ATE291567T1 - Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten - Google Patents

Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten

Info

Publication number: ATE291567T1
Authority: AT; Austria
Prior art keywords: derivatives; aspirine; producing; nitroxymethylphenyl; esters
Prior art date: 1999-01-26

Application number

AT00904925T

Other languages

English (en)

Inventor

Soldato Piero Del

Michele Garufi

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-26

Filing date

2000-01-18

Publication date

2005-04-15

2000-01-18 Application filed by Nicox Sa filed Critical Nicox Sa

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291567T1 publication Critical patent/ATE291567T1/de

Links

BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical class CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title abstract 2
-1 NITROXYMETHYLPHENYL Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00904925T 1999-01-26 2000-01-18 Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten ATE291567T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI000134A IT1307928B1 (it)	1999-01-26	1999-01-26	Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
PCT/EP2000/000353 WO2000044705A1 (en)	1999-01-26	2000-01-18	Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Publications (1)

Publication Number	Publication Date
ATE291567T1 true ATE291567T1 (de)	2005-04-15

Family

ID=11381613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00904925T ATE291567T1 (de)	1999-01-26	2000-01-18	Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten

Country Status (18)

Country	Link
US (1)	US6512137B1 (de)
EP (1)	EP1147074B1 (de)
JP (1)	JP2002535380A (de)
KR (1)	KR100732147B1 (de)
CN (2)	CN1572787A (de)
AT (1)	ATE291567T1 (de)
AU (1)	AU766497B2 (de)
BR (1)	BR0007643A (de)
CA (1)	CA2361454A1 (de)
DE (1)	DE60018902T2 (de)
ES (1)	ES2239588T3 (de)
HU (1)	HUP0105011A3 (de)
IL (1)	IL144234A0 (de)
IT (1)	IT1307928B1 (de)
PT (1)	PT1147074E (de)
RU (1)	RU2232747C2 (de)
WO (1)	WO2000044705A1 (de)
ZA (1)	ZA200105705B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6297260B1 (en)	1998-10-30	2001-10-02	Nitromed, Inc.	Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1312115B1 (it)	1999-06-24	2002-04-04	Nicox Sa	Composti amorfi e relative composizioni farmaceutiche
ITMI991517A1 (it)	1999-07-09	2001-01-09	Nicox Sa	Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
US6649629B2 (en)	1999-12-23	2003-11-18	Nitromed, Inc.	Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
IT1319202B1 (it) *	2000-10-12	2003-09-26	Nicox Sa	Farmaci per le malattie a base infiammatoria.
DE60122939T2 (de)	2000-12-21	2007-01-11	Nitromed, Inc., Bedford	Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
ITMI20011308A1 (it)	2001-06-21	2002-12-21	Nicox Sa	Farmaci per il dolore cronico
ITMI20011307A1 (it) *	2001-06-21	2002-12-21	Nicox Sa	Farmaci per l'epilessia
US7220749B2 (en)	2002-06-11	2007-05-22	Nitromed, Inc.	Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7211598B2 (en)	2002-06-28	2007-05-01	Nitromed, Inc.	Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004004648A2 (en) *	2002-07-03	2004-01-15	Nitromed, Inc.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en)	2002-07-29	2004-02-16	Nicox S.A.	Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
WO2005054175A2 (en) *	2003-11-20	2005-06-16	Nicox S.A.	New process for the preparation of nitrooxyderivatives of paracetamol
WO2005065361A2 (en) *	2003-12-31	2005-07-21	Khosrow Kashfi	Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
JP5198063B2 (ja)	2004-08-26	2013-05-15	アッパラオ・サティアム	新規バイオ開裂性リンカー
TW200616604A (en)	2004-08-26	2006-06-01	Nicholas Piramal India Ltd	Nitric oxide releasing prodrugs containing bio-cleavable linker
JP2007275193A (ja) *	2006-04-04	2007-10-25	Fujifilm Corp	光プローブおよび光断層画像化装置
CN101820755B (zh)	2007-08-10	2013-05-15	巴赛尔·雷盖斯	抗炎化合物及其应用
ES2362894B1 (es) *	2009-11-16	2012-05-21	Ferrer Internacional S.A.	Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
KR20150085509A (ko) *	2012-09-21	2015-07-23	바질 리가스	염증-관련 장애, 통증 및 열, 피부 장애, 암 및 이의 전암성 질환의 치료용 조성물
WO2014052889A1 (en) *	2012-09-27	2014-04-03	The Board Of Trustees Of The University Of Illinois	Anti-inflammatory agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1243367B (it) *	1990-07-26	1994-06-10	Italfarmaco Spa	Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1276071B1 (it) *	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
SV1997000108A (es) *	1997-12-18	1999-11-24	Manufacturas Humberto Bukele E	Sintesis de acido acetilsalicilico en presencia de oxido de calcio

1999
- 1999-01-26 IT IT1999MI000134A patent/IT1307928B1/it active
2000
- 2000-01-18 BR BR0007643-0A patent/BR0007643A/pt not_active Application Discontinuation
- 2000-01-18 DE DE60018902T patent/DE60018902T2/de not_active Expired - Fee Related
- 2000-01-18 KR KR1020017009285A patent/KR100732147B1/ko not_active Expired - Fee Related
- 2000-01-18 CN CNA2004100636418A patent/CN1572787A/zh active Pending
- 2000-01-18 WO PCT/EP2000/000353 patent/WO2000044705A1/en not_active Ceased
- 2000-01-18 AU AU26645/00A patent/AU766497B2/en not_active Ceased
- 2000-01-18 RU RU2001120697/04A patent/RU2232747C2/ru not_active IP Right Cessation
- 2000-01-18 HU HU0105011A patent/HUP0105011A3/hu unknown
- 2000-01-18 AT AT00904925T patent/ATE291567T1/de not_active IP Right Cessation
- 2000-01-18 ES ES00904925T patent/ES2239588T3/es not_active Expired - Lifetime
- 2000-01-18 US US09/868,932 patent/US6512137B1/en not_active Expired - Fee Related
- 2000-01-18 CN CNB008051801A patent/CN1191228C/zh not_active Expired - Fee Related
- 2000-01-18 CA CA002361454A patent/CA2361454A1/en not_active Abandoned
- 2000-01-18 EP EP00904925A patent/EP1147074B1/de not_active Expired - Lifetime
- 2000-01-18 PT PT00904925T patent/PT1147074E/pt unknown
- 2000-01-18 IL IL14423400A patent/IL144234A0/xx unknown
- 2000-01-18 JP JP2000595962A patent/JP2002535380A/ja not_active Withdrawn
2001
- 2001-07-11 ZA ZA200105705A patent/ZA200105705B/en unknown

Also Published As

Publication number	Publication date
DE60018902D1 (de)	2005-04-28
ES2239588T3 (es)	2005-10-01
PT1147074E (pt)	2005-07-29
KR20010101653A (ko)	2001-11-14
AU2664500A (en)	2000-08-18
CA2361454A1 (en)	2000-08-03
EP1147074A1 (de)	2001-10-24
JP2002535380A (ja)	2002-10-22
DE60018902T2 (de)	2006-03-30
US6512137B1 (en)	2003-01-28
EP1147074B1 (de)	2005-03-23
HUP0105011A3 (en)	2002-12-28
CN1191228C (zh)	2005-03-02
ZA200105705B (en)	2002-10-11
KR100732147B1 (ko)	2007-06-25
CN1344244A (zh)	2002-04-10
WO2000044705A1 (en)	2000-08-03
BR0007643A (pt)	2001-10-16
CN1572787A (zh)	2005-02-02
HUP0105011A2 (hu)	2002-04-29
IL144234A0 (en)	2002-05-23
IT1307928B1 (it)	2001-11-29
ITMI990134A1 (it)	2000-07-26
RU2232747C2 (ru)	2004-07-20
AU766497B2 (en)	2003-10-16

Legal Events

Date

Code

Title

Description

2005-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1147074

Country of ref document: EP

2009-10-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE60018902D1 (de)	2005-04-28	Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten
DE69835357D1 (de)	2006-09-07	Verfahren zur Herstellung von Synthesegas
DE59814185D1 (de)	2008-04-17	Verfahren zur herstellung von verzweigten polycarbonaten
AT7109U3 (de)	2005-05-25	Verfahren zur herstellung von amlodipinmaleat
DE60143903D1 (de)	2011-03-03	Verfahren zur herstellung von estern
DE69902638D1 (de)	2002-10-02	Integriertes verfahren zur herstellung von dien-komplexen
DE60005779D1 (de)	2003-11-13	Verfahren zur herstellung von polyarylaten
DE60019561D1 (de)	2005-05-25	Verfahren zur herstellung von glycerolcarbonat
DE69802534D1 (de)	2001-12-20	Verfahren zur herstellung von fluorkohlenwasserstoffen
DE69909929D1 (de)	2003-09-04	Verfahren zur Herstellung von Methanol
DE50104778D1 (de)	2005-01-13	Verfahren zur herstellung von polyisobutenylphenolen
DE60003264D1 (de)	2003-07-17	Verfahren zur herstellung von glycerylethern
DE60032894D1 (de)	2007-02-22	Verfahren zur herstellung von stadtgas
DE69811870D1 (de)	2003-04-10	Verfahren zur Herstellung von Methanol
DE59707046D1 (de)	2002-05-23	Kontinuierliches Verfahren zur Herstellung von 4-Aminopiperidinen
DE69928463D1 (de)	2005-12-29	Verfahren zur Herstellung von Stahlkomponenten
DE50006772D1 (de)	2004-07-15	Verfahren zur herstellung von oxindolen
EP1320367A4 (de)	2007-01-17	Verfahren zur herstellung von dinapsolin
DE60113157D1 (de)	2005-10-06	Verbessertes verfahren zur herstellung von simvastatin
ATE238316T1 (de)	2003-05-15	Verfahren zur herstellung von phosphonomethylglycin
DE60109786D1 (de)	2005-05-04	Verfahren zur herstellung von hydroxylactonen
DE59811275D1 (de)	2004-06-03	Verfahren zur Herstellung von Akustik-Bauteilen
ATE233238T1 (de)	2003-03-15	Verfahren zur herstellung von 3-acyl-indolen
ATE268753T1 (de)	2004-06-15	Verfahren zur herstellung von 24(s)- hydroxyvitamin d2
DE60030483D1 (de)	2006-10-12	Ein verfahren zur herstellung von simvastatin