ATE287883T1 - Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten - Google Patents

Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten

Info

Publication number: ATE287883T1
Authority: AT; Austria
Prior art keywords: diazepine; benzo; dihydro; derivatives; mglur2 antagonists
Prior art date: 2001-04-12

Application number

AT02735209T

Other languages

English (en)

Inventor

Geo Adam

Erwin Goetschi

Vincent Mutel

Juergen Wichmann

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-02

Publication date

2005-02-15

2002-04-02 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE287883T1 publication Critical patent/ATE287883T1/de

Links

101150016175 Grm2 gene Proteins 0.000 title 1
102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02735209T 2001-04-12 2002-04-02 Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten ATE287883T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01109126		2001-04-12
PCT/EP2002/003643 WO2002083665A1 (en)	2001-04-12	2002-04-02	DIHYDRO-BENZO[b][1,4]DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS I

Publications (1)

Publication Number	Publication Date
ATE287883T1 true ATE287883T1 (de)	2005-02-15

Family

ID=8177127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02735209T ATE287883T1 (de)	2001-04-12	2002-04-02	Dihydro-benzo(b)(1,4)diazepin-2-on-derivate als mglur2 antagonisten

Country Status (37)

Country	Link
US (1)	US6548495B2 (de)
EP (1)	EP1379522B1 (de)
JP (1)	JP4043953B2 (de)
KR (1)	KR100566178B1 (de)
CN (1)	CN1268626C (de)
AR (1)	AR035456A1 (de)
AT (1)	ATE287883T1 (de)
AU (1)	AU2002310912B2 (de)
BG (1)	BG108253A (de)
BR (1)	BR0208887A (de)
CA (1)	CA2441771C (de)
CZ (1)	CZ20033002A3 (de)
DE (1)	DE60202761T2 (de)
DK (1)	DK1379522T3 (de)
EC (1)	ECSP034796A (de)
ES (1)	ES2235044T3 (de)
GT (1)	GT200200072A (de)
HR (1)	HRP20030791B1 (de)
HU (1)	HUP0400991A3 (de)
IL (2)	IL158021A0 (de)
JO (1)	JO2273B1 (de)
MA (1)	MA27011A1 (de)
MX (1)	MXPA03009317A (de)
MY (1)	MY130369A (de)
NO (1)	NO325300B1 (de)
NZ (1)	NZ528345A (de)
PA (1)	PA8543201A1 (de)
PE (1)	PE20021072A1 (de)
PL (1)	PL367086A1 (de)
PT (1)	PT1379522E (de)
RU (1)	RU2270197C2 (de)
SI (1)	SI1379522T1 (de)
SK (1)	SK13692003A3 (de)
UY (1)	UY27259A1 (de)
WO (1)	WO2002083665A1 (de)
YU (1)	YU79103A (de)
ZA (1)	ZA200307242B (de)

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ATE261945T1 (de)	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
ATE374030T1 (de) *	2003-07-25	2007-10-15	Hoffmann La Roche	Kombination eines mglur2 antagonists und eines ache inhibitors zur behandlung von akuten und/oder chronischen neurologischen krankheiten
ATE400557T1 (de)	2004-11-05	2008-07-15	Hoffmann La Roche	Verfahren zur herstellung von isonikotinsäurederivaten
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
BRPI0810655A2 (pt)	2007-04-19	2014-11-04	Hoffmann La Roche	Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida
BRPI0817101A2 (pt)	2007-09-14	2017-05-09	Addex Pharmaceuticals Sa	4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
SI2203439T1 (sl)	2007-09-14	2011-05-31	Ortho Mcneil Janssen Pharm	1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
ES2409215T3 (es) *	2007-09-14	2013-06-25	Janssen Pharmaceuticals, Inc.	4-fenil-1H-piridin-2-onas 1-3-disustituidas
ES2637794T3 (es)	2007-11-14	2017-10-17	Janssen Pharmaceuticals, Inc.	Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
ES2439291T3 (es)	2008-09-02	2014-01-22	Janssen Pharmaceuticals, Inc.	Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
CA2738849C (en)	2008-10-16	2016-06-28	Addex Pharma S.A.	Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
ES2401691T3 (es)	2008-11-28	2013-04-23	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato
SG176018A1 (en)	2009-05-12	2011-12-29	Janssen Pharmaceuticals Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2440001T3 (es)	2009-05-12	2014-01-27	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
CA2814998C (en)	2010-11-08	2019-10-29	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (es)	2010-11-08	2015-11-30	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
CN103298809B (zh)	2010-11-08	2016-08-31	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2602248A1 (de)	2011-12-05	2013-06-12	University Of Leicester	Neue Pyrrol Verbindungen
KR20150070187A (ko)	2012-10-23	2015-06-24	에프. 호프만-라 로슈 아게	자폐 장애의 치료를 위한 ｍｇｌｕ２／３ 길항제
PT2963043T (pt) *	2013-02-28	2018-10-09	Eisai R&D Man Co Ltd	Derivado de tetrahidroimidazo[1,5-d][1,4]oxazepina
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US10537573B2 (en)	2014-01-21	2020-01-21	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
IL279202B2 (en)	2014-01-21	2023-09-01	Janssen Pharmaceutica Nv	Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
KR20160143853A (ko)	2014-04-23	2016-12-14	에프. 호프만-라 로슈 아게	지적 장애의 치료를 위한 mglu2/3 길항제
WO2015191630A1 (en) *	2014-06-10	2015-12-17	Sanford-Burnham Medical Research Institute	Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU953819A1 (ru) *	1980-08-25	1991-09-23	Физико-химический институт АН УССР	1-(Гидразинокарбонил)алкил-1,2-дигидро-3Н-1,4-бенздиазепин-2-оны, обладающие транквилизирующими и противосудорожными свойствами
WO2001010846A2 (en) *	1999-08-05	2001-02-15	Igt Pharma Inc.	1,4-diazepine derivatives for the treatment of diseases related to the central nervous system
ATE250039T1 (de) *	1999-10-15	2003-10-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
ATE261945T1 (de) *	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten

2002
- 2002-04-02 NZ NZ528345A patent/NZ528345A/en unknown
- 2002-04-02 JP JP2002581420A patent/JP4043953B2/ja not_active Expired - Fee Related
- 2002-04-02 KR KR1020037013398A patent/KR100566178B1/ko not_active Expired - Fee Related
- 2002-04-02 MX MXPA03009317A patent/MXPA03009317A/es active IP Right Grant
- 2002-04-02 AT AT02735209T patent/ATE287883T1/de active
- 2002-04-02 HU HU0400991A patent/HUP0400991A3/hu not_active Application Discontinuation
- 2002-04-02 AU AU2002310912A patent/AU2002310912B2/en not_active Ceased
- 2002-04-02 DK DK02735209T patent/DK1379522T3/da active
- 2002-04-02 CZ CZ20033002A patent/CZ20033002A3/cs unknown
- 2002-04-02 PT PT02735209T patent/PT1379522E/pt unknown
- 2002-04-02 EP EP02735209A patent/EP1379522B1/de not_active Expired - Lifetime
- 2002-04-02 PL PL02367086A patent/PL367086A1/xx not_active Application Discontinuation
- 2002-04-02 BR BR0208887-8A patent/BR0208887A/pt active Search and Examination
- 2002-04-02 SK SK1369-2003A patent/SK13692003A3/sk unknown
- 2002-04-02 WO PCT/EP2002/003643 patent/WO2002083665A1/en not_active Ceased
- 2002-04-02 ES ES02735209T patent/ES2235044T3/es not_active Expired - Lifetime
- 2002-04-02 CA CA002441771A patent/CA2441771C/en not_active Expired - Fee Related
- 2002-04-02 RU RU2003130648/04A patent/RU2270197C2/ru not_active IP Right Cessation
- 2002-04-02 DE DE60202761T patent/DE60202761T2/de not_active Expired - Lifetime
- 2002-04-02 IL IL15802102A patent/IL158021A0/xx unknown
- 2002-04-02 SI SI200230075T patent/SI1379522T1/xx unknown
- 2002-04-02 YU YU79103A patent/YU79103A/sh unknown
- 2002-04-02 CN CNB028078217A patent/CN1268626C/zh not_active Expired - Fee Related
- 2002-04-02 HR HR20030791A patent/HRP20030791B1/xx not_active IP Right Cessation
- 2002-04-03 US US10/116,597 patent/US6548495B2/en not_active Expired - Lifetime
- 2002-04-09 PA PA20028543201A patent/PA8543201A1/es unknown
- 2002-04-10 AR ARP020101313A patent/AR035456A1/es not_active Application Discontinuation
- 2002-04-10 JO JO200233A patent/JO2273B1/en active
- 2002-04-10 PE PE2002000299A patent/PE20021072A1/es not_active Application Discontinuation
- 2002-04-11 GT GT200200072A patent/GT200200072A/es unknown
- 2002-04-11 UY UY27259A patent/UY27259A1/es not_active Application Discontinuation
- 2002-04-11 MY MYPI20021346A patent/MY130369A/en unknown
2003
- 2003-09-16 ZA ZA200307242A patent/ZA200307242B/en unknown
- 2003-09-18 IL IL158021A patent/IL158021A/en not_active IP Right Cessation
- 2003-10-08 NO NO20034496A patent/NO325300B1/no unknown
- 2003-10-08 EC EC2003004796A patent/ECSP034796A/es unknown
- 2003-10-08 MA MA27345A patent/MA27011A1/fr unknown
- 2003-10-10 BG BG108253A patent/BG108253A/bg unknown

Also Published As

Publication number	Publication date
RU2003130648A (ru)	2005-04-10
PT1379522E (pt)	2005-05-31
ZA200307242B (en)	2004-12-16
HUP0400991A3 (en)	2009-06-29
HRP20030791A2 (en)	2005-06-30
NZ528345A (en)	2005-04-29
ES2235044T3 (es)	2005-07-01
MA27011A1 (fr)	2004-12-20
GT200200072A (es)	2003-06-19
SI1379522T1 (en)	2005-04-30
EP1379522B1 (de)	2005-01-26
HUP0400991A2 (hu)	2004-08-30
WO2002083665A1 (en)	2002-10-24
CN1522252A (zh)	2004-08-18
US20020198197A1 (en)	2002-12-26
NO20034496L (no)	2003-10-08
AU2002310912B2 (en)	2005-06-16
JO2273B1 (en)	2005-04-07
PE20021072A1 (es)	2002-12-07
IL158021A (en)	2010-04-15
AR035456A1 (es)	2004-05-26
PL367086A1 (en)	2005-02-21
UY27259A1 (es)	2002-10-31
PA8543201A1 (es)	2002-10-31
EP1379522A1 (de)	2004-01-14
BR0208887A (pt)	2004-06-29
CN1268626C (zh)	2006-08-09
CZ20033002A3 (cs)	2004-03-17
NO325300B1 (no)	2008-03-25
HRP20030791B1 (en)	2006-06-30
JP4043953B2 (ja)	2008-02-06
KR20030088502A (ko)	2003-11-19
DK1379522T3 (da)	2005-05-30
DE60202761D1 (de)	2005-03-03
MXPA03009317A (es)	2004-02-12
ECSP034796A (es)	2003-12-01
US6548495B2 (en)	2003-04-15
SK13692003A3 (sk)	2004-05-04
NO20034496D0 (no)	2003-10-08
YU79103A (sh)	2006-05-25
BG108253A (bg)	2005-03-31
CA2441771A1 (en)	2002-10-24
CA2441771C (en)	2008-12-30
JP2004525965A (ja)	2004-08-26
RU2270197C2 (ru)	2006-02-20
MY130369A (en)	2007-06-29
DE60202761T2 (de)	2006-01-12
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