NO20005103L - Nye cyanoindol serotonin-reopptaks-inhibitorforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem - Google Patents

Nye cyanoindol serotonin-reopptaks-inhibitorforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem

Info

Publication number: NO20005103L
Authority: NO; Norway
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; cyanoindole; novel
Prior art date: 1999-10-12

Application number

NO20005103A

Other languages

English (en)

Other versions

NO321242B1 (no

NO20005103D0 (no

Inventor

Gilbert Lavielle

Olivier Muller

Mark Millan

Didier Cussac

Anne Dekeyne

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-12

Filing date

2000-10-10

Publication date

2001-04-17

2000-10-10 Application filed by Adir filed Critical Adir

2000-10-10 Publication of NO20005103D0 publication Critical patent/NO20005103D0/no

2001-04-17 Publication of NO20005103L publication Critical patent/NO20005103L/no

2006-04-10 Publication of NO321242B1 publication Critical patent/NO321242B1/no

Links

CBTITARLOCZPDU-UHFFFAOYSA-N 1h-indole-2-carbonitrile Chemical compound C1=CC=C2NC(C#N)=CC2=C1 CBTITARLOCZPDU-UHFFFAOYSA-N 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
229940126570 serotonin reuptake inhibitor Drugs 0.000 title 1
239000003772 serotonin uptake inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20005103A 1999-10-12 2000-10-10 Nye cyanoindol serotonin-reopptaks-inhibitorforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem NO321242B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9912668A FR2799463B1 (fr)	1999-10-12	1999-10-12	Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number	Publication Date
NO20005103D0 NO20005103D0 (no)	2000-10-10
NO20005103L true NO20005103L (no)	2001-04-17
NO321242B1 NO321242B1 (no)	2006-04-10

Family

ID=9550799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005103A NO321242B1 (no)	1999-10-12	2000-10-10	Nye cyanoindol serotonin-reopptaks-inhibitorforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Country Status (22)

Country	Link
US (1)	US6492366B1 (no)
EP (1)	EP1092715B1 (no)
JP (1)	JP3274454B2 (no)
KR (1)	KR100470692B1 (no)
CN (1)	CN1146568C (no)
AT (1)	ATE291577T1 (no)
AU (1)	AU774741B2 (no)
BR (1)	BR0004764A (no)
CA (1)	CA2323703C (no)
DE (1)	DE60018869T2 (no)
DK (1)	DK1092715T3 (no)
EA (1)	EA003831B1 (no)
ES (1)	ES2238260T3 (no)
FR (1)	FR2799463B1 (no)
HU (1)	HUP0003991A2 (no)
MX (1)	MXPA00009642A (no)
NO (1)	NO321242B1 (no)
NZ (1)	NZ507458A (no)
PL (1)	PL343148A1 (no)
PT (1)	PT1092715E (no)
SI (1)	SI1092715T1 (no)
ZA (1)	ZA200005625B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6693202B1 (en)	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
EP1381600A1 (en)	2001-04-24	2004-01-21	Wyeth, A Corporation of the State of Delaware	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en)	2001-04-24	2006-05-09	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US7276603B2 (en)	2003-05-02	2007-10-02	Wyeth	Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
WO2005112906A2 (en) *	2004-05-21	2005-12-01	Duke University	Method for augmenting the effects of serotonin reuptake inhibitors
ES2703255T3 (es)	2010-10-22	2019-03-07	Univ Duke	Formulaciones de liberación lenta de 5-hidroxitriptófano como un complemento para terapias pro-serotoninérgicas

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2043709C (en) *	1990-06-29	2002-01-22	David W. Smith	Antimigraine alkoxypyrimidine derivatives
PL168919B1 (pl) *	1990-10-15	1996-05-31	Pfizer	Sposób wytwarzania nowych pochodnych indolu PL PL PL PL
GB9208161D0 (en) *	1992-04-14	1992-05-27	Pfizer Ltd	Indoles
FR2701026B1 (fr) *	1993-02-02	1995-03-31	Adir	Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) *	1993-04-08	1997-05-27	Boehringer Ingelheim Italia	Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
ES2079323B1 (es) *	1994-06-21	1996-10-16	Vita Invest Sa	Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
WO1996001865A1 (en) *	1994-07-11	1996-01-25	Dsm N.V.	Multihydroxy-functional oligophenylene oxide
AR004229A1 (es) *	1995-11-06	1998-11-04	Wyeth Corp	Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US5912256A (en) *	1996-06-20	1999-06-15	Eli Lilly And Company	Compounds having effects on serotonin-related systems
US5998462A (en) *	1996-12-16	1999-12-07	Allelix Biopharmaceuticals Inc.	5-alkyl indole compounds

1999
- 1999-10-12 FR FR9912668A patent/FR2799463B1/fr not_active Expired - Fee Related
2000
- 2000-10-02 MX MXPA00009642A patent/MXPA00009642A/es active IP Right Grant
- 2000-10-10 NO NO20005103A patent/NO321242B1/no unknown
- 2000-10-10 BR BR0004764-3A patent/BR0004764A/pt not_active IP Right Cessation
- 2000-10-11 EA EA200000929A patent/EA003831B1/ru not_active IP Right Cessation
- 2000-10-11 AT AT00402799T patent/ATE291577T1/de not_active IP Right Cessation
- 2000-10-11 EP EP00402799A patent/EP1092715B1/fr not_active Expired - Lifetime
- 2000-10-11 SI SI200030652T patent/SI1092715T1/xx unknown
- 2000-10-11 DE DE60018869T patent/DE60018869T2/de not_active Expired - Fee Related
- 2000-10-11 NZ NZ507458A patent/NZ507458A/xx unknown
- 2000-10-11 ES ES00402799T patent/ES2238260T3/es not_active Expired - Lifetime
- 2000-10-11 US US09/686,056 patent/US6492366B1/en not_active Expired - Fee Related
- 2000-10-11 PT PT00402799T patent/PT1092715E/pt unknown
- 2000-10-11 DK DK00402799T patent/DK1092715T3/da active
- 2000-10-12 PL PL00343148A patent/PL343148A1/xx not_active Application Discontinuation
- 2000-10-12 JP JP2000311550A patent/JP3274454B2/ja not_active Expired - Fee Related
- 2000-10-12 CA CA002323703A patent/CA2323703C/fr not_active Expired - Fee Related
- 2000-10-12 HU HU0003991A patent/HUP0003991A2/hu unknown
- 2000-10-12 AU AU65479/00A patent/AU774741B2/en not_active Ceased
- 2000-10-12 CN CNB001314068A patent/CN1146568C/zh not_active Expired - Fee Related
- 2000-10-12 KR KR10-2000-0060013A patent/KR100470692B1/ko not_active Expired - Fee Related
- 2000-10-12 ZA ZA200005625A patent/ZA200005625B/xx unknown

Also Published As

Publication number	Publication date
HK1036062A1 (en)	2001-12-21
FR2799463A1 (fr)	2001-04-13
FR2799463B1 (fr)	2004-04-16
ZA200005625B (en)	2001-05-02
EP1092715A2 (fr)	2001-04-18
NO321242B1 (no)	2006-04-10
BR0004764A (pt)	2001-05-29
JP2001151772A (ja)	2001-06-05
EP1092715B1 (fr)	2005-03-23
NO20005103D0 (no)	2000-10-10
EA003831B1 (ru)	2003-10-30
EA200000929A2 (ru)	2001-04-23
NZ507458A (en)	2002-03-28
DE60018869T2 (de)	2006-02-02
ES2238260T3 (es)	2005-09-01
US6492366B1 (en)	2002-12-10
HUP0003991A2 (en)	2002-06-29
CA2323703A1 (fr)	2001-04-12
CN1146568C (zh)	2004-04-21
PT1092715E (pt)	2005-06-30
EA200000929A3 (ru)	2001-06-25
SI1092715T1 (en)	2005-06-30
AU6547900A (en)	2001-04-26
JP3274454B2 (ja)	2002-04-15
AU774741B2 (en)	2004-07-08
DK1092715T3 (da)	2005-07-25
EP1092715A3 (fr)	2001-08-08
KR20010050984A (ko)	2001-06-25
PL343148A1 (en)	2001-04-23
HU0003991D0 (en)	2000-12-28
CN1296010A (zh)	2001-05-23
MXPA00009642A (es)	2002-05-23
CA2323703C (fr)	2005-08-16
ATE291577T1 (de)	2005-04-15
DE60018869D1 (de)	2005-04-28
KR100470692B1 (ko)	2005-03-07

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