

Country	Link
US (1)	US20020103172A1 (de)
EP (1)	EP0944592B1 (de)
JP (1)	JP2001506610A (de)
KR (1)	KR20000057417A (de)
CN (1)	CN1129577C (de)
AT (1)	ATE287873T1 (de)
AU (1)	AU719081B2 (de)
CA (1)	CA2272148A1 (de)
CZ (1)	CZ198399A3 (de)
DE (1)	DE69732369T2 (de)
ES (1)	ES2236830T3 (de)
GB (1)	GB9625271D0 (de)
HU (1)	HUP9904603A3 (de)
NZ (1)	NZ335862A (de)
PL (1)	PL189092B1 (de)
PT (1)	PT944592E (de)
RU (1)	RU2175318C2 (de)
WO (1)	WO1998024762A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20110104186A1 (en)	2004-06-24	2011-05-05	Nicholas Valiante	Small molecule immunopotentiators and assays for their detection
ATE469883T1 (de)	2004-11-22	2010-06-15	Wisconsin Alumni Res Found	2-methylen-19-nor-1alpha-hydroxy-17- enhormopregnacalziferol und anwendungen davon
US7893043B2 (en)	2008-07-10	2011-02-22	Wisconsin Alumni Research Foundation	2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
US7888339B2 (en)	2008-07-10	2011-02-15	Wisconsin Alumni Research Foundation	2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US8222236B2 (en)	2008-07-10	2012-07-17	Wisconsin Alumni Research Foundation	2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
CN102210828B (zh) *	2011-06-03	2012-07-25	祖冲	治疗牛皮癣的中药胶囊
JP2018513849A (ja)	2015-03-16	2018-05-31	ザトラスティーズオブザユニバーシティオブペンシルバニア	対象における全身性免疫応答を抑制または低減するための組成物および方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5087619A (en) *	1988-01-20	1992-02-11	Hoffman-La Roche Inc.	Vitamin D3 analogs
DK0398217T3 (da) *	1989-05-18	1994-02-14	Hoffmann La Roche	Dehydrocholecalciferolderivater
ATE141914T1 (de) *	1992-05-20	1996-09-15	Hoffmann La Roche	Fluorierte analoge vitamins d3
US5401733A (en) *	1993-10-01	1995-03-28	Hoffmann-La Roche Inc.	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
TW403735B (en) *	1995-11-22	2000-09-01	Hoffmann La Roche	25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) *	1996-03-21	1999-08-12	F. Hoffmann-La Roche Ag	1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives

1996
- 1996-12-04 GB GBGB9625271.3A patent/GB9625271D0/en active Pending
1997
- 1997-11-28 CN CN97180993A patent/CN1129577C/zh not_active Expired - Fee Related
- 1997-11-28 AU AU51171/98A patent/AU719081B2/en not_active Ceased
- 1997-11-28 CA CA002272148A patent/CA2272148A1/en not_active Abandoned
- 1997-11-28 DE DE69732369T patent/DE69732369T2/de not_active Expired - Fee Related
- 1997-11-28 WO PCT/DK1997/000546 patent/WO1998024762A1/en not_active Ceased
- 1997-11-28 CZ CZ991983A patent/CZ198399A3/cs unknown
- 1997-11-28 PT PT97945802T patent/PT944592E/pt unknown
- 1997-11-28 ES ES97945802T patent/ES2236830T3/es not_active Expired - Lifetime
- 1997-11-28 AT AT97945802T patent/ATE287873T1/de not_active IP Right Cessation
- 1997-11-28 RU RU99114858/04A patent/RU2175318C2/ru not_active IP Right Cessation
- 1997-11-28 KR KR1019990704988A patent/KR20000057417A/ko not_active Ceased
- 1997-11-28 US US09/319,784 patent/US20020103172A1/en not_active Abandoned
- 1997-11-28 JP JP52508298A patent/JP2001506610A/ja not_active Ceased
- 1997-11-28 NZ NZ335862A patent/NZ335862A/xx unknown
- 1997-11-28 EP EP97945802A patent/EP0944592B1/de not_active Expired - Lifetime
- 1997-11-28 HU HU9904603A patent/HUP9904603A3/hu unknown
- 1997-11-28 PL PL97333794A patent/PL189092B1/pl not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU5117198A (en)	1998-06-29
HK1023991A1 (en)	2000-09-29
WO1998024762A1 (en)	1998-06-11
HUP9904603A2 (hu)	2000-06-28
EP0944592B1 (de)	2005-01-26
CZ198399A3 (cs)	1999-10-13
HUP9904603A3 (en)	2000-09-28
RU2175318C2 (ru)	2001-10-27
PT944592E (pt)	2005-04-29
US20020103172A1 (en)	2002-08-01
DE69732369T2 (de)	2006-05-11
CN1129577C (zh)	2003-12-03
CA2272148A1 (en)	1998-06-11
NZ335862A (en)	2000-11-24
KR20000057417A (ko)	2000-09-15
PL189092B1 (pl)	2005-06-30
EP0944592A1 (de)	1999-09-29
ES2236830T3 (es)	2005-07-16
JP2001506610A (ja)	2001-05-22
DE69732369D1 (de)	2005-03-03
AU719081B2 (en)	2000-05-04
CN1241999A (zh)	2000-01-19
GB9625271D0 (en)	1997-01-22

Legal Events

Date	Code	Title	Description
2005-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
EP0648207A1 (de)	1995-04-19	Vitamin d derivate.
NO930193L (no)	1993-07-23	Biarylsubstituerte 4-aminosmoersyreamider
FI956108A0 (fi)	1995-12-19	Uudet D-vitamiinianalogit
DK1449511T3 (da)	2007-02-05	Anvendelse af idebenon til beskyttelse af præparater
CA2251991A1 (en)	1997-11-06	Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
DE69732369D1 (de)	2005-03-03	Vitamin d3-derivate
GR3022768T3 (en)	1997-06-30	Novel vitamin d analogues.
ATE216361T1 (de)	2002-05-15	Vitamin d derivate
IL127542A0 (en)	1999-10-28	Administration regimen of H+ K+ -ATPase inhibitors
IE42409L (en)	1976-09-18	Acetylene derivatives of aminoacids.
NZ332237A (en)	2000-07-28	Vitamin D analogues
EP0662953A1 (de)	1995-07-19	Neue vitamin d derivate.
GR3034198T3 (en)	2000-11-30	Vitamin d analogues
IL125628A0 (en)	1999-04-11	Benzo[c] quinolizine derivatives their preparation and use as 5alpha-reductase inhibitors
OHTA et al.	1998	Potent retinoid synergists with a diphenylamine skeleton
IT1254996B (it)	1995-10-11	Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione
GB1433308A (en)	1976-04-28	Acetamidophenyl esters of salicylic acid derivatives
NZ510439A (en)	2002-09-27	N-alkylaspartyldipeptide ester derivatives used as food sweeteners
IS5623A (is)	2000-09-11	Ný efnasambönd
CA2227938A1 (en)	1997-10-16	Novel vitamin d analogues