ATE291918T1 - Kombinationstherapie zur behandlung von tumoren - Google Patents

Kombinationstherapie zur behandlung von tumoren

Info

Publication number: ATE291918T1
Authority: AT; Austria
Prior art keywords: combination therapy; tumors; treatment; gastrin; combination
Prior art date: 1998-05-15

Application number

AT99921972T

Other languages

English (en)

Inventor

Philip C Gevas

Stephen Grimes

Stephen L Karr

Susan A Watson

Dov Michaeli

Original Assignee

Aphton Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-15

Filing date

1999-05-14

Publication date

2005-04-15

1999-05-14 Application filed by Aphton Corp filed Critical Aphton Corp

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291918T1 publication Critical patent/ATE291918T1/de

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
238000002648 combination therapy Methods 0.000 title abstract 2
FOQYDURHXZVLFT-UHFFFAOYSA-N 2-phenyl-2-pyridin-2-ylethanethioamide Chemical compound C=1C=CC=NC=1C(C(=S)N)C1=CC=CC=C1 FOQYDURHXZVLFT-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
102100021022 Gastrin Human genes 0.000 abstract 1
108010052343 Gastrins Proteins 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
229940127089 cytotoxic agent Drugs 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
229960002949 fluorouracil Drugs 0.000 abstract 1
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 1
235000008191 folinic acid Nutrition 0.000 abstract 1
239000011672 folinic acid Substances 0.000 abstract 1
238000002649 immunization Methods 0.000 abstract 1
230000003053 immunization Effects 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1
229960001691 leucovorin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2207—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Mycology (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT99921972T 1998-05-15 1999-05-14 Kombinationstherapie zur behandlung von tumoren ATE291918T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8568798P	1998-05-15	1998-05-15
PCT/US1999/010750 WO1999059628A2 (en)	1998-05-15	1999-05-14	Combination therapy for the treatment of tumors

Publications (1)

Publication Number	Publication Date
ATE291918T1 true ATE291918T1 (de)	2005-04-15

Family

ID=22193286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99921972T ATE291918T1 (de)	1998-05-15	1999-05-14	Kombinationstherapie zur behandlung von tumoren

Country Status (15)

Country	Link
EP (1)	EP1076561B1 (de)
JP (1)	JP2002515457A (de)
KR (1)	KR100699574B1 (de)
CN (1)	CN1216605C (de)
AT (1)	ATE291918T1 (de)
AU (1)	AU745749B2 (de)
CA (1)	CA2327439C (de)
DE (1)	DE69924483T2 (de)
DK (1)	DK1076561T3 (de)
ES (1)	ES2237103T3 (de)
HU (1)	HUP0101947A3 (de)
PL (1)	PL193109B1 (de)
PT (1)	PT1076561E (de)
WO (1)	WO1999059628A2 (de)
ZA (1)	ZA200005962B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005508838A (ja) *	2001-03-23	2005-04-07	アフトンコーポレーション	膵癌の組合せ治療
JP2004536835A (ja) *	2001-07-09	2004-12-09	アフトンコーポレーション	肝臓、肺および食道の癌性ならびに前癌性状態の治療および防止
US20040208920A1 (en) *	2002-07-03	2004-10-21	Dov Michaeli	Liposomal vaccine
JP4689597B2 (ja)	2003-03-28	2011-05-25	レセプターバイオロジックスインク．	ガストリンホルモン免疫アッセイ
US20050053664A1 (en) *	2003-09-08	2005-03-10	Eliezer Zomer	Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
CN101797382B (zh) *	2010-03-03	2013-11-20	戚胜美	抗人前胃液素多肽免疫组合物
US8674064B2 (en)	2010-03-03	2014-03-18	Onkologix Ltd	Immunogenic compositions against human progastrin peptides
EA201100464A1 (ru) *	2011-04-06	2012-10-30	Ооо "Метамакс" (Ооо "Метамах")	Фармацевтическая композиция для лечения гиперпролиферативных заболеваний и её применение
DK3071206T3 (da)	2013-11-22	2021-05-25	CL BioSciences LLC	Gastrinantagonister (eg yf476, netazepid) til behandling og forebyggelse af osteoporose
US12150978B2 (en)	2017-06-15	2024-11-26	Cancer Advances Inc.	Compositions and methods for preventing tumors and cancer
WO2018232230A1 (en)	2017-06-15	2018-12-20	Cancer Advances Inc.	Compositions and methods for inducing humoral and cellular immunities against tumors and cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341281C (en) *	1986-07-09	2001-08-07	Hubert J.P. Schoemaker	Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen
ES2063912T3 (es) *	1989-01-24	1995-01-16	Aphton Corp	Composiciones inmunogenicas frente a peptidos de gastrina.
US5468494A (en) *	1993-11-12	1995-11-21	Aphton Corp.	Immunogenic compositions against human gastrin 17

1999
- 1999-05-14 KR KR1020007012783A patent/KR100699574B1/ko not_active Expired - Fee Related
- 1999-05-14 ES ES99921972T patent/ES2237103T3/es not_active Expired - Lifetime
- 1999-05-14 PL PL344414A patent/PL193109B1/pl not_active IP Right Cessation
- 1999-05-14 HU HU0101947A patent/HUP0101947A3/hu unknown
- 1999-05-14 EP EP99921972A patent/EP1076561B1/de not_active Expired - Lifetime
- 1999-05-14 AU AU39045/99A patent/AU745749B2/en not_active Expired
- 1999-05-14 CA CA002327439A patent/CA2327439C/en not_active Expired - Lifetime
- 1999-05-14 JP JP2000549292A patent/JP2002515457A/ja active Pending
- 1999-05-14 AT AT99921972T patent/ATE291918T1/de not_active IP Right Cessation
- 1999-05-14 DK DK99921972T patent/DK1076561T3/da active
- 1999-05-14 DE DE69924483T patent/DE69924483T2/de not_active Expired - Lifetime
- 1999-05-14 CN CN998060119A patent/CN1216605C/zh not_active Expired - Lifetime
- 1999-05-14 PT PT99921972T patent/PT1076561E/pt unknown
- 1999-05-14 WO PCT/US1999/010750 patent/WO1999059628A2/en not_active Ceased
2000
- 2000-10-24 ZA ZA200005962A patent/ZA200005962B/en unknown

Also Published As

Publication number	Publication date
HUP0101947A2 (hu)	2001-11-28
WO1999059628A2 (en)	1999-11-25
EP1076561A2 (de)	2001-02-21
KR100699574B1 (ko)	2007-03-23
KR20010052355A (ko)	2001-06-25
CA2327439A1 (en)	1999-11-25
DE69924483D1 (de)	2005-05-04
JP2002515457A (ja)	2002-05-28
CN1216605C (zh)	2005-08-31
DK1076561T3 (da)	2005-06-06
AU3904599A (en)	1999-12-06
CN1303288A (zh)	2001-07-11
AU745749B2 (en)	2002-03-28
ZA200005962B (en)	2002-01-24
DE69924483T2 (de)	2006-02-09
PL193109B1 (pl)	2007-01-31
ES2237103T3 (es)	2005-07-16
PT1076561E (pt)	2005-08-31
CA2327439C (en)	2005-07-05
EP1076561B1 (de)	2005-03-30
WO1999059628A3 (en)	2000-01-13
PL344414A1 (en)	2001-11-05
HK1032360A1 (en)	2001-07-20
HUP0101947A3 (en)	2001-12-28

Legal Events

Date

Code

Title

Description

2006-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1076561

Country of ref document: EP

2010-02-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
EA200000994A1 (ru)	2001-02-26	Применение кабэрголина при лечении синдрома усталых ног
ATE393831T1 (de)	2008-05-15	Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
DE10199020I2 (de)	2004-05-06	Galanthamin oder dessen Analoge zur Behandlung derAlzheimerschen Krankheit.
DE69733132D1 (de)	2005-06-02	Verwendung von antioxidantien zur behandlung cholestatischer lebererkrankungen
UA42747C2 (uk)	2001-11-15	Похідні пептиду,фармацевтична композиція та спосіб стимулювання секреції гормону росту
ATE331534T1 (de)	2006-07-15	Anwendung von zielgerichtetem radium 223 für palliative und therapeutische behandlung von knochenkrebs
DE3684190D1 (de)	1992-04-16	Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
GR3034162T3 (en)	2000-11-30	Liposome-encapsulated taxol, its preparation and its use
DK85786A (da)	1986-09-06	Biologisk aktive fragmenter af human antihaemofilisk faktor og fremgangsmaade til fremstilling deraf
SE9404196D0 (sv)	1994-12-02	New antithrombotic formulation
ES2114616T5 (es)	2002-07-16	Acidos dicarboxilicos alifaticos insaturados.
DE69731652D1 (de)	2004-12-23	Verfahren zur behandlung von endothelialen verletzungen
ATE232394T1 (de)	2003-02-15	Verwendung von modifiziertem c-reaktiven protein zur herstellung eines medikaments zur behandlung von krebs
BR9813318A (pt)	2000-08-22	Processo de tratamento de tumores e degeneração macular em paciente humano ou veterinário, composição farmacêutica para tratamento de tumores e degeneração macular em um paciente humano ou veterinário
GR3022321T3 (en)	1997-04-30	Use of il-4 to treat solid tumors
ATE368455T1 (de)	2007-08-15	Verwendung von (+)-tramadol, o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz
DE69924483D1 (de)	2005-05-04	Kombinationstherapie zur behandlung von tumoren
DE69310528D1 (de)	1997-06-12	Verwendung von parathormone, seinen biologisch aktiven fragmenten oder von verwandten peptiden zur behandlung von schwangerschaft
DE69316013D1 (de)	1998-02-05	Verwendung von phosphinate zur behandlung der osteoporose
MX9701187A (es)	1997-05-31	Nuevas lactamas naftofusionadas n-substituidas.
ATE201598T1 (de)	2001-06-15	Verwendung von moxonidin zur behandlung neuropathischer schmerzen
IL133172A (en)	2005-03-20	Diphosphonic acid salts for the treatment of osteoporosis
MXPA00010254A (es)	2002-08-06	Tratamiento de disfuncion sexual en ciertos grupos de pacientes.
DE69818809D1 (de)	2003-11-13	Verfahren zur behandlung von narbengewebe
DE69734349D1 (de)	2006-02-23	Behandlung von knochenleiden mit adrenomedullin