ATE289997T1 - Herstellung von warfarin-natrium aus warfarin- säure - Google Patents

Herstellung von warfarin-natrium aus warfarin- säure

Info

Publication number: ATE289997T1
Authority: AT; Austria
Prior art keywords: warfarin; sodium; acid; production; low temperature
Prior art date: 2001-02-28

Application number

AT01991574T

Other languages

English (en)

Inventor

Michel Ashkar

Sorin Bercovici

Robert Graf

Original Assignee

Taro Pharma Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-28

Filing date

2001-12-28

Publication date

2005-03-15

2001-12-28 Application filed by Taro Pharma Ind filed Critical Taro Pharma Ind

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE289997T1 publication Critical patent/ATE289997T1/de

Links

KYITYFHKDODNCQ-UHFFFAOYSA-M sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [Na+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 KYITYFHKDODNCQ-UHFFFAOYSA-M 0.000 title abstract 3
229960002647 warfarin sodium Drugs 0.000 title abstract 3
239000002253 acid Substances 0.000 title abstract 2
229960005080 warfarin Drugs 0.000 title abstract 2
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 title abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 1
238000000354 decomposition reaction Methods 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000003495 polar organic solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
229910000029 sodium carbonate Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01991574T 2001-02-28 2001-12-28 Herstellung von warfarin-natrium aus warfarin- säure ATE289997T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/794,212 US6673944B2 (en)	2001-02-28	2001-02-28	Preparation of warfarin sodium from warfarin acid
PCT/US2001/050512 WO2002070505A1 (en)	2001-02-28	2001-12-28	Preparation of warfarin sodium from warfarin acid

Publications (1)

Publication Number	Publication Date
ATE289997T1 true ATE289997T1 (de)	2005-03-15

Family

ID=25162028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01991574T ATE289997T1 (de)	2001-02-28	2001-12-28	Herstellung von warfarin-natrium aus warfarin- säure

Country Status (13)

Country	Link
US (1)	US6673944B2 (de)
EP (1)	EP1363894B1 (de)
JP (1)	JP2004520427A (de)
CN (1)	CN1492862A (de)
AT (1)	ATE289997T1 (de)
BR (1)	BR0116918A (de)
CA (1)	CA2438407A1 (de)
DE (1)	DE60109212T2 (de)
ES (1)	ES2239169T3 (de)
IL (1)	IL157553A0 (de)
MX (1)	MXPA03007768A (de)
RU (1)	RU2003129001A (de)
WO (1)	WO2002070505A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8327137B1 (en) *	2005-03-25	2012-12-04	Advanced Micro Devices, Inc.	Secure computer system with service guest environment isolated driver
WO2006138534A2 (en) *	2005-06-15	2006-12-28	Morton Grove Pharmaceuticals, Inc.	Stable warfarin sodium liquid formulation and method of making same
WO2008044246A2 (en) *	2006-10-10	2008-04-17	Matrix Laboratories Ltd	A process for the preparation of warfarin sodium
ES2363964B1 (es)	2009-11-20	2012-08-22	Gp Pharm, S.A.	Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
WO2011145007A1 (en)	2010-05-20	2011-11-24	Alembic Pharmaceuticals Limited	A process for the preparation of amorphous warfarin sodium
WO2011143747A1 (en) *	2010-05-20	2011-11-24	Apotex Pharmachem Inc.	Polymorphic forms of warfarin potassium and preparations thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2427578A (en)	1945-04-02	1947-09-16	Wisconsin Alumni Res Found	3-substituted 4-hydroxycoumarin and process of making it
US2777859A (en)	1953-02-05	1957-01-15	Wisconsin Alumni Res Found	Warfarin-alkali metal derivatives and processes of preparing the same
US2752360A (en)	1953-03-23	1956-06-26	S B Penick & Company Inc	Improvement in the manufacture of 3-substituted 4-hydroxycoumarins
US2765321A (en)	1955-05-27	1956-10-02	Wisconsin Alumni Res Found	Process of making crystalline warfarin sodium
US3192232A (en)	1961-02-21	1965-06-29	Wisconsin Alumni Res Found	Warfarin alkali metal derivative process
USRE25866E (en)	1961-02-21	1965-09-21		Warfarin sodium
US3239529A (en)	1962-03-01	1966-03-08	Wisconsin Alumni Res Found	Resolution of warfarin and marcoumar
US3246013A (en)	1963-02-15	1966-04-12	Wisconsin Alumni Res Found	Preparation of crystalline warfarin sodium-isopropyl alcohol complex
FR1397213A (fr)	1963-05-14	1965-04-30	Frosst & Co Charles E	Nouveau procédé de préparation de la warfarine-sodium
US4113744A (en)	1974-08-13	1978-09-12	Nasri W. Badran	Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making
DE3142985A1 (de)	1981-10-29	1983-05-11	Gebrüder Lödige Maschinenbau-Gesellschaft mbH, 4790 Paderborn	Verfahren und vorrichtung zum entfernen von loesungsmitteln aus schuettguetern
US4826689A (en)	1984-05-21	1989-05-02	University Of Rochester	Method for making uniformly sized particles from water-insoluble organic compounds
IL122924A0 (en)	1995-07-13	1998-08-16	Du Pont Merck Pharma	A novel asymmetric synthesis of r and s warfarin and its analogs
ZA965853B (en)	1995-07-13	1998-01-12	Du Pont Merck Pharma	Asymmetric synthesis of r and s warfarin and its analogs.
US5696274A (en)	1995-12-28	1997-12-09	Hoechst Celanese Corporation	Syntheses based on 2-hydroxyacetophenone

2001
- 2001-02-28 US US09/794,212 patent/US6673944B2/en not_active Expired - Fee Related
- 2001-12-28 DE DE60109212T patent/DE60109212T2/de not_active Expired - Fee Related
- 2001-12-28 AT AT01991574T patent/ATE289997T1/de not_active IP Right Cessation
- 2001-12-28 MX MXPA03007768A patent/MXPA03007768A/es unknown
- 2001-12-28 BR BR0116918-1A patent/BR0116918A/pt not_active IP Right Cessation
- 2001-12-28 IL IL15755301A patent/IL157553A0/xx unknown
- 2001-12-28 CN CNA018229026A patent/CN1492862A/zh active Pending
- 2001-12-28 WO PCT/US2001/050512 patent/WO2002070505A1/en not_active Ceased
- 2001-12-28 ES ES01991574T patent/ES2239169T3/es not_active Expired - Lifetime
- 2001-12-28 RU RU2003129001/04A patent/RU2003129001A/ru unknown
- 2001-12-28 CA CA002438407A patent/CA2438407A1/en not_active Abandoned
- 2001-12-28 JP JP2002569825A patent/JP2004520427A/ja not_active Withdrawn
- 2001-12-28 EP EP01991574A patent/EP1363894B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2004520427A (ja)	2004-07-08
DE60109212D1 (de)	2005-04-07
ES2239169T3 (es)	2005-09-16
WO2002070505A1 (en)	2002-09-12
IL157553A0 (en)	2004-03-28
MXPA03007768A (es)	2004-11-12
CN1492862A (zh)	2004-04-28
US20020120157A1 (en)	2002-08-29
CA2438407A1 (en)	2002-09-12
EP1363894A1 (de)	2003-11-26
RU2003129001A (ru)	2005-02-27
US6673944B2 (en)	2004-01-06
EP1363894B1 (de)	2005-03-02
BR0116918A (pt)	2004-04-27
DE60109212T2 (de)	2006-01-12

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Legal Events

Date	Code	Title	Description
2005-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties