ATE290863T1 - Verwendung von prolactinmodulatoren und diät zur herstellung eines medikamentes zur behandlung der fettleibigkeit - Google Patents

Verwendung von prolactinmodulatoren und diät zur herstellung eines medikamentes zur behandlung der fettleibigkeit

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Publication number
ATE290863T1
ATE290863T1 AT95907471T AT95907471T ATE290863T1 AT E290863 T1 ATE290863 T1 AT E290863T1 AT 95907471 T AT95907471 T AT 95907471T AT 95907471 T AT95907471 T AT 95907471T AT E290863 T1 ATE290863 T1 AT E290863T1
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AT
Austria
Prior art keywords
subject
treatment
obesity
prolactin
reduction
Prior art date
Application number
AT95907471T
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English (en)
Inventor
Anthony H Cincotta
Albert H Meier
Original Assignee
Pliva D D
Univ Louisiana State
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Application filed by Pliva D D, Univ Louisiana State filed Critical Pliva D D
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Publication of ATE290863T1 publication Critical patent/ATE290863T1/de

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
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    • A61K31/13Amines
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    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/47Quinolines; Isoquinolines
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
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AT95907471T 1994-01-07 1995-01-06 Verwendung von prolactinmodulatoren und diät zur herstellung eines medikamentes zur behandlung der fettleibigkeit ATE290863T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/178,569 US5744477A (en) 1988-05-10 1994-01-07 Method for treatment of obesity using prolactin modulators and diet
PCT/US1995/000663 WO1995018614A1 (en) 1994-01-07 1995-01-06 Method for treatment of obesity using prolactin modulators and diet

Publications (1)

Publication Number Publication Date
ATE290863T1 true ATE290863T1 (de) 2005-04-15

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AT95907471T ATE290863T1 (de) 1994-01-07 1995-01-06 Verwendung von prolactinmodulatoren und diät zur herstellung eines medikamentes zur behandlung der fettleibigkeit

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US (2) US5744477A (de)
EP (1) EP0808164B1 (de)
JP (2) JPH09510960A (de)
AT (1) ATE290863T1 (de)
AU (1) AU1569395A (de)
CA (1) CA2180479C (de)
DE (1) DE69534084T2 (de)
DK (1) DK0808164T3 (de)
ES (1) ES2239316T3 (de)
MX (1) MX9602701A (de)
PT (1) PT808164E (de)
WO (1) WO1995018614A1 (de)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
US5668155A (en) * 1988-05-10 1997-09-16 The General Hospital Corporation Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders
IL143197A0 (en) 1998-11-20 2002-04-21 Rtp Pharma Inc Dispersible phospholipid stabilized microparticles
US20030082647A1 (en) * 2000-12-12 2003-05-01 Reenan Robert A. Transporter protein
EP1399553A2 (de) 2000-12-12 2004-03-24 The University of Connecticut Für zelluläre transportproteine kodierende nukleinsäuren und methoden zur verwendung daraus
NZ527408A (en) * 2001-02-22 2005-04-29 Skyepharma Canada Inc Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia
US20040018959A1 (en) * 2002-05-02 2004-01-29 Randall S. Hickle System and methods of lipid removal from the body
US9655865B2 (en) 2002-07-29 2017-05-23 Veroscience, Llc Therapeutic treatment for metabolic syndrome, type 2 diabetes, obesity, or prediabetes
US8821915B2 (en) 2002-08-09 2014-09-02 Veroscience, Llc Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
US20040081678A1 (en) * 2002-08-09 2004-04-29 Anthony Cincotta Therapeutic process for the treatment of obesity and associated metabolic disorders
EP3524248A1 (de) 2007-06-21 2019-08-14 VeroScience LLC Verfahren zur behandlung von metabolischen störungen und depressionen mit dopaminrezeptoragonisten
US20100035886A1 (en) 2007-06-21 2010-02-11 Veroscience, Llc Parenteral formulations of dopamine agonists
US8741918B2 (en) * 2007-06-21 2014-06-03 Veroscience Llc Parenteral formulations of dopamine agonists
PL386294A1 (pl) 2008-10-16 2010-04-26 Ryszka Florian Biochefa Farmaceutyczny Zakład Naukowo-Produkcyjny Sposób przyśpieszenia rozwoju prosiąt ssących
US9352025B2 (en) 2009-06-05 2016-05-31 Veroscience Llc Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders
PL389116A1 (pl) * 2009-09-24 2011-03-28 Ryszka Florian Biochefa Farmaceutyczny Zakład Naukowo-Produkcyjny Sposób przyśpieszenia rozwoju ssaków użytkowych
US8431155B1 (en) 2012-04-30 2013-04-30 Veroscience Llc Bromocriptine formulations
DK3445362T3 (da) 2016-04-20 2021-10-11 Veroscience Llc Sammensætning og fremgangsmåde til behandling af stofskiftesygdomme
WO2019079623A1 (en) 2017-10-18 2019-04-25 Veroscience Llc ENHANCED BROMOCRIPTINE FORMULATIONS
US11607455B2 (en) 2019-09-23 2023-03-21 Veroscience Llc Method for inducing tumor regression

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
IT1157365B (it) * 1977-10-24 1987-02-11 Sandoz Ag Medicamenti per trattare l'obesita' o ridurre il peso del corpo
US4749709A (en) * 1986-03-07 1988-06-07 Louisiana State University And Agricultural And Mechanical College Method of inhibiting body fat stores
US4783469A (en) * 1986-03-07 1988-11-08 Meier Albert H Method of inhibiting body fat stores
US4659715A (en) * 1986-03-07 1987-04-21 Louisiana State University And Agricultural And Mechanical College Method of inhibiting body fat stores
DE3722383A1 (de) * 1986-07-14 1988-01-28 Sandoz Ag Neue verwendung von bromocriptin
US5585347A (en) * 1988-05-10 1996-12-17 Ergo Science Incorporated Methods for the determination and adjustment of prolactin daily rhythms
US5344832A (en) * 1990-01-10 1994-09-06 The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College Method for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates
US5006526A (en) * 1988-10-17 1991-04-09 Louisiana State University Method of treating a vertebrate animal to reduce plasma triglycerides and cholesterol levels and to alleviate and prevent atherosclerosis
CA2030174C (en) * 1990-01-10 1996-12-24 Anthony H. Cincotta Process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hypoglycemia in vertebrates
FI904677A7 (fi) * 1990-09-24 1992-03-25 Ahlstroem Consumer Prod Menetelmä sterilointikääreen pakkaamiseksi
ES2050556T3 (es) * 1990-12-20 1994-05-16 Audi Ag Estructura sustentante de una carroceria para un turismo.
WO1993012793A1 (en) * 1991-12-23 1993-07-08 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College A therapeutic process for the treatment of the pathologies of type ii diabetes

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JPH09510960A (ja) 1997-11-04
PT808164E (pt) 2005-05-31
US5760047A (en) 1998-06-02
EP0808164A1 (de) 1997-11-26
DE69534084D1 (de) 2005-04-21
DE69534084T2 (de) 2006-02-09
ES2239316T3 (es) 2005-09-16
EP0808164A4 (de) 2001-02-07
JP2007332163A (ja) 2007-12-27
CA2180479A1 (en) 1995-07-13
DK0808164T3 (da) 2005-06-27
AU1569395A (en) 1995-08-01
MX9602701A (es) 1997-04-30
CA2180479C (en) 2009-10-06
EP0808164B1 (de) 2005-03-16
US5744477A (en) 1998-04-28

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