ATE289309T1 - Neue cyclohexenyl-phenyl diazepine als vasopressin- und oxytocin-rezeptormodulatoren - Google Patents

Neue cyclohexenyl-phenyl diazepine als vasopressin- und oxytocin-rezeptormodulatoren

Info

Publication number: ATE289309T1
Authority: AT; Austria
Prior art keywords: disorders; treating; oxytocin; diazepines; vasopressin
Prior art date: 2001-04-12

Application number

AT02728749T

Other languages

English (en)

Inventor

Amedeo Arturo Failli

William Jennings Sanders

Eugene John Trybulski

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-11

Publication date

2005-03-15

2002-04-11 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE289309T1 publication Critical patent/ATE289309T1/de

Links

-1 CYCLOHEXENYL-PHENYL DIAZEPINES Chemical class 0.000 title 1
102000004279 Oxytocin receptors Human genes 0.000 title 1
108090000876 Oxytocin receptors Proteins 0.000 title 1
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 title 1
102000004136 Vasopressin Receptors Human genes 0.000 title 1
108090000643 Vasopressin Receptors Proteins 0.000 title 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 title 1
229960003726 vasopressin Drugs 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
208000035475 disorder Diseases 0.000 abstract 3
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 2
230000002708 enhancing effect Effects 0.000 abstract 2
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010053567 Coagulopathies Diseases 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
208000004145 Endometritis Diseases 0.000 abstract 1
208000008967 Enuresis Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
101800000989 Oxytocin Proteins 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
206010047139 Vasoconstriction Diseases 0.000 abstract 1
102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
230000000740 bleeding effect Effects 0.000 abstract 1
208000015294 blood coagulation disease Diseases 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
230000009852 coagulant defect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010064 diabetes insipidus Diseases 0.000 abstract 1
125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000012173 estrus Effects 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
208000031169 hemorrhagic disease Diseases 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000027939 micturition Effects 0.000 abstract 1
206010029446 nocturia Diseases 0.000 abstract 1
208000005346 nocturnal enuresis Diseases 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000003336 oxytocin antagonist Substances 0.000 abstract 1
229940121361 oxytocin antagonists Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1
230000025033 vasoconstriction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

AT02728749T 2001-04-12 2002-04-11 Neue cyclohexenyl-phenyl diazepine als vasopressin- und oxytocin-rezeptormodulatoren ATE289309T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28326501P	2001-04-12	2001-04-12
PCT/US2002/011531 WO2002083681A1 (en)	2001-04-12	2002-04-11	Novel cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators

Publications (1)

Publication Number	Publication Date
ATE289309T1 true ATE289309T1 (de)	2005-03-15

Family

ID=23085256

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02728749T ATE289309T1 (de)	2001-04-12	2002-04-11	Neue cyclohexenyl-phenyl diazepine als vasopressin- und oxytocin-rezeptormodulatoren

Country Status (12)

Country	Link
US (1)	US7022699B2 (de)
EP (1)	EP1377584B1 (de)
JP (1)	JP2004530671A (de)
CN (1)	CN1501935A (de)
AT (1)	ATE289309T1 (de)
BR (1)	BR0208940A (de)
CA (1)	CA2443565A1 (de)
DE (1)	DE60203000T2 (de)
DK (1)	DK1377584T3 (de)
ES (1)	ES2236511T3 (de)
MX (1)	MXPA03009335A (de)
WO (1)	WO2002083681A1 (de)

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US6977254B2 (en)	2001-04-12	2005-12-20	Wyeth	Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
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US10464955B2 (en)	2014-02-28	2019-11-05	Hangzhou Dac Biotech Co., Ltd.	Charged linkers and their uses for conjugation
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US7064120B2 (en)	2001-04-12	2006-06-20	Wyeth	Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6900200B2 (en)	2001-04-12	2005-05-31	Wyeth	Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
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2002
- 2002-04-10 US US10/119,611 patent/US7022699B2/en not_active Expired - Fee Related
- 2002-04-11 CA CA002443565A patent/CA2443565A1/en not_active Abandoned
- 2002-04-11 AT AT02728749T patent/ATE289309T1/de not_active IP Right Cessation
- 2002-04-11 WO PCT/US2002/011531 patent/WO2002083681A1/en not_active Ceased
- 2002-04-11 DK DK02728749T patent/DK1377584T3/da active
- 2002-04-11 JP JP2002581436A patent/JP2004530671A/ja active Pending
- 2002-04-11 MX MXPA03009335A patent/MXPA03009335A/es unknown
- 2002-04-11 BR BR0208940-8A patent/BR0208940A/pt not_active IP Right Cessation
- 2002-04-11 EP EP02728749A patent/EP1377584B1/de not_active Expired - Lifetime
- 2002-04-11 ES ES02728749T patent/ES2236511T3/es not_active Expired - Lifetime
- 2002-04-11 CN CNA028080467A patent/CN1501935A/zh active Pending
- 2002-04-11 DE DE60203000T patent/DE60203000T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2002083681A1 (en)	2002-10-24
JP2004530671A (ja)	2004-10-07
EP1377584A1 (de)	2004-01-07
ES2236511T3 (es)	2005-07-16
DK1377584T3 (da)	2005-05-23
US20020198196A1 (en)	2002-12-26
BR0208940A (pt)	2004-04-27
DE60203000D1 (de)	2005-03-24
CA2443565A1 (en)	2002-10-24
US7022699B2 (en)	2006-04-04
MXPA03009335A (es)	2005-10-05
CN1501935A (zh)	2004-06-02
DE60203000T2 (de)	2006-03-23
EP1377584B1 (de)	2005-02-16

Legal Events

Date	Code	Title	Description
2005-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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