ATE291588T1 - Endothel-spezifischer expression unter einfluss von epcr kontrollelementen - Google Patents

Endothel-spezifischer expression unter einfluss von epcr kontrollelementen

Info

Publication number
ATE291588T1
ATE291588T1 AT97948205T AT97948205T ATE291588T1 AT E291588 T1 ATE291588 T1 AT E291588T1 AT 97948205 T AT97948205 T AT 97948205T AT 97948205 T AT97948205 T AT 97948205T AT E291588 T1 ATE291588 T1 AT E291588T1
Authority
AT
Austria
Prior art keywords
seq
endothelial cells
epcr
promoter
nucleotides
Prior art date
Application number
AT97948205T
Other languages
English (en)
Inventor
Charles T Esmon
Jian-Ming Gu
Original Assignee
Oklahoma Med Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of ATE291588T1 publication Critical patent/ATE291588T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cultivation Receptacles Or Flower-Pots, Or Pots For Seedlings (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Cultivation Of Seaweed (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Character Discrimination (AREA)
  • Glass Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT97948205T 1996-11-08 1997-11-07 Endothel-spezifischer expression unter einfluss von epcr kontrollelementen ATE291588T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3071896P 1996-11-08 1996-11-08
US5453397P 1997-08-04 1997-08-04
PCT/US1997/020364 WO1998020041A1 (en) 1996-11-08 1997-11-07 Endothelium specific expression regulated by epcr control elements

Publications (1)

Publication Number Publication Date
ATE291588T1 true ATE291588T1 (de) 2005-04-15

Family

ID=26706383

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97948205T ATE291588T1 (de) 1996-11-08 1997-11-07 Endothel-spezifischer expression unter einfluss von epcr kontrollelementen

Country Status (8)

Country Link
US (1) US6200751B1 (de)
EP (1) EP0937104B1 (de)
JP (1) JP2001503273A (de)
AT (1) ATE291588T1 (de)
AU (1) AU719629B2 (de)
CA (1) CA2270160A1 (de)
DE (1) DE69732847T2 (de)
WO (1) WO1998020041A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5695993A (en) 1994-08-12 1997-12-09 Oklahoma Medical Research Foundation Cloning and regulation of an endothelial cell protein C/activated protein C receptor
AU5321299A (en) * 1998-07-28 2000-02-21 Advanced Tissue Sciences, Inc. Genetically engineered cells and tissues
US6953568B1 (en) 1998-08-25 2005-10-11 Oklahoma Medical Research Foundation Targeting of molecules to large vessel endothelium using EPCR
ATE319826T1 (de) * 1998-10-19 2006-03-15 Powderject Vaccines Inc Minimale promotoren und ihre verwendung
US8039261B2 (en) * 2000-11-17 2011-10-18 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US20070286845A1 (en) * 2000-11-17 2007-12-13 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US20100282634A1 (en) * 2000-11-17 2010-11-11 Dror Harats Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis
US8071740B2 (en) 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
CA2463816C (en) 2001-10-19 2014-07-08 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
US20070142272A1 (en) * 2003-01-24 2007-06-21 Zlokovic Berislav V Neuroprotective activity of activated protein c independent of its anticoagulant activity
JP2008507561A (ja) * 2004-07-23 2008-03-13 ザ ユニバーシティ オブ ロチェスター 活性化プロテインｃによる、脳内のプラスミノゲン活性化因子の不都合な作用の阻害
WO2014123749A1 (en) 2013-01-30 2014-08-14 Board Of Regents Of The University Of Nebraska Compositions and methods for treating complications associated with diabetes
CN109897108B (zh) * 2019-03-11 2021-04-02 上海恒赛生物科技有限公司 抗人内皮蛋白c受体的羊驼单域抗体及应用
CN114457003A (zh) 2020-11-10 2022-05-10 维思尔治疗有限公司 预调节血管细胞用于转导的方法、转导方法和保存转导的细胞的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4244946A (en) 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
US4305872A (en) 1979-10-19 1981-12-15 Kenneth Wingrove Polypeptide derivatives
US4316891A (en) 1980-06-14 1982-02-23 The Salk Institute For Biological Studies Extended N-terminal somatostatin
US4792525A (en) 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4629784A (en) 1983-08-16 1986-12-16 The University Of Georgia Research Foundation, Inc. Synthesis of cyclopropane amino acids
WO1987000201A1 (en) 1985-07-05 1987-01-15 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4789734A (en) 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
EP0545913B1 (de) 1986-08-18 1999-02-24 Emisphere Technologies, Inc. Abgabesysteme für Arzneimittel
US5009889A (en) 1987-12-31 1991-04-23 Oklahoma Medical Research Foundation Treatment of dysfunctional vascular endothelium using activated protein C
US5298422A (en) * 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
US5466596A (en) 1992-08-25 1995-11-14 Mount Sinai Hospital Corporation Tissue specific transcriptional regulatory element
US5695993A (en) * 1994-08-12 1997-12-09 Oklahoma Medical Research Foundation Cloning and regulation of an endothelial cell protein C/activated protein C receptor

Also Published As

Publication number Publication date
EP0937104A1 (de) 1999-08-25
WO1998020041A1 (en) 1998-05-14
EP0937104B1 (de) 2005-03-23
CA2270160A1 (en) 1998-05-14
JP2001503273A (ja) 2001-03-13
DE69732847D1 (de) 2005-04-28
US6200751B1 (en) 2001-03-13
AU719629B2 (en) 2000-05-11
AU5431798A (en) 1998-05-29
DE69732847T2 (de) 2006-04-13

Similar Documents

Publication Publication Date Title
ATE291588T1 (de) Endothel-spezifischer expression unter einfluss von epcr kontrollelementen
ATE76428T1 (de) Expression und sekretion von polypeptiden in eukaryoten unter kontrolle eines adenoviruspromotors.
Keski-Oja et al. Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-beta
Dichek et al. Thrombin regulation of mRNA levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells
IL157644A0 (en) Method for the purification of a protein preparation with erythropoietin activity
JPS6485084A (en) Constellation of protein c
EP0212474A3 (de) Morphogenetische Knochenpeptide
MX9709549A (es) Adenovirus recombinantes, su uso para preparar aav, linea celular complementaria y composiciones farmaceuticas que los contienen.
EP0267851A3 (en) Hybrid promoter, expression controlling dna sequence and expression vector
ZA942778B (en) Recombinant viruses, and their preparation and use in gene therapy.
NO881670D0 (no) Diagnostisk proeve paa inhibitor for plasminogenaktivatorer av vev- og urokinasetype, samt gen som koder for inhibitoren.
NZ510121A (en) Use of VEGF-C or VEGF-D gene or protein to prevent restenosis of blood vessels
DE3688900D1 (de) Expression von protein c.
ES2103266T3 (es) Procedimiento de dna recombinante y celulas huesped.
CA2091102A1 (en) Microsomal triglyceride transfer protein
EP0321196A3 (de) Transkriptionsaktivator des 780 T-DNA-Gens
DK1045901T3 (da) Ribozymale nucleinsyrer, der spalter CCR5 eller CXCR4
Sandler et al. A novel protein interacts with the major transforming growth factor-beta responsive element in the plasminogen activator inhibitor type-1 gene.
IL155940A0 (en) Promoters exhibiting endothelial cell specificity and method of using same
FR2693463B1 (fr) Promoteur de levure et son utilisation.
Kim Cellular signaling in tissue regeneration
DE69433902D1 (de) Neuartige tyrosinkinase
Medcalf et al. Regulation of human tissue-type plasminogen activator gene transcription by epidermal growth factor and 3′, 5′-cyclic adenosine monophosphate
ATE199169T1 (de) Zusammensetzung von antwortelementen und ihre verwendung als proben
Stopeck et al. Transfer and expression of the interferon gamma gene in human endothelial cells inhibits vascular smooth muscle cell growth in vitro

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties