ATE288962T1 - Verbessertes verfahren zur fermentativen herstellung von cephalosporin - Google Patents
Verbessertes verfahren zur fermentativen herstellung von cephalosporinInfo
- Publication number
- ATE288962T1 ATE288962T1 AT98925484T AT98925484T ATE288962T1 AT E288962 T1 ATE288962 T1 AT E288962T1 AT 98925484 T AT98925484 T AT 98925484T AT 98925484 T AT98925484 T AT 98925484T AT E288962 T1 ATE288962 T1 AT E288962T1
- Authority
- AT
- Austria
- Prior art keywords
- cephalosporin
- organic solvent
- extraction
- cephalosporin compound
- substituted
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 8
- 229940124587 cephalosporin Drugs 0.000 title abstract 8
- 150000001780 cephalosporins Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000012262 fermentative production Methods 0.000 title 1
- -1 cephalosporin compound Chemical class 0.000 abstract 4
- 238000000605 extraction Methods 0.000 abstract 4
- 239000003960 organic solvent Substances 0.000 abstract 4
- 238000000855 fermentation Methods 0.000 abstract 3
- 230000004151 fermentation Effects 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201201 | 1997-04-22 | ||
| PCT/EP1998/002459 WO1998048036A1 (en) | 1997-04-22 | 1998-04-22 | Improved process for the fermentative production of cephalosporin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288962T1 true ATE288962T1 (de) | 2005-02-15 |
Family
ID=8228241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98925484T ATE288962T1 (de) | 1997-04-22 | 1998-04-22 | Verbessertes verfahren zur fermentativen herstellung von cephalosporin |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6319684B1 (de) |
| EP (1) | EP0918878B1 (de) |
| JP (1) | JP2000512510A (de) |
| CN (1) | CN1137271C (de) |
| AT (1) | ATE288962T1 (de) |
| AU (1) | AU7759298A (de) |
| BR (1) | BR9804855A (de) |
| DE (1) | DE69828940T2 (de) |
| ES (1) | ES2237840T3 (de) |
| PL (1) | PL330706A1 (de) |
| PT (1) | PT918878E (de) |
| RO (1) | RO120653B1 (de) |
| RU (1) | RU2203323C2 (de) |
| TW (1) | TW565612B (de) |
| WO (1) | WO1998048036A1 (de) |
| ZA (1) | ZA983383B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE226954T1 (de) * | 1998-03-27 | 2002-11-15 | Dsm Nv | Verfahren zur fermentativen herstellung von cephalosporin |
| IL152643A0 (en) * | 2000-05-13 | 2003-06-24 | Smithkline Beecham Plc | Process for the purification of a salt of clavulanic acid |
| JP2002316991A (ja) * | 2001-04-18 | 2002-10-31 | Otsuka Chem Co Ltd | ペニシリン及びセファロスポリン化合物 |
| EP2614066B1 (de) | 2010-09-07 | 2017-11-29 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Verfahren zur herstellung von cephalosporinen |
| WO2012117038A1 (en) | 2011-03-03 | 2012-09-07 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Degradation of penicillin compounds |
| CN111875621A (zh) * | 2020-08-26 | 2020-11-03 | 山东鲁抗医药股份有限公司 | 一种注射用头孢菌素盐的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1299883A (fr) * | 1961-09-06 | 1962-07-27 | Pfizer & Co C | Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses |
| GB1473100A (de) * | 1973-05-10 | 1977-05-11 | ||
| DE3729338A1 (de) * | 1987-09-02 | 1989-03-23 | Biotechnolog Forschung Gmbh | Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion |
| US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| KR100227711B1 (ko) * | 1991-10-15 | 1999-12-01 | 한스 발터 라벤 | 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정 |
| BR9407108A (pt) | 1993-07-30 | 1996-08-27 | Gist Brocades Nv | Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido |
| US5731165A (en) * | 1995-06-02 | 1998-03-24 | Gist-Brocades, B.V. | Process for the production of 7-ADCA via expandase activity on penicillin G |
-
1998
- 1998-04-22 US US09/202,370 patent/US6319684B1/en not_active Expired - Fee Related
- 1998-04-22 JP JP10545044A patent/JP2000512510A/ja active Pending
- 1998-04-22 PT PT98925484T patent/PT918878E/pt unknown
- 1998-04-22 EP EP98925484A patent/EP0918878B1/de not_active Expired - Lifetime
- 1998-04-22 RU RU99101489/13A patent/RU2203323C2/ru not_active IP Right Cessation
- 1998-04-22 DE DE69828940T patent/DE69828940T2/de not_active Expired - Fee Related
- 1998-04-22 ES ES98925484T patent/ES2237840T3/es not_active Expired - Lifetime
- 1998-04-22 CN CNB988005212A patent/CN1137271C/zh not_active Expired - Lifetime
- 1998-04-22 ZA ZA983383A patent/ZA983383B/xx unknown
- 1998-04-22 AU AU77592/98A patent/AU7759298A/en not_active Abandoned
- 1998-04-22 BR BR9804855A patent/BR9804855A/pt not_active IP Right Cessation
- 1998-04-22 WO PCT/EP1998/002459 patent/WO1998048036A1/en not_active Ceased
- 1998-04-22 AT AT98925484T patent/ATE288962T1/de not_active IP Right Cessation
- 1998-04-22 PL PL98330706A patent/PL330706A1/xx unknown
- 1998-04-22 RO RO98-01711A patent/RO120653B1/ro unknown
- 1998-05-12 TW TW087107317A patent/TW565612B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| TW565612B (en) | 2003-12-11 |
| CN1137271C (zh) | 2004-02-04 |
| RO120653B1 (ro) | 2006-05-30 |
| RU2203323C2 (ru) | 2003-04-27 |
| CN1224470A (zh) | 1999-07-28 |
| US6319684B1 (en) | 2001-11-20 |
| JP2000512510A (ja) | 2000-09-26 |
| EP0918878B1 (de) | 2005-02-09 |
| ES2237840T3 (es) | 2005-08-01 |
| PT918878E (pt) | 2005-05-31 |
| WO1998048036A1 (en) | 1998-10-29 |
| AU7759298A (en) | 1998-11-13 |
| DE69828940T2 (de) | 2005-12-29 |
| BR9804855A (pt) | 1999-08-24 |
| DE69828940D1 (de) | 2005-03-17 |
| PL330706A1 (en) | 1999-05-24 |
| ZA983383B (en) | 1998-10-27 |
| EP0918878A1 (de) | 1999-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0918878 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |