ATE291231T1 - Umgekehrtes labelierungsverfahren zur schnellen identifikation von marker/ziel-proteinen - Google Patents
Umgekehrtes labelierungsverfahren zur schnellen identifikation von marker/ziel-proteinenInfo
- Publication number
- ATE291231T1 ATE291231T1 AT01988064T AT01988064T ATE291231T1 AT E291231 T1 ATE291231 T1 AT E291231T1 AT 01988064 T AT01988064 T AT 01988064T AT 01988064 T AT01988064 T AT 01988064T AT E291231 T1 ATE291231 T1 AT E291231T1
- Authority
- AT
- Austria
- Prior art keywords
- labeling
- proteins
- isotope
- marker
- rapid identification
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 8
- 108090000623 proteins and genes Proteins 0.000 title abstract 8
- 238000002372 labelling Methods 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000003550 marker Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000010348 incorporation Methods 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-NJFSPNSNSA-N ((18)O)water Chemical compound [18OH2] XLYOFNOQVPJJNP-NJFSPNSNSA-N 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 abstract 1
- 239000013068 control sample Substances 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Measurement Of Radiation (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25755900P | 2000-12-22 | 2000-12-22 | |
| US33296501P | 2001-11-19 | 2001-11-19 | |
| PCT/EP2001/015228 WO2002052271A2 (en) | 2000-12-22 | 2001-12-21 | Inverse labeling method for the rapid identification of marker/target proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE291231T1 true ATE291231T1 (de) | 2005-04-15 |
Family
ID=26946044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01988064T ATE291231T1 (de) | 2000-12-22 | 2001-12-21 | Umgekehrtes labelierungsverfahren zur schnellen identifikation von marker/ziel-proteinen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20020090652A1 (de) |
| EP (1) | EP1346229B1 (de) |
| JP (1) | JP2004516486A (de) |
| AT (1) | ATE291231T1 (de) |
| AU (1) | AU2002240866B2 (de) |
| CA (1) | CA2432052A1 (de) |
| DE (1) | DE60109490T2 (de) |
| DK (1) | DK1346229T3 (de) |
| ES (1) | ES2238493T3 (de) |
| PT (1) | PT1346229E (de) |
| WO (1) | WO2002052271A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7846748B2 (en) * | 2002-12-02 | 2010-12-07 | The University Of North Carolina At Chapel Hill | Methods of quantitation and identification of peptides and proteins |
| GB0228429D0 (en) * | 2002-12-05 | 2003-01-08 | Novartis Ag | Organic compounds |
| EP1588145B1 (de) * | 2003-01-30 | 2011-07-06 | Life Technologies Corporation | Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung |
| US20050014279A1 (en) * | 2003-07-14 | 2005-01-20 | Nguyen Hoa Duc | Method of analysis of amine by mass spectrometry |
| JP2005181011A (ja) * | 2003-12-17 | 2005-07-07 | Yoshio Yamauchi | タンパク質解析方法 |
| CA2553223A1 (en) * | 2004-01-15 | 2005-08-04 | Cedars-Sinai Medical Center | System and method for expression proteomics based on isotope ratio modification |
| EP1711833A2 (de) * | 2004-02-06 | 2006-10-18 | Applera Corporation | Herstellung biologisch abgeleiteter fluide zur biomarkerbestimmung mittels massenspektrometrie |
| JP2008541701A (ja) * | 2005-05-04 | 2008-11-27 | ユニヴァーシティ オブ サウス フロリダ | がんの対象における処置応答の予測 |
| WO2006133192A2 (en) * | 2005-06-03 | 2006-12-14 | Waters Investments Limited | Generation and use of a catalog of polypeptide-related information for chemical analyses |
| WO2007013699A1 (ja) * | 2005-07-29 | 2007-02-01 | Eisai R & D Management Co., Ltd. | 化合物に対するタンパク質の結合力を解析する方法 |
| WO2007072648A1 (ja) * | 2005-12-21 | 2007-06-28 | Japan Health Sciences Foundation | 質量分析システムおよび質量分析方法 |
| JP5535622B2 (ja) * | 2006-07-03 | 2014-07-02 | フィジクロン | 多帯電イオンのための一次質量選択を行わないタンデム質量分光測定の方法および装置 |
| JP2008039608A (ja) * | 2006-08-07 | 2008-02-21 | Hitachi High-Technologies Corp | 質量分析システム |
| US7879799B2 (en) * | 2006-08-10 | 2011-02-01 | Institute For Systems Biology | Methods for characterizing glycoproteins and generating antibodies for same |
| WO2009025920A2 (en) * | 2007-06-04 | 2009-02-26 | Rosetta Inpharmatics Llc | Finding paired isotope groups |
| DK2205342T3 (en) * | 2007-10-02 | 2014-03-03 | Iroa Technologies Llc | GENERATION AND USE OF isotopic PATTERNS In mass spectrometric FÆNOTYPESAMMENLIGNING OF ORGANISMS |
| DE102009053225A1 (de) * | 2009-11-06 | 2011-05-12 | Deutsche Sporthochschule Köln | Verfahren zur Bestimmung der totalen Hämoglobinmenge im Körper eines Lebewesens |
| US9366678B2 (en) * | 2012-10-25 | 2016-06-14 | Wisconsin Alumni Research Foundation | Neutron encoded mass tags for analyte quantification |
| CN105301119B (zh) * | 2014-07-15 | 2017-06-06 | 中国科学院大连化学物理研究所 | 基于两端非等重标记的蛋白质氨基酸序列从头测序方法 |
| KR20200067193A (ko) | 2017-10-20 | 2020-06-11 | 에프. 호프만-라 로슈 아게 | 항체에 대한 카피 보호 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4224031A (en) * | 1977-11-15 | 1980-09-23 | Mee John M L | CI Mass spectrometric analysis of physiologically active compounds |
| US5209919A (en) * | 1990-07-13 | 1993-05-11 | Regents Of The University Of California | Method of measurement in biological systems |
| CA2027714C (en) * | 1990-07-13 | 2003-01-28 | Kenneth W. Turtletaub | Method of measurement in biological systems |
| US5338686A (en) * | 1992-04-29 | 1994-08-16 | Hellerstein Marc K | Method for measuring in vivo synthesis of biopolymers |
| US5538897A (en) * | 1994-03-14 | 1996-07-23 | University Of Washington | Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases |
| CA2274587A1 (en) * | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| AU745236B2 (en) * | 1997-02-14 | 2002-03-14 | George Washington University, The | An assay for the measurement of DNA synthesis rates |
| US5939229A (en) * | 1997-02-25 | 1999-08-17 | The United States Of America As Represented By The Secretary Of The Army | Method for determining chemical cross talk or isotopic scrambling induced by analytical procedures |
| US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| US6432651B1 (en) * | 1998-07-10 | 2002-08-13 | Cetek Corporation | Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry |
| ATE253126T1 (de) * | 1998-08-25 | 2003-11-15 | Univ Washington | Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen |
| CA2341157A1 (en) * | 1998-08-31 | 2000-03-09 | University Of Washington | Stable isotope metabolic labeling for analysis of biopolymers |
| US6147344A (en) * | 1998-10-15 | 2000-11-14 | Neogenesis, Inc | Method for identifying compounds in a chemical mixture |
| US6629040B1 (en) * | 1999-03-19 | 2003-09-30 | University Of Washington | Isotope distribution encoded tags for protein identification |
| US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
| US6391649B1 (en) * | 1999-05-04 | 2002-05-21 | The Rockefeller University | Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy |
| DE60124265D1 (de) * | 2000-05-05 | 2006-12-14 | Purdue Research Foundation | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen |
| WO2001094935A2 (en) * | 2000-06-09 | 2001-12-13 | Mds Proteomics, Inc. | Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing |
-
2001
- 2001-12-10 US US10/016,627 patent/US20020090652A1/en not_active Abandoned
- 2001-12-21 EP EP01988064A patent/EP1346229B1/de not_active Expired - Lifetime
- 2001-12-21 AT AT01988064T patent/ATE291231T1/de not_active IP Right Cessation
- 2001-12-21 CA CA002432052A patent/CA2432052A1/en not_active Abandoned
- 2001-12-21 PT PT01988064T patent/PT1346229E/pt unknown
- 2001-12-21 ES ES01988064T patent/ES2238493T3/es not_active Expired - Lifetime
- 2001-12-21 AU AU2002240866A patent/AU2002240866B2/en not_active Ceased
- 2001-12-21 JP JP2002553119A patent/JP2004516486A/ja active Pending
- 2001-12-21 DK DK01988064T patent/DK1346229T3/da active
- 2001-12-21 DE DE60109490T patent/DE60109490T2/de not_active Expired - Fee Related
- 2001-12-21 WO PCT/EP2001/015228 patent/WO2002052271A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2432052A1 (en) | 2002-07-04 |
| DE60109490D1 (de) | 2005-04-21 |
| AU2002240866B2 (en) | 2005-03-24 |
| US20020090652A1 (en) | 2002-07-11 |
| EP1346229A2 (de) | 2003-09-24 |
| WO2002052271A3 (en) | 2002-10-31 |
| JP2004516486A (ja) | 2004-06-03 |
| WO2002052271A2 (en) | 2002-07-04 |
| EP1346229B1 (de) | 2005-03-16 |
| ES2238493T3 (es) | 2005-09-01 |
| DK1346229T3 (da) | 2005-05-30 |
| DE60109490T2 (de) | 2006-04-13 |
| PT1346229E (pt) | 2005-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1346229 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |