ATE291080T1 - Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden - Google Patents

Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden

Info

Publication number
ATE291080T1
ATE291080T1 AT97953093T AT97953093T ATE291080T1 AT E291080 T1 ATE291080 T1 AT E291080T1 AT 97953093 T AT97953093 T AT 97953093T AT 97953093 T AT97953093 T AT 97953093T AT E291080 T1 ATE291080 T1 AT E291080T1
Authority
AT
Austria
Prior art keywords
gene
compositions
methods
polypeptides encoded
human lipase
Prior art date
Application number
AT97953093T
Other languages
English (en)
Inventor
Michael C Jaye
Kim-Anh Thi Doan
John A Krawiec
Kevin J Lynch
Dilip V Amin
Victoria J South
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE291080T1 publication Critical patent/ATE291080T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97953093T 1996-12-06 1997-12-05 Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden ATE291080T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3278396P 1996-12-06 1996-12-06
US3225496P 1996-12-06 1996-12-06
PCT/US1997/022331 WO1998024888A2 (en) 1996-12-06 1997-12-05 Polypeptides encoded by a human lipase-like gene, compositions and methods

Publications (1)

Publication Number Publication Date
ATE291080T1 true ATE291080T1 (de) 2005-04-15

Family

ID=26708180

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97953093T ATE291080T1 (de) 1996-12-06 1997-12-05 Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden

Country Status (21)

Country Link
US (4) US6395530B1 (de)
EP (1) EP0948609B1 (de)
JP (2) JP4615634B2 (de)
KR (1) KR100516561B1 (de)
CN (2) CN100497610C (de)
AP (1) AP1313A (de)
AT (1) ATE291080T1 (de)
AU (1) AU750891B2 (de)
BG (1) BG64798B1 (de)
BR (1) BR9713847A (de)
CA (1) CA2273823C (de)
CZ (1) CZ299055B6 (de)
DE (2) DE948609T1 (de)
EA (1) EA003293B1 (de)
ES (1) ES2239367T3 (de)
IL (2) IL129986A0 (de)
NO (1) NO326140B1 (de)
OA (1) OA11057A (de)
PL (1) PL191624B1 (de)
SK (1) SK287687B6 (de)
WO (1) WO1998024888A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008776B1 (en) * 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
US6395530B1 (en) * 1996-12-06 2002-05-28 Aventis Pharmaceuticals Inc. LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies
US7692067B2 (en) * 2002-09-18 2010-04-06 Mendel Biotechnology, Inc. Yield and stress tolerance in transgenic plants
KR20050044812A (ko) * 1999-03-26 2005-05-12 아벤티스 파마슈티칼스 인크. Ｌｉｐｇ의 발현을 저하시키고 고밀도 지단백질(ｈｄｌ)콜레스테롤 및 아포지단백질 ａｉ의 수준을 증가시키는조성물
GB9920334D0 (en) 1999-08-28 1999-11-03 Glaxo Group Ltd Method
US6337187B1 (en) 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
AU1361601A (en) * 1999-11-05 2001-05-14 Millennium Pharmaceuticals, Inc. 18892, a novel human lipase
US20030165845A1 (en) * 2000-09-25 2003-09-04 Millennium Pharmaceuticals, Inc. 47647, a novel human lipase and uses therefor
US7507808B2 (en) * 2002-12-12 2009-03-24 Isis Pharmaceuticals, Inc. Modulation of endothelial lipase expression
CN102250854B (zh) * 2011-07-01 2013-03-27 浙江商达环保有限公司 用于处理油脂污染物的脂肪酶、编码基因及其应用
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
MA41035A (fr) * 2014-08-19 2017-08-15 Shire Human Genetic Therapies Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë
TWI688575B (zh) * 2014-09-11 2020-03-21 日商塩野義製藥股份有限公司 阻礙血管內皮脂酶之酵素活性的人類化單株抗體
EP4713003A1 (de) * 2023-05-17 2026-03-25 Institut National de la Santé et de la Recherche Médicale Lipc-variante zur behandlung von hypercholesterinämie und atherosklerotischer kardiovaskulärer erkrankung

Family Cites Families (33)

* Cited by examiner, † Cited by third party
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US5691181A (en) * 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
FR2573436B1 (fr) 1984-11-20 1989-02-17 Pasteur Institut Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
JP2764264B2 (ja) 1987-10-01 1998-06-11 株式会社ミドリ十字 線溶活性増強剤
US4944944A (en) * 1987-11-19 1990-07-31 Oklahoma Medical Research Foundation Dietary compositions and methods using bile salt-activated lipase
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5364777A (en) 1992-04-03 1994-11-15 American Air Liquide Method of improving lipase activity using noble gases
HRP930935A2 (en) * 1992-06-11 1994-12-31 Astra Ab New dna sequences
DK88892D0 (da) 1992-07-06 1992-07-06 Novo Nordisk As Forbindelse
AU687010B2 (en) 1992-07-17 1998-02-19 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
US5998189A (en) * 1992-12-16 1999-12-07 Warner-Lambert Company Polypeptide derivatives of dog gastric lipase and pharmaceutical compositions containing same
ES2164699T3 (es) * 1993-03-05 2002-03-01 Univ Catholique Louvain Anticuerpo lo-cd2a y usos del mismo para inhibir la activacion y la proliferacion de las celulas t.
FR2704556B1 (fr) 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
FR2706486B1 (fr) 1993-06-16 1995-09-01 Rhone Poulenc Rorer Sa Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
SK282843B6 (sk) 1993-07-13 2002-12-03 Rhone-Poulenc Rorer S. A. Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
DE69527835T2 (de) 1994-02-22 2003-04-10 Novozymes A/S, Bagsvaerd Methode zur herstellung einer variante eines lipolytischen enzymes
US5807746A (en) 1994-06-13 1998-09-15 Vanderbilt University Method for importing biologically active molecules into cells
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US6051220A (en) 1995-05-31 2000-04-18 Medzyme N.V. And Simon Lodewijk Scharpe Composition to improve digestibility and utilization of nutrients
US7008776B1 (en) 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
US6395530B1 (en) * 1996-12-06 2002-05-28 Aventis Pharmaceuticals Inc. LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies
WO1999032611A1 (en) 1997-12-19 1999-07-01 Progenitor, Inc. A lipase expressed in endothelial cells and methods for its use
US6337187B1 (en) * 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
US6558936B1 (en) * 1999-10-01 2003-05-06 Millennium Pharmaceuticals, Inc. Human lipase proteins, nucleic acids encoding them, and uses of both of these

Also Published As

Publication number Publication date
DE69732789T2 (de) 2005-08-11
BG64798B1 (bg) 2006-04-28
US20030108538A1 (en) 2003-06-12
US20120114660A1 (en) 2012-05-10
JP5416053B2 (ja) 2014-02-12
PL191624B1 (pl) 2006-06-30
US20070101451A1 (en) 2007-05-03
NO326140B1 (no) 2008-10-06
HK1068636A1 (zh) 2005-04-29
CA2273823A1 (en) 1998-06-11
US6395530B1 (en) 2002-05-28
EP0948609A2 (de) 1999-10-13
AU750891B2 (en) 2002-08-01
CN1167793C (zh) 2004-09-22
US7056720B2 (en) 2006-06-06
DE948609T1 (de) 2000-03-09
HK1024929A1 (en) 2000-10-27
CZ9902003A3 (cs) 2000-10-11
EP0948609B1 (de) 2005-03-16
EA199900522A1 (ru) 2000-02-28
ES2239367T3 (es) 2005-09-16
CN100497610C (zh) 2009-06-10
US7579447B2 (en) 2009-08-25
IL129986A (en) 2006-07-05
BG103472A (en) 2001-01-31
WO1998024888A3 (en) 1998-08-13
JP4615634B2 (ja) 2011-01-19
KR20000069336A (ko) 2000-11-25
BR9713847A (pt) 2000-02-29
US8343494B2 (en) 2013-01-01
NO992735D0 (no) 1999-06-04
AU5690598A (en) 1998-06-29
AP9901548A0 (en) 1999-06-30
CN1539849A (zh) 2004-10-27
SK75399A3 (en) 2001-02-12
EA003293B1 (ru) 2003-04-24
CN1240000A (zh) 1999-12-29
JP2001505769A (ja) 2001-05-08
OA11057A (en) 2002-03-08
IL129986A0 (en) 2000-02-29
CZ299055B6 (cs) 2008-04-09
DE69732789D1 (de) 2005-04-21
KR100516561B1 (ko) 2005-09-22
WO1998024888A2 (en) 1998-06-11
JP2010284171A (ja) 2010-12-24
SK287687B6 (sk) 2011-06-06
AP1313A (en) 2004-10-04
CA2273823C (en) 2007-06-05
NO992735L (no) 1999-08-05

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