ATE291567T1 - Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten - Google Patents

Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten

Info

Publication number: ATE291567T1
Authority: AT; Austria
Prior art keywords: derivatives; aspirine; producing; nitroxymethylphenyl; esters
Prior art date: 1999-01-26

Application number

AT00904925T

Other languages

English (en)

Inventor

Soldato Piero Del

Michele Garufi

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-26

Filing date

2000-01-18

Publication date

2005-04-15

2000-01-18 Application filed by Nicox Sa filed Critical Nicox Sa

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291567T1 publication Critical patent/ATE291567T1/de

Links

BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical class CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title abstract 2
-1 NITROXYMETHYLPHENYL Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Indole Compounds (AREA)

AT00904925T 1999-01-26 2000-01-18 Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten ATE291567T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI000134A IT1307928B1 (it)	1999-01-26	1999-01-26	Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
PCT/EP2000/000353 WO2000044705A1 (en)	1999-01-26	2000-01-18	Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Publications (1)

Publication Number	Publication Date
ATE291567T1 true ATE291567T1 (de)	2005-04-15

Family

ID=11381613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00904925T ATE291567T1 (de)	1999-01-26	2000-01-18	Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten

Country Status (18)

Country	Link
US (1)	US6512137B1 (de)
EP (1)	EP1147074B1 (de)
JP (1)	JP2002535380A (de)
KR (1)	KR100732147B1 (de)
CN (2)	CN1191228C (de)
AT (1)	ATE291567T1 (de)
AU (1)	AU766497B2 (de)
BR (1)	BR0007643A (de)
CA (1)	CA2361454A1 (de)
DE (1)	DE60018902T2 (de)
ES (1)	ES2239588T3 (de)
HU (1)	HUP0105011A3 (de)
IL (1)	IL144234A0 (de)
IT (1)	IT1307928B1 (de)
PT (1)	PT1147074E (de)
RU (1)	RU2232747C2 (de)
WO (1)	WO2000044705A1 (de)
ZA (1)	ZA200105705B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6297260B1 (en)	1998-10-30	2001-10-02	Nitromed, Inc.	Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1312115B1 (it)	1999-06-24	2002-04-04	Nicox Sa	Composti amorfi e relative composizioni farmaceutiche
ITMI991517A1 (it)	1999-07-09	2001-01-09	Nicox Sa	Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
AP2002002582A0 (en)	1999-12-23	2002-09-30	Nitromed Inc	Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
IT1319202B1 (it) *	2000-10-12	2003-09-26	Nicox Sa	Farmaci per le malattie a base infiammatoria.
DE60122939T2 (de)	2000-12-21	2007-01-11	Nitromed, Inc., Bedford	Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
ITMI20011308A1 (it)	2001-06-21	2002-12-21	Nicox Sa	Farmaci per il dolore cronico
ITMI20011307A1 (it) *	2001-06-21	2002-12-21	Nicox Sa	Farmaci per l'epilessia
CA2487414A1 (en)	2002-06-11	2003-12-18	Nitromed, Inc.	Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005535642A (ja)	2002-06-28	2005-11-24	ニトロメッドインコーポレーティッド	オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
AU2003247792B2 (en) *	2002-07-03	2009-09-24	Nicox S.A.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) *	2002-07-29	2007-07-17	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
DE602004014822D1 (de) *	2003-11-20	2008-08-14	Nicox Sa	Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol
WO2005065361A2 (en) *	2003-12-31	2005-07-21	Khosrow Kashfi	Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
TW200616604A (en)	2004-08-26	2006-06-01	Nicholas Piramal India Ltd	Nitric oxide releasing prodrugs containing bio-cleavable linker
KR20070053214A (ko)	2004-08-26	2007-05-23	니콜라스 피라말 인디아 리미티드	신규 생분해성 링커를 함유하는 프로드럭
JP2007275193A (ja) *	2006-04-04	2007-10-25	Fujifilm Corp	光プローブおよび光断層画像化装置
EP2180788B1 (de)	2007-08-10	2016-12-21	Basil Rigas	Entzündungshemmende verbindungen und ihre verwendungen
ES2362894B1 (es) *	2009-11-16	2012-05-21	Ferrer Internacional S.A.	Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
EP2897621A4 (de) *	2012-09-21	2016-08-10	Basil Rigas	Verbindungen und zusammensetzungen zur verwendung bei der prävention und behandlung von entzündlichen erkrankungen, schmerzen und fieber, hauterkrankungen, krebs und präkanzerösen leiden
WO2014052889A1 (en) *	2012-09-27	2014-04-03	The Board Of Trustees Of The University Of Illinois	Anti-inflammatory agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1243367B (it) *	1990-07-26	1994-06-10	Italfarmaco Spa	Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1276071B1 (it) *	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
SV1997000108A (es) *	1997-12-18	1999-11-24	Manufacturas Humberto Bukele E	Sintesis de acido acetilsalicilico en presencia de oxido de calcio

1999
- 1999-01-26 IT IT1999MI000134A patent/IT1307928B1/it active
2000
- 2000-01-18 BR BR0007643-0A patent/BR0007643A/pt not_active Application Discontinuation
- 2000-01-18 HU HU0105011A patent/HUP0105011A3/hu unknown
- 2000-01-18 DE DE60018902T patent/DE60018902T2/de not_active Expired - Fee Related
- 2000-01-18 CA CA002361454A patent/CA2361454A1/en not_active Abandoned
- 2000-01-18 IL IL14423400A patent/IL144234A0/xx unknown
- 2000-01-18 CN CNB008051801A patent/CN1191228C/zh not_active Expired - Fee Related
- 2000-01-18 RU RU2001120697/04A patent/RU2232747C2/ru not_active IP Right Cessation
- 2000-01-18 PT PT00904925T patent/PT1147074E/pt unknown
- 2000-01-18 AU AU26645/00A patent/AU766497B2/en not_active Ceased
- 2000-01-18 JP JP2000595962A patent/JP2002535380A/ja not_active Withdrawn
- 2000-01-18 US US09/868,932 patent/US6512137B1/en not_active Expired - Fee Related
- 2000-01-18 WO PCT/EP2000/000353 patent/WO2000044705A1/en not_active Ceased
- 2000-01-18 EP EP00904925A patent/EP1147074B1/de not_active Expired - Lifetime
- 2000-01-18 AT AT00904925T patent/ATE291567T1/de not_active IP Right Cessation
- 2000-01-18 ES ES00904925T patent/ES2239588T3/es not_active Expired - Lifetime
- 2000-01-18 KR KR1020017009285A patent/KR100732147B1/ko not_active Expired - Fee Related
- 2000-01-18 CN CNA2004100636418A patent/CN1572787A/zh active Pending
2001
- 2001-07-11 ZA ZA200105705A patent/ZA200105705B/en unknown

Also Published As

Publication number	Publication date
WO2000044705A1 (en)	2000-08-03
EP1147074B1 (de)	2005-03-23
IT1307928B1 (it)	2001-11-29
ES2239588T3 (es)	2005-10-01
CA2361454A1 (en)	2000-08-03
KR100732147B1 (ko)	2007-06-25
RU2232747C2 (ru)	2004-07-20
BR0007643A (pt)	2001-10-16
AU766497B2 (en)	2003-10-16
DE60018902D1 (de)	2005-04-28
IL144234A0 (en)	2002-05-23
JP2002535380A (ja)	2002-10-22
CN1572787A (zh)	2005-02-02
KR20010101653A (ko)	2001-11-14
CN1344244A (zh)	2002-04-10
ITMI990134A1 (it)	2000-07-26
ZA200105705B (en)	2002-10-11
DE60018902T2 (de)	2006-03-30
PT1147074E (pt)	2005-07-29
HUP0105011A3 (en)	2002-12-28
US6512137B1 (en)	2003-01-28
CN1191228C (zh)	2005-03-02
HUP0105011A2 (hu)	2002-04-29
EP1147074A1 (de)	2001-10-24
AU2664500A (en)	2000-08-18

Legal Events

Date

Code

Title

Description

2005-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1147074

Country of ref document: EP

2009-10-15

REN

Ceased due to non-payment of the annual fee

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