ATE287883T1 - Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten - Google Patents

Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten

Info

Publication number: ATE287883T1
Authority: AT; Austria
Prior art keywords: diazepine; benzo; dihydro; derivatives; mglur2 antagonists
Prior art date: 2001-04-12

Application number

AT02735209T

Other languages

English (en)

Inventor

Geo Adam

Erwin Goetschi

Vincent Mutel

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-02

Publication date

2005-02-15

2002-04-02 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE287883T1 publication Critical patent/ATE287883T1/de

Links

101150016175 Grm2 gene Proteins 0.000 title 1
102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02735209T 2001-04-12 2002-04-02 Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten ATE287883T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01109126		2001-04-12
PCT/EP2002/003643 WO2002083665A1 (en)	2001-04-12	2002-04-02	DIHYDRO-BENZO[b][1,4]DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I

Publications (1)

Publication Number	Publication Date
ATE287883T1 true ATE287883T1 (de)	2005-02-15

Family

ID=8177127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02735209T ATE287883T1 (de)	2001-04-12	2002-04-02	Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten

Country Status (37)

Country	Link
US (1)	US6548495B2 (de)
EP (1)	EP1379522B1 (de)
JP (1)	JP4043953B2 (de)
KR (1)	KR100566178B1 (de)
CN (1)	CN1268626C (de)
AR (1)	AR035456A1 (de)
AT (1)	ATE287883T1 (de)
AU (1)	AU2002310912B2 (de)
BG (1)	BG108253A (de)
BR (1)	BR0208887A (de)
CA (1)	CA2441771C (de)
CZ (1)	CZ20033002A3 (de)
DE (1)	DE60202761T2 (de)
DK (1)	DK1379522T3 (de)
EC (1)	ECSP034796A (de)
ES (1)	ES2235044T3 (de)
GT (1)	GT200200072A (de)
HR (1)	HRP20030791B1 (de)
HU (1)	HUP0400991A3 (de)
IL (2)	IL158021A0 (de)
JO (1)	JO2273B1 (de)
MA (1)	MA27011A1 (de)
MX (1)	MXPA03009317A (de)
MY (1)	MY130369A (de)
NO (1)	NO325300B1 (de)
NZ (1)	NZ528345A (de)
PA (1)	PA8543201A1 (de)
PE (1)	PE20021072A1 (de)
PL (1)	PL367086A1 (de)
PT (1)	PT1379522E (de)
RU (1)	RU2270197C2 (de)
SI (1)	SI1379522T1 (de)
SK (1)	SK13692003A3 (de)
UY (1)	UY27259A1 (de)
WO (1)	WO2002083665A1 (de)
YU (1)	YU79103A (de)
ZA (1)	ZA200307242B (de)

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ATE261945T1 (de)	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
ES2293287T3 (es) *	2003-07-25	2008-03-16	F. Hoffmann-La Roche Ag	Combinacion de antagonista de mglur2 y de inhibidor de ache para el tratamiento de trastornos neurologicos agudos y/o cronicos.
ES2309814T3 (es)	2004-11-05	2008-12-16	F. Hoffmann-La Roche Ag	Proceso para la obtencion de derivados del acido isonicotinico.
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
ES2369866T3 (es) *	2007-04-19	2011-12-07	F. Hoffmann-La Roche Ag	Derivados de dihidro-benzo[b][1,4]diazepin-2-ona-sulfonamida.
PL2200985T3 (pl)	2007-09-14	2011-12-30	Ortho Mcneil Janssen Pharmaceuticals Inc	1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony
CN101801930B (zh) *	2007-09-14	2013-01-30	奥梅-杨森制药有限公司	1,3-二取代的-4-苯基-1h-吡啶-2-酮
SI2203439T1 (sl)	2007-09-14	2011-05-31	Ortho Mcneil Janssen Pharm	1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
CN101861316B (zh)	2007-11-14	2013-08-21	奥梅-杨森制药有限公司	咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2344470B1 (de)	2008-09-02	2013-11-06	Janssen Pharmaceuticals, Inc.	3-azabicyclo[3.1.0]hexylderivate als modulatoren von metabotropen glutamatrezeptoren
WO2010043396A1 (en)	2008-10-16	2010-04-22	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
JP5690277B2 (ja)	2008-11-28	2015-03-25	ジャンセンファーマシューティカルズ，インコーポレイテッド．	代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BRPI1010831A2 (pt)	2009-05-12	2016-04-05	Addex Pharmaceuticals Sa	derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
US9271967B2 (en)	2010-11-08	2016-03-01	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
ES2536433T3 (es)	2010-11-08	2015-05-25	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
AU2011328203B2 (en)	2010-11-08	2015-03-19	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
EP2602248A1 (de)	2011-12-05	2013-06-12	University Of Leicester	Neue Pyrrol Verbindungen
CN104736140A (zh)	2012-10-23	2015-06-24	霍夫曼-拉罗奇有限公司	用于治疗自闭症的mGlu2/3拮抗剂
JP5654715B1 (ja) *	2013-02-28	2015-01-14	エーザイ・アール・アンド・ディー・マネジメント株式会社	テトラヒドロイミダゾ［１，５−ｄ］［１，４］オキサゼピン誘導体（ＴＥＴＲＡＨＹＤＲＯＩＭＩＤＡＺＯ［１，５−ｄ］［１，４］ＯＸＡＺＥＰＩＮＥＤＥＲＩＶＡＴＩＶＥ）
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
MX386697B (es)	2014-01-21	2025-03-19	Janssen Pharmaceutica Nv	Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso
ME03518B (de)	2014-01-21	2020-04-20	Janssen Pharmaceutica Nv	Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung
JP2017513844A (ja)	2014-04-23	2017-06-01	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	知的障害の処置のためのｍＧｌｕ２／３アンタゴニスト
WO2015191630A1 (en) *	2014-06-10	2015-12-17	Sanford-Burnham Medical Research Institute	Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof

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MXPA02001340A (es) *	1999-08-05	2004-07-16	Prescient Neuropharma Inc	Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos.
BR0014859A (pt) *	1999-10-15	2002-07-16	Hoffmann La Roche	Derivados de benzodiazepina
ATE261945T1 (de) *	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten

2002
- 2002-04-02 BR BR0208887-8A patent/BR0208887A/pt active Search and Examination
- 2002-04-02 SK SK1369-2003A patent/SK13692003A3/sk unknown
- 2002-04-02 RU RU2003130648/04A patent/RU2270197C2/ru not_active IP Right Cessation
- 2002-04-02 NZ NZ528345A patent/NZ528345A/en unknown
- 2002-04-02 HU HU0400991A patent/HUP0400991A3/hu not_active Application Discontinuation
- 2002-04-02 AT AT02735209T patent/ATE287883T1/de active
- 2002-04-02 HR HR20030791A patent/HRP20030791B1/xx not_active IP Right Cessation
- 2002-04-02 CZ CZ20033002A patent/CZ20033002A3/cs unknown
- 2002-04-02 YU YU79103A patent/YU79103A/sh unknown
- 2002-04-02 PL PL02367086A patent/PL367086A1/xx not_active Application Discontinuation
- 2002-04-02 SI SI200230075T patent/SI1379522T1/xx unknown
- 2002-04-02 KR KR1020037013398A patent/KR100566178B1/ko not_active Expired - Fee Related
- 2002-04-02 JP JP2002581420A patent/JP4043953B2/ja not_active Expired - Fee Related
- 2002-04-02 DE DE60202761T patent/DE60202761T2/de not_active Expired - Lifetime
- 2002-04-02 CA CA002441771A patent/CA2441771C/en not_active Expired - Fee Related
- 2002-04-02 WO PCT/EP2002/003643 patent/WO2002083665A1/en not_active Ceased
- 2002-04-02 EP EP02735209A patent/EP1379522B1/de not_active Expired - Lifetime
- 2002-04-02 AU AU2002310912A patent/AU2002310912B2/en not_active Ceased
- 2002-04-02 PT PT02735209T patent/PT1379522E/pt unknown
- 2002-04-02 ES ES02735209T patent/ES2235044T3/es not_active Expired - Lifetime
- 2002-04-02 DK DK02735209T patent/DK1379522T3/da active
- 2002-04-02 IL IL15802102A patent/IL158021A0/xx unknown
- 2002-04-02 MX MXPA03009317A patent/MXPA03009317A/es active IP Right Grant
- 2002-04-02 CN CNB028078217A patent/CN1268626C/zh not_active Expired - Fee Related
- 2002-04-03 US US10/116,597 patent/US6548495B2/en not_active Expired - Lifetime
- 2002-04-09 PA PA20028543201A patent/PA8543201A1/es unknown
- 2002-04-10 JO JO200233A patent/JO2273B1/en active
- 2002-04-10 AR ARP020101313A patent/AR035456A1/es not_active Application Discontinuation
- 2002-04-10 PE PE2002000299A patent/PE20021072A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200072A patent/GT200200072A/es unknown
- 2002-04-11 UY UY27259A patent/UY27259A1/es not_active Application Discontinuation
- 2002-04-11 MY MYPI20021346A patent/MY130369A/en unknown
2003
- 2003-09-16 ZA ZA200307242A patent/ZA200307242B/en unknown
- 2003-09-18 IL IL158021A patent/IL158021A/en not_active IP Right Cessation
- 2003-10-08 EC EC2003004796A patent/ECSP034796A/es unknown
- 2003-10-08 MA MA27345A patent/MA27011A1/fr unknown
- 2003-10-08 NO NO20034496A patent/NO325300B1/no unknown
- 2003-10-10 BG BG108253A patent/BG108253A/bg unknown

Also Published As

Publication number	Publication date
HK1068339A1 (en)	2005-04-29
EP1379522A1 (de)	2004-01-14
KR100566178B1 (ko)	2006-03-29
UY27259A1 (es)	2002-10-31
SK13692003A3 (sk)	2004-05-04
NO325300B1 (no)	2008-03-25
JO2273B1 (en)	2005-04-07
RU2003130648A (ru)	2005-04-10
MXPA03009317A (es)	2004-02-12
NO20034496L (no)	2003-10-08
AU2002310912B2 (en)	2005-06-16
MA27011A1 (fr)	2004-12-20
HRP20030791A2 (en)	2005-06-30
PL367086A1 (en)	2005-02-21
CA2441771C (en)	2008-12-30
MY130369A (en)	2007-06-29
PE20021072A1 (es)	2002-12-07
US20020198197A1 (en)	2002-12-26
HUP0400991A2 (hu)	2004-08-30
CA2441771A1 (en)	2002-10-24
CN1268626C (zh)	2006-08-09
KR20030088502A (ko)	2003-11-19
ES2235044T3 (es)	2005-07-01
NO20034496D0 (no)	2003-10-08
PT1379522E (pt)	2005-05-31
ECSP034796A (es)	2003-12-01
EP1379522B1 (de)	2005-01-26
PA8543201A1 (es)	2002-10-31
JP4043953B2 (ja)	2008-02-06
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