ATE289065T1 - Verfahren und vorrichtung zur ortung und konzentration von polaren analyten mittels eines elektrischen wechselfeldes - Google Patents

Verfahren und vorrichtung zur ortung und konzentration von polaren analyten mittels eines elektrischen wechselfeldes

Info

Publication number
ATE289065T1
ATE289065T1 AT01918488T AT01918488T ATE289065T1 AT E289065 T1 ATE289065 T1 AT E289065T1 AT 01918488 T AT01918488 T AT 01918488T AT 01918488 T AT01918488 T AT 01918488T AT E289065 T1 ATE289065 T1 AT E289065T1
Authority
AT
Austria
Prior art keywords
concentration
location
electrical field
alternating electrical
polar analytes
Prior art date
Application number
AT01918488T
Other languages
English (en)
Inventor
Zbigniew T Bryning
Theresa B Taylor
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of ATE289065T1 publication Critical patent/ATE289065T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Electrostatic Separation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
AT01918488T 2000-03-10 2001-03-08 Verfahren und vorrichtung zur ortung und konzentration von polaren analyten mittels eines elektrischen wechselfeldes ATE289065T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/522,638 US6537433B1 (en) 2000-03-10 2000-03-10 Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
PCT/US2001/007576 WO2001069230A2 (en) 2000-03-10 2001-03-08 Methods and apparatus for the location and concentration of polar analytes using an alternating electric field

Publications (1)

Publication Number Publication Date
ATE289065T1 true ATE289065T1 (de) 2005-02-15

Family

ID=24081685

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01918488T ATE289065T1 (de) 2000-03-10 2001-03-08 Verfahren und vorrichtung zur ortung und konzentration von polaren analyten mittels eines elektrischen wechselfeldes

Country Status (8)

Country Link
US (4) US6537433B1 (de)
EP (1) EP1261863B1 (de)
JP (1) JP2003527601A (de)
AT (1) ATE289065T1 (de)
AU (1) AU2001245558A1 (de)
CA (1) CA2402189A1 (de)
DE (1) DE60108848T2 (de)
WO (1) WO2001069230A2 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
AU2001288249A1 (en) * 2000-08-14 2002-02-25 The Regents Of The University Of California Biosensors and methods for their use
US7147441B2 (en) * 2000-12-20 2006-12-12 Board Of Trustees Of The University Of Arkansas, N.A. Microfluidics and small volume mixing based on redox magnetohydrodynamics methods
DE60221240T2 (de) * 2001-05-02 2007-10-31 Applera Corp., Foster City Konzentration und reinigung von analyten mit elektrischen feldern
US7014744B2 (en) * 2001-08-24 2006-03-21 Applera Corporation Method of purification and concentration using AC fields with a transfer tip
US6814859B2 (en) * 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
GB0215779D0 (en) * 2002-07-08 2002-08-14 Deltadot Ltd Material separation device
JP3956389B2 (ja) * 2002-12-11 2007-08-08 横河電機株式会社 ハイブリダイゼーション法およびハイブリダイゼーション用装置
JP4128084B2 (ja) * 2003-01-07 2008-07-30 クラスターテクノロジー株式会社 試料の特性化方法およびその装置
CN1761865A (zh) * 2003-03-19 2006-04-19 日本电气株式会社 微芯片和提取样品方法、分离样品方法、分析样品方法及回收样品方法
US7147764B2 (en) * 2003-03-28 2006-12-12 Applera Corporation Dual electrode injection of analyte into a capillary electrophoretic device
EP1613962B1 (de) * 2003-04-14 2008-10-29 Caliper Life Sciences, Inc. Reduktion der migrations-shift-assay-interferenz
JP4773348B2 (ja) 2003-07-12 2011-09-14 アクセラー８ テクノロジー コーポレイション 高感度かつ迅速なバイオ検出法
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
JP4453334B2 (ja) * 2003-10-21 2010-04-21 ソニー株式会社 ハイブリダイゼーション装置及び方法
US7384791B2 (en) * 2004-01-21 2008-06-10 Hewlett-Packard Development Company, L.P. Method of analyzing blood
US7160425B2 (en) * 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
US8057655B1 (en) * 2004-08-20 2011-11-15 The Board Of Trustees Of The Leland Stanford Junior University Sub-micron object control arrangement and approach therefor
JP4619728B2 (ja) * 2004-09-02 2011-01-26 株式会社エンプラス 試料分析装置
WO2006066216A2 (en) * 2004-12-16 2006-06-22 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
JP4462051B2 (ja) * 2005-01-28 2010-05-12 富士ゼロックス株式会社 微粒子分散液の濃縮方法、及び微粒子分散液の濃縮装置
EP1931979B1 (de) * 2005-10-04 2015-11-18 Headway Technologies, Inc. Mikrofluidischer nachweis von analyten
EP1984723B1 (de) * 2006-02-01 2019-05-15 Ecole Polytechnique Federale de Lausanne (EPFL) Vorrichtung zur impedanzmessung von partikeln in einem mikrokanal
US8029657B1 (en) * 2006-03-14 2011-10-04 University Of Tennessee Research Foundation Parallel plate electrodes for particle concentration or removal
US7731826B2 (en) * 2006-08-17 2010-06-08 Electronic Bio Sciences, Llc Controlled translocation of a polymer in an electrolytic sensing system
US8293086B2 (en) * 2007-02-06 2012-10-23 Board Of Trustees Of Michigan State University Classification scheme for nanoobjects
WO2008124706A2 (en) 2007-04-06 2008-10-16 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Devices and methods for target molecule characterization
BRPI0813718A2 (pt) * 2007-07-13 2014-12-30 Univ Leland Stanford Junior Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados
EP2183202A2 (de) * 2007-07-20 2010-05-12 Siemens Medical Solutions USA, Inc. Mikrofluidische radiosynthese einer radioaktiv markierten verbindung anhand elektrochemischen einfangens und freisetzens
US7655124B2 (en) * 2007-10-05 2010-02-02 Mady Attila Apparatus to assist platelet manipulation to prevent and treat endovascular disease and its sequelae
WO2009044902A1 (ja) * 2007-10-05 2009-04-09 Kyushu Institute Of Technology 誘電泳動装置および方法
GB0804491D0 (en) * 2008-03-11 2008-04-16 Iti Scotland Ltd Detecting analytes
US8968540B2 (en) 2008-10-06 2015-03-03 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Trans-base tunnel reader for sequencing
JP5047928B2 (ja) * 2008-11-11 2012-10-10 シャープ株式会社 電気泳動装置およびその構成器具
US8398839B1 (en) * 2009-06-05 2013-03-19 Sandia Corporation System for particle concentration and detection
EP2475787A2 (de) * 2009-09-07 2012-07-18 Caerus Molecular Diagnostics Incorporated Sequenzbestimmung durch anwendung entgegengesetzter kräfte
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
EP2710359B1 (de) * 2011-02-16 2020-09-16 Centrul International de Biodinamica Systeme und verfahren zum nachweis und zur quantifizierung von analyten mittels einer impedanzanalyse
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
US11053535B2 (en) 2011-09-12 2021-07-06 The University Of North Carolina At Chapel Hill Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
US8691067B2 (en) 2011-09-16 2014-04-08 International Business Machines Corporation Charged entities as locomotive to control motion of polymers through a nanochannel
US11198126B2 (en) * 2011-10-31 2021-12-14 Fluid-Screen, Inc. Apparatus for pathogen detection
EP3591408A1 (de) 2012-02-10 2020-01-08 The University of North Carolina at Chapel Hill Vorrichtungen mit fluidischen nanotrichtern, zugehörige verfahren, herstellung und analysesysteme
GB2499428B (en) * 2012-02-16 2014-09-24 Microvisk Ltd Surface patterned micro-sensor based fluid test strip
CN104379261A (zh) * 2012-04-16 2015-02-25 昆南诺股份有限公司 用于生物分子检测的纳米毛细管装置、流体网络结构和其制造方法
EP2682478A1 (de) * 2012-07-02 2014-01-08 Institut Curie Verfahren und Vorrichtung zur Detektion von Makroionen in einem flüssigen Medium
EP2906720A4 (de) 2012-10-10 2016-06-01 Univ Arizona Systeme und vorrichtungen zur molekülerfassung und verfahren zur herstellung davon
US10261065B2 (en) * 2013-02-28 2019-04-16 The University Of North Carolina At Chapel Hill Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis
EP2971180A4 (de) * 2013-03-13 2016-11-23 Univ Arizona State Systeme, vorrichtungen und verfahren zur translokationssteuerung
US9970898B2 (en) 2013-03-13 2018-05-15 The University Of North Carolina At Chapel Hill Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US10012613B2 (en) 2013-10-04 2018-07-03 Michigan Technological University Methods and systems for identifying a particle using dielectrophoresis
KR101664552B1 (ko) * 2014-08-11 2016-10-10 엘지전자 주식회사 입자 검출장치
WO2016113883A1 (ja) * 2015-01-15 2016-07-21 株式会社島津製作所 磁性体粒子操作用デバイスおよび磁性体粒子の操作方法
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
AU2016243656A1 (en) 2015-03-30 2017-11-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
WO2017213123A1 (ja) * 2016-06-07 2017-12-14 国立大学法人東京大学 流体デバイス
US10596567B2 (en) * 2017-03-27 2020-03-24 International Business Machines Corporation Microfluidic ratchets for displacing particles
DE102017121326B4 (de) 2017-09-14 2021-01-14 Leica Microsystems Cms Gmbh Sammeleinrichtung und Verfahren zum Sammeln dissektierter oder ablatierter Proben und Mikroskop mit einer solchen Einrichtung
US12204085B2 (en) * 2018-04-27 2025-01-21 Hewlett-Packard Development Company, L.P. Nonrotating nonuniform electric field object rotation
US11686705B2 (en) * 2020-05-08 2023-06-27 Seagate Technology Llc Gel electrophoresis for DNA purification
JP7515391B2 (ja) * 2020-12-14 2024-07-12 浜松ホトニクス株式会社 微粒子捕捉方法及び微粒子捕捉装置
CN117772306B (zh) * 2024-01-30 2025-09-23 山东大学 一种基于微液滴的稀释制冷用微流控芯片及系统
USD1111186S1 (en) * 2024-05-07 2026-02-03 Portal Biotechnologies, Inc. Tabletop cell mechanoporation system

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2417850A (en) 1942-04-14 1947-03-25 Willis M Winslow Method and means for translating electrical impulses into mechanical force
US4680201A (en) 1985-10-30 1987-07-14 Stellan Hjerten Coating for electrophoresis tube
US4690749A (en) 1985-12-16 1987-09-01 Universities Space Research Association Polymer-coated surfaces to control surface zeta potential
US5059294A (en) 1985-12-26 1991-10-22 The University Of Puerto Rico Method for separating nucleic acids and nucleic acid probes
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US4874507A (en) * 1986-06-06 1989-10-17 Whitlock David R Separating constituents of a mixture of particles
US4911806A (en) * 1987-02-27 1990-03-27 Biotronics Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields
US5202010A (en) 1987-11-25 1993-04-13 Princeton Biochemicals, Inc. Automated capillary electrophoresis apparatus
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5132012A (en) 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
US4956065A (en) * 1988-11-03 1990-09-11 Kaler Karen V I S Method and apparatus for three dimensional dynamic dielectric levitation
DD279984A1 (de) * 1989-02-02 1990-06-20 Univ Berlin Humboldt Dielektrisches mikromechanisches element
US5110514A (en) 1989-05-01 1992-05-05 Soane Technologies, Inc. Controlled casting of a shrinkable material
US5344535A (en) 1989-11-27 1994-09-06 British Technology Group Limited Dielectrophoretic characterization of micro-organisms and other particles
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5275710A (en) * 1990-05-14 1994-01-04 Labintelligence, Inc. Gel electrophoresis system including optical stage, sample applicator and sample retriever
US5569591A (en) * 1990-08-03 1996-10-29 University College Of Wales Aberystwyth Analytical or monitoring apparatus and method
US6149789A (en) * 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
DE59108006D1 (de) 1991-01-28 1996-08-22 Ciba Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
JP3104995B2 (ja) * 1991-01-31 2000-10-30 ワーナー−ランバート・コンパニー 抗炎症剤として有用な４，６−ジ−第三ブチル−５−ヒドロキシ−１，３−ピリミジンの置換されたヘテロアリール類似体
DE4143573C2 (de) * 1991-08-19 1996-07-04 Fraunhofer Ges Forschung Vorrichtung zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter, dielektrischer Teilchen
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
DE59108591D1 (de) 1991-12-06 1997-04-10 Ciba Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
GB9208357D0 (en) * 1992-04-16 1992-06-03 British Tech Group Apparatus for separating a mixture
US5489506A (en) * 1992-10-26 1996-02-06 Biolife Systems, Inc. Dielectrophoretic cell stream sorter
AU1254295A (en) 1993-12-17 1995-07-03 Perkin-Elmer Corporation, The Uncharged polymers for separation of biomolecules by capillary electrophoresis
US5948328A (en) * 1994-02-24 1999-09-07 Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Shaping of microparticles in electric-field cages
WO1995023245A1 (en) * 1994-02-25 1995-08-31 Labintelligence, Inc. Real time in-gel assay
JPH07238290A (ja) * 1994-03-01 1995-09-12 Nippon Oil Co Ltd 電気粘性流体
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
DE19500683B4 (de) 1994-12-10 2007-03-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Trapping von Molekülen und Mikropartikeln in Feldkäfigen
US5630924A (en) * 1995-04-20 1997-05-20 Perseptive Biosystems, Inc. Compositions, methods and apparatus for ultrafast electroseparation analysis
EP0830595A1 (de) 1995-06-08 1998-03-25 Visible Genetics Inc. Elektroforetischer mikrochip zur bewegung und trennung von nukleinsäuren und von anderen geladenen molekülen
US5626734A (en) * 1995-08-18 1997-05-06 University Technologies International, Inc. Filter for perfusion cultures of animal cells and the like
DE19544127C1 (de) * 1995-11-27 1997-03-20 Gimsa Jan Dr Verfahren und Vorrichtung zur Erzeugung von Resonanzerscheinungen in Partikelsuspensionen und ihre Verwendung
WO1997027933A1 (en) 1996-01-31 1997-08-07 Board Of Regents, The University Of Texas System Fractionation using dielectrophoresis and field flow fractionation
JP2002503334A (ja) * 1996-09-04 2002-01-29 テクニカル ユニバーシティ オブ デンマーク 粒子の分離と分析用のマイクロフローシステム
GB9619093D0 (en) * 1996-09-12 1996-10-23 Scient Generics Ltd Methods of analysis/separation
DE19653659C1 (de) * 1996-12-20 1998-05-20 Guenter Prof Dr Fuhr Elektrodenanordnung für Feldkäfige
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US5869004A (en) * 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
AU9792098A (en) * 1997-10-06 1999-04-27 California Institute Of Technology Electrostatic particle transportation
DE19815882A1 (de) * 1998-04-08 1999-10-14 Fuhr Guenther Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen
DE19983263T1 (de) * 1998-05-29 2001-05-31 Ind Res Ltd Verfahren und Vorrichtung zum Konzentrieren und/oder Positionieren von Teilchen oder Zellen
AU4546899A (en) 1998-06-05 1999-12-20 Sarnoff Corporation Apparatus for separating molecules
US6093370A (en) * 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
JP2002519183A (ja) * 1998-06-29 2002-07-02 エボテック バイオシステムズ アクチェン ゲゼルシャフト マイクロシステム内の粒子を操作する方法と装置
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6572830B1 (en) * 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6203683B1 (en) * 1998-11-09 2001-03-20 Princeton University Electrodynamically focused thermal cycling device
DE19859461A1 (de) * 1998-12-22 2000-06-29 Evotec Biosystems Ag Verfahren und Vorrichtung zur konvektiven Bewegung von Flüssigkeiten in Mikrosystemen
US6352838B1 (en) * 1999-04-07 2002-03-05 The Regents Of The Universtiy Of California Microfluidic DNA sample preparation method and device
US6942776B2 (en) * 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
AU4773400A (en) 1999-05-28 2000-12-18 Leisamon (Israel), Ltd. Methods and apparatus for nonlinear mobility electrophoresis separation
US6824664B1 (en) * 1999-11-04 2004-11-30 Princeton University Electrode-less dielectrophorises for polarizable particles
US6605453B2 (en) * 1999-12-01 2003-08-12 The Regents Of The University Of California Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells
US6537433B1 (en) 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
CN1319761A (zh) * 2000-03-15 2001-10-31 清华大学 高通量电旋转检测的装置和方法
EP1263532A2 (de) * 2000-03-16 2002-12-11 Sri International Labormikrovorrichtungen und -verfahren
EP1716926A3 (de) * 2000-04-13 2007-08-29 Wako Pure Chemical Industries Ltd Elektroden-Bau für dielektrophoretische Anordnung und dielektrophoretische Trennung
WO2001079529A1 (en) * 2000-04-17 2001-10-25 Purdue Research Foundation Biosensor and related method
CN1325909C (zh) * 2000-09-27 2007-07-11 清华大学 用于微粒操纵与微粒导向的装置及其使用方法
US6780584B1 (en) * 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
CN100495030C (zh) * 2000-09-30 2009-06-03 清华大学 多力操纵装置及其应用
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US6744038B2 (en) * 2000-11-13 2004-06-01 Genoptix, Inc. Methods of separating particles using an optical gradient
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6833542B2 (en) * 2000-11-13 2004-12-21 Genoptix, Inc. Method for sorting particles
US6784420B2 (en) * 2000-11-13 2004-08-31 Genoptix, Inc. Method of separating particles using an optical gradient
US6787018B1 (en) * 2000-12-08 2004-09-07 The Regents Of The University Of California Dielectrophoretic concentration of particles under electrokinetic flow
US6764583B2 (en) * 2000-12-13 2004-07-20 The Regents Of The University Of California Using impedance measurements for detecting pathogens trapped in an electric field
US6685812B2 (en) * 2001-01-09 2004-02-03 The Regents Of The University Of California Movement of particles using sequentially activated dielectrophoretic particle trapping
WO2002069016A2 (en) * 2001-02-28 2002-09-06 Lightwave Microsystems Corporation Microfluid control for waveguide optical switches, variable attenuators, and other optical devices
US6706163B2 (en) * 2001-03-21 2004-03-16 Michael Seul On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces
US6761811B2 (en) * 2001-03-27 2004-07-13 The Regents Of The University Of California Multi-stage separations based on dielectrophoresis
US6730204B2 (en) * 2001-03-27 2004-05-04 The Regents Of The University Of California Three dimensional separation trap based on dielectrophoresis and use thereof
US6660493B2 (en) * 2001-03-28 2003-12-09 The Regents Of The University Of California Hydrodynamic enhanced dielectrophoretic particle trapping
ES2217208T3 (es) 2002-02-01 2004-11-01 Leister Process Technologies Componente microfluido y procedimiento para la clasificacion de particulas en un fluido.
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices

Also Published As

Publication number Publication date
US20060081474A1 (en) 2006-04-20
US8083917B2 (en) 2011-12-27
AU2001245558A1 (en) 2001-09-24
US7704363B2 (en) 2010-04-27
WO2001069230A2 (en) 2001-09-20
WO2001069230A3 (en) 2002-06-20
DE60108848D1 (de) 2005-03-17
EP1261863A2 (de) 2002-12-04
US6537433B1 (en) 2003-03-25
US6969454B2 (en) 2005-11-29
JP2003527601A (ja) 2003-09-16
EP1261863B1 (de) 2005-02-09
US20030057094A1 (en) 2003-03-27
DE60108848T2 (de) 2006-02-09
CA2402189A1 (en) 2001-09-20
US20100203580A1 (en) 2010-08-12

Similar Documents

Publication Publication Date Title
DE60108848D1 (de) Verfahren und vorrichtung zur ortung und konzentration von polaren analyten mittels eines elektrischen wechselfeldes
DE60325482D1 (de) Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie
ATE367205T1 (de) Konzentration und reinigung von analyten mit elektrischen feldern
ATE498838T1 (de) Elektronische verfahren und vorrichtung zum nachweis von analyten
DE60223548D1 (de) System und verfahren zum messung von bioelektrischem widerstand in gegenwart von störungen
DE60141455D1 (de) Faims apparatur und verfahren unter verwendung eines trägergases von gemischter zusammensetzung
DE60028883D1 (de) Vorrichtung und Verfahren zum optischen Erfassen von Lichtbogenfehler in elektrischen Leistungssystemen in Gegenwart von anderen LIchtquellen
EP1456648A4 (de) Automatische probenvorbereitungsverfahren und -vorrichtungen
DE60335921D1 (de) Thrombusdetektor, vorrichtung zur behandlung von thromben und verfahren dafür
ATE290208T1 (de) Vorrichtung und verfahren zur ausführung elektrischer messungen an gegenständen
ATE437940T1 (de) Behältnis und vorrichtung zur erzeugung von elektrischen feldern in einzelnen reaktionsräumen
DE60133383D1 (de) Verfahren und Vorrichtung zur Oberflächenplasmonenmikroskopie
DE60235813D1 (de) Verfahren und vorrichtung für mikrojet aktivierte, niederenergetische ionen-erzeugung und -transport in der plasmabehandlung
DE60117686D1 (de) Verfahren und vorrichtung zur abtrennung von ionenarten aus einer flüssigkeit
DE60135775D1 (de) Vorrichtung enthaltend nanosensoren zur ekennung eines analyten und verfahren zu ihrer herstellung
DE60234491D1 (de) Vorrichtung zur Überwachung von Änderungen in den Behandlungsparametern in Elektronenstrahlgeräten und entsprechendes Überwachungsverfahren
DE50003766D1 (de) Verfahren und vorrichtung zum nachweis und zur quantifizierung von biomolekülen
DE60130217D1 (de) Verfahren und vorrichtung zum herstellen von fluorwasserstoff
DE60213355D1 (de) Verfahren und Vorrichtung zum Identifizierung eines störenden mobilen Endgeräts mittels Änderungen der Leistungsmodulation
DE69941157D1 (de) Verfahren und vorrichtung zur behandlung von blutplasma oder blutplasmakonzentrat
DE50107728D1 (de) Verfahren zur Kontaktierung eines Hochleistungsdiodenlaserbarrens und eine Hochleistungsdiodenlaserbarren-Kontakt-Anordnung
DE59901114D1 (de) Verfahren und vorrichtung zum verdampfen von flüssigem sauerstoff
DE60209582D1 (de) Vorrichtung und Verfahren zur Durchführung von Immunoanalysen
DE3782401D1 (de) Verfahren und vorrichtung zur steuerung eines elektromagneten, dessen erregung durch wechselstrom die kontaktgabe von zwei stuecken hervorruft.
DE602004017304D1 (de) Vorrichtung und verfahren zur bindung und/oder auf einer probe

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties