ATE290001T1 - Neue substituierte imidazolverbindungen - Google Patents

Neue substituierte imidazolverbindungen

Info

Publication number: ATE290001T1
Authority: AT; Austria
Prior art keywords: imidazole compounds; substituted imidazole; new substituted; new; compounds
Prior art date: 1997-07-02

Application number

AT98934247T

Other languages

English (en)

Inventor

Jerry L Adams

Ralph F Hall

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-02

Filing date

1998-07-01

Publication date

2005-03-15

1998-07-01 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE290001T1 publication Critical patent/ATE290001T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Obesity (AREA)
Oncology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)

AT98934247T 1997-07-02 1998-07-01 Neue substituierte imidazolverbindungen ATE290001T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5159297P	1997-07-02	1997-07-02
PCT/US1998/013809 WO1999001130A1 (en)	1997-07-02	1998-07-01	Novel substituted imidazole compounds

Publications (1)

Publication Number	Publication Date
ATE290001T1 true ATE290001T1 (de)	2005-03-15

Family

ID=21972242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98934247T ATE290001T1 (de)	1997-07-02	1998-07-01	Neue substituierte imidazolverbindungen

Country Status (22)

Country	Link
EP (2)	EP1014976B1 (de)
JP (2)	JP2002507992A (de)
KR (1)	KR20010014420A (de)
CN (1)	CN1134420C (de)
AR (1)	AR016294A1 (de)
AT (1)	ATE290001T1 (de)
AU (1)	AU8381298A (de)
BR (1)	BR9810342A (de)
CA (2)	CA2294522A1 (de)
CO (1)	CO4950624A1 (de)
CZ (1)	CZ9904750A3 (de)
DE (2)	DE69829192T2 (de)
ES (2)	ES2207847T3 (de)
HU (1)	HUP0002050A3 (de)
IL (3)	IL133035A0 (de)
NO (1)	NO996572L (de)
NZ (1)	NZ500922A (de)
PL (1)	PL337738A1 (de)
TR (1)	TR200000014T2 (de)
TW (1)	TW536539B (de)
WO (2)	WO1999001130A1 (de)
ZA (1)	ZA985763B (de)

Families Citing this family (39)

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US5916891A (en)	1992-01-13	1999-06-29	Smithkline Beecham Corporation	Pyrimidinyl imidazoles
US6979686B1 (en)	2001-12-07	2005-12-27	Pharmacia Corporation	Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en)	1997-05-22	2003-02-04	G.D. Searle & Company	Substituted pyrazoles as p38 kinase inhibitors
JP2002502380A (ja)	1997-05-22	2002-01-22	ジー．ディー．サールアンドカンパニー	ｐ３８キナーゼ阻害剤としてのピラゾール誘導体
WO1998056377A1 (en)	1997-06-13	1998-12-17	Smithkline Beecham Corporation	Novel pyrazole and pyrazoline substituted compounds
WO1998057966A1 (en)	1997-06-19	1998-12-23	Smithkline Beecham Corporation	Novel aryloxy substituted pyrimidine imidazole compounds
GB9713726D0 (en)	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
US7301021B2 (en)	1997-07-02	2007-11-27	Smithkline Beecham Corporation	Substituted imidazole compounds
US6489325B1 (en)	1998-07-01	2002-12-03	Smithkline Beecham Corporation	Substituted imidazole compounds
US6562832B1 (en)	1997-07-02	2003-05-13	Smithkline Beecham Corporation	Substituted imidazole compounds
WO1999017776A1 (en)	1997-10-08	1999-04-15	Smithkline Beecham Corporation	Novel cycloalkenyl substituted compounds
US6858617B2 (en)	1998-05-26	2005-02-22	Smithkline Beecham Corporation	Substituted imidazole compounds
EP1112070B1 (de)	1998-08-20	2004-05-12	Smithkline Beecham Corporation	Neue substituierte triazolverbindungen
US6548503B1 (en)	1998-11-04	2003-04-15	Smithkline Beecham Corporation	Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US7053099B1 (en)	1999-11-23	2006-05-30	Smithkline Beecham Corporation	3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
WO2001038314A1 (en)	1999-11-23	2001-05-31	Smithkline Beecham Corporation	3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
JP2003528043A (ja)	1999-11-23	2003-09-24	スミスクライン・ビーチャム・コーポレイション	ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物
EA008242B1 (ru)	1999-12-08	2007-04-27	Фармация Корпорейшн	Композиции на основе ингибитора циклооксигеназы-2 с быстро наступающим терапевтическим действием и способы лечения заболеваний
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
AR038957A1 (es)	2001-08-15	2005-02-02	Pharmacia Corp	Terapia de combinacion para el tratamiento del cancer
US20030225089A1 (en) *	2002-04-10	2003-12-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
WO2004004725A2 (en) *	2002-07-09	2004-01-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
AU2003291227A1 (en)	2002-11-05	2004-06-07	Smithkline Beecham Corporation	Antibacterial agents
PE20050676A1 (es)	2003-12-12	2005-11-02	Wyeth Corp	Quinolinas referidas a enfermedades cardiovasculares
TWI332003B (en) *	2004-01-30	2010-10-21	Lilly Co Eli	Kinase inhibitors
TWI326282B (en)	2004-04-28	2010-06-21	Mitsubishi Tanabe Pharma Corp	Heterocyclic compound
KR100793479B1 (ko) *	2004-04-28	2008-01-14	다나베 미츠비시 세이야꾸 가부시키가이샤	염증성 질환을 치료하기 위한 ｐ３８ＭＡＰ- 키나제억제제로서의４-２-(시클로알킬아미노)피리딘-4-일-(페닐)-이미다졸린-2-온 유도체
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
WO2006062110A1 (ja) *	2004-12-06	2006-06-15	Banyu Pharmaceutical Co., Ltd.	ピペラジン誘導体
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
CA2627497C (en)	2005-10-28	2014-10-14	Takeda Pharmaceutical Company Limited	Heterocyclic amide compound and use thereof
EP1992344A1 (de)	2007-05-18	2008-11-19	Institut Curie	P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
CA2890018A1 (en) *	2012-11-05	2014-05-08	Nant Holdings Ip, Llc	Substituted indol-5-ol derivatives and their therapeutical applications
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071144A1 (en)	2017-10-05	2019-04-11	Fulcrum Therapeutics, Inc.	USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION
CA3159250A1 (en) *	2019-11-29	2021-06-03	Facio Intellectual Property B.V.	New compounds for treatment of diseases related to dux4 expression
US20230271953A1 (en) *	2019-11-29	2023-08-31	Facio Intellectual Property B.V.	Novel compounds for treatment of diseases related to DUX4 expression

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NZ188244A (en) *	1977-09-13	1981-04-24	Ici Australia Ltd	2-substituted pyrimidines compositions growth regulating processes
CA1175431A (en) *	1980-07-25	1984-10-02	Alfred Sallmann	Tri-substituted imidazole derivatives, processes for their manufacture, pharmaceutical preparations containing them, and their use
US4503065A (en) *	1982-08-03	1985-03-05	E. I. Du Pont De Nemours And Company	Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
US4725600A (en) *	1984-07-13	1988-02-16	Fujisawa Pharmaceutical Co., Ltd.	Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
JPH082883B2 (ja) *	1986-06-06	1996-01-17	クミアイ化学工業株式会社	２−フエノキシピリミジン誘導体および除草剤
IL83467A0 (en) *	1986-08-15	1988-01-31	Fujisawa Pharmaceutical Co	Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
US5593992A (en) *	1993-07-16	1997-01-14	Smithkline Beecham Corporation	Compounds
US5670527A (en) *	1993-07-16	1997-09-23	Smithkline Beecham Corporation	Pyridyl imidazole compounds and compositions
US5593991A (en) *	1993-07-16	1997-01-14	Adams; Jerry L.	Imidazole compounds, use and process of making
NZ302117A (en) *	1995-01-12	1999-10-28	Smithkline Beecham Corp	1-cycloalkyl or cycloalkylalkyl 4,5-trisubstituted imidazole derivatives and medicaments
IL118544A (en) *	1995-06-07	2001-08-08	Smithkline Beecham Corp	History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
TR199801361T2 (xx) *	1996-01-11	1998-10-21	Smithkline Beecham Corporation	Yeni ikameli imidazol bile�imleri.
JP2000507224A (ja) *	1996-03-08	2000-06-13	スミスクライン・ビーチャム・コーポレイション	Ｃｓａｉｄ化合物の血管形成の抑制物質としての使用
WO1997035856A1 (en) *	1996-03-25	1997-10-02	Smithkline Beecham Corporation	Novel treatment for cns injuries

1998
- 1998-06-30 AR ARP980103180A patent/AR016294A1/es not_active Application Discontinuation
- 1998-07-01 DE DE69829192T patent/DE69829192T2/de not_active Expired - Fee Related
- 1998-07-01 WO PCT/US1998/013809 patent/WO1999001130A1/en not_active Ceased
- 1998-07-01 ZA ZA985763A patent/ZA985763B/xx unknown
- 1998-07-01 JP JP50738599A patent/JP2002507992A/ja active Pending
- 1998-07-01 CN CNB988066440A patent/CN1134420C/zh not_active Expired - Fee Related
- 1998-07-01 CO CO98037026A patent/CO4950624A1/es unknown
- 1998-07-01 CA CA002294522A patent/CA2294522A1/en not_active Abandoned
- 1998-07-01 EP EP98934247A patent/EP1014976B1/de not_active Expired - Lifetime
- 1998-07-01 AU AU83812/98A patent/AU8381298A/en not_active Abandoned
- 1998-07-01 DE DE69818266T patent/DE69818266T2/de not_active Expired - Fee Related
- 1998-07-01 TR TR2000/00014T patent/TR200000014T2/xx unknown
- 1998-07-01 HU HU0002050A patent/HUP0002050A3/hu active IP Right Revival
- 1998-07-01 CZ CZ19994750A patent/CZ9904750A3/cs unknown
- 1998-07-01 ES ES98934244T patent/ES2207847T3/es not_active Expired - Lifetime
- 1998-07-01 BR BR9810342-3A patent/BR9810342A/pt not_active Application Discontinuation
- 1998-07-01 ES ES98934247T patent/ES2237843T3/es not_active Expired - Lifetime
- 1998-07-01 IL IL13303598A patent/IL133035A0/xx unknown
- 1998-07-01 NZ NZ500922A patent/NZ500922A/en unknown
- 1998-07-01 CA CA002294524A patent/CA2294524A1/en not_active Abandoned
- 1998-07-01 WO PCT/US1998/013805 patent/WO1999001131A1/en not_active Ceased
- 1998-07-01 KR KR1019997012604A patent/KR20010014420A/ko not_active Ceased
- 1998-07-01 JP JP50738999A patent/JP2002507994A/ja active Pending
- 1998-07-01 EP EP98934244A patent/EP0996446B1/de not_active Expired - Lifetime
- 1998-07-01 PL PL98337738A patent/PL337738A1/xx unknown
- 1998-07-01 AT AT98934247T patent/ATE290001T1/de not_active IP Right Cessation
- 1998-08-27 TW TW087110613A patent/TW536539B/zh not_active IP Right Cessation
1999
- 1999-12-30 NO NO996572A patent/NO996572L/no not_active Application Discontinuation
2008
- 2008-03-17 IL IL190216A patent/IL190216A0/en unknown
- 2008-03-17 IL IL190215A patent/IL190215A0/en unknown

Also Published As

Publication number	Publication date
IL133035A0 (en)	2001-03-19
HUP0002050A3 (en)	2002-04-29
AU8381598A (en)	1999-01-25
CO4950624A1 (es)	2000-09-01
DE69829192T2 (de)	2006-02-16
NZ500922A (en)	2001-12-21
JP2002507992A (ja)	2002-03-12
DE69818266D1 (de)	2003-10-23
IL190216A0 (en)	2008-11-03
WO1999001130A1 (en)	1999-01-14
IL190215A0 (en)	2008-11-03
TR200000014T2 (tr)	2000-11-21
NO996572D0 (no)	1999-12-30
ZA985763B (en)	1999-01-19
EP0996446B1 (de)	2003-09-17
HUP0002050A2 (hu)	2001-04-28
EP0996446A4 (de)	2001-08-29
ES2207847T3 (es)	2004-06-01
DE69829192D1 (de)	2005-04-07
CN1134420C (zh)	2004-01-14
CA2294522A1 (en)	1999-01-14
AR016294A1 (es)	2001-07-04
CA2294524A1 (en)	1999-01-14
CN1261277A (zh)	2000-07-26
EP0996446A1 (de)	2000-05-03
EP1014976A4 (de)	2001-08-29
WO1999001131A1 (en)	1999-01-14
TW536539B (en)	2003-06-11
PL337738A1 (en)	2000-08-28
EP1014976A1 (de)	2000-07-05
ES2237843T3 (es)	2005-08-01
KR20010014420A (ko)	2001-02-26
EP1014976B1 (de)	2005-03-02
AU737637B2 (en)	2001-08-23
CZ9904750A3 (cs)	2001-12-12
JP2002507994A (ja)	2002-03-12
NO996572L (no)	1999-12-30
BR9810342A (pt)	2000-09-05
AU8381298A (en)	1999-01-25
DE69818266T2 (de)	2004-07-15

Legal Events

Date	Code	Title	Description
2005-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE264105T1 (de)	2004-04-15	Neue substituierte imidazolverbindungen
DE69829192D1 (de)	2005-04-07	Neue substituierte imidazolverbindungen
ATE261964T1 (de)	2004-04-15	Neue antiarrhytmische bispidin-verbindungen
PT860428E (pt)	2005-04-29	Compostos pirimidiona
IS5479A (is)	2000-05-03	Efnasambönd
IS5478A (is)	2000-05-03	Efnasambönd
IS5477A (is)	2000-05-03	Efnasambönd
ATE225792T1 (de)	2002-10-15	Neue spiroazabizyklische heterozyklische verbindungen
IS5354A (is)	2000-01-20	Ný efnasambönd
ID22850A (id)	1999-12-09	Senyawa-senyawa pirazina
NO994877D0 (no)	1999-10-07	Kalsilytiske forbindelser
ID20323A (id)	1998-11-26	Senyawa-senyawa triazinilaminostilbena
IS5208A (is)	1999-10-05	Efnasambönd
IS5237A (is)	1999-11-01	Efnasambönd
EE9900602A (et)	2000-08-15	Ühendid
ID22983A (id)	1999-12-23	Senyawa-senyawa fluorometoksimino
NO995007D0 (no)	1999-10-14	Forbindelser
DE59804807D1 (de)	2002-08-22	Pi-komplex-verbindungen
DE69737634D1 (de)	2007-05-31	Insektizide oxadiazinverbindungen
SE9701397D0 (sv)	1997-04-15	Compounds
ID18388A (id)	1998-04-02	Senyawa-senyawa heterosiklik
ID21202A (id)	1999-05-06	Senyawa heterosiklik
SE9701964D0 (sv)	1997-05-26	Compounds
SE9704837D0 (sv)	1997-12-22	New compounds
SE9702746D0 (sv)	1997-07-18	New compounds