ATE291018T1 - Pyrazol verbindungen und ihre verwendung - Google Patents

Pyrazol verbindungen und ihre verwendung

Info

Publication number: ATE291018T1
Authority: AT; Austria
Prior art keywords: pyrazole compounds; same; compounds; organism; directed
Prior art date: 1998-12-24

Application number

AT99966665T

Other languages

English (en)

Inventor

Bradley B Brown

Patrick J Casey

Zita Latona

Casey Pritchard Purdy

Sarah Tavares

Original Assignee

Ppd Discovery Inc

Univ Duke

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-24

Filing date

1999-12-21

Publication date

2005-04-15

1999-12-21 Application filed by Ppd Discovery Inc, Univ Duke filed Critical Ppd Discovery Inc

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291018T1 publication Critical patent/ATE291018T1/de

Links

WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000013823 prenylation Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Indole Compounds (AREA)

AT99966665T 1998-12-24 1999-12-21 Pyrazol verbindungen und ihre verwendung ATE291018T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11394898P	1998-12-24	1998-12-24
US09/440,209 US6191147B1 (en)	1998-12-24	1999-11-15	Pyrazole compounds and uses thereof
PCT/US1999/030951 WO2000039083A2 (en)	1998-12-24	1999-12-21	Pyrazole compounds and uses thereof

Publications (1)

Publication Number	Publication Date
ATE291018T1 true ATE291018T1 (de)	2005-04-15

Family

ID=26811662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99966665T ATE291018T1 (de)	1998-12-24	1999-12-21	Pyrazol verbindungen und ihre verwendung

Country Status (8)

Country	Link
US (1)	US6191147B1 (de)
EP (1)	EP1140900B1 (de)
JP (1)	JP2002533436A (de)
AT (1)	ATE291018T1 (de)
AU (2)	AU772943B2 (de)
CA (1)	CA2359462C (de)
DE (1)	DE69924292T2 (de)
WO (1)	WO2000039083A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL152097A0 (en) *	2000-05-19	2003-05-29	Applied Research Systems	Use of pyrazole derivatives for treating infertility
EP1457205A4 (de)	2001-11-30	2006-07-05	Santen Pharmaceutical Co Ltd	Angiogenesehemmer
AU2003265395A1 (en) *	2002-08-14	2004-03-03	Ppd Discovery, Inc.	Prenylation inhibitors and methods of their synthesis and use
WO2004016741A2 (en) *	2002-08-14	2004-02-26	Ppd Discovery, Inc.	Prenylation inhibitors containing dimethyl-cyclobutane and methods of their synthesis and use
US6649638B1 (en) *	2002-08-14	2003-11-18	Ppd Discovery, Inc.	Prenylation inhibitors and methods of their synthesis and use
JP4691041B2 (ja)	2003-11-20	2011-06-01	チルドレンズホスピタルメディカルセンター	Ｇｔｐアーゼ阻害剤および使用方法
US6799739B1 (en) *	2003-11-24	2004-10-05	The Boeing Company	Aircraft control surface drive system and associated methods
US7826982B2 (en)	2005-07-29	2010-11-02	Children's Hospital Medical Center	Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE
EP1939181A1 (de) *	2006-12-27	2008-07-02	sanofi-aventis	Heteroaryl-substituierte Carboxamide und deren Verwendung für die Stimulierung der NO Synthase Expression
TWI448284B (zh) *	2007-04-24	2014-08-11	Theravance Inc	雙效抗高血壓劑
CN101801194A (zh) *	2007-08-15	2010-08-11	记忆医药公司	具有5-ht6受体亲和力的3’取代的化合物
US20110009463A1 (en) *	2007-10-17	2011-01-13	Yuri Karl Petersson	Geranylgeranyl transferase inhibitors and methods of making and using the same
WO2010032874A1 (ja) *	2008-09-19	2010-03-25	住友化学株式会社	農業用組成物
FR2949463B1 (fr) *	2009-08-26	2011-09-16	Commissariat Energie Atomique	Inhibiteurs de mmp
WO2011161645A1 (en)	2010-06-25	2011-12-29	Ranbaxy Laboratories Limited	5-lipoxygenase inhibitors
EP2588465B1 (de)	2010-06-30	2017-01-25	Ironwood Pharmaceuticals, Inc.	Sgc-stimulatoren
CN107266433A (zh)	2010-11-09	2017-10-20	铁木医药有限公司	sGC刺激剂
CN106117194A (zh)	2011-12-27	2016-11-16	铁木医药有限公司	可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类
US9980942B2 (en)	2012-05-02	2018-05-29	Children's Hospital Medical Center	Rejuvenation of precursor cells
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
CN114450027A (zh)	2019-08-16	2022-05-06	儿童医院医疗中心	用cdc42特异性抑制剂治疗受试者的方法
CN111961048B (zh) *	2020-08-26	2022-05-13	南通大学	含取代β-咔啉结构的三氟甲基吡唑酰胺及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4826868A (en)	1986-05-29	1989-05-02	Ortho Pharmaceutical Corporation	1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
US5164381A (en)	1986-05-29	1992-11-17	Ortho Pharmaceutical Corporation	Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
PH27357A (en) *	1989-09-22	1993-06-21	Fujisawa Pharmaceutical Co	Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2665898B1 (fr)	1990-08-20	1994-03-11	Sanofi	Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
DE4414974A1 (de)	1994-04-29	1995-11-02	Bayer Ag	Substituierte Pyrazolinderivate
DE69635114T2 (de) *	1995-08-09	2006-03-02	Banyu Pharmaceutical Co., Ltd.	Proteinfarnesyltransferase-inhibitoren in kombination mit hmgcoa-reduktase-inhibitoren zur behandlung von aids
US5633388A (en)	1996-03-29	1997-05-27	Viropharma Incorporated	Compounds, compositions and methods for treatment of hepatitis C
DE19623892A1 (de)	1996-06-06	1997-12-11	Hoechst Schering Agrevo Gmbh	Substituierte Pyrazolyl-pyrazolderivate
AU754830C (en)	1997-05-22	2004-02-12	G.D. Searle Llc	Substituted pyrazoles as p38 kinase inhibitors

1999
- 1999-11-15 US US09/440,209 patent/US6191147B1/en not_active Expired - Lifetime
- 1999-12-21 JP JP2000590996A patent/JP2002533436A/ja active Pending
- 1999-12-21 EP EP99966665A patent/EP1140900B1/de not_active Expired - Lifetime
- 1999-12-21 DE DE69924292T patent/DE69924292T2/de not_active Expired - Lifetime
- 1999-12-21 AT AT99966665T patent/ATE291018T1/de not_active IP Right Cessation
- 1999-12-21 WO PCT/US1999/030951 patent/WO2000039083A2/en not_active Ceased
- 1999-12-21 CA CA2359462A patent/CA2359462C/en not_active Expired - Fee Related
- 1999-12-21 AU AU22166/00A patent/AU772943B2/en not_active Ceased
2004
- 2004-06-29 AU AU2004202912A patent/AU2004202912A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1140900A4 (de)	2002-04-10
CA2359462A1 (en)	2000-07-06
CA2359462C (en)	2010-07-06
DE69924292D1 (de)	2005-04-21
AU2216600A (en)	2000-07-31
WO2000039083A2 (en)	2000-07-06
AU772943B2 (en)	2004-05-13
EP1140900B1 (de)	2005-03-16
JP2002533436A (ja)	2002-10-08
EP1140900A2 (de)	2001-10-10
US6191147B1 (en)	2001-02-20
WO2000039083A3 (en)	2000-11-02
DE69924292T2 (de)	2006-04-13
AU2004202912A1 (en)	2004-07-22

Legal Events

Date	Code	Title	Description
2005-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE291018T1 (de)	2005-04-15	Pyrazol verbindungen und ihre verwendung
ATE219765T1 (de)	2002-07-15	Indolderivate als cgmp-pde inhibitoren
TR200101499T1 (tr)	2002-09-23	Azepinoindol türevleri, hazırlanmaları ve kullanımları.
TR200200778T2 (tr)	2002-06-21	Pirazol türevleri.
EA200300248A1 (ru)	2003-08-28	Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
ATE228507T1 (de)	2002-12-15	Substituierte 6-phenylphenanthridine
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
MY126862A (en)	2006-10-31	Purine derivatives inhibitors of tyrosine protein kinase syk
SE9504661D0 (sv)	1995-12-22	New compounds
DK1070056T3 (da)	2004-11-08	Phthalazinon-PDE III/IV-inhibitorer
DK0738270T3 (da)	1998-10-07	Dihydropyrazolopyrroler
TR200102338T2 (tr)	2002-07-22	Siklik ikame edilmiş bağlı pirolokarbazoller ve izoindolonlar.
DE60045508D1 (de)	2011-02-24	Dalda-analoge und ihre verwendung
ATE230392T1 (de)	2003-01-15	Amidinophenyl-pyrrolidine, -pyrroline und - isoxazolidine und ihre derivate
BG100069A (bg)	1996-04-30	Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им
ATE316962T1 (de)	2006-02-15	Pyrimidin-derivate als selective inhibitoren von cox-2
AP2000001761A0 (en)	2000-03-31	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
TR200200125T2 (tr)	2002-09-23	Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar.
TR200103789T2 (tr)	2002-04-22	Tirozin kinaz inhibitörleri olarak ikameli 1,4-dihidroindeno[1,2-C]pirazoller.
SE9504662D0 (sv)	1995-12-22	New compounds
AP2000001760A0 (en)	2000-03-31	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
AP2002002595A0 (en)	2002-09-30	Heterocyclic amide derivatives.
DE59803066D1 (de)	2002-03-21	Substituierte benzyloxyimino-verbindungen
TR200003877T2 (tr)	2001-06-21	İnsan CD23 üretiminin ve TNF salınmasının ihhibitörleri olan hiydroxamic acid türevleri
TR200100475T2 (tr)	2001-06-21	N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları.