ATE288923T1 - Cd4-gamma2- und cd4-igg2-chimären - Google Patents
Cd4-gamma2- und cd4-igg2-chimärenInfo
- Publication number
- ATE288923T1 ATE288923T1 AT03012917T AT03012917T ATE288923T1 AT E288923 T1 ATE288923 T1 AT E288923T1 AT 03012917 T AT03012917 T AT 03012917T AT 03012917 T AT03012917 T AT 03012917T AT E288923 T1 ATE288923 T1 AT E288923T1
- Authority
- AT
- Austria
- Prior art keywords
- igg2
- gamma2
- chimeras
- provides
- expression vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Automatic Cycles, And Cycles In General (AREA)
- Steering Control In Accordance With Driving Conditions (AREA)
- Control Of Driving Devices And Active Controlling Of Vehicle (AREA)
- Regulating Braking Force (AREA)
- Vehicle Body Suspensions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65368491A | 1991-02-08 | 1991-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288923T1 true ATE288923T1 (de) | 2005-02-15 |
Family
ID=24621912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03012917T ATE288923T1 (de) | 1991-02-08 | 1992-02-10 | Cd4-gamma2- und cd4-igg2-chimären |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6451313B1 (de) |
| EP (2) | EP0528011A4 (de) |
| JP (1) | JP3670276B2 (de) |
| AT (1) | ATE288923T1 (de) |
| AU (1) | AU660662B2 (de) |
| CA (1) | CA2080226C (de) |
| DE (1) | DE69233480T2 (de) |
| ES (1) | ES2237727T3 (de) |
| WO (1) | WO1992013947A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070991B2 (en) * | 1991-02-08 | 2006-07-04 | Progenics Pharmaceuticals, Inc. | Cells expressing a CD4-IgG2 chimeric heterotetramer |
| JP3670276B2 (ja) * | 1991-02-08 | 2005-07-13 | プロゲニクス・ファーマスーティカルズ、インコーポレイテッド | ＣＤ４― ガンマ・２キメラ及びＣＤ４ ― ＩｇＧ２・キメラ |
| JPH08503125A (ja) | 1992-08-07 | 1996-04-09 | プロジェニクス・ファーマスーティカルス・インコーポレーテッド | 非ペプチジル成分と複合化されたＣＤ４−ガンマ２およびＣＤ４−ＩｇＧ２免疫複合体、並びにその使用 |
| US5817767A (en) * | 1993-02-24 | 1998-10-06 | Progenics Pharmaceuticals, Inc. | Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same |
| JPH10506613A (ja) * | 1994-07-13 | 1998-06-30 | プロジェニクス・ファーマスーティカルス・インコーポレーテッド | 試料中よりｈｉｖ−１を除去するための製造物、及び該製造物の使用方法 |
| WO2003040311A2 (en) * | 2001-10-25 | 2003-05-15 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4 |
| US20030211470A1 (en) * | 2002-03-15 | 2003-11-13 | Olson William C. | CD4-IgG2-based salvage therapy of HIV-1 infection |
| WO2004084816A2 (en) * | 2003-03-21 | 2004-10-07 | Progenics Pharmaceuticals, Inc. | IMPROVED CD4-IgG2 FORMULATIONS |
| ES2383300T3 (es) | 2003-11-13 | 2012-06-20 | Hanmi Holdings Co., Ltd | Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| KR101276422B1 (ko) * | 2004-03-15 | 2013-06-19 | 넥타르 테라퓨틱스 | Ｈｉｖ 유입 억제제의 중합체-기재 조성물 및 콘쥬게이트 |
| KR100754667B1 (ko) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Ｆｃ 단편 및이를 포함하는 약제학적 조성물 |
| CA2637600A1 (en) | 2006-01-17 | 2007-07-26 | Health Research, Inc. | Heteroduplex tracking assay |
| US20080051503A1 (en) * | 2006-08-28 | 2008-02-28 | The Goodyear Tire & Rubber Company | Method of mixing fiber loaded compounds using a Y-mix cycle |
| MX2011000861A (es) | 2008-07-23 | 2011-06-21 | Hanmi Holdings Co Ltd | Un complejo polipeptidico que consiste en un polimero no-peptidil que posee tres terminaciones funcionales. |
| BR112012017164A2 (pt) * | 2009-12-22 | 2019-09-24 | Novartis Ag | proteína de fusão de região constante de anticorpo-cd47 tetravalente |
| AR096891A1 (es) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| EA202090632A1 (ru) * | 2014-06-04 | 2020-07-31 | Акселерон Фарма Инк. | Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов |
| EP3274457A4 (de) | 2015-03-26 | 2018-08-08 | Acceleron Pharma Inc. | Follistatin-assoziierte fusionsproteine und verwendungen davon |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4664911A (en) * | 1983-06-21 | 1987-05-12 | Board Of Regents, University Of Texas System | Immunotoxin conjugates employing toxin B chain moieties |
| DE3751751T2 (de) | 1986-08-21 | 1996-10-17 | Univ Columbia | Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids |
| JPH02501192A (ja) | 1987-09-04 | 1990-04-26 | バイオジェン インコーポレイテッド | 可溶性ｔ４蛋白を製造するためのｄｎａ配列、組換ｄｎａ分子および方法 |
| PT88641B (pt) | 1987-10-02 | 1993-04-30 | Genentech Inc | Metodo para a preparacao de uma variante de adesao |
| US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| IL87902A0 (en) | 1987-10-08 | 1989-03-31 | Dana Farber Cancer Inst Inc | Soluble human cd4 fragments and applications thereof |
| PT89484B (pt) * | 1988-01-22 | 1994-03-31 | Gen Hospital Corp | Genes clonados codificadores de proteinas de fusao ig-cd4 e sua utilizacao |
| IL91070A (en) * | 1988-07-23 | 1995-03-30 | Us Commerce | Cytotoxic agents against certain viral infections |
| JPH02107393A (ja) * | 1988-10-18 | 1990-04-19 | Asahi Chem Ind Co Ltd | 排水中の塩素系溶剤の除去方法 |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| EP0394827A1 (de) * | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimärische CD4-Immunoglobulin-Polypeptide |
| ES2096590T3 (es) * | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
| AU1438592A (en) * | 1991-02-08 | 1992-09-07 | Progenics Pharmaceuticals, Inc. | Cd4-gamma1 and cd4-igg1 chimeras |
| JP3670276B2 (ja) * | 1991-02-08 | 2005-07-13 | プロゲニクス・ファーマスーティカルズ、インコーポレイテッド | ＣＤ４― ガンマ・２キメラ及びＣＤ４ ― ＩｇＧ２・キメラ |
| AU1423792A (en) * | 1991-02-12 | 1992-09-07 | Colorado State University Research Foundation | Reagents and methods for identification of vaccines |
| JPH08503125A (ja) * | 1992-08-07 | 1996-04-09 | プロジェニクス・ファーマスーティカルス・インコーポレーテッド | 非ペプチジル成分と複合化されたＣＤ４−ガンマ２およびＣＤ４−ＩｇＧ２免疫複合体、並びにその使用 |
-
1992
- 1992-02-10 JP JP50704992A patent/JP3670276B2/ja not_active Expired - Fee Related
- 1992-02-10 CA CA002080226A patent/CA2080226C/en not_active Expired - Fee Related
- 1992-02-10 DE DE69233480T patent/DE69233480T2/de not_active Expired - Fee Related
- 1992-02-10 EP EP19920907272 patent/EP0528011A4/en not_active Withdrawn
- 1992-02-10 AU AU14400/92A patent/AU660662B2/en not_active Ceased
- 1992-02-10 WO PCT/US1992/001143 patent/WO1992013947A1/en not_active Ceased
- 1992-02-10 ES ES03012917T patent/ES2237727T3/es not_active Expired - Lifetime
- 1992-02-10 AT AT03012917T patent/ATE288923T1/de not_active IP Right Cessation
- 1992-02-10 EP EP03012917A patent/EP1340769B1/de not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/484,681 patent/US6451313B1/en not_active Expired - Fee Related
- 1995-06-07 US US08/485,372 patent/US6187748B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU660662B2 (en) | 1995-07-06 |
| WO1992013947A1 (en) | 1992-08-20 |
| JPH05507854A (ja) | 1993-11-11 |
| US6451313B1 (en) | 2002-09-17 |
| US6187748B1 (en) | 2001-02-13 |
| AU1440092A (en) | 1992-09-07 |
| DE69233480T2 (de) | 2006-01-05 |
| JP3670276B2 (ja) | 2005-07-13 |
| EP0528011A1 (de) | 1993-02-24 |
| DE69233480D1 (de) | 2005-03-17 |
| EP0528011A4 (en) | 1993-06-30 |
| CA2080226C (en) | 2004-05-04 |
| ES2237727T3 (es) | 2005-08-01 |
| HK1059789A1 (en) | 2004-07-16 |
| EP1340769B1 (de) | 2005-02-09 |
| CA2080226A1 (en) | 1992-08-09 |
| EP1340769A1 (de) | 2003-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1340769 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |