ATE291577T1 - Cyanoindol-derivate als inhibitoren der wiederaufnahme von serotonin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen - Google Patents

Cyanoindol-derivate als inhibitoren der wiederaufnahme von serotonin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE291577T1
Authority: AT; Austria
Prior art keywords: reuppost; cyanoindole; serotonin; inhibitors; derivatives
Prior art date: 1999-10-12

Application number

AT00402799T

Other languages

English (en)

Inventor

Gilbert Lavielle

Olivier Muller

Mark Millan

Didier Cussac

Anne Dekeyne

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-12

Filing date

2000-10-11

Publication date

2005-04-15

2000-10-11 Application filed by Servier Lab filed Critical Servier Lab

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291577T1 publication Critical patent/ATE291577T1/de

Links

CBTITARLOCZPDU-UHFFFAOYSA-N 1h-indole-2-carbonitrile Chemical class C1=CC=C2NC(C#N)=CC2=C1 CBTITARLOCZPDU-UHFFFAOYSA-N 0.000 title abstract 3
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
239000003112 inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
229940076279 serotonin Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT00402799T 1999-10-12 2000-10-11 Cyanoindol-derivate als inhibitoren der wiederaufnahme von serotonin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen ATE291577T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9912668A FR2799463B1 (fr)	1999-10-12	1999-10-12	Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE291577T1 true ATE291577T1 (de)	2005-04-15

Family

ID=9550799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00402799T ATE291577T1 (de)	1999-10-12	2000-10-11	Cyanoindol-derivate als inhibitoren der wiederaufnahme von serotonin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen

Country Status (22)

Country	Link
US (1)	US6492366B1 (de)
EP (1)	EP1092715B1 (de)
JP (1)	JP3274454B2 (de)
KR (1)	KR100470692B1 (de)
CN (1)	CN1146568C (de)
AT (1)	ATE291577T1 (de)
AU (1)	AU774741B2 (de)
BR (1)	BR0004764A (de)
CA (1)	CA2323703C (de)
DE (1)	DE60018869T2 (de)
DK (1)	DK1092715T3 (de)
EA (1)	EA003831B1 (de)
ES (1)	ES2238260T3 (de)
FR (1)	FR2799463B1 (de)
HU (1)	HUP0003991A2 (de)
MX (1)	MXPA00009642A (de)
NO (1)	NO321242B1 (de)
NZ (1)	NZ507458A (de)
PL (1)	PL343148A1 (de)
PT (1)	PT1092715E (de)
SI (1)	SI1092715T1 (de)
ZA (1)	ZA200005625B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6693202B1 (en)	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
US7041683B2 (en)	2001-04-24	2006-05-09	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
WO2002085896A1 (en) *	2001-04-24	2002-10-31	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7276603B2 (en) *	2003-05-02	2007-10-02	Wyeth	Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
EP1751312A4 (de) *	2004-05-21	2010-01-27	Univ Duke	Polymorphismus bei tryptophanhydroxylase-2 als steuerung der gehirnserotoninsynthese
WO2012054815A1 (en)	2010-10-22	2012-04-26	Duke University	Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2043709C (en) *	1990-06-29	2002-01-22	David W. Smith	Antimigraine alkoxypyrimidine derivatives
HU225055B1 (en) *	1990-10-15	2006-05-29	Pfizer	Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
GB9208161D0 (en) *	1992-04-14	1992-05-27	Pfizer Ltd	Indoles
FR2701026B1 (fr) *	1993-02-02	1995-03-31	Adir	Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) *	1993-04-08	1997-05-27	Boehringer Ingelheim Italia	Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
ES2079323B1 (es) *	1994-06-21	1996-10-16	Vita Invest Sa	Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
WO1996001865A1 (en) *	1994-07-11	1996-01-25	Dsm N.V.	Multihydroxy-functional oligophenylene oxide
AR004229A1 (es) *	1995-11-06	1998-11-04	Wyeth Corp	Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US5912256A (en) *	1996-06-20	1999-06-15	Eli Lilly And Company	Compounds having effects on serotonin-related systems
US5998462A (en) *	1996-12-16	1999-12-07	Allelix Biopharmaceuticals Inc.	5-alkyl indole compounds

1999
- 1999-10-12 FR FR9912668A patent/FR2799463B1/fr not_active Expired - Fee Related
2000
- 2000-10-02 MX MXPA00009642A patent/MXPA00009642A/es active IP Right Grant
- 2000-10-10 BR BR0004764-3A patent/BR0004764A/pt not_active IP Right Cessation
- 2000-10-10 NO NO20005103A patent/NO321242B1/no unknown
- 2000-10-11 PT PT00402799T patent/PT1092715E/pt unknown
- 2000-10-11 SI SI200030652T patent/SI1092715T1/xx unknown
- 2000-10-11 EP EP00402799A patent/EP1092715B1/de not_active Expired - Lifetime
- 2000-10-11 EA EA200000929A patent/EA003831B1/ru not_active IP Right Cessation
- 2000-10-11 DE DE60018869T patent/DE60018869T2/de not_active Expired - Fee Related
- 2000-10-11 NZ NZ507458A patent/NZ507458A/xx unknown
- 2000-10-11 AT AT00402799T patent/ATE291577T1/de not_active IP Right Cessation
- 2000-10-11 US US09/686,056 patent/US6492366B1/en not_active Expired - Fee Related
- 2000-10-11 ES ES00402799T patent/ES2238260T3/es not_active Expired - Lifetime
- 2000-10-11 DK DK00402799T patent/DK1092715T3/da active
- 2000-10-12 CN CNB001314068A patent/CN1146568C/zh not_active Expired - Fee Related
- 2000-10-12 CA CA002323703A patent/CA2323703C/fr not_active Expired - Fee Related
- 2000-10-12 KR KR10-2000-0060013A patent/KR100470692B1/ko not_active Expired - Fee Related
- 2000-10-12 JP JP2000311550A patent/JP3274454B2/ja not_active Expired - Fee Related
- 2000-10-12 AU AU65479/00A patent/AU774741B2/en not_active Ceased
- 2000-10-12 ZA ZA200005625A patent/ZA200005625B/xx unknown
- 2000-10-12 PL PL00343148A patent/PL343148A1/xx not_active Application Discontinuation
- 2000-10-12 HU HU0003991A patent/HUP0003991A2/hu unknown

Also Published As

Publication number	Publication date
MXPA00009642A (es)	2002-05-23
SI1092715T1 (en)	2005-06-30
KR100470692B1 (ko)	2005-03-07
US6492366B1 (en)	2002-12-10
EP1092715B1 (de)	2005-03-23
CA2323703A1 (fr)	2001-04-12
CA2323703C (fr)	2005-08-16
HUP0003991A2 (en)	2002-06-29
HK1036062A1 (en)	2001-12-21
NZ507458A (en)	2002-03-28
BR0004764A (pt)	2001-05-29
PT1092715E (pt)	2005-06-30
DK1092715T3 (da)	2005-07-25
JP2001151772A (ja)	2001-06-05
EA200000929A3 (ru)	2001-06-25
NO20005103L (no)	2001-04-17
CN1146568C (zh)	2004-04-21
HU0003991D0 (en)	2000-12-28
EA003831B1 (ru)	2003-10-30
EP1092715A2 (de)	2001-04-18
CN1296010A (zh)	2001-05-23
NO20005103D0 (no)	2000-10-10
DE60018869T2 (de)	2006-02-02
ES2238260T3 (es)	2005-09-01
EA200000929A2 (ru)	2001-04-23
JP3274454B2 (ja)	2002-04-15
KR20010050984A (ko)	2001-06-25
EP1092715A3 (de)	2001-08-08
AU6547900A (en)	2001-04-26
AU774741B2 (en)	2004-07-08
PL343148A1 (en)	2001-04-23
NO321242B1 (no)	2006-04-10
FR2799463A1 (fr)	2001-04-13
DE60018869D1 (de)	2005-04-28
ZA200005625B (en)	2001-05-02
FR2799463B1 (fr)	2004-04-16

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2005-12-15

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